Abstract：
:Intravenous injection of prostacyclin (100 micrograms/kg) in rats resulted in a decrease of systolic blood pressure within 2 minutes. Concentrations of cAMP in 15 brain regions and nuclei were determined by radioimmunoassay. In lower brain stem nuclei, such as the nucleus of the solitary tract and the lateral reticular nucleus (A1 and C1 catecholaminergic cell groups) cAMP levels were depleted significantly, while in others, including the locus coeruleus and the periaqueductal central gray, cAMP levels did not show any alterations. Levels of cAMP were also depleted in some of the hypothalamic nuclei (periventricular, anterior hypothalamic, ventromedial), and in cerebral cortical areas. Lowered cAMP levels in brain areas might indicate lower cellular activity in cells participating in baroreceptor control mechanisms.
journal_name
Life Scijournal_title
Life sciencesauthors
Schmid G,Bahner U,Palkovits M,Geiger H,Heidland Adoi
10.1016/0024-3205(87)90439-5subject
Has Abstractpub_date
1987-12-07 00:00:00pages
2547-53issue
23eissn
0024-3205issn
1879-0631pii
0024-3205(87)90439-5journal_volume
41pub_type
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