Acute changes in cerebral blood flow after smoking marijuana.

abstract：:The binding characteristics of the sigma-1 selective benzomorphan [3H]-(+)-pentazocine were determined in human cerebellar membranes. Saturation binding analysis revealed two affinity sites with a KDH of 1.4 +/- 0.7 nM and a KDL of 33.6 +/- 11.9 nM. Kinetic studies performed at 25 degrees C demonstrated reversible bin...

journal_title：Life sciences

authors： Zabetian CP,Staley JK,Flynn DD,Mash DC

更新日期：1994-01-01 00:00:00

abstract：AIMS:The beneficial effects of cannabinoid type 2 receptor (CB2R) activation have been verified in various tissue repair processes. Our recent study revealed CB2R activation promotes myogenesis partly through Nrf2 signaling in a mouse skeletal muscle ischemia-reperfusion (IR) injury model. Other relevant mechanisms nee...

journal_title：Life sciences

authors： Jiang P,Wang L,Zhang M,Zhang M,Wang C,Zhao R,Guan D

更新日期：2020-09-01 00:00:00

abstract：:Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There...

journal_title：Life sciences

authors： Li C,Li Q,Mei Q,Lu T

更新日期：2015-04-01 00:00:00

abstract：:Identification of the neural substrates subserving audiogenic convulsions in the GEPR is an important task and while it is not yet complete, many laboratories employing various techniques have contributed importantly to our current understanding. The present review focuses on the use of lesions to identify the neural ...

journal_title：Life sciences

authors： Browning RA

更新日期：1986-09-08 00:00:00

abstract：:Sustained levels of leucine comparable to those of human Maple Syrup Urine Disease (MSUD) were achieved in blood and brain of rats by subcutaneous leucine administration twice a day from the 6th to the 28th day of life. Control rats were treated with saline in the same volumes. Behavioral studies using aversive and no...

journal_title：Life sciences

authors： Mello CF,Feksa L,Brusque AM,Wannmacher CM,Wajner M

更新日期：1999-01-01 00:00:00

abstract：:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-...

journal_title：Life sciences

authors： Matera MG,D'agostino B,Cardone M,Calderaro V,Rossi F

更新日期：1995-02-17 00:00:00

abstract：:The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...

journal_title：Life sciences

authors： Bhattacharya D,Majrashi M,Ramesh S,Govindarajulu M,Bloemer J,Fujihashi A,Crump BR,Hightower H,Bhattacharya S,Moore T,Suppiramaniam V,Dhanasekaran M

更新日期：2018-02-01 00:00:00

abstract：:Adult female Sprague-Dawley rats were prepared with permanent cortical EEG and temporalis EMG electrodes and i.v. cannulae. They were made tolerant to and physically dependent on morphine by automatic, hourly injections. These physically dependent rats were then trained to lever press for 10 mg/kg injections of morphi...

journal_title：Life sciences

authors： Khazan N,Young GA,Calligaro D

更新日期：1983-01-01 00:00:00

abstract：:New types of alpha1-adrenoceptor antagonists (tamsulosin, KMD-3213 and JTH-601) are currently receiving a great deal of attention, especially in terms of developing effective therapeutic agents to treat bladder outlet obstruction with less side effects, such as postural hypotension, in patients with benign prostatic h...

journal_title：Life sciences

authors： Yamada S,Ohkura T,Kimura R,Kawabe K

更新日期：1998-01-01 00:00:00

abstract：:Vanilloid spice principles, including capsaicin, stimulate vasoconstriction in the rat hindlimb perfused at constant flow and, depending on dose, either stimulate or inhibit oxygen consumption by this vascular bed. We now present metabolic and functional evidence for two different vanilloid (VN1 and VN2) receptor type...

journal_title：Life sciences

authors： Colquhoun EQ,Eldershaw TP,Bennett KL,Hall JL,Dora KA,Clark MG

更新日期：1995-01-01 00:00:00

abstract：AIM:Myokines are associated with regulation of bone and muscle mass. However, limited information is available regarding the impact of myokines on glucocorticoid (GC) mediated adverse effects on the musculoskeletal system. This study investigates the role of myokine fibroblast growth factor-2 (FGF-2) in regulating GC-i...

journal_title：Life sciences

authors： Adhikary S,Choudhary D,Tripathi AK,Karvande A,Ahmad N,Kothari P,Trivedi R

更新日期：2019-07-15 00:00:00

abstract：:The specific binding of 35S-t-butylbicyclophosphorothionate (TBPS) was studied in synaptosomal membranes of rat cerebral cortex. The displacing potencies of eleven CNS depressants and three convulsants were determined in the presence of 1 microM GABA and 10 nM R 5135. GABA enhanced the displacing potencies of depressa...

journal_title：Life sciences

authors： Maksay G,Ticku MK

更新日期：1988-01-01 00:00:00

abstract：:Chronic social defeat stress (CSDS) is an ethologically relevant psychosocial stress animal model and has been widely used in depression studies. Ginsenoside Rg1 (Rg1) is the major active ingredients of ginseng with low toxicity and neuroprotective effects. The present study aims to investigate the antidepressant effe...

journal_title：Life sciences

authors： Jiang N,Lv J,Wang H,Huang H,Wang Q,Lu C,Zeng G,Liu XM

更新日期：2020-07-01 00:00:00

abstract：:Certain pharmacological properties of methyl beta-carboline-3-carboxylate (beta-CCM), a benzodiazepine receptor ligand, have been investigated in chicks. Although beta-CCM has been established previously as an "inverse agonist" of benzodiazepine receptors in rodents, having effects opposite to those of benzodiazepines...

journal_title：Life sciences

authors： Venault P,Prado de Carvalho L,Brown CL,Dodd RH,Rossier J,Chapouthier G

更新日期：1986-09-22 00:00:00

abstract：AIM:Although constitutive autophagy is linked to redox state and participates in cell homeostasis, it is scarcely known if redox state, autophagy, and lysosomal function depend on sex, a factor that largely influences health and diseases. Therefore, we evaluated the existence of sex differences in redox state and const...

journal_title：Life sciences

authors： Campesi I,Straface E,Occhioni S,Montella A,Franconi F

更新日期：2013-08-06 00:00:00

abstract：AIMS:Aristolochic acid (AA) nephrotoxicity is related to accumulation of methylglyoxal (MGO) and N(ε)-(carboxymethyl)lysine (CML) in the mouse kidney. We studied the activity of renal semicarbazide-sensitive amine oxidase (SSAO), a key enzyme involved in MGO generation, in AA-treated mice, and investigated nephroprotec...

journal_title：Life sciences

authors： Huang TC,Chen SM,Li YC,Lee JA

更新日期：2014-09-26 00:00:00

abstract：:The circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been determined in male and female rats at 3 weeks and at 2, 8, 14 and 20 months of age. All animals have a pronounced circadian pattern of aMT6s excretion under a 12 hour dark: 12 hour light cycle. A significant increase in aMT6s excretion is observe...

journal_title：Life sciences

authors： Yie SM,Liu GY,Johansson E,Brown C,Brown GM

更新日期：1992-01-01 00:00:00

abstract：:The effect of local pH on the in vivo efflux of endogenous dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) following administration of d-amphetamine (AMPH) was examined in the striatum of the anesthetized rat using two bilaterally placed push-pull cannulae. At both pH 7.3 and 6.4, the baseline efflux values f...

journal_title：Life sciences

authors： Guan XM,McBride WJ

更新日期：1988-01-01 00:00:00

abstract：:The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...

journal_title：Life sciences

authors： Abe F,Ueyama J,Kimata A,Kato M,Hayashi T,Nadai M,Saito H,Takeyama N,Noguchi H,Hasegawa T

更新日期：2008-08-15 00:00:00

abstract：:Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats. ...

journal_title：Life sciences

authors： Bolander HG,Kourtopoulos H

更新日期：1985-03-11 00:00:00

abstract：:Muscarinic receptors are expressed in smooth muscle throughout the body. In most instances, the muscarinic receptor population in smooth muscle is composed of mainly the M2 and M3 subtypes in an 80% to 20% mixture. The M3 subtype mediates phosphoinositide hydrolysis and calcium mobilization, whereas the M2 subtype med...

journal_title：Life sciences

authors： Ehlert FJ,Ostrom RS,Sawyer GW

更新日期：1997-01-01 00:00:00

abstract：:Sodium-dependent transport of D-glucose has been reported only in epithelial cells of small intestine and kidney, and well-differentiated tumors thereof. We observed a two-fold decrease (p < 0.05) in the intracellular distribution volume (Vic, defined as steady-state intracellular uptake divided by extracellular conce...

journal_title：Life sciences

authors： Bading JR,Mircheff AK,Kan-Mitchell J

更新日期：1996-01-01 00:00:00

abstract：AIMS:Lithium is a common mood stabilizer to treat bipolar disorder. It has a narrow window of therapeutic action and its mechanism of action and possible side effects are still not fully understood. Lithium is a potent inhibitor of glycogen synthase kinase 3β (GSK-3β). Previous studies indicated that lithium can induce...

journal_title：Life sciences

authors： Tsui MM,Tai WC,Wong WY,Hsiao WL

更新日期：2012-09-24 00:00:00

abstract：:Electrically evoked release of dopamine from the caudate nucleus is reduced by the dopamine receptor agonists, apomorphine and bromocriptine, and facilitated by neuroleptic drugs, which act as dopamine autoreceptor antagonists. The potencies of chlorpromazine, fluphenazine, levomepromazine and their hydroxy-metabolite...

journal_title：Life sciences

authors： Nowak JZ,Arbilla S,Dahl SG,Langer SZ

更新日期：1990-01-01 00:00:00

abstract：AIMS:Although dexamethasone (Dex) is used widely as an anti-inflammatory and immunosuppressive drug, Dex appears to have severe side-effects, including osteoporosis. This study determined the effects of Dex on duodenal and renal expressions of the calcium-processing genes transient receptor potential cation channel, su...

journal_title：Life sciences

authors： Kim MH,Lee GS,Jung EM,Choi KC,Jeung EB

更新日期：2009-07-17 00:00:00

abstract：:DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are ...

journal_title：Life sciences

authors： Zhou Q,You C,Zheng C,Gu Y,Gu H,Zhang R,Wu H,Sun B

更新日期：2018-08-01 00:00:00

abstract：:[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorp...

journal_title：Life sciences

authors： Young E,Walker JM,Houghten R,Akil H

更新日期：1983-01-01 00:00:00

abstract：:Lymphocyte apoptosis occurs in response to stressors such as thermal injury, trauma, sepsis, and surgery. This study evaluated the effect of a single bout of physical exercise stress on the induction of apoptosis in murine thymocytes and splenic lymphocytes. Female C57BL/6 mice, treadmill exercised at a submaximal int...

journal_title：Life sciences

authors： Hoffman-Goetz L,Zajchowski S,Aldred A

更新日期：1999-01-01 00:00:00

abstract：:Efficacy of chemotherapy may be maximized and its toxicity can be minimized if drugs would be administered at specified daily times. The present study was aimed to examine if the protection of amifostine against cisplatin toxicity is time dependent. Amifostine is an organic thiophosphate that protects selectively norm...

journal_title：Life sciences

authors： Asna N,Lewy H,Ashkenazi IE,Deutsch V,Peretz H,Inbar M,Ron IG

更新日期：2005-03-04 00:00:00

abstract：:P-glycoprotein (P-gp) is found to play a very significant role in intestinal and biliary transport of irinotecan and its active metabolite, SN-38. This makes P-gp inhibition a logical strategy for improving irinotecan's oral efficacy and reducing its toxicity. The objective of the present study was to identify the mos...

journal_title：Life sciences

authors： Bansal T,Awasthi A,Jaggi M,Khar RK,Talegaonkar S

更新日期：2008-08-15 00:00:00