Age-associated changes and sex differences in urinary 6-sulphatoxymelatonin circadian rhythm in the rat.

abstract：AIMS:The aim of the present study was to investigate the protective effects of AGK2 as a selective SIRT2 inhibitor on thioacetamide (TAA)-induced acute liver failure (ALF) in mice and its potential mechanism. MAIN METHODS:All male C57BL/6 mice were separated into control, TAA, AGK2 + TAA, and AGK2 groups. The histolog...

journal_title：Life sciences

authors： Jiao FZ,Wang Y,Zhang WB,Zhang HY,Chen Q,Shi CX,Wang LW,Gong ZJ

更新日期：2019-08-01 00:00:00

abstract：AIMS:Currently, chronic gastritis is a high incidence of digestive diseases, along with loss of appetite, abdominal pain and diarrhea. Baicalin belongs to the major bioactive flavonoids compounds from Scutellariae Radix, it exhibited anti-inflammatory and anti-bacteria activities. Nonetheless, the protective effects of...

journal_title：Life sciences

authors： Ji W,Liang K,An R,Wang X

更新日期：2019-12-15 00:00:00

abstract：:The purpose of the present study was to investigate whether Lewis (LEW) and spontaneously hypertensive rats (SHR), characterized in numerous behavioral tests as strains with high-anxiety and low-anxiety, respectively, could differ in their sensitivity to the effects of ethanol in the elevated plus maze (EPM) and the o...

journal_title：Life sciences

authors： Da Silva GE,Vendruscolo LF,Takahashi RN

更新日期：2005-06-24 00:00:00

abstract：AIMS:Although approving new anticonvulsants was a major breakthrough in the field of epilepsy control, so far we have met limited success in almost one third of patients suffering from epilepsy and a definite and reliable method is yet to be found. Levosimendan demonstrated neuroprotective effects and reduced mortality...

journal_title：Life sciences

authors： Gooshe M,Tabaeizadeh M,Aleyasin AR,Mojahedi P,Ghasemi K,Yousefi F,Vafaei A,Amini-Khoei H,Amiri S,Dehpour AR

更新日期：2017-01-01 00:00:00

abstract：:Platelet functions are becoming the useful tool for delineating the etiology of pregnancy induced hypertension. Electronmicroscopic studies, efflux and content of 5-HT in platelets and platelet aggregation responses towards various aggregating agents have been measured in 25 normotensive pregnant subjects and 31 PIH s...

journal_title：Life sciences

authors： Gujrati VR,Goyal A,Gaur SP,Singh N,Shanker K,Chandravati

更新日期：1994-01-01 00:00:00

abstract：:We investigated serum levels of type III procollagen aminopeptide (CIII), 7S type IV collagen (CIV), and tissue inhibitor of metalloproteinase (TIMP) in 33 patients with type II diabetes mellitus (DM) without uremia (serum creatinine less than 1.5 mg/dl). The patients were divided into three groups based on measuremen...

journal_title：Life sciences

authors： Ishimura E,Nishizawa Y,Shoji S,Mori H

更新日期：1996-01-01 00:00:00

abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Regulation of SSAT gene transcription requires the additional interaction of Nr...

journal_title：Life sciences

authors： Stephenson AH,Seidel ER

更新日期：2006-08-22 00:00:00

abstract：:The immunosuppressive effects of microcolin A, a lipopeptide extracted from the marine blue green alga Lyngbya majuscula were investigated. Microcolin A suppressed concanavalin A (IC50 = 5.8 nM), phytohemagglutinin (IC50 = 12.5 nM) and lipopolysaccharide (IC50 = 8.0 nM) induced proliferation of murine splenocytes. Mix...

journal_title：Life sciences

authors： Zhang LH,Longley RE,Koehn FE

更新日期：1997-01-01 00:00:00

abstract：:Strips of bovine mesenteric arteries brought to sustained contraction by the addition of 3.0 microM phenylephrine relaxed when exposed to ultraviolet radiation (366 nm). The relaxation was reversible and associated with a rapid increase in the cGMP content. After termination of the radiation the cGMP level rapidly dec...

journal_title：Life sciences

authors： Karlsson JO,Axelsson KL,Andersson RG

更新日期：1984-04-16 00:00:00

abstract：:The present investigation was aimed at comparing the influence of the partial dopamine (DA) receptor agonist (-)-3-PPP (preclamol) on prolactin release in acutely hyperprolactinemic but otherwise intact female rats and female rats subjected to chronic DA depletion. One group of animals received daily vehicle injection...

journal_title：Life sciences

authors： Carlsson M,Eriksson E

更新日期：1988-01-01 00:00:00

abstract：AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. M...

journal_title：Life sciences

authors： Yousefvand S,Hadjzadeh MA,Vafaee F,Dolatshad H

更新日期：2020-12-15 00:00:00

abstract：:Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was d...

journal_title：Life sciences

authors： Margareto J,Aguado M,Osés-Prieto JA,Rivero I,Monge A,Aldana I,Marti A,Martínez JA

更新日期：2000-11-24 00:00:00

abstract：:It was examined whether the digoxin-like immunoreactive substance (DLIS) extracted from cord blood has a natriuretic activity. The DLIS was prepared from cord blood of healthy fullterm infants by acetone-HCl extraction and a gel filtration column. A solution (solution A) containing 1.0 ng/ml of DLIS or another solutio...

journal_title：Life sciences

authors： Ebara H,Suzuki S,Nagashima K,Kuroume T

更新日期：1988-01-01 00:00:00

abstract：:Subcutaneous administration of naloxone at 1 to 10 mg/kg produced a dose-related decrease in feed intake of broiler chicks. Food deprivation for 3, 6, 12, and 24 hours produced a significant increase in feed intake compared to non-food deprived birds. Subcutaneous administration of naloxone at 1 to 10 mg/kg failed to ...

journal_title：Life sciences

authors： Sangiah S,Alavi FK,Teeter RG,Amouzadeh HR,Mauromoustakos A

更新日期：1988-01-01 00:00:00

abstract：:The present study investigated the protective actions of the antioxidant scutellarin against the cytotoxicity produced by exposure to H2O2 in PC12 cells. This was done by assaying for MTT (3,(4,5-dimethylthiazole-2-yl)2,5-diphenyl-tetrazolium bromide) reduction and lactate dehydrogenase (LDH) release. Reactive oxygen ...

journal_title：Life sciences

authors： Hong H,Liu GQ

更新日期：2004-04-30 00:00:00

abstract：AIMS:Peptides and a dysregulated immune system play a role in the pathophysiology of autism. Dysfunctions in prolyl endopeptidase (PEP) and dipeptidyl peptidase IV (DPP-IV) may underpin both the peptidergic and immune alterations in autism. The aims of this study are to: (i) delineate serum PEP and DPP-IV enzyme activi...

journal_title：Life sciences

authors： Frenssen F,Croonenberghs J,Van den Steene H,Maes M

更新日期：2015-09-01 00:00:00

abstract：:The effects of sucrose feeding on parameters associated with (Na+,K+)-ATPase in brown adipose tissue were compared in rats treated with parenteral 6-hydroxydopamine and vehicle. Sucrose feeding significantly increased K+-p-nitrophenylphosphatase and ouabain binding in brown adipose tissue from rats treated with vehicl...

journal_title：Life sciences

authors： Swann AC

更新日期：1984-01-23 00:00:00

abstract：:The effects of various vasorelaxant agents on aortas from control and genetically diabetic rats were examined. The concentration-response curves for the isoproterenol (ISO)-induced relaxation of both aortic strips with and without endothelium are shifted to the right in diabetic rats. The relaxation responses of diabe...

journal_title：Life sciences

authors： Miyata N,Yamaura H,Tsuchida K,Otomo S,Kamata K,Kasuya Y

更新日期：1992-01-01 00:00:00

abstract：:The distribution pattern of ascorbic acid in the endocrine organs and/or tissues was investigated during various sexual states of female rats to demonstrate a correlation between ascorbic acid concentration and sex hormone activity. The concentration of ascorbic acid was estimated in the plasma, liver, pancreas, thyro...

journal_title：Life sciences

authors： Das PC,Das KP,Bagchi K,Dey CD

更新日期：1993-01-01 00:00:00

abstract：:Nitric oxide is involved in a countless number of physiological processes and is known to have cytoprotective as well as cytotoxic effects. Increased knowledge about the multifaceted role of nitric oxide in a variety of disease states has led to the design of multiple treatment strategies involving the nitric oxide sy...

journal_title：Life sciences

authors： Grant MK,El-Fakahany EE

更新日期：2004-02-20 00:00:00

abstract：AIMS:Considering the implications that arose from several recent experimental studies using recombinant human erythropoietin in rodents, erythropoietin has been regarded as a pharmacological preconditioning agent. The purpose of the present study was to evaluate whether erythropoietin has a preconditioning effect again...

journal_title：Life sciences

authors： Sayan H,Ozacmak VH,Sen F,Cabuk M,Atik DY,Igdem AA,Ozacmak ID

更新日期：2009-03-13 00:00:00

abstract：AIMS:Several lines of evidence support the hypothesis that the oxidation of low density lipoprotein (LDL) may play a crucial role in the initiation and progression of atherosclerosis. Various studies have shown a positive effect of antioxidant compounds on oxidative modification of LDL and atherogenesis. In view of thi...

journal_title：Life sciences

authors： de Lima Portella R,Barcelos RP,de Bem AF,Carratu VS,Bresolin L,da Rocha JB,Soares FA

更新日期：2008-12-19 00:00:00

abstract：AIMS:Epigenetic and genetic alterations are crucial events in the onset and progression of human cancers including colorectal cancer (CRC). This work aims to probe the relevance of lysine demethylase 5B (KDM5B) to the progression of CRC and the possible molecules involved. MATERIALS AND METHODS:KDM5B expression in CRC...

journal_title：Life sciences

authors： Yan G,Li S,Yue M,Li C,Kang Z

更新日期：2021-01-01 00:00:00

abstract：:It is known that K(ATP) channel openers inhibit the release and refilling of Ca(2+) from intracellular stores. The present study was designed to test the effects of levcromakalim in human umbilical artery (HUA) rings stimulated by serotonin (5-HT) and KCl in Ca-free medium. Umbilical cords were obtained at vaginal or ...

journal_title：Life sciences

authors： Tufan H,Ayan-Polat B,Tecder-Unal M,Polat G,Kayhan Z,Oğüş E

更新日期：2003-02-07 00:00:00

abstract：:Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. The acetone extract of Bupleurum scorzonerifolium (AE-BS) showed a dose-dependently antiproliferative effect on the proliferation of A549 human lung cancer cells. The IC(50) of AE-BS, i.e., the con...

journal_title：Life sciences

authors： Cheng YL,Chang WL,Lee SC,Liu YG,Lin HC,Chen CJ,Yen CY,Yu DS,Lin SZ,Harn HJ

更新日期：2003-09-19 00:00:00

abstract：:The intracellular ionic content of human erythrocytes may be altered by hyperglycaemia. Despite this, very little is known about the cellular mechanisms linking glucose and cellular magnesium homeostasis. We measured intracellular ionized magnesium in human lymphocytes, by means of a fluorimetric technique, total intr...

journal_title：Life sciences

authors： Delva P,Degan M,Pastori C,Faccini G,Lechi A

更新日期：2002-09-20 00:00:00

abstract：AIMS:Endothelin-1 (ET-1) and endothelin-2 (ET-2; Trp(6)Leu(7)ET-1) are expressed by different cell types, but are considered to display identical pharmacological properties on endothelin receptors. We studied agonist-dependent aspects of endothelin(A) (ET(A))-receptor function and the importance of amino acids 6 and 7 ...

journal_title：Life sciences

authors： Compeer MG,Suylen DP,Hackeng TM,De Mey JG

更新日期：2012-10-15 00:00:00

abstract：:Thymic hormones have immunomodulatory effects on T cells and hence have been used clinically to restore the immunity of immunodeficient patients as well as to enhance the cellular immunity of cancer patients. Prothymosin alpha, which is a member of the thymic hormone family, has recently been suggested to act as a nuc...

journal_title：Life sciences

authors： Wu CL,Shiau AL,Lin CS

更新日期：1997-01-01 00:00:00

abstract：AIM:The objective of this study was to investigate the potential of aerobic exercise training (AET) to prevent kidney lipid accumulation and the contribution of renal metabolism to mediate this response. MAIN METHODS:Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n = 13), CHOW-TR (chow di...

journal_title：Life sciences

authors： Muller CR,Américo ALV,Fiorino P,Evangelista FS

更新日期：2018-10-15 00:00:00

abstract：:Repeated intermittent administration of amphetamine in mice caused reverse tolerance to 5-hydroxy-L-tryptophan (5-HTP)-induced head twitch, as well as to amphetamine-induced stereotypy. The repeated administration of 5-HTP alone also resulted in reverse tolerance in the head-twitch test. Daily pretreatment with halope...

journal_title：Life sciences

authors： Karler R,Calder LD,Turkanis SA

更新日期：1990-01-01 00:00:00