Effects of castration and testosterone treatment on the hexobarbital sensitivity in male rats.

abstract：AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...

journal_title：Life sciences

authors： Peixoto P,Aires RD,Lemos VS,Bissoli NS,Santos RLD

更新日期：2017-08-15 00:00:00

abstract：:The present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthe...

journal_title：Life sciences

authors： Ko JK,Tang F,Cho CH

更新日期：1997-01-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors have been shown to inhibit intimal thickening following balloon catheterization of rat carotid arteries. To assess the role of the renin-angiotensin pathway and the angiotensin type-I (AT1) receptor in this effect, the nonpeptide Ang II antagonist losartan (DuP 753) or vehicle ...

journal_title：Life sciences

authors： Kauffman RF,Bean JS,Zimmerman KM,Brown RF,Steinberg MI

更新日期：1991-01-01 00:00:00

abstract：:P-glycoprotein (P-gp) is found to play a very significant role in intestinal and biliary transport of irinotecan and its active metabolite, SN-38. This makes P-gp inhibition a logical strategy for improving irinotecan's oral efficacy and reducing its toxicity. The objective of the present study was to identify the mos...

journal_title：Life sciences

authors： Bansal T,Awasthi A,Jaggi M,Khar RK,Talegaonkar S

更新日期：2008-08-15 00:00:00

abstract：:Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was a...

journal_title：Life sciences

authors： Carrillo MC,Kanai S,Nokubo M,Kitani K

更新日期：1991-01-01 00:00:00

abstract：:A radioimmunoassay for orexin A has been developed. Anti-orexin A antiserum was raised in New Zealand white rabbits immunized with a conjugate of synthetic orexin A with bovine serum albumin. This antibody did not crossreact with orexin B, hypothalamic hormones, pituitary hormones, neuropeptides or gut hormones. Radio...

journal_title：Life sciences

authors： Mitsuma T,Hirooka Y,Kayama M,Mori Y,Yokoi Y,Rhue N,Ping J,Izumi M,Ikai R,Adachi K,Nogimori T

更新日期：2000-01-01 00:00:00

abstract：:Ro 15-1788 (10 mg/kg, ip) and CGS 8216 (10 mg/kg, ip) significantly reversed the inhibitory effect of diazepam (5 mg/kg, ip) on electrically induced head-turning in rats. Neither antagonist alone, at the dose level which blocked diazepam, had any intrinsic activity in this model. The specificity of the interaction bet...

journal_title：Life sciences

authors： Goldstein JM,Sutton EB,Malick JB

更新日期：1986-02-03 00:00:00

abstract：:The role of extracellular acidosis in inflammatory airway diseases is not well known. One consequence of tissue acidification is the stimulation of sensory nerves via the polymodal H(+)-gated transmembrane channels ASICs and TRPV1 receptor. The present study investigated the effect of acidosis on airway basal tone and...

journal_title：Life sciences

authors： Faisy C,Planquette B,Naline E,Risse PA,Frossard N,Fagon JY,Advenier C,Devillier P

更新日期：2007-09-08 00:00:00

abstract：AIMS:In this study, we used a cross-junction microfluidic device for preparation of alendronate-loaded chitosan nanoparticles with desired characteristics to introduce a suitable element for bone tissue engineering scaffolds. MAIN METHODS:By controlling the reaction condition in microfluidic device, six types of alend...

journal_title：Life sciences

authors： Moradikhah F,Doosti-Telgerd M,Shabani I,Soheili S,Dolatyar B,Seyedjafari E

更新日期：2020-08-01 00:00:00

abstract：:We have previously shown that transforming growth factor-beta1 (TGF-beta1) is involved in the fibroblast-induced organization and differentiation of transformed phenotypically crypt-like T84 intestinal epithelial cells into absorptive enterocyte-like cells, when cultured within a three-dimensional collagen gel. We hav...

journal_title：Life sciences

authors： Lindfors K,Halttunen T,Kainulainen H,Mäki M

更新日期：2001-08-10 00:00:00

abstract：:To characterize the pharmacokinetics of protein-free granisetron in blood and brain we implanted microdialysis probes into the jugular vein and cerebral frontal cortex of the rat. Granisetron (3 or 6 mg/kg, i.v., n=6) was then administered, and microdialysates from blood and brain were collected from both sites and as...

journal_title：Life sciences

authors： Huang CT,Chen CF,Tsai TH

更新日期：1999-01-01 00:00:00

abstract：:The kinetics of lymphocyte function associated antigen 1 (LFA-1) expression on spleen cells (SPC) and liver non-parenchymal cells (NPC), and intercellular adhesion molecule 1 (ICAM-1) expression on hepatocytes (HC) was examined in acute liver injury mice induced by a DTH reaction to picryl chloride (PCl). The peak exp...

journal_title：Life sciences

authors： Xu Q,Jiang J,Cao J,Wu F,Fujii H,Saiki I

更新日期：1998-01-01 00:00:00

abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...

journal_title：Life sciences

authors： Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

更新日期：1999-10-29 00:00:00

abstract：AIMS:Activation of the renin-angiotensin system (RAS), renal oxidative stress and inflammation are constantly present in experimental hypertension. Nitric oxide (NO) inhibition with N(w)-nitro-L-arginine methyl ester (L-NAME) has previously been reported to produce hypertension, increased expression of Angiotensin II (...

journal_title：Life sciences

authors： Rincón J,Correia D,Arcaya JL,Finol E,Fernández A,Pérez M,Yaguas K,Talavera E,Chávez M,Summer R,Romero F

更新日期：2015-03-01 00:00:00

abstract：:Investigated in this study are the effects and mechanisms of exercise and chlorpromazine (CPZ), a widely used conventional antipsychotic drug, on the hepatic insulin sensitivity of 90% pancreatectomized (Px) male Sprague-Dawley rats. The Px diabetic rats were provided with 0, 5, or 50 mg CPZ per kg of body weight (No-...

journal_title：Life sciences

authors： Park S,Hong SM,Lee JE,Sung SR

更新日期：2007-06-06 00:00:00

abstract：:Despite the considerable number of published studies in the field of S-nitrosothiols (RSNO), the determination of these compounds in biological samples still represents an analytical challenge, due to several technical obstacles and often long sample preparation procedures. Other problems derive from the intrinsic lab...

journal_title：Life sciences

authors： Bramanti E,Angeli V,Paolicchi A,Pompella A

更新日期：2011-01-17 00:00:00

abstract：AIMS:To investigate the effects of aerobic exercise training on cardiomyocyte ultrastructure, oxidative stress, and activation of protein synthesis pathways in a model of cardiomyopathy induced by doxorubicin (Dox). MAIN METHODS:Male Sprague Dawley rats were randomly assigned to Control (saline, sedentary), Dox/sedent...

journal_title：Life sciences

authors： Sequeira CM,Martins MA,Alves R,Nascimento ALR,Botti GCRM,Rocha VN,Matsuura C

更新日期：2021-01-01 00:00:00

abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

journal_title：Life sciences

authors： Pertwee RG

更新日期：1999-01-01 00:00:00

abstract：:Inhaled antimuscarinics, often called anticholinergics in clinical medicine, are established as first line bronchodilators in COPD. Tiotropium has been developed as a new generation antimuscarinic following ipratropium. Tiotropium is a specific, highly potent antimuscarinic, demonstrating very slow dissociation from m...

journal_title：Life sciences

authors： Disse B,Speck GA,Rominger KL,Witek TJ Jr,Hammer R

更新日期：1999-01-01 00:00:00

abstract：:Anandamide (arachidonylethanolamide), isolated from porcine brain, has been shown to bind to the cannabinoid receptor and also to produce cannabimimetic activity in pharmacological assays. This study examined structure-activity relationships in alkylated anandamide analogs. The analogs were evaluated for their ability...

journal_title：Life sciences

authors： Adams IB,Ryan W,Singer M,Razdan RK,Compton DR,Martin BR

更新日期：1995-01-01 00:00:00

abstract：AIM:Myokines are associated with regulation of bone and muscle mass. However, limited information is available regarding the impact of myokines on glucocorticoid (GC) mediated adverse effects on the musculoskeletal system. This study investigates the role of myokine fibroblast growth factor-2 (FGF-2) in regulating GC-i...

journal_title：Life sciences

authors： Adhikary S,Choudhary D,Tripathi AK,Karvande A,Ahmad N,Kothari P,Trivedi R

更新日期：2019-07-15 00:00:00

abstract：:According to recent epidemiological reports, almost 40% of American population use complimentary and alternative medicine (CAM) during their lifetime. Patients detected with HIV or cancer often consume herbal products especially St. John's wort (SJW) for antidepressants in combination with prescription medicines. Such...

journal_title：Life sciences

authors： Pal D,Mitra AK

更新日期：2006-03-27 00:00:00

abstract：:Loperamide effects on hepatobiliary function, analgesia and gut transit were studied in mice. Varying doses of the antidiarrheal drug, loperamide, were administered to mice by intracerebroventricular, intravenous, subcutaneous and intragastric routes. Gut motility was determined by intestinal transit of India ink, ana...

journal_title：Life sciences

authors： Hurwitz A,Sztern MI,Looney GA,Ben-Zvi Z

更新日期：1994-01-01 00:00:00

abstract：:The effects of sucrose feeding on parameters associated with (Na+,K+)-ATPase in brown adipose tissue were compared in rats treated with parenteral 6-hydroxydopamine and vehicle. Sucrose feeding significantly increased K+-p-nitrophenylphosphatase and ouabain binding in brown adipose tissue from rats treated with vehicl...

journal_title：Life sciences

authors： Swann AC

更新日期：1984-01-23 00:00:00

abstract：:The effects of vasoactive intestinal peptide (VIP)-ellipticine (E) derivatives were investigated on breast cancer cells. VIP-ALALA-E and VIP-LALA-E inhibited 125I-VIP binding to MCF-7 cells with an IC(50) values of 1 and 0.2 microM respectively. VIP-ALALA-E and VIP-LALA-E caused elevation of cAMP in MCF-7 cells with E...

journal_title：Life sciences

authors： Moody TW,Czerwinski G,Tarasova NI,Michejda CJ

更新日期：2002-07-19 00:00:00

abstract：:Responses to synthetic human adrenomedullin, a novel hypotensive peptide localized in several organ systems, including the lung, and the carboxy terminal 15-52 amino acid fragment of adrenomedullin (ADM15-52) were investigated in the pulmonary vascular bed of the intact-chest cat. Under constant flow conditions when b...

journal_title：Life sciences

authors： Cheng DY,DeWitt BJ,Wegmann MJ,Coy DH,Bitar K,Murphy WA,Kadowitz PJ

更新日期：1994-01-01 00:00:00

abstract：AIMS:The aim of this work was to examine the antitumor effects and mechanisms of M4IDP, a zoledronic acid derivative, on human colorectal cancer (CRC) HCT116 cells. MAIN METHODS:The effects of M4IDP on proliferation, cell cycle and ROS production were determined by CCK-8 and flow cytometry assays. Annexin-V-FITC/PI, H...

journal_title：Life sciences

authors： Peng Y,Qiu L,Xu D,Zhang L,Yu H,Ding Y,Deng L,Lin J

更新日期：2017-09-15 00:00:00

abstract：:Inhibitors of neuronal norepinephrine (NE) uptake are useful for the treatment of a variety of diseases including depression and urinary incontinence. In the present study, we synthesized and evaluated a novel analog of the potent and selective NE uptake inhibitor, nisoxetine. Thionisoxetine more potently inhibited th...

journal_title：Life sciences

authors： Gehlert DR,Hemrick-Luecke SK,Schober DA,Krushinski J,Howbert JJ,Robertson DW,Wong DT,Fuller RW

更新日期：1995-01-01 00:00:00

abstract：AIMS:The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS:The animals ...

journal_title：Life sciences

authors： Kalayci M,Kocdor MA,Kuloglu T,Sahin İ,Sarac M,Aksoy A,Yardim M,Dalkilic S,Gursu O,Aydin S,Akkoc RF,Ugras M,Artas G,Ozercan İH,Ugur K,Aydin S

更新日期：2017-10-01 00:00:00

abstract：:Grape seed extract (GSE) is a commonly available dietary supplement taken for the anti-oxidant activity that's attributed to its proanthocyanidin (oligomers of monomeric polyphenols) content. Similar polyphenol-enriched preparations from blueberries and soy have shown protection against ovariectomy-induced or age-rela...

journal_title：Life sciences

authors： Kim H,Deshane J,Barnes S,Meleth S

更新日期：2006-03-27 00:00:00