VIP-ellipticine derivatives inhibit the growth of breast cancer cells.

Abstract:

:The effects of vasoactive intestinal peptide (VIP)-ellipticine (E) derivatives were investigated on breast cancer cells. VIP-ALALA-E and VIP-LALA-E inhibited 125I-VIP binding to MCF-7 cells with an IC(50) values of 1 and 0.2 microM respectively. VIP-ALALA-E and VIP-LALA-E caused elevation of cAMP in MCF-7 cells with ED(50) values of 1 and 0.1 microM. VIP-LALA-E caused increased c-fos mRNA in MCF-7 cells. Radiolabeled VIP-LALA-E was internalized at 37 degrees C and delivered the cytotoxic E into MCF-7 cells. VIP-LALA-E inhibited the clonal growth of MCF-7 cells, decreased cell viability based on trypan blue exclusion and reduced 35S-methionine uptake. These results indicate that VIP-E derivatives function as breast cancer VPAC(1) receptor agonists which inhibit MCF-7 cellular viability.

journal_name

Life Sci

journal_title

Life sciences

authors

Moody TW,Czerwinski G,Tarasova NI,Michejda CJ

doi

10.1016/s0024-3205(02)01741-1

subject

Has Abstract

pub_date

2002-07-19 00:00:00

pages

1005-14

issue

9

eissn

0024-3205

issn

1879-0631

pii

S0024320502017411

journal_volume

71

pub_type

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