Abstract：
:Loperamide effects on hepatobiliary function, analgesia and gut transit were studied in mice. Varying doses of the antidiarrheal drug, loperamide, were administered to mice by intracerebroventricular, intravenous, subcutaneous and intragastric routes. Gut motility was determined by intestinal transit of India ink, analgesia by warm water tail flick latency, and hepatobiliary function by retention of the anionic dye, sulfobromophthalein in plasma and liver. When given by all routes at modest doses, loperamide slowed intestinal transit. Analgesia, a centrally mediated opiate effect, was only detected after intracerebroventricular or subcutaneous loperamide at high, near-toxic doses. Elevations of plasma and liver sulfobromophthalein were noted at routes and doses which slowed gut transit, well below those needed for analgesia. Intragastric loperamide at one fortieth its LD50 caused marked elevation of sulfobromophthalein levels and gut slowing, but no analgesia. Sulfobromophthalein elevation and gut slowing by intragastric loperamide were not affected by spinal cord transection but were reversed by naltrexone, an opiate antagonist. Non-toxic doses of loperamide slow gut transit and modify hepatobiliary function in mice by opiate actions at peripheral sites.
journal_name
Life Scijournal_title
Life sciencesauthors
Hurwitz A,Sztern MI,Looney GA,Ben-Zvi Zdoi
10.1016/0024-3205(94)00609-1subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1687-98issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(94)00609-1journal_volume
54pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90593-z
更新日期：1991-01-01 00:00:00
abstract：:The present study was carried out in order to identify the changes in expression of multidrug resistance-associated protein (Mrp) 2 and P-glycoprotein (P-gp) in the intestine and remote organs after intestinal ischemia-reperfusion (I/R). Mrp2 expression in the jejunum and liver was decreased at 6 h after I/R. This dec...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.04.019
更新日期：2008-06-20 00:00:00
abstract：:The thyrotropin receptor is proposed to contain both a glycoprotein and a ganglioside component. Monoclonal antibodies have been developed against soluble thyroid TSH receptor preparations and using Graves' lymphocytes. These show that initial recognition of thyrotropin requires the glycoprotein component, but that mo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90170-4
更新日期：1983-01-03 00:00:00
abstract：:Bacterial infection can negatively affect different parts of the male genital tract and subsequently cause impaired spermatogenesis and male fertility. However, most of the previous studies have focused on the infected organs of the male genital tract and there are not many studies that investigated the direct effect ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.117891
更新日期：2020-09-01 00:00:00
abstract：:The profile of endogenous opioid peptides in the peptide-rich fraction obtained from a homogenate of an ACTH-secreting human pituitary tumor is presented. Gradient RP-HPLC is used to separate the mixture into peptide constituents. A preparation of opioid receptors is used in a radioreceptor assay with ethorphine - a r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90225-5
更新日期：1985-11-11 00:00:00
abstract：:Morning urine samples were assayed for human EGF (hEGF) in 137 non-insulin dependent diabetic patients with normal serum creatinine and beta 2-microglobulin levels. Serving as controls, 80 age- and sex-matched healthy subjects were also examined. A significant positive correlation between hEGF excretion and the level ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90100-h
更新日期：1993-01-01 00:00:00
abstract：:The fructose analogue 2,5-anhydro-D-mannitol (2,5-AM), that inhibits glucose release and ATP formation in liver cells, seems to stimulate feeding by acting on the liver, because hepatic portal injection was more effective than jugular vein injection and because hepatic branch vagotomy attenuated 2,5-AM's hyperphagic e...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00081-2
更新日期：1998-01-01 00:00:00
abstract：:Net water, Na+, Cl- and HCO3- fluxes were measured in in vivo rabbit ileal loops, while mucus secretion was assessed by measuring the glycoprotein or total sialic acid secreted into the lumen, or by measuring the luminal fluid viscosity. Inoculating loops with cholera enterotoxin (CT) produced a sustained secretion of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90220-5
更新日期：1983-02-21 00:00:00
abstract：:The effects of subcutaneous (sc) administration of estradiol (50 micrograms/100 microliters/day x 10 day) or testosterone (15 mg/100 microliters twice a week x 2 weeks) on ANF release were examined in isolated perfused rat atria. The concentration of ANF in the perfusate was measured by radioimmunoassay, under basal c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90245-x
更新日期：1993-01-01 00:00:00
abstract：AIMS:Elevated levels of epidermal growth factor (EGF) receptor are observed on several human tumors, e.g. cervical carcinoma and mamma carcinomas. The natural ligand EGF is an alternative to established antibodies and tyrosine kinase inhibitors for targeting EGF receptor-overexpressing tumor cells for therapy. Conjugat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.11.012
更新日期：2011-01-31 00:00:00
abstract：:Prolidase deficiency seems to be a rather rare metabolic disorder. However, many new cases can be detected because screening is easy to perform and enzymatic confirmation allows the differentiation from other iminodipeptidurias . Clinical symptoms are briefly reviewed, while biological considerations and prolidase pro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90363-1
更新日期：1984-05-21 00:00:00
abstract：AIMS:To determine whether ginsenoside Rg1 is involved in scratch wound healing through altered expression of related molecules in astrocytes and improved functional recovery after spinal cord injury (SCI). MATERIALS AND METHODS:Astrocytes were isolated from rats, followed by Rg1 treatment. The wound healing test was p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117642
更新日期：2020-07-01 00:00:00
abstract：:We examined the effect of beta-alanyl-L-histidinato zinc (AHZ) on the differentiation of human periodontal ligament (HPDL) cells. HPDL cells were cultured with alpha-minimum essential medium containing 10% fetal bovine serum with or without 10(-4) or 10(-5) M AHZ for up to 10 days. The expression of runt-related trans...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.09.069
更新日期：2004-04-02 00:00:00
abstract：:Identification of the neural substrates subserving audiogenic convulsions in the GEPR is an important task and while it is not yet complete, many laboratories employing various techniques have contributed importantly to our current understanding. The present review focuses on the use of lesions to identify the neural ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90367-x
更新日期：1986-09-08 00:00:00
abstract：:In this study, we have identified the E-NTPDase family members and ecto-5'-nucleotidase/CD73 in rat heart left ventricle. Moreover, we characterize the biochemical properties and enzyme activities from synaptosomes of the nerve terminal endings of heart left ventricle. We observe divalent cation-dependent enzymes that...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.12.003
更新日期：2008-02-27 00:00:00
abstract：AIMS:We previously reported that cysteinyl leukotriene receptor 2 (CysLT(2)) mediates ischemic astrocyte injury, and leukotriene D(4)-activated CysLT(2) receptor up-regulates the water channel aquaporin 4 (AQP4). Here we investigated the mechanism underlying CysLT(2) receptor-mediated ischemic astrocyte injury induced ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.10.025
更新日期：2011-01-03 00:00:00
abstract：:The sphincter of Oddi (SO) plays an important role in regulating the bile flow into the duodenum. This study was designed to investigate the effect of Chinese Medicinal Herbs Muh-Shiang-Bin-Lang-Wan (MSBLW) and their mechanism of action on regulating the motility of SO in rabbits. The activity of SO in anesthetized ra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.09.032
更新日期：2003-12-12 00:00:00
abstract：:Flavonoids from the leaves of Diospyros kaki L (FLDK-P70) are main therapeutic components of NaoXingQing, which is a novel and patented Traditional Chinese Medicine drug used for the treatment of syndrome of apoplexy for years in China. The present study investigated the effects of FLDK-P70 on hydrogen peroxide (H2O2)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.09.031
更新日期：2005-03-11 00:00:00
abstract：:Defects in the mitochondrial genome have been associated with Parkinson's and Alzheimer's disease, and apoptosis can be triggered by the presence of energetically compromised mitochondria. Thus, in this study we have examined whether the divalent cations Cu2+ and Mn2+ could influence mitochondrial function in vitro. M...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)00948-1
更新日期：2001-02-23 00:00:00
abstract：:Aspartate (ASP), glutamate (GLU), noradrenaline (NA), dopamine (DA) and its acidic metabolites DOPAC and HVA, serotonin (5-HT) and its metabolite 5-HIAA were simultaneously investigated in post-mortem tissue samples from right parahippocampal gyrus (temporal cortex) and frontal cortical pole (frontal cortex) of adults...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00067-2
更新日期：1997-01-01 00:00:00
abstract：:Opioid peptides have been demonstrated to stimulate prolactin secretion, and it has been postulated that this is mediated, at least in part, by an effect on hypothalamic prolactin releasing and release-inhibiting factors and neurotransmitters. The aim of this study was to investigate the effect of opioid peptides and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90314-6
更新日期：1987-03-09 00:00:00
abstract：:Since many patients complain about halitosis without there being any clinical evidence of its cause, psychological symptoms have been pointed out as halitosis-inducing factors. The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC). Seventeen undergraduate m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.010
更新日期：2006-07-10 00:00:00
abstract：:The influence of different neuropeptides related to pro-opiomelanocortin were tested on acquisition of heroin self-administration in rats. The animals were allowed to self-administer heroin intravenously on a continuous reinforcement schedule during 6 h daily sessions on 5 consecutive days. Treatment was performed sub...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90261-8
更新日期：1983-12-05 00:00:00
abstract：:Evidence for the ability of the opiate antagonist naloxone to block a variety of metabolic effects exerted by morphine and non-opiate drugs is reviewed. Naloxone prevents or reverses the following effects in the rat: (a) the chronic morphine-induced increase in liver [NADPH]; (b) the consequent chronic morphine-induce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90608-2
更新日期：1983-01-01 00:00:00
abstract：:Phenol sulfotransferase (PST, EC 2.8.2.1) and glutathione-S-transferase (GST, EC 2.5.1.18), the phase II biotransformation enzymes inactivate many exo- and endogenous compounds. The effect of PST substrates (catecholamines, simple phenols, selected phenolic drugs) and PST products (phenolic sulfates) on GST activity w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00807-2
更新日期：1997-01-01 00:00:00
abstract：AIMS:This study evaluates ocular (iris, ciliary body and ciliary process) and nonocular (atria and lung) beta-adrenoceptors in rabbit to characterize the plasma membrane beta-adrenoceptors and binding affinities of beta-adrenoceptor antagonists. MAIN METHODS:The tissue segment binding method with a hydrophilic radioli...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.016
更新日期：2009-01-30 00:00:00
abstract：AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118618
更新日期：2021-01-01 00:00:00
abstract：:Recent studies in animals have demonstrated that the steroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one (3A5P), is a potent analgesic when given intracerebroventricularly. Several studies in humans report that spinal steroids are effective in the treatment of chronic low-back pain when given in combination with morphine....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90095-7
更新日期：1992-01-01 00:00:00
abstract：:In Madin-Darby canine kidney (MDCK) cells, the effect of 2-O-methyl PAF, an inactive analogue of platelet activating factor (PAF), on intracellular Ca2+ concentration ([Ca2+]i) was measured by using the Ca2+-sensitive fluorescent dye fura-2. 2-O-methyl PAF (> or = 15 microM) caused a rapid rise of [Ca2+]i in a concent...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.064
更新日期：2005-06-03 00:00:00
abstract：AIMS:Sepsis is a major cause of morbidity and mortality in the elderly population. In prior studies, we have shown that in vivo, the inflammatory response in aged animals is exaggerated as compared to young animals and that this response likely accounts for the increased morbidity and mortality. Part of this uncontroll...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.03.009
更新日期：2010-05-08 00:00:00
