Ginsenoside Rg1-induced activation of astrocytes promotes functional recovery via the PI3K/Akt signaling pathway following spinal cord injury.

abstract：AIMS:Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS). NO has been involved in the pathophysiology of epilepsy, but available data are conflicting and the actual role...

journal_title：Life sciences

authors： Prieto-Martín AI,Llorens S,Pardal-Fernández JM,Muñoz LJ,López DE,Escribano J,Nava E,de Cabo C

更新日期：2012-04-09 00:00:00

abstract：AIMS:Serotonergic neurons and amino acid neurons are involved in the central nervous control of lower urinary tract function. We investigated the role of the serotonergic system in the central regulation of micturition, as well as the relationship between serotonergic neurons and amino acid neurons in the lumbosacral c...

journal_title：Life sciences

authors： Kadekawa K,Nishijima S,Sugaya K,Miyazato M,Saito S

更新日期：2009-10-07 00:00:00

abstract：:Memory impairment induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats is associated with impaired brain glucose and energy metabolism, oxidative stress and impaired cholinergic neurotransmission. Treatment with antioxidants and cholinergic agonists has been reported to produce beneficial...

journal_title：Life sciences

authors： Pathan AR,Viswanad B,Sonkusare SK,Ramarao P

更新日期：2006-11-02 00:00:00

abstract：:The mechanism for the development of insulin resistance in normal pregnancy is complex and is associated with serum levels of sex hormones. However, the influence of these hormones on the early steps of insulin action has not been extensively studied, although the potentially beneficial effect of estradiol on glucose ...

journal_title：Life sciences

authors： González C,Alonso A,Grueso NA,Esteban MM,Fernández S,Patterson AM

更新日期：2002-02-22 00:00:00

abstract：:We examined whether H(+)-ATPase is involved in the control of cellular action of arginine vasopressin (AVP) to produce adenosine 3', 5'-monophosphate (cAMP) and mobilize cellular free calcium ([Ca2+]i) in rat renal papillary collecting tubule cells in culture. N-Ethylmaleimide (NEM), an inhibitor of H(+)-ATPase, reduc...

journal_title：Life sciences

authors： Ishikawa S,Sakuma N,Okada K,Saito T

更新日期：1993-01-01 00:00:00

abstract：AIMS:Evidence suggests that hypobaric hypoxia (HH) exposure causes biochemical and molecular level perturbations in brain resulting in associated cognitive dysfunction. However, the possible effect of HH on amygdala and the associated limbic regions based functions remains elusive. Regulated fear expression is essentia...

journal_title：Life sciences

authors： Kumari P,Roy K,Wadhwa M,Chauhan G,Alam S,Kishore K,Ray K,Panjwani U

更新日期：2020-08-01 00:00:00

abstract：:The requirement for calcium in the serotonin-mediated aldosterone secretion was investigated using rat adrenal capsular cells. In the calcium-free medium both basal as well as serotonin-stimulated aldosterone secretion (at concentrations of 10(-7) M and 10(-8) M of serotonin) were significantly impaired. The effects o...

journal_title：Life sciences

authors： Ganguly A,Hampton T

更新日期：1985-04-15 00:00:00

abstract：AIMS:JM-1232(-) ((-)-3-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-2-phenyl-3,5,6,7-tetrahydrocyclopenta[f] isoindole-1(2H)-one) is a novel isoindoline compound that acts on benzodiazepine receptors. Clinical trials are being conducted to assess its potential clinical use as an intravenous anesthetic or sedative agent. In ...

journal_title：Life sciences

authors： Kato R,Watanabe R,Miki H,Ijiri Y,Hayashi T,Tanaka K

更新日期：2009-11-18 00:00:00

abstract：:The present study was performed to determine if the attenuated pressor response to vasopressin in conscious non-estrous female rats is due in part to an enhanced V2-like receptor vasodilator action. In male rats, infusion of vasopressin at a rate of 1 ng.min(-1).kg body weight-1 (wt) resulted in an increase in mean ar...

journal_title：Life sciences

authors： Wang YX,Crofton JT,Liu H,Sato K,Share L

更新日期：1996-01-01 00:00:00

abstract：:The intestinal mucosa of infant rats was found to produce ketones when incubated in Krebs-Ringer-Bicarbonate solution. No production was found in weaned rats. Ketogenesis could be inhibited by D-carnitine or tetradecylglycidic acid (TDGA) an inhibitor of long-chain acylcarnitine transferase, suggesting that ketone pro...

journal_title：Life sciences

authors： Hahn P,Taller M

更新日期：1987-09-21 00:00:00

abstract：:The pure estrogen antagonist ICI-182780, at doses above 50 micrograms/kg, effectively inhibited the initiation of embryo implantation in rats when administered on day 4 of pregnancy (day 1 = sperm positive). The same dose inhibited the implantation initiating effect of intravenous 25 ng of estradiol-17 beta in delayed...

journal_title：Life sciences

authors： Chatterjee S,Johnson DC

更新日期：1993-01-01 00:00:00

abstract：:BIM 23014 is a somatostatin analog displaying an increased biological half life due to resistance to enzymatic degradation. This peptide inhibits GH release directly at the level of pituitary somatotrophs. In addition, an action of BIM 23014 at the level of the hypothalamus is possible since somatostatinergic fibers a...

journal_title：Life sciences

authors： Magnan E,Cataldi M,Guillaume V,Conte-Devolx B,Graziani N,Figaroli JC,Thomas F,Chihara K,Oliver C

更新日期：1992-01-01 00:00:00

abstract：:Green tea polyphenols like epigallocatechin gallate (EGCG) have been proposed as a cancer chemopreventative. Several studies have shown that EGCG can act as an antioxidant by trapping proxyl radicals and inhibiting lipid peroxidation. The main propose of this study is to investigate the antioxidant capacity of EGCG us...

journal_title：Life sciences

authors： Saffari Y,Sadrzadeh SM

更新日期：2004-02-06 00:00:00

abstract：:The present investigation examined the interaction between fluoxetine enantiomers and LSD in rats trained with LSD as a discriminative stimulus. The dose response relationships for LSD alone and in combination with either (+)- or (-)-fluoxetine were determined. In both instances, the LSD dose response relationship was...

journal_title：Life sciences

authors： Fiorella D,Helsley S,Rabin RA,Winter JC

更新日期：1996-01-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) receptor-mediated 36chloride (36Cl-) uptake was measured in synaptoneurosomes from rat brain. GABA and GABA agonists stimulated 36Cl- uptake in a concentration-dependent manner with the following order of potency: Muscimol greater than GABA greater than piperidine-4-sulfonic acid (P4S)gr...

journal_title：Life sciences

authors： Luu MD,Morrow AL,Paul SM,Schwartz RD

更新日期：1987-09-07 00:00:00

abstract：:Intracerebroventricularly (i.c.v.)-administered [D-Ala2]deltorphin II (20 micrograms) produced a marked locomotor hyperactivity in male ICR mice. The locomotor hyperactivity induced in response to i.c.v. [D-Ala2]deltorphin II (20 micrograms) was suppressed by pretreatment with naltriben (NTB, 10 micrograms) but not 7-...

journal_title：Life sciences

authors： Mizoguchi H,Narita M,Nagase H,Suzuki T,Quock RM,Tseng LF

更新日期：1996-01-01 00:00:00

abstract：:Lewis rats were trained to self-stimulate the medial forebrain bundle (MFB) using a rate-frequency paradigm. They were then tested for the effects of the cannabinoid receptor agonist CP 55,940, the selective cannabinoid receptor antagonist SR 141716 and the dopamine D1 receptor antagonist SCH 23390. CP 55,940 (0, 10, ...

journal_title：Life sciences

authors： Arnold JC,Hunt GE,McGregor IS

更新日期：2001-11-21 00:00:00

abstract：:Activation of GABA(B) receptors produces analgesia in acute and chronic pain models. Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord. While much more potent GABA(B) receptor agonists (CGP 44532) have been ...

journal_title：Life sciences

authors： Enna SJ,Harstad EB,McCarson KE

更新日期：1998-01-01 00:00:00

abstract：:Bu-Zhong-Yi-Qi-Tang (BZYQT), a Chinese herbal medicine, inhibited the proliferation of human hepatoma cell lines (Hep3B, HepG2 and HA22T) dose-dependently. The IC50s of BZYQT on the proliferation of Hep3B, HepG2 and HA22T were 432.5+/-31.8 microg/ml, 455.4+/-24.2 microg/ml, and 2284.3+/-77.2 microg/ml respectively on ...

journal_title：Life sciences

authors： Kao ST,Yeh CC,Hsieh CC,Yang MD,Lee MR,Liu HS,Lin JG

更新日期：2001-08-17 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...

journal_title：Life sciences

authors： Lambert GW,Eisenhofer G,Cox HS,Horne M,Kalff V,Kelly M,Jennings GL,Esler MD

更新日期：1991-01-01 00:00:00

abstract：:Palytoxin induced increases in cytosolic Ca2+ and tension, which were dependent on external Ca2+, and depolarized the membrane in endothelium-denuded porcine coronary arteries. When the endothelium was present, however, these effects were greatly inhibited, suggesting that some factors from endothelium inhibited the p...

journal_title：Life sciences

authors： Ishii K,Ito KM,Ikeda M,Uemura D,Ito K

更新日期：1997-01-01 00:00:00

abstract：AIMS:Aging and drug-induced side effects may contribute to deteriorate mitochondrial bioenergetics in many tissues, including kidney and liver. One possibility is that the combination of both aging and drug toxicity accelerates the process of mitochondrial degradation, leading to progressive bioenergetic disruption. We...

journal_title：Life sciences

authors： Rocha-Rodrigues S,Santos-Alves E,Coxito PM,Marques-Aleixo I,Passos E,Guimarães JT,Martins MJ,Oliveira PJ,Magalhães J,Ascensão A

更新日期：2013-09-03 00:00:00

abstract：:A number of experimental studies report that biological systems can be affected by in vivo exposure to low frequency and extremely low frequency electromagnetic fields. However, attempts to independently replicate some of these studies have shown the reported effects to be elusive. The difficulty in replicating result...

journal_title：Life sciences

authors： Ubeda A,Díaz-Enriquez M,Martínez-Pascual MA,Parreño A

更新日期：1997-01-01 00:00:00

abstract：:Homocysteine (Hcy), an intermediate in methionine metabolism, has been proposed to be involved in hepatic fibrogenesis. Impaired liver function can alter Hcy metabolism. The aim of the present study was to determine plasma Hcy alterations in acute obstructive cholestasis and the subsequent biliary cirrhosis. Cholestas...

journal_title：Life sciences

authors： Ebrahimkhani MR,Sadeghipour H,Dehghani M,Kiani S,Payabvash S,Riazi K,Honar H,Pasalar P,Mirazi N,Amanlou M,Farsam H,Dehpour AR

更新日期：2005-04-08 00:00:00

abstract：:Central administration of the selective mu opioid agonist, dermorphin, produces a concurrent diuretic and antinatriuretic response in conscious rats. To determine whether central mu opioids differentially affect the renal excretion of water and sodium, we examined changes in renal function produced by intracerebrovent...

journal_title：Life sciences

authors： Kapusta DR,Dzialowski EM

更新日期：1995-01-01 00:00:00

abstract：:Preliminary data suggest that amygdalar corticotropin-releasing factor (CRF) is regulated by nicotinic agonists. We sought to confirm and extend these observations by determining the effects of various concentrations of nicotine on CRF messenger RNA expression in the AR-5 immortalized amygdalar cell line. Nicotine pro...

journal_title：Life sciences

authors： Kasckow JW,Regmi A,Sheriff S,Mulchahey J,Geracioti TD Jr

更新日期：1999-01-01 00:00:00

abstract：:Vascular disease is one of the complicating features of diabetes mellitus. Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetes complications. Several studies have indicated that hypertension in diabetic patients is an independent altered reaction of blood vessel...

journal_title：Life sciences

authors： Soltani N,Keshavarz M,Sohanaki H,Dehpour AR,Zahedi Asl S

更新日期：2005-02-11 00:00:00

abstract：AIMS:The molecular pathogenesis of COVID-19 is similar to other coronavirus (CoV) infections viz. severe acute respiratory syndrome (SARS) in human. Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. MATERIA...

journal_title：Life sciences

authors： Hazra S,Chaudhuri AG,Tiwary BK,Chakrabarti N

更新日期：2020-09-15 00:00:00

abstract：:Transitory immunosupression is reported after intense exercise, especially after an increase in training overload and in overtraining. The influence of intense exercise on plasma hormones and glutamine concentration may contribute to this effect. However, the effect of such exercise-induced changes upon lymphocyte and...

journal_title：Life sciences

authors： Santos RV,Caperuto EC,Costa Rosa LF

更新日期：2007-01-16 00:00:00