Regulation of corticotropin-releasing factor messenger RNA by nicotine in an immortalized amygdalar cell line.

abstract：:Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium-dependent calcium-stimulated adenosine triphosphatase ( ( Ca + Mg)-ATPase, EC 3.6.1.3.) of the red cell plasma membrane was not significantly changed. Maximal ...

journal_title：Life sciences

authors： Cameron BF,Green L

更新日期：1983-08-29 00:00:00

abstract：AIM:There is a specific frequency of extremely low-frequency electromagnetic field (ELF-EMF) that promotes neuronal differentiation. Although several mechanisms are known to regulate ELF-EMF-induced neuronal differentiation, a key factor that mediates neurogenic potentials by the ELF-EMF is largely unknown. Also, the p...

journal_title：Life sciences

authors： Seong Y,Moon J,Kim J

更新日期：2014-04-25 00:00:00

abstract：:[3H]ET (etorphine), which is considered either as an "universal" ligand or a mu agonist, interacts with identical affinities KD = 0.33-0.38 nM to hybrid cells and rabbit cerebellum, pure delta and mu-enriched opioid receptor preparations, respectively. In rat brain tissue, [3H]ET binding is inhibited by DAGO (Tyr-D-Al...

journal_title：Life sciences

authors： Delay-Goyet P,Roques BP,Zajac JM

更新日期：1987-08-10 00:00:00

abstract：:The enkephalin analogs, [D-Pen2,L-Cys5]- and [D-Pen2,D-Cys5]-enkephalin are cyclic compounds, conformationally constrained by virtue of their 14-membered, disulfide containing rings and by the rigidizing effect of the beta, beta dimethyl substituents of the penicillamine side chain. The analogs exhibit profound delta ...

journal_title：Life sciences

authors： Mosberg HI,Hurst R,Hruby VJ,Galligan JJ,Burks TF,Gee K,Yamamura HI

更新日期：1983-05-30 00:00:00

abstract：:We administered intravenous adenosine to 11 neonatal rabbits. Adenosine depressed respiration in 10 of 11 rabbits. For the group as a whole the adenosine-induced respiratory depression was highly significant (p less than 0.001). After aminophylline administration to the same animals the respiratory effect of intraveno...

journal_title：Life sciences

authors： Watt AH,Buss DC,Routledge PA

更新日期：1987-01-05 00:00:00

abstract：:In the present study the formation of thrombin-antithrombin-complexes (TAT) during incubation of thrombin (0.89, 4.5, 8.9 nmol/l) and antithrombin (4.6 micromol/l) on the surface of cultured human EC, derived from different parts of the circulation, and on the surface of human vessel segments was studied. In the absen...

journal_title：Life sciences

authors： Ruzicka K,Wojta J,Artemiou O,Birsan T,Quehenberger P,Kapiotis S,Hofbauer R,Speiser W

更新日期：1998-01-01 00:00:00

abstract：:Two breeds of rats, Charles River Wistar [Crl(Wi)Br.] and HSD Wistar [Wistar per LATI (Budapest) Br.], with remarkable difference in learning performance were selected. The rats were trained in the shuttle box with 100 trials per day and the number of conditioned avoidance responses (CARs), the escape failures (EFs) t...

journal_title：Life sciences

authors： Knoll J,Knoll B,Miklya I

更新日期：1996-01-01 00:00:00

abstract：:Viperid, elapid and crotalid snake venoms were screened in vitro for antiviral activity against Sendai virus. The hemolysis of 10(8) human erythrocytes in 1 ml, caused by 70 HAU of Sendai virus, was abolished when the virions were pretreated with 10 ug of the viperid venom of Echis coloratus, and was considerably dimi...

journal_title：Life sciences

authors： Borkow G,Ovadia M

更新日期：1992-01-01 00:00:00

abstract：:An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...

journal_title：Life sciences

authors： Gambacciani M,Yen SS,Rasmussen DD

更新日期：1988-01-01 00:00:00

abstract：:Cd2+ (0.4 mg/kg) administration to growing rats (45 +/- 5 g) intraperitoneally, daily for 30 days was found to decrease the activity of superoxide dismutase (SOD) in all the brain regions, except hippocampus. The concentrations of lipid peroxides were significantly elevated in the cerebellum, cerebral cortex, corpus s...

journal_title：Life sciences

authors： Shukla GS,Hussain T,Chandra SV

更新日期：1987-11-09 00:00:00

abstract：:Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and suli...

journal_title：Life sciences

authors： Dairam A,Antunes EM,Saravanan KS,Daya S

更新日期：2006-11-10 00:00:00

abstract：:The effects of methadone and morphine on fetal behavior were studied following their administration to either the mother (5micrograms/kg/min) or fetus (0.5micrograms/kg maternal wt./min) using the chronically-instrumented pregnant ewe model. Fourteen unanesthetized, unrestrained pregnant ewes between 130-141 days gest...

journal_title：Life sciences

authors： Umans JG,Szeto HH

更新日期：1983-01-01 00:00:00

abstract：:P-glycoprotein (P-gp) is found to play a very significant role in intestinal and biliary transport of irinotecan and its active metabolite, SN-38. This makes P-gp inhibition a logical strategy for improving irinotecan's oral efficacy and reducing its toxicity. The objective of the present study was to identify the mos...

journal_title：Life sciences

authors： Bansal T,Awasthi A,Jaggi M,Khar RK,Talegaonkar S

更新日期：2008-08-15 00:00:00

abstract：:Hypoxic preconditioning (HPC) has been well demonstrated to have potent protective effects in many cell types; however, the mechanisms responsible for this phenomenon are not fully understood. Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic ...

journal_title：Life sciences

authors： Pan YX,Ren AJ,Zheng J,Rong WF,Chen H,Yan XH,Wu C,Yuan WJ,Lin L

更新日期：2007-09-08 00:00:00

abstract：:A review of the rapidly accumulating data in the literature continues to support the notion that catecholamines regulate ovarian function, and extends the complexity of catecholaminergic effects on the ovary via interactions with pituitary and adrenal hormones. It is clear that catecholamines affect growth and differe...

journal_title：Life sciences

authors： Spicer LJ

更新日期：1986-11-10 00:00:00

abstract：:The sphincter of Oddi (SO) plays an important role in regulating the bile flow into the duodenum. This study was designed to investigate the effect of Chinese Medicinal Herbs Muh-Shiang-Bin-Lang-Wan (MSBLW) and their mechanism of action on regulating the motility of SO in rabbits. The activity of SO in anesthetized ra...

journal_title：Life sciences

authors： Kuo YI,Chiu JH,Lin JG,Hsieh CL,Wu CW

更新日期：2003-12-12 00:00:00

abstract：:Buddlejasaponin I and saikosaponin 1 and 2, biologically active compounds from Scrophularia scorodonia and Bupleurum rigidum respectively, exert potent in vivo antiinflammatory effects on mouse ear edema induced by phorbol myristate acetate (PMA). The effects of these compounds on swelling and other inflammatory param...

journal_title：Life sciences

authors： Bermejo Benito P,Abad Martínez MJ,Silván Sen AM,Sanz Gómez A,Fernández Matellano L,Sánchez Contreras S,Díaz Lanza AM

更新日期：1998-01-01 00:00:00

abstract：:Insulin therapy remains the standard of care for achieving and maintaining adequate glycemic control, especially in hospitalized patients with critical and noncritical illnesses. Insulin therapy is more effective against elevated fasting glycaemia but less in the reduction of postprandial hyperglycaemia. It is associa...

journal_title：Life sciences

authors： Bavec A

更新日期：2014-03-18 00:00:00

abstract：:Endothelin-1 (ET-1) has been proposed as one of the possible mediators of the vasoconstriction seen following ischemia and reperfusion. We investigated the effect of ischemia and reperfusion on the contractile response of canine renal and iliac arteries to the dihydropyridine-type calcium channel agonist (+/-)Bay K 86...

journal_title：Life sciences

authors： Edwards JD,McGregor PE,Dovgan PS,Agrawal DK

更新日期：1995-01-01 00:00:00

abstract：AIMS:Schisandra is a good choice in Traditional Chinese Medicine for the therapy of cardiovascular diseases, but whether it contains a or some specific component (s) responsible these effects are still unclear. In the present study, we explored whether Schisantherin A (SCA) causes vasorelaxation in isolated rat thoraci...

journal_title：Life sciences

authors： Yang S,Xu Z,Lin C,Li H,Sun J,Chen J,Wang C

更新日期：2020-03-15 00:00:00

abstract：:Pulmonary fibrosis (PF), which is characterized by excessive matrix formation, may ultimately lead to irreversible lung damage and thus death. Fibroblast activation has been regarded as a central event during PF pathogenesis. In our previous study, we confirmed that the miR-627/high-mobility group box protein 1 (HMGB1...

journal_title：Life sciences

authors： Li J,Zhang X,Wang T,Li J,Su Q,Zhong C,Chen Z,Liang Y

更新日期：2021-01-20 00:00:00

abstract：AIMS:Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are...

journal_title：Life sciences

authors： Cui YL,Xue RQ,Xi He,Ming Zhao,Yu XJ,Liu LZ,Wu Q,Si Yang,Li DL,Zang WJ

更新日期：2019-04-01 00:00:00

abstract：:The ileal Na+/bile acid cotransporter (IBAT) maintains the reabsorption of bile acids from the intestine in the enterohepatic circulation of bile acids. In the present study, we showed that S-8921 could dose-dependently inhibit the uptake of [3H] taurocholate in the COS7 cell line which constitutively expresses hamste...

journal_title：Life sciences

authors： Hara S,Higaki J,Higashino K,Iwai M,Takasu N,Miyata K,Tonda K,Nagata K,Goh Y,Mizui T

更新日期：1997-01-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), a major steroid secreted by the adrenal gland, is known to have antiproliferative effects but the mechanism is unclear. We recently reported that DHEA induces growth inhibition and apoptosis in BV-2 cells and these effects are inversely associated with glucose concentrations in the mediu...

journal_title：Life sciences

authors： Yang NC,Jeng KC,Ho WM,Hu ML

更新日期：2002-03-15 00:00:00

abstract：AIMS:Prior work suggests that ischemic preconditioning increases the level of CD39 in the heart and contributes to cardiac protection. Therefore, we examined if targeted cardiac expression of CD39 protects against myocardial injury. MAIN METHODS:Mice with cardiac-specific expression of human CD39 (αMHC/hCD39-Tg) were ...

journal_title：Life sciences

authors： Smith SB,Xu Z,Novitskaya T,Zhang B,Chepurko E,Pu XA,Wheeler DG,Ziolo M,Gumina RJ

更新日期：2017-06-15 00:00:00

abstract：:The role of islet amyloid polypeptide, also known as amylin, in insulin resistance and in the etiology of diabetes has been a subject of debate. Increased plasma amylin levels have been observed in both obese and type II diabetic patients. However, data on endogenous amylin levels with relation to pharmacological inte...

journal_title：Life sciences

authors： Gill AM,Yen TT

更新日期：1991-01-01 00:00:00

abstract：:Grape seed extract (GSE) is a commonly available dietary supplement taken for the anti-oxidant activity that's attributed to its proanthocyanidin (oligomers of monomeric polyphenols) content. Similar polyphenol-enriched preparations from blueberries and soy have shown protection against ovariectomy-induced or age-rela...

journal_title：Life sciences

authors： Kim H,Deshane J,Barnes S,Meleth S

更新日期：2006-03-27 00:00:00

abstract：:In experiments on conscious rats it was found that preliminary microinjection of 100 nl 100 microM glutamic acid to the rostral commissural part of the solitary tract nucleus or to the caudal ventrolateral medulla increased a rise in colonic temperature induced by systemically applied endotoxin (3 microg/kg Escherichi...

journal_title：Life sciences

authors： Koulchitsky SV,Levkovets VS,Tchitchkan DN,Soltanov VV,Kulchitsky VA

更新日期：1999-01-01 00:00:00

abstract：AIMS:Aristolochic acid (AA) nephrotoxicity is related to accumulation of methylglyoxal (MGO) and N(ε)-(carboxymethyl)lysine (CML) in the mouse kidney. We studied the activity of renal semicarbazide-sensitive amine oxidase (SSAO), a key enzyme involved in MGO generation, in AA-treated mice, and investigated nephroprotec...

journal_title：Life sciences

authors： Huang TC,Chen SM,Li YC,Lee JA

更新日期：2014-09-26 00:00:00

abstract：:The aims of the current study were: 1) to determine if the epsilonPKC pseudosubstrate peptide (epsilonphi) (NH(2)-RKRQGAVRRRVHQVNG-COOH) could be used as an epsilonPKC-selective inhibitor in neonatal cardiac myocytes (NCMs) and 2) to determine if differences in the alpha and epsilonPKC autoinhibitory pseudosubstrate m...

journal_title：Life sciences

authors： Johnson JA

更新日期：2004-05-07 00:00:00