Regulation of corticotropin-releasing factor messenger RNA by nicotine in an immortalized amygdalar cell line.

abstract：:According to our previously proposed auto-addiction hypothesis of chronic anorexia nervosa, patients become addicted to an initial period of dieting through endogenous opioid mediated mechanisms. Morphine causes hyperactivity and anorexia in the mouse, symptoms of anorexia nervosa but responses opposite to those of mo...

journal_title：Life sciences

authors： Buck M,Marrazzi MA

更新日期：1987-08-10 00:00:00

abstract：:We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine...

journal_title：Life sciences

authors： Kamei J,Saitoh A

更新日期：1996-01-01 00:00:00

abstract：:Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detected by metabolic labeling, Western blot analyses and immunofluorescence...

journal_title：Life sciences

authors： Forsman T,Lautala P,Lundström K,Monastyrskaia K,Ouzzine M,Burchell B,Taskinen J,Ulmanen I

更新日期：2000-10-06 00:00:00

abstract：AIMS:Dorsal root ganglia contain heterogeneous populations of primary afferent neurons that transmit various sensory stimuli. This functional diversity may be correlated with differential expression of voltage-gated K(+) (Kv) channels. Here, we examine cellular distributions of Kv4 pore-forming and ancillary subunits t...

journal_title：Life sciences

authors： Matsuyoshi H,Takimoto K,Yunoki T,Erickson VL,Tyagi P,Hirao Y,Wanaka A,Yoshimura N

更新日期：2012-09-17 00:00:00

abstract：:The in vitro and in vivo regulation of [3H]Ro 5-4864 binding to peripheral benzodiazepine receptors (PBR) by ion transport/exchange inhibitors was studied in the kidney. The potencies of 9-anthroic acid, furosemide, bumetanide, hydrochlorothiazide and SITS as inhibitors of [3H]Ro 5-4864 binding to renal membranes were...

journal_title：Life sciences

authors： Basile AS,Lueddens HW,Skolnick P

更新日期：1988-01-01 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

journal_title：Life sciences

authors： Privratsky JR,Newman DK,Newman PJ

更新日期：2010-07-17 00:00:00

abstract：:Since the discovery of leptin in 1994 by Zhang et al., there have been a number of reports showing its implication in the development of a wide range of cardiovascular diseases. However, there exists some controversy about how leptin can induce or preserve cardiovascular function, as different authors have found contr...

journal_title：Life sciences

authors： Feijóo-Bandín S,Portolés M,Roselló-Lletí E,Rivera M,González-Juanatey JR,Lago F

更新日期：2015-11-01 00:00:00

abstract：AIMS:The protein kinase C (PKC) family of enzymes has been implicated in cellular proliferation, differentiation, and apoptosis. However, the distribution of specific PKC isoforms with varying functions in normal and malignant human tissues remains to be determined. The objective of this study was to investigate the ex...

journal_title：Life sciences

authors： Ali S,Al-Sukhun S,El-Rayes BF,Sarkar FH,Heilbrun LK,Philip PA

更新日期：2009-05-22 00:00:00

abstract：:Previous research in this laboratory has shown that chronic treatment of adult male rats with an anabolic-androgenic steroid (AAS) produced anxiolytic behavior and increased the functional response of cortical gamma-aminobutyric acid(A) (GABA(A)) receptors. The experiments reported here were aimed at further character...

journal_title：Life sciences

authors： Bitran D,Hilvers RJ,Frye CA,Erskine MS

更新日期：1996-01-01 00:00:00

abstract：:Alpha2-adrenoceptor (alpha2-AR)-regulated binding of the labelled GTP analog, guanosine 5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS), to guanine-nucleotide-binding proteins (G proteins) was studied in human platelet membranes. Under optimal conditions, the potent alpha2-AR agonist, 5-bromo-6-(2-imidazolin-2-ylamino...

journal_title：Life sciences

authors： Gessi S,Campi F,Varani K,Borea PA

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:HDAC4/5 and Smad7 are potential therapeutic targets for the onset and progression of B-cell acute lymphocytic leukemia (B-ALL) and indices for clinical prognosis. In contrast, HO-1 (heat shock protein 32) plays a key role in protecting tumor cells from apoptosis. METHODS:HDAC4/5, HO-1 and Smad7 expressions in ...

journal_title：Life sciences

authors： Guo Y,Fang Q,Ma D,Yu K,Cheng B,Tang S,Lu T,Wang W,Wang J

更新日期：2018-08-15 00:00:00

abstract：:18-Hydroxycorticosterone (18-OHB) is a precursor of aldosterone and is the only corticosteroid, other than aldosterone, that is synthesized predominantly in the zona glomerulosa. Administration of the dopamine antagonist, metoclopramide results in parallel rises in plasma 18-OHB and aldosterone levels without affectin...

journal_title：Life sciences

authors： Sowers JR,Beck FW,Stern N

更新日期：1983-12-19 00:00:00

abstract：:Cyclic octapeptide analogues of somatostatin (SS) like SMS 201-995 [H-(D) Phe-Cys-Phe-(D) Trp-Lys-Thr-Cys-Thr(ol)] or its Tyr3-derivative 204-090, displaced [125I-Tyr11]-SS 100% from pancreatic membranes but only 62-75% from brain membranes; the remaining sites were displaced by SS. These data indicate that some mini-...

journal_title：Life sciences

authors： Reubi JC

更新日期：1985-05-13 00:00:00

abstract：:In vivo microdialysis was used to investigate the effects of acute injections of norharman on extraneuronal concentrations of dopamine (DA) in the nucleus accumbens of rats. Administration of norharman (2.44 and 43.97 mumol/kg, i.p.) elicited an increase of the DA efflux by 70% and 160% respectively which returned to ...

journal_title：Life sciences

authors： Baum SS,Hill R,Rommelspacher H

更新日期：1995-01-01 00:00:00

abstract：AIMS:Previous work has demonstrated that ketogenic diets promote white fat browning; however, the exact mechanisms underlying this phenomenom have yet to be elucidated. Recently, an in vitro study showed that supraphysiological concentrations of β-hydroxybutyrate (βHB) had a strong influence on the induction of adipocy...

journal_title：Life sciences

authors： de Oliveira Caminhotto R,Andreotti S,Komino ACM,de Fatima Silva F,Sertié RAL,Christoffolete MA,Reis GB,Lima FB

更新日期：2019-09-01 00:00:00

abstract：:Interactions of the synthetic pyrethroid allethrin with the nicotinic acetylcholine (ACh) receptor/channel were studied in membranes from Torpedo electric organ. Allethrin did not inhibit binding of [3H]ACh to the receptor sites, but inhibited noncompetitively binding of [3H]perhydrohistrionicotoxin ([3H]H12-HTX) to t...

journal_title：Life sciences

authors： Abbassy MA,Eldefrawi ME,Eldefrawi AT

更新日期：1982-10-11 00:00:00

abstract：:Intestinal mucosa, bone marrow hematopoietic cells and brain have limited capacity for the de novo synthesis of nucleosides (NSs) and nucleotides (NTs). Whereas the role of dietary NS and NT in the former two tissues is known, it is not known in the brain. Therefore we studied the effect of dietary NS and NT mixture o...

journal_title：Life sciences

authors： Chen TH,Huang HP,Matsumoto Y,Wu SH,Wang MF,Chung SY,Uezu K,Moriyama T,Uezu E,Korin T,Sato S,Yamamoto S

更新日期：1996-01-01 00:00:00

abstract：:Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal myositis is poorly understood. Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotens...

journal_title：Life sciences

authors： Souza-Silva TG,Vilas-Boas DF,Gonçalves-Santos E,Mazzeti AL,Caldas IS,Gonçalves RV,Diniz LF,Novaes RD

更新日期：2020-09-15 00:00:00

abstract：:Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of gr...

journal_title：Life sciences

authors： Fisher CE,Hughes RN

更新日期：1996-01-01 00:00:00

abstract：AIMS:slc26a proteins are responsible for a large number of functions either in normal physiology or in human disease. We have previously reported that proximal tubular epithelial (PTE) cells immortalized from spontaneously hypertensive rats (SHRs) were endowed with increased Cl(-)/HCO3(-) exchanger activity and slc26a6...

journal_title：Life sciences

authors： Simão S,Gomes P,Pinho MJ,Soares-da-Silva P

更新日期：2013-10-06 00:00:00

abstract：:The hyperphagia and rapid body weight gain normally observed in young obese (ob/ob) mice were abolished by removal of their adrenal glands, whereas food intake and weight gain of lean mice were not significantly affected by adrenalectomy. Adrenalectomy lowered body energy density (kcal/g carcass) in obese mice more th...

journal_title：Life sciences

authors： Vander Tuig JG,Ohshima K,Yoshida T,Romsos DR,Bray GA

更新日期：1984-04-09 00:00:00

abstract：:We investigated the combined effect of 5-hydroxytryptamine (5-HT, serotonin) and calcium ionophore (A23187) on human platelet aggregation. Aggregation, monitored at 37 degrees C using a Dual-channel Lumi-aggregometer, was recorded for 5 min after challenge by a change in light transmission as a function of time. 5-HT ...

journal_title：Life sciences

authors： Connor JD,Rasheed H,Gilani AH,Cheema M,Rizvi Z,Saeed SA

更新日期：2001-10-26 00:00:00

abstract：AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...

journal_title：Life sciences

authors： Cui F,Guan Y,Guo J,Tian YM,Hu HF,Zhang XJ,Zhang Y

更新日期：2018-07-15 00:00:00

abstract：:In this study, we determined the expression of protein kinase C (PKC) isoforms during pregnancy. At pregnant duration, PKC alpha was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC...

journal_title：Life sciences

authors： Shyu JC,Hsieh YS,Chang CL,Tsai CC,Liu HC,Chang AC,Yang LC,Lin LY,Liu JY

更新日期：1999-01-01 00:00:00

abstract：:It has been shown that lesions of the medial preoptic/suprachiasmatic nuclei (MPO/SCN) abolish the estrogen-induced afternoon prolactin (PRL) surge. Recent studies using both dopamine antagonist and thyrotropin-releasing hormone (TRH) successfully induced an increase in plasma PRL in various animal models. The same dr...

journal_title：Life sciences

authors： Pan JT,Gala RR

更新日期：1988-01-01 00:00:00

abstract：:Ribonucleotide reductase is the rate limiting enzyme of de novo DNA synthesis; its activity is significantly increased in tumor cells related to the proliferation rate. Therefore the enzyme is considered to be an excellent target for cancer chemotherapy. In the present study we tested the in vitro and in vivo antitumo...

journal_title：Life sciences

authors： Fritzer-Szekeres M,Novotny L,Romanova D,Göbl R,Sedlak J,Vachalkova A,Rauko P,Elford HL,Szekeres T

更新日期：1998-01-01 00:00:00

abstract：:Although exposure to broad band (0.2-20 MHz) electromagnetic fields (EMF) is part of the treatment of several diseases, little is known as to their effects on myocardial protein expression and resistance to ischemia-reperfusion (I/R). We exposed Sprague-Dawley rats to either high (H, 10 min/day at 200 V/m, 36.1 microT...

journal_title：Life sciences

authors： Ronchi R,Marano L,Braidotti P,Bianciardi P,Calamia M,Fiorentini C,Samaja M

更新日期：2004-09-03 00:00:00

abstract：:11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors have been shown to treat type 2 diabetes (T2D). Since gossypol is an 11β-HSD1 inhibitor, the objective of the present study was to treat T2D and T2D-related liver fibrosis in rat model using low-dose gossypol. T2D was induced by feeding with high fat diet plus i...

journal_title：Life sciences

authors： Chen G,Wang R,Chen H,Wu L,Ge RS,Wang Y

更新日期：2016-03-15 00:00:00

abstract：AIMS:Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its GABAergic activity. Other aromatic alcohols have also been reported as able to protect neurons agains...

journal_title：Life sciences

authors： Delgado-Marín L,Sánchez-Borzone M,García DA

更新日期：2017-04-15 00:00:00

abstract：:The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...

journal_title：Life sciences

authors： Chen SW,Xin Q,Kong WX,Min L,Li JF

更新日期：2003-11-07 00:00:00