Abstract：
:Since the discovery of leptin in 1994 by Zhang et al., there have been a number of reports showing its implication in the development of a wide range of cardiovascular diseases. However, there exists some controversy about how leptin can induce or preserve cardiovascular function, as different authors have found contradictory results about leptin beneficial or detrimental effects in leptin deficient/resistant murine models and in wild type tissue and cardiomyocytes. Here, we will focus on the main discoveries about the leptin functions at cardiac level within the last two decades, focusing on its role in cardiac metabolism, remodeling and contractile function.
journal_name
Life Scijournal_title
Life sciencesauthors
Feijóo-Bandín S,Portolés M,Roselló-Lletí E,Rivera M,González-Juanatey JR,Lago Fdoi
10.1016/j.lfs.2015.02.016subject
Has Abstractpub_date
2015-11-01 00:00:00pages
10-8eissn
0024-3205issn
1879-0631pii
S0024-3205(15)00133-2journal_volume
140pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：:The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90595-7
更新日期：1983-01-01 00:00:00
abstract：AIMS:Although dexamethasone (Dex) is used widely as an anti-inflammatory and immunosuppressive drug, Dex appears to have severe side-effects, including osteoporosis. This study determined the effects of Dex on duodenal and renal expressions of the calcium-processing genes transient receptor potential cation channel, su...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.05.013
更新日期：2009-07-17 00:00:00
abstract：:Many persistent pesticides have been implicated in reproductive and developmental adverse effects, in man and wildlife. It has been hypothesized that these so-called xeno-hormones could upset the endocrine system function by binding to human estrogen receptor alpha and beta (ERalpha, beta) and thus be responsible for ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.03.023
更新日期：2006-08-15 00:00:00
abstract：:The effect of i.v. injection of various doses of naloxone (NAL) on plasma adrenocorticotropin (ACTH) and prolactin (Prl) in conscious animals bearing an indwelling intrajugular catheter was assessed. The effects were evaluated in animals which were left undisturbed and in others subjected to either restraint or ether ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90426-8
更新日期：1989-01-01 00:00:00
abstract：AIMS:Histone deacetylase inhibitors (HDACis) are promising anticancer drugs that open new areas of epigenetic drug discovery. Multiple myeloma (MM) is a malignant tumor of the blood system that is difficult to cure and often relapses. Here, we investigated the in vitro effects of a novel HDACi, LMK-235, on MM cells, an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.011
更新日期：2019-04-15 00:00:00
abstract：:Anorexia, nausea/emesis and peripheral sensorial neuropathy are frequent adverse effects associated with chemotherapy. Cannabinoids have been proposed to alleviate these effects, but their preventive properties in long-term experimental models have not been tested. This study was conducted to determine whether or not ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.06.012
更新日期：2007-07-19 00:00:00
abstract：:In situ radioligand binding and quantitative autoradiography have been used to measure the density of striatal D1-like, D2-like, and GABAA receptors in rats treated with haloperidol at 0.01 or 0.1 mg/kg/ day or chlorpromazine, olanzapine or clozapine at 0.1 or 1.0 mg/kg/day for 1, 3 or 7 months. [3H]SCH23390 binding t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01214-0
更新日期：2001-08-03 00:00:00
abstract：:Environmental estrogens (endocrine disruptive chemicals) have been shown to affect reproduction in wild life and it has been reported that maternal exposure with those chemicals have adverse effects on the male reproductive tract. However, little is known about the potential effects of prepubertal or pubertal exposure...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00502-0
更新日期：1999-01-01 00:00:00
abstract：:SDZ PGU 693 acts as a hypoglycemic agent by stimulating glucose utilisation in insulin-sensitive peripheral tissues, such as skeletal muscle and fat. In a 28 day toxicity study the compound was found to induce hepatocellular hypertrophy in Wistar rats treated with 300 mg/kg/day. To gain insights into the pathomechanis...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00509-8
更新日期：1998-01-01 00:00:00
abstract：:The effects of subcutaneous (sc) administration of estradiol (50 micrograms/100 microliters/day x 10 day) or testosterone (15 mg/100 microliters twice a week x 2 weeks) on ANF release were examined in isolated perfused rat atria. The concentration of ANF in the perfusate was measured by radioimmunoassay, under basal c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90245-x
更新日期：1993-01-01 00:00:00
abstract：:In vitro studies showed that organophosphate insecticides have different IC50 values (i.e., concentration of inhibitor required to inhibit 50% enzyme activity) for acetylcholinesterases (AChE's) from different species. Since previous reports indicated that the binding of active cholinesterase inhibitors to non-critica...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90426-x
更新日期：1982-07-12 00:00:00
abstract：AIMS:Endothelin-1 (ET-1) and endothelin-2 (ET-2; Trp(6)Leu(7)ET-1) are expressed by different cell types, but are considered to display identical pharmacological properties on endothelin receptors. We studied agonist-dependent aspects of endothelin(A) (ET(A))-receptor function and the importance of amino acids 6 and 7 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.02.011
更新日期：2012-10-15 00:00:00
abstract：:There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lympho...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90607-q
更新日期：1992-01-01 00:00:00
abstract：:Resveratrol, a polyphenolic phytoaxelin present in red wine, has been suggested to protect against atherosclerosis and cardiovascular disease because of its antioxidant effects. Intercellular adhesion molecule (ICAM-1), induced by cytokines, has been hypothesized to play a role in the early events during atheroscleros...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.052
更新日期：2005-12-12 00:00:00
abstract：:As a decrease in cholinergic neurons has been observed in Alzheimer's Disease (AD), therapeutic approaches to AD include inhibition of acetylcholinesterase to increase acetylcholine levels. Evidence suggests that acetylcholine release in the CNS is modulated by negative feedback via presynaptic M2 receptors, blockade ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00598-0
更新日期：1999-01-01 00:00:00
abstract：:Clinical studies of cholinergic pharmacotherapy, together with the putative role of the muscarinic receptor system in the neurophysiology of human behavior, support a possible muscarinic cholinergic involvement in schizophrenia. The present study has measured the density of [3H]AF-DX 384 labelled receptors (muscarinic...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00114-9
更新日期：1999-01-01 00:00:00
abstract：:Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity. A higher percentage of SP pre-treated cells in RA exposures resembled mature myelocytes or granulocytes; greater increase in ALP activity was observed. In cel...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90688-y
更新日期：1993-01-01 00:00:00
abstract：:Phospholipase C (PLC), an enzyme involved in the hydrolysis of membrane phospholipid- phosphatidylinositol-bisphosphate to inositol triphosphate and diacylglycerol, and Phorbol 12, myristate 13, acetate (PMA), a tumor promoting agent, could significantly stimulate testosterone (T) secretion from Leydig cells. Arachido...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90223-2
更新日期：1987-07-27 00:00:00
abstract：AIMS:Parathyroid hormone-related protein (PTHrP) is a peptide growth factor produced in a wide range of tissues from brain and parathyroid, to kidney and uterus. The purpose of this study was to determine whether the adrenal cortical hormones, hydrocortisone (cortisol), modulate PTHrP expression and glucocorticoid rece...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.08.001
更新日期：2011-10-24 00:00:00
abstract：:Rats administered cocaine 10 mg/kg i.p. exhibited hyperlocomotion which occurred within 5 min post injection. Subsequently, rats were injected with 10 mg/kg cocaine and brain and serum concentrations of cocaine were measured at 5, 10, and 20 min post injection. Within this time frame, cocaine concentration in limbic b...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00339-4
更新日期：1994-01-01 00:00:00
abstract：:Lipopolysaccharide (LPS) has been known to induce endotoxin shock via production of inflammatory modulators such as tumor necrosis factor alpha (TNF-alpha), or nitric oxide (NO). In this study, we have examined the effect of naringin (NG), one of the flavonoids, on LPS-induced endotoxin shock in mice and NO production...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.051
更新日期：2006-01-11 00:00:00
abstract：AIMS:Endothelin-1 (ET-1) is a mediator of various physiological and pathological processes, including vascular inflammation, cell proliferation and vasoconstriction. Attenuation of ET action using ET-1 antagonists reduces pulmonary vascular leakage and inflammation in several models of lung injuries and experimental ac...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.04.001
更新日期：2014-11-24 00:00:00
abstract：AIM:Exosomes, the nano-units (<200 nm), released from diverse cell types in the extracellular body fluid, possess non-immunogenic property and ability to cross the blood-brain barrier (BBB). Since exosomes carry biological information from their cells of origin, we hypothesize that priming cells with potential therapeu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.04.018
更新日期：2014-06-27 00:00:00
abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117339
更新日期：2020-03-01 00:00:00
abstract：:Decreased heart rate variability (HRV) and heart rate turbulence (HRT) are independent predictors of mortality after acute myocardial infarction (AMI). There are no previous studies on the relationship between warm-up phenomenon and cardiac autonomic control in stable coronary artery disease (CAD). We investigated the...
journal_title：Life sciences
pub_type： 临床试验,杂志文章
doi：10.1016/j.lfs.2004.06.033
更新日期：2005-03-25 00:00:00
abstract：:Clinical and preclinical studies have suggested that fluctuations in the peripheral and brain concentrations of progesterone and deoxycorticosterone and its metabolites 3alpha,5alpha-tetrahydroprogesterone and 3alpha,5alpha-tetrahydrodeoxycorticosterone, respectively, might play an important role in certain pathologic...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2003.12.002
更新日期：2004-05-14 00:00:00
abstract：:Phenylephrine effect on liver and kidney cortex mitochondrial pyruvate concentration was investigated. While in liver the alpha 1-adrenergic agent produced a decrease in pyruvate content, a significant increase was observed in kidney, even in the presence of 0.5 mM alpha-cyano-4-hydroxy-cinnamate. These changes were n...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90297-5
更新日期：1990-01-01 00:00:00
abstract：AIMS:Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and has been reported as having a wide range of activities that are potentially beneficial for human health. This study aimed to investigate the effects of pretreatment of vitamin D3 (100, 1000, and 10,000 IU/kg) against lipopolysacchar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117703
更新日期：2020-07-15 00:00:00
abstract：:Since many patients complain about halitosis without there being any clinical evidence of its cause, psychological symptoms have been pointed out as halitosis-inducing factors. The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC). Seventeen undergraduate m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.010
更新日期：2006-07-10 00:00:00
abstract：:Hexokinase and glucose-6-phosphate dehydrogenase activities were studied in brain regions after intraventricular injection of kainic acid. Hexokinase activity was decreased by 10-15% in various regions while glucose-6-phosphate dehydrogenase activity remained unaltered. Soluble hexokinase activity, which remained the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90471-m
更新日期：1991-01-01 00:00:00
