Abstract：
:In this study, we determined the expression of protein kinase C (PKC) isoforms during pregnancy. At pregnant duration, PKC alpha was down-modulated in the deciduomata but not in the myometrium. Down-modulation was compatible with the increase in cell mitosis, which reached a maximum at 8-9 days. On the other hand, PKC zeta was not down-modulated. It was increased both in the cytosolic and particulate fractions of the deciduomata, and paralleled the frequency of decidual cell mitosis. The other PKC isoform of delta was also increased, but it was associated with the cell regression. Therefore, these findings confirmed that the variable expression of PKC isoforms in decidualizing tissue may be involved in the modulation of decidual cell growth.
journal_name
Life Scijournal_title
Life sciencesauthors
Shyu JC,Hsieh YS,Chang CL,Tsai CC,Liu HC,Chang AC,Yang LC,Lin LY,Liu JYdoi
10.1016/s0024-3205(99)00190-3subject
Has Abstractpub_date
1999-01-01 00:00:00pages
2367-73issue
25eissn
0024-3205issn
1879-0631pii
S0024320599001903journal_volume
64pub_type
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