A convulsant, 3-mercaptopropionic acid, decreases the level of GABA in pancreatic islets of rat as well as that of brain.

abstract：:In acute coronary syndromes such as unstable angina and myocardial infarction, serum concentration of brain natriuretic peptide, a cardiac hormone with potent vasodilatatory, natriuretic and diuretic activities, is elevated. Little is known about the effect of elevated BNP plasma concentration on free radical-mediated...

journal_title：Life sciences

authors： Garlichs CD,Zhang H,Schmeisser A,Daniel WG

更新日期：1999-01-01 00:00:00

abstract：:Incubation of racemic methylenedioxyamphetamine (MDA) or methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes, in the presence of NADPH, generated a spectrally observed inhibitory complex with cytochrome P-450. The complex inhibited product formation from MDA and MDMA as well as other P-450 dependent react...

journal_title：Life sciences

authors： Brady JF,Di Stefano EW,Cho AK

更新日期：1986-10-20 00:00:00

abstract：:We examined the effects of repeated administration of the selective serotonin uptake inhibitor (SSRI) fluoxetine (Flx) (5, 10, or 15 mg/kg i.p., twice daily for 21 days) on brain and plasma concentrations of the parent drug and its active desmethyl metabolite, norfluoxetine (NFlx), in rats during the 21-day regimen as...

journal_title：Life sciences

authors： Gardier AM,Lepoul E,Trouvin JH,Chanut E,Dessalles MC,Jacquot C

更新日期：1994-01-01 00:00:00

abstract：:Immunotherapy with immune checkpoint inhibitors, such as anti-PD-1 drugs, is an area in increasing development for its efficacy and advantages in the treatment of advanced metastatic melanoma. In fact, immunotherapy has been the target of several and recent studies in different types of cancer, namely in melanoma, a g...

journal_title：Life sciences

authors： Moreira RS,Bicker J,Musicco F,Persichetti A,Pereira AMPT

更新日期：2020-01-01 00:00:00

abstract：AIMS:Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS). NO has been involved in the pathophysiology of epilepsy, but available data are conflicting and the actual role...

journal_title：Life sciences

authors： Prieto-Martín AI,Llorens S,Pardal-Fernández JM,Muñoz LJ,López DE,Escribano J,Nava E,de Cabo C

更新日期：2012-04-09 00:00:00

abstract：:DL-alpha-difluoromethylornithine (DFMO), 4-deoxypyridoxine (4-DOP), and methylglyoxal bis (guanylhydrazone) (MGBG) were tested as inhibitors of acute skin graft rejection. Proximal full thickness tail skins were exchanged between C57BL/6 and Balb/C mice. Distal autografts were placed to monitor healing. Inhibitors wer...

journal_title：Life sciences

authors： Campbell RA,Kurtz GL,Norton-Reel DJ

更新日期：1991-01-01 00:00:00

abstract：:Alpha(1)-adrenergic receptors are one of the three subfamilies of G protein coupled receptors activated by epinephrine and norepinephrine to control important functions in many target organs. Three human subtypes (alpha(1A), alpha(1B), alpha(1D)) are derived from separate genes and are highly homologous in their trans...

journal_title：Life sciences

authors： Hague C,Chen Z,Uberti M,Minneman KP

更新日期：2003-12-12 00:00:00

abstract：:Extracellular phospholipase A2 (PLA2) with proinflammatory activity has recently been discovered in synovial fluids in inflammatory arthritides. In the search for the sources of synovial fluid PLA2, human synovium and articular cartilage were found to contain large quantities of the enzyme. In rheumatoid arthritis (RA...

journal_title：Life sciences

authors： Pruzanski W,Bogoch E,Stefanski E,Wloch M,Vadas P

更新日期：1991-01-01 00:00:00

abstract：:Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low...

journal_title：Life sciences

authors： Geetha RK,Vasudevan DM

更新日期：2004-11-19 00:00:00

abstract：:The gastric mucosa is frequently exposed to different exogenous and endogenous ulcerative agents. Alcoholism is one of the risk factors for the development of mucosal damage in the stomach. This study aimed to assess if a probiotic strain Lactobacillus rhamnosus GG (LGG) is capable of protecting the gastric mucosa fro...

journal_title：Life sciences

authors： Lam EKY,Tai EKK,Koo MWL,Wong HPS,Wu WKK,Yu L,So WHL,Woo PCY,Cho CH

更新日期：2007-05-16 00:00:00

abstract：:Virgin, male Sprague-Dawley rats were used to study the production of cardiac failure by a single subcutaneous injection of 85 mg/kg dl-isoproterenol (ISO) and the possible preservation of cardiac function by a pre-treatment of 50 mg/kg verapamil (VER) 5 min prior to 85 mg/kg ISO. At 24 hrs after drug injections cardi...

journal_title：Life sciences

authors： Yeager JC,Whitehurst ME

更新日期：1982-01-18 00:00:00

abstract：:Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T ce...

journal_title：Life sciences

authors： Tsao CW,Lin YS,Cheng JT

更新日期：1998-01-01 00:00:00

abstract：:Electroshock induced seizures in the rat enhanced high affinity specific Na+ independent binding of 3H-gamma aminobutyric acid (GABA) to frozen, Triton X-100 treated cerebral synaptic membranes 30 minutes after exposures to electroshock, although no change in 3H GABA binding was observed in similarly treated preparati...

journal_title：Life sciences

authors： Ross SM,Craig CR

更新日期：1982-11-29 00:00:00

abstract：AIMS:We have developed biochemical and cell based assays to characterize small therapeutic molecules that inhibit the DNA damage checkpoint enzyme, Chk1 (Checkpoint kinase 1). MAIN METHODS:To prepare a screen of large chemical libraries, we purified the full-length and the catalytic domain versions of human Chk1. We c...

journal_title：Life sciences

authors： Ferry G,Studeny A,Bossard C,Kubara PM,Zeyer D,Renaud JP,Casara P,de Nanteuil G,Wierzbicki M,Pfeiffer B,Prudhomme M,Leonce S,Pierré A,Boutin JA,Golsteyn RM

更新日期：2011-08-15 00:00:00

abstract：:Alpha-adrenergic receptors may play an important role in regulating vascular tone and reactivity. To study alpha-adrenergic receptors in blood vessels, we have developed a method to characterize and quantitate alpha-adrenergic receptors in a particulate fraction of individual rabbit aortas using the high specific acti...

journal_title：Life sciences

authors： Tsujimoto G,Bristow MR,Hoffman BB

更新日期：1984-02-13 00:00:00

abstract：UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...

journal_title：Life sciences

authors： Husain SS,Szabo IL,Pai R,Soreghan B,Jones MK,Tarnawski AS

更新日期：2001-11-09 00:00:00

abstract：:The number of GABAergic neurons as determined by GAD immunocytochemistry and total neurons as determined from Nissl preparations were counted and classified at the light microscopic level in the inferior colliculus (IC) of the genetically epilepsy prone rat (GEPR) and the non-epileptic Sprague-Dawley (SD) strain of ra...

journal_title：Life sciences

authors： Roberts RC,Ribak CE

更新日期：1986-09-01 00:00:00

abstract：:Circadian rhythms might be involved in addictive behaviors. The pineal secretory product melatonin decreases cocaine sensitization in rats; mice mutant for the critical melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase (AANAT), exhibit altered behaviors. We hypothesized that AANAT/melatonin system, whi...

journal_title：Life sciences

authors： Uz T,Javaid JI,Manev H

更新日期：2002-05-10 00:00:00

abstract：AIMS:To investigate the roles of neutrophil alkaline phosphatase (NAP) in the migration, reactive oxygen species (ROS) generation and apoptosis of neutrophils. MAIN METHODS:NAP was overexpressed in neutrophil-like differentiated HL-60 cells via transfecting coding sequence of NAP by lentivirus. NAP overexpression in H...

journal_title：Life sciences

authors： Li H,Zhao Y,Li W,Yang J,Wu H

更新日期：2016-07-15 00:00:00

abstract：:Using a two-lever drug discrimination procedure, six rats were trained to discriminate 0.5 mg/kg of racemic 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) from saline. Once trained, the animals demonstrated a dose-related decrease in discriminative performance upon administration of lower doses of DOI (ED50 = 0.1...

journal_title：Life sciences

authors： Glennon RA

更新日期：1986-09-01 00:00:00

abstract：:There is evidence that senescence affects neurotransmission at different levels. In particular, this review summarizes the studies on age-dependent modifications in protein phosphorylation, which represents the final pathway in the action of transmitters and hormones at neuronal level. Cyclic AMP-dependent protein kin...

journal_title：Life sciences

authors： Magnoni MS,Govoni S,Battaini F,Trabucchi M

更新日期：1991-01-01 00:00:00

abstract：:The purpose of this study is to report the development of a non-radioactive fluorescent peptide assay for measuring protein kinase C activity (PKC). The assay is based on a glycogen synthase derived fluorescent peptide that is phosphorylated by PKC. Phosphorylation causes the peptide to migrate toward the anode while ...

journal_title：Life sciences

authors： Isbell JC,Christian ST,Mashburn NA,Bell PD

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been found to contribute to the failure of ovarian carcinoma treatment. Oridonin is a natural en-kaurane tetracyclic diterpenoid compound discovered in Rabdosia rubescene (Henmsl.) Hara. Herein, we tested whether oridonin could exert chemo-sensitization activity on cisplatin-resistan...

journal_title：Life sciences

authors： Zhao Y,Xia H

更新日期：2019-09-15 00:00:00

abstract：AIMS:The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pathways in antihyperalgesic effectiveness of zonisamide i...

journal_title：Life sciences

authors： Bektas N,Arslan R,Ozturk Y

更新日期：2014-01-24 00:00:00

abstract：:Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy in preventing soman...

journal_title：Life sciences

authors： Wang YA,Zhou WX,Li JX,Liu YQ,Yue YJ,Zheng JQ,Liu KL,Ruan JX

更新日期：2005-11-26 00:00:00

abstract：AIMS:This study sought to determine the impact of in vitro exposure to the herbicide atrazine (ATR) or its major mammalian metabolite diaminochlorotriazine (DACT) on dopaminergic cell differentiation. MAIN METHODS:N27 dopaminergic cells were exposed for 24 or 48 h to ATR or DACT (12-300 μM) and their effects on cell v...

journal_title：Life sciences

authors： Lin Z,Dodd CA,Filipov NM

更新日期：2013-01-17 00:00:00

abstract：:The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...

journal_title：Life sciences

authors： Chen SW,Xin Q,Kong WX,Min L,Li JF

更新日期：2003-11-07 00:00:00

abstract：AIMS:Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicin...

journal_title：Life sciences

authors： Makarević J,Tsaur I,Juengel E,Borgmann H,Nelson K,Thomas C,Bartsch G,Haferkamp A,Blaheta RA

更新日期：2016-02-15 00:00:00

abstract：AIMS:The objective of this study was to establish a more accurate analytical model and method for grip strength test of mice and to investigate the beneficial effects of lifelong exercise training to prevent functional decline of muscle during aging. MAIN METHODS:Fifty randomly selected adult male BALB/c mice (24-56 w...

journal_title：Life sciences

authors： Zhao Y,Shen F,Gong M,Jin L,Ren X,Liu K,Lu J

更新日期：2020-06-15 00:00:00

abstract：:The effects of tetrandrine (TET) on the contractile responses of rat aortic rings and perfused rat mesenteric arteries to phenylephrine (PE) were investigated. TET inhibited the maximal contraction to PE in a concentration-dependent manner. TET significantly inhibited the transient contraction in Ca(2+)-free medium pr...

journal_title：Life sciences

authors： Kwan CY,Chen YY,Ma MF,Daniel EE,Hui SC

更新日期：1996-01-01 00:00:00