Abstract：
:Changes in neuroendocrine function have been shown to occur in diabetic animals. The aim of the present study was to examine both the prolactin (PRL) and corticosterone (CORT) responses to a short period of restraint stress after the animals had been made diabetic for six weeks. The streptozotocin - induced diabetic rats had resting CORT levels which were significantly higher than the control animals. Acute restraint significantly increased CORT levels in both the control and diabetic rats. The CORT levels after stress were higher in the diabetic rats. However, the magnitude of the response (percent increase) was less in these animals. The resting PRL levels were not significantly different in the diabetic and control animals. The PRL levels significantly increased in both the control and diabetic rats when they were exposed to the restraint stress. The PRL levels after stress were significantly less in the diabetic rats, indicating a blunted PRL stress response. These results indicate that the diabetic state can affect an animals PRL and CORT response to a new acute stress.
journal_name
Life Scijournal_title
Life sciencesauthors
Ratner A,Pasternack LB,Weiss GKdoi
10.1016/0024-3205(91)90035-asubject
Has Abstractpub_date
1991-01-01 00:00:00pages
887-91issue
9eissn
0024-3205issn
1879-0631pii
0024-3205(91)90035-Ajournal_volume
48pub_type
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