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A spin label study of the membrane effect of various psychoactive drugs in human erythrocytes.

Abstract：

:The effect of psychoactive agents with different clinical actions: three sedative neuroleptics (trifluoperazine, alimemazine tartrate, chlorpromazine), an anticholinergic agent (trihexyphenidyl hydrochloride), two tricyclic antidepressants (imipramine, desipramine) and lithium carbonate on the rotational correlation frequency (V+) of the spin label 16NS has been comparatively investigated in whole human erythrocytes. V+ was about 40% increased by the three neuroleptics, the anticholinergic agent and the antidepressant molecules at 0.2 mM. By contrast, lithium did not induce any significant change in V+ at the same concentrations. It can be suggested that the increase in "membrane fluidity", observed with a wide variety of drugs, is a non specific effect, unrelated to the psychotropic action, that can be ascribed to the amphiphilic properties of the tested drugs.

journal_name

Life Sci

journal_title

Life sciences

authors

Lejoyeux M,Daveloose D,Mazière JC,Adès J,Viret J

doi

10.1016/0024-3205(93)90144-r

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

PL7-11

issue

2

eissn

0024-3205

issn

1879-0631

pii

0024-3205(93)90144-R

journal_volume

52

pub_type

杂志文章

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