Abstract:
:The acute dose-dependent effects of epinephrine and cocaine on heart rate and coronary flow rate (CFR) were examined in isolated, perfused (Langendorff) rat hearts from animals: i) pretreated with daily cocaine injections (20 mg/kg/day) for 8 weeks; ii) after 2-day withdrawal from 8-week cocaine pretreatment; iii) vehicle-treated controls. Chronic cocaine (CC) hearts were significantly less sensitive to the chronotropic effects of epinephrine than control (C) or withdrawal (CW) hearts. CW hearts exhibited significantly higher heart rates in response to epinephrine than C and CC hearts. Epinephrine alone (2.5 x 10(-7) M) decreased CFR 11% (C), 9%(CC), 14%(CW) from respective baseline levels. Cocaine alone had no significant effect on CFR in C hearts but produced slight dose-dependent decrements in CFR in CC and particularly CW hearts at higher doses. Cocaine plus epinephrine markedly decreased CFR in all groups, particularly in CW hearts. The results indicate that chronic daily cocaine administration produces a functional tolerance of the heart to the chronotropic actions of epinephrine but a 2-day withdrawal from chronic cocaine results in a rebound supersensitivity to adrenergic stimulation and cocaine's sympathomimetic effects. In addition, cocaine produces only minor decrements in coronary flow in the rat heart, while cocaine acts synergisticallly with epinephrine to produce a marked decrease in CFR.
journal_name
Life Scijournal_title
Life sciencesauthors
Avakian EV,LeRoy M,St John-Allan K,Sayre FW,Malone MHdoi
10.1016/0024-3205(90)90390-dsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
1569-74issue
22eissn
0024-3205issn
1879-0631pii
0024-3205(90)90390-Djournal_volume
46pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The effect of dihydropyridine calcium channel antagonist isradipine (PN 200-110) on morphine reinforcement has been investigated using i.v. self-administration test in rats. Rats were given the opportunity to self-administer a solution of morphine (1 mg/ml, i.v.) in a 1 hr limited access paradigm (FR = 1). Within 5-7 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00397-9
更新日期:1996-01-01 00:00:00
abstract::In order to determine whether CCl4, CBrCl3, CBr4 or CHCl3 undergo oxidative metabolism to electrophilic halogens by liver microsomes, they were incubated with liver microsomes from phenobarbital pretreated rats in the presence of NADPH and 2,6-dimethylphenol. The analysis of the reaction mixtures by capillary gas chro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90644-0
更新日期:1982-01-11 00:00:00
abstract:AIM:The objective of this study was to investigate the potential of aerobic exercise training (AET) to prevent kidney lipid accumulation and the contribution of renal metabolism to mediate this response. MAIN METHODS:Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n = 13), CHOW-TR (chow di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.09.017
更新日期:2018-10-15 00:00:00
abstract::The lymphatic vessels have been implicated in maintenance of interstitial fluid homeostasis and immune responses, and pathological conditions including inflammation, wound healing, lymphedema and tumor progression. The knowledge about the lymphatic structure and function in muscles, especially in muscular disorders, r...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.09.043
更新日期:2018-10-15 00:00:00
abstract::Cannabinoid agonists such as Delta9-tetrahydrocannabinol (THC) produce a wide range of pharmacological effects both in the central nervous system and in the periphery. One of the most striking features of cannabinoids such as THC is the magnitude to tolerance that can be produced upon repetitive administration of this...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2005.05.005
更新日期:2005-08-19 00:00:00
abstract::Inhaled antimuscarinics, often called anticholinergics in clinical medicine, are established as first line bronchodilators in COPD. Tiotropium has been developed as a new generation antimuscarinic following ipratropium. Tiotropium is a specific, highly potent antimuscarinic, demonstrating very slow dissociation from m...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/s0024-3205(98)00588-8
更新日期:1999-01-01 00:00:00
abstract::The present study attempts to indirectly determine if a neuronal cannabinoid (CB1) receptor mediates the intraocular pressure (IOP) reduction effects of arachidonoyl ethanolamide (AEA), its R-alpha-isopropyl analog, and the non-classical cannabinoid, CP-55,940. A series of these cannabinoids were dissolved in an aqueo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00499-8
更新日期:1998-01-01 00:00:00
abstract:AIMS:β-Adrenoceptors (β-ADRs) mediating the relaxation of rat superior mesenteric arteries (SMAs) were pharmacologically identified, and the effects of chemical sympathetic denervation on β-ADR-mediated relaxation were examined. MAIN METHODS:The tension changes of endothelium-denuded SMAs were isometrically recorded a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.117155
更新日期:2020-01-15 00:00:00
abstract::Beriberi is a disease caused by thiamine deficiency (TD), which may lead to heart problems, including heart failure. Despite the fact that thiamine prevalence is reduced in the industrialized world, it remains a health hazard especially due to chronic alcohol consumption. Diagnosing the presence of TD based on both el...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2013.12.029
更新日期:2014-03-07 00:00:00
abstract::The effect of the Type I benzodiazepine (BDZ) receptor agonist, CL 218,872, on convulsions generated by low doses of methyl beta-carboline-3-carboxylic acid ( MBCC ), bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice was examined. Low doses of CL 218,872 enhanced the convulsions produced by all agents excep...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90321-7
更新日期:1984-05-28 00:00:00
abstract::The influence of prior incubation on [3H]tryptamine binding was investigated in rat brain synaptic plasma membranes. A 55 min preincubation of the membranes at 37 degrees C induced an approx. 2.4-fold increase in the specific binding of [3H]ligand to the subsequently washed preparations and this phenomenon was quite t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90428-5
更新日期:1986-04-07 00:00:00
abstract:AIM:Cyclophosphamide (CYP) chemotherapy induces bladder toxicity and hemorrhagic cystitis in cancer patients constituting a current clinical concern. Oxidative inflammatory cascades have been implicated as the mechanism contributing to CYP bladder urotoxicity. We thus assayed to explore whether zinc (Zn) supplementatio...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118913
更新日期:2021-02-01 00:00:00
abstract::Two recently isolated peptides, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), are highly selective micro-opioid receptor agonists with analgesic actions in the tail-flick test. To further assess the analgesic properties of these peptides, the effects of endomorphin-1, endomorphin-2, and ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00689-5
更新日期:2000-07-14 00:00:00
abstract::The patterns of prolactin release after bilateral ECT and after 0.4 mg TRH i.v. were studied in 11 female melancholic patients in a 5-min sampling protocol. Mean prolactin peaking times were 10.2 min after ECT and 20.5 min after TRH. The elimination rate coefficients were significantly lower--and the corresponding hal...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90206-2
更新日期:1987-09-07 00:00:00
abstract:AIMS:Paraquat (PQ) is known to induce pulmonary injury via a redox cyclic reaction. The present study was aimed to determine the protective effects of quercetin against PQ-induced pulmonary injury in association with its antioxidant activity. MAIN METHODS:Male rats were challenged acutely by PQ (50 mg/kg, i.p.) with o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.06.011
更新日期:2010-07-31 00:00:00
abstract::We have investigated the possible involvement of arachidonic acid metabolites in dopamine-induced inhibition of adrenocortical steroidogenesis. Administration of dopamine (5 x 10(-5) M) for 20 min to perifused frog adrenal slices caused a marked reduction of the release of both prostaglandin E2 (PGE2) and 6-keto-PGF1 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90292-0
更新日期:1989-01-01 00:00:00
abstract::The effect of orchiectomy on peripheral benzodiazepine receptors (PBZr) in the rabbit prostate was studied. The mean PBZr density in the mitochondrial fraction isolated from prostates of intact (non castrated) rabbits was 4066 fmol/mg protein which following castration increased to 7236 fmol/mg protein (p less than 0....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90358-v
更新日期:1992-01-01 00:00:00
abstract::This work analyzes the 24-hour changes of hypothalamic-pituitary-adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24-hour cycle (n=8-10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland cort...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.06.001
更新日期:2008-07-18 00:00:00
abstract:AIMS:Splenectomy is sometimes required in bone fracture patients. The present study aims to investigate the effect of splenectomy on fracture healing in rats. MAIN METHODS:Rats underwent osteotomy were subjected to splenectomy. The effects of splenectomy were evaluated at day 0, 3, 15 and 30 post-fracture. Double immu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.12.005
更新日期:2017-03-15 00:00:00
abstract::An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90475-x
更新日期:1989-01-01 00:00:00
abstract::The composition of various amino acids and related compounds in the aorta, ventricle, atria, liver, kidney, pancreas, bronchi and adrenals of rats is presented. These patterns are qualitatively similar, but quantitatively different. Stress changed these patterns. In the aorta, alpha-aminobutyric acid and ammonia are d...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02156-d
更新日期:1995-01-01 00:00:00
abstract::The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00241-6
更新日期:1999-01-01 00:00:00
abstract::Cocaine cues elicit craving and physiological responses. The cerebral circuits involved in these are poorly understood. The purpose of this study was to assess the relation between regional brain activation and cocaine cue elicited responses. Thirteen right-handed cocaine abusers were scanned with positron emission to...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00619-5
更新日期:1999-01-01 00:00:00
abstract:AIMS:To examine the effects of metoprolol on expression of myocardial inflammatory cytokines and myocardial function in rats following coronary microembolization (CME). MAIN METHODS:Male rats were randomly assigned to receive either sham-operation (control group), CME plus saline (CME group), or CME plus metoprolol (m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.03.012
更新日期:2011-06-06 00:00:00
abstract::Using an isolated, perfused rat lung model, we examined the hypoxic pulmonary vasoconstriction (HPV). We studied the alterations in HPV induced by the selective DA1 receptor agonist, fenoldopam, the selective DA1 antagonist, SCH 23390, as well as a combination of these agents. Fenoldopam significantly attenuated HPV. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90630-8
更新日期:1992-01-01 00:00:00
abstract::Maintenance of the cellular calcium homeostasis plays an important role for neuronal cell function and interneuronal cell to cell communication. Therefore, alterations of the neuronal Ca2+ homeostasis may play a crucial role for brain aging in general and for age-related deficits in cognitive functions particularly. N...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(94)00381-5
更新日期:1994-01-01 00:00:00
abstract::Hemi-pituitary glands of ovariectomized rats were superfused for 4 h with either LHRH or the analog buserelin (HOE 766) at several concentrations, and thereafter with medium only for another 1.5 h. In a further experiment glands were exposed for 2.5 h to LHRH or buserelin at a single concentration (5 ng/ml) and subseq...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90524-2
更新日期:1986-08-04 00:00:00
abstract::Almost all diabetic complications are known to be associated with vascular dysfunctions of different tissues. Oxidative stress, on the other hand, has been implicated in the pathogenesis of diabetes mellitus. Therefore in the present study we have investigated the correlation between redox status and oxidative stress ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00662-3
更新日期:2003-10-03 00:00:00
abstract::In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmente...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(96)00561-9
更新日期:1996-01-01 00:00:00
abstract:AIMS:The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2010.11.014
更新日期:2011-02-28 00:00:00