Abstract：
:This work analyzes the 24-hour changes of hypothalamic-pituitary-adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24-hour cycle (n=8-10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland corticosterone levels. Plasma and adrenal corticosterone levels attained high levels during all the scotophase, concomitantly with the maxima in ACTH levels, whereas in aged rats only a brief plasma corticosterone peak at the early scotophase and no time of day variations of adrenal corticosterone were observed. Aging augmented circulating leptin, with a significant interaction "agextime" in the factorial ANOVA, i.e. only in young rats time of day changes were significant, with the lowest values of leptin at the middle of the light period and higher values at night. When plasma leptin was expressed on body weight basis, the age-related differences became not significant but the daily pattern of plasma leptin found in young rats persisted. Plasma and adrenal corticosterone levels correlated significantly with plasma ACTH only in young rats. Likewise, plasma leptin correlated with plasma corticosterone only in young rats. These changes can be attributed to a disrupting effect of aging on the homeostatic mechanisms modulating HPA activity and leptin release.
journal_name
Life Scijournal_title
Life sciencesauthors
Cano P,Cardinali DP,Spinedi E,Esquifino AIdoi
10.1016/j.lfs.2008.06.001subject
Has Abstractpub_date
2008-07-18 00:00:00pages
142-8issue
3-4eissn
0024-3205issn
1879-0631pii
S0024-3205(08)00234-8journal_volume
83pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90195-5
更新日期：1986-09-22 00:00:00
abstract：:This study aimed to evaluate the role for adenosine A2A receptors in the autoregulatory vasodilation to hypotension in relation with cerebral blood flow (CBF) autoregulation in rat pial arteries. Changes in pial artery diameters were observed directly through a closed cranial window. Vasodilation induced by adenosine ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00737-2
更新日期：2000-08-11 00:00:00
abstract：:This study analyses possible changes during surgical and chemical castration in the expression and pharmacological characteristics of alpha1-adrenoceptor in adult rat seminal vesicle. Ribonuclease protection assays indicated that alpha1a--was the predominant mRNA, while alpha1b-and alpha1d-adrenoceptor transcripts wer...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.03.011
更新日期：2004-08-06 00:00:00
abstract：:To characterize the pharmacokinetics of protein-free granisetron in blood and brain we implanted microdialysis probes into the jugular vein and cerebral frontal cortex of the rat. Granisetron (3 or 6 mg/kg, i.v., n=6) was then administered, and microdialysates from blood and brain were collected from both sites and as...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00143-5
更新日期：1999-01-01 00:00:00
abstract：:Even though conventional systemic doses of cimetidine and other histamine H(2) antagonists display minimal brain penetration, central nervous system (CNS) effects (including seizures and analgesia) have been reported after administration of these drugs in animals and man. To test the hypothesis that cimetidine-like dr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.05.020
更新日期：2004-10-08 00:00:00
abstract：:This paper demonstrates marked differences between blood levels and those in the CSF for three anterior pituitary peptide hormones, prolactin, luteinizing hormone (LH) and adrenocorticotrophin (ACTH) in the rhesus monkey. CSF levels of endogenous prolactin (measured by radioimmunoassay) are about 20% of those in the b...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90064-4
更新日期：1983-04-18 00:00:00
abstract：:Palytoxin induced increases in cytosolic Ca2+ and tension, which were dependent on external Ca2+, and depolarized the membrane in endothelium-denuded porcine coronary arteries. When the endothelium was present, however, these effects were greatly inhibited, suggesting that some factors from endothelium inhibited the p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00682-0
更新日期：1997-01-01 00:00:00
abstract：:Polyinosinic polycytidylic acid (poly I:C) is an analog of double stranded RNA, which is a common replication intermediate for many viruses. It acts through a toll-like receptor (TLR3) to induce a group of cytokines that can mediate host resistance to viruses and some cancers. The effect of ethanol (EtOH) on induction...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)02507-9
更新日期：2003-03-07 00:00:00
abstract：AIMS:In this study, we conducted a meta-analysis to systematically compare the diagnostic accuracy of IGRAs performed for extrasanguinous body fluids with that performed for blood in the diagnosis of TB. MAIN METHODS:Multiple English and Chinese databases were searched up to November 2017. Studies that complied with t...
journal_title：Life sciences
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.lfs.2018.02.004
更新日期：2018-03-15 00:00:00
abstract：:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90130-j
更新日期：1990-01-01 00:00:00
abstract：:Guinea pig ileum longitudinal muscle/myenteric plexus preparations contain functional mu- and kappa-opioid receptors. A preparation with blocked kappa receptors was obtained by pretreating guinea pigs with 0.1-10.0 mg/kg intraperitoneal doses of a new kappa-selective affinity label, DIPPA (2-(3,4-dichlorophenyl)-N-met...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00076-3
更新日期：1997-01-01 00:00:00
abstract：:The present study shows that morphine reduces the pulmonary inflammatory response to intranasal influenza virus infection in rats. Rats were infected with rat-adapted influenza virus (RAIV), which is a unique infectious agent because normal rats develop an acute pulmonary inflammatory response to RAIV and rapidly clea...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00348-3
更新日期：1999-01-01 00:00:00
abstract：:Alpha-adrenergic receptors may play an important role in regulating vascular tone and reactivity. To study alpha-adrenergic receptors in blood vessels, we have developed a method to characterize and quantitate alpha-adrenergic receptors in a particulate fraction of individual rabbit aortas using the high specific acti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90227-3
更新日期：1984-02-13 00:00:00
abstract：AIMS:The objective of this study is to investigate glucosamine (GlcN) as a transcriptional regulator of iNOS and other genes in association with the dynamic O-GlcNAcylation of RNA polymerase II (RNAPII). MAIN METHODS:The LPS- and/or GlcN-stimulated transcriptional activities of various Gal4-binding site/TATA-box-conta...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.06.011
更新日期：2014-08-21 00:00:00
abstract：:Despite the considerable number of published studies in the field of S-nitrosothiols (RSNO), the determination of these compounds in biological samples still represents an analytical challenge, due to several technical obstacles and often long sample preparation procedures. Other problems derive from the intrinsic lab...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2010.10.024
更新日期：2011-01-17 00:00:00
abstract：:The effects of different kinds of acute stress on collagen-induced whole blood platelet aggregation and fibrinolysis in relation to blood serotonergic measures were studied. In rats water-immersion restraint stress resulted in a shortening of euglobulin clot lysis time (ECLT), an increase in tissue plasminogen activat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00855-8
更新日期：1994-01-01 00:00:00
abstract：:N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. The mechanism of NOS inhibition by L-NAME is uncertain. L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). Concommitantly, L-NAME was hydrolyzed, non-enzymatically, to N(G)-Nitro-L-a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00140-9
更新日期：1997-01-01 00:00:00
abstract：AIMS:To study the underlying mechanisms of sulforaphane, a natural histone deacetylase (HDAC) inhibitor, in inhibiting triple negative breast cancer cells growth and the therapeutic effects of combination of sulforaphane and doxorubicin in TNBC treatment. MATERIALS AND METHODS:The antineoplastic activity of sulforapha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.10.034
更新日期：2018-11-15 00:00:00
abstract：:In this study we analyzed the N-formyl-Met-Leu-Phe (fMLP)-induced calcium signal in alveolar macrophages (AM) isolated from ovalbumin-sensitized (OA-sensitized AM) and naive (naive AM) guinea-pigs. Guinea-pigs were sensitized by subcutaneous injection of OA and AM were isolated by bronchoalveolar lavage 6 weeks therea...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01239-5
更新日期：2001-08-24 00:00:00
abstract：:It has been shown that the antagonism of glutamate receptors activity was able inhibit proliferation and induce apoptosis in several neuronal and non-neuronal cancer cell lines. In addition, it has been shown that glutamate might facilitate the spread and growth of leukemia T cells through interactions with AMPA recep...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.03.051
更新日期：2016-05-01 00:00:00
abstract：:A novel bioactive lipid, cyclic phosphatidic acid (cPA), was identified in lipids bound to human serum albumin. A cPA fraction was extracted and purified from human serum albumin by use of a combination of preparative TLC and HPLC. Electrospray ionization mass spectrometry of the purified fraction showed molecular ion...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00483-x
更新日期：1999-01-01 00:00:00
abstract：AIMS:In our model, we aimed to explore the cytotoxicity of 5-Aza-2'-deoxycytidine (5-Aza-CdR) against the colorectal cell line, Lovo, and further characterize the possible mechanisms. MAIN METHODS:After Lovo cells were treated with 5-Aza-CdR at different concentrations for different periods of time, the cell viability...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.12.015
更新日期：2009-02-27 00:00:00
abstract：AIMS:Benidipine is a dihydropyridine (DHP) derived Ca2+ antagonist, can block triple Ca2+ channels (L, N, and T). It has been used as a safety anti-hypertensive drug because of its long-acting relaxant effect on vascular smooth muscle (VSM). However, whether benidipine has similar pharmacological actions in airway smoo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.04.036
更新日期：2019-06-15 00:00:00
abstract：:Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal myositis is poorly understood. Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotens...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118067
更新日期：2020-09-15 00:00:00
abstract：:Purification of endothelin converting enzyme (ECE) from endothelial cells has been hindered by the difficulty in obtaining primary endothelial cells in large quantity. We therefore tested transformed human umbilical vein endothelial cells (EA.hy926) for ECE activity. Our data clearly demonstrate that this transformed ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00227-w
更新日期：1995-01-01 00:00:00
abstract：:Interleukin (IL)-1 beta is a pro-inflammatory cytokine that has been shown to play a pivotal role in the onset of inflammatory bowel disease (IBD), however, the molecular mechanisms underlying the production of IL-1 beta in IBD are not fully understood. We investigated dextran sulfate sodium (DSS)-induced IL-1 beta pr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.05.022
更新日期：2007-07-12 00:00:00
abstract：:Insulin therapy remains the standard of care for achieving and maintaining adequate glycemic control, especially in hospitalized patients with critical and noncritical illnesses. Insulin therapy is more effective against elevated fasting glycaemia but less in the reduction of postprandial hyperglycaemia. It is associa...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2013.12.210
更新日期：2014-03-18 00:00:00
abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90092-1
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND/AIMS:Previous studies have demonstrated that Galactooligosaccharides (GOS), known as "bifidus factor", has anti-inflammatory effects. Colitis, a kind of colonic inflammatory damage could be induced by different chemicals. The pathogenesis and mechanism of colitis remains unclear, and may be related to intest...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117220
更新日期：2020-02-01 00:00:00
abstract：AIMS:Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have only examined the eff...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.08.005
更新日期：2014-10-02 00:00:00
