Abstract:
:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and result in increased intimal permeability, the initiating event in atherosclerosis. The present studies show that the glucose transport inhibitor cytochalasin B blocked the uptake of 3H-2-deoxy-D-glucose (2.5 mg%) by mouse 3T3 fibroblasts. Cytochalasin B also blocked the uptake of 14C-L-ascorbic acid (1.25 mg%). The results of these studies further support the hypothesis that glucose and ascorbate share a common transport system. This may have important implications concerning the vascular pathology associated with diabetes mellitus.
journal_name
Life Scijournal_title
Life sciencesauthors
Fay MJ,Bush MJ,Verlangieri AJdoi
10.1016/0024-3205(90)90130-jsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
619-24issue
9eissn
0024-3205issn
1879-0631pii
0024-3205(90)90130-Jjournal_volume
46pub_type
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