Bacitracin U.S.P. contains a factor that stimulates receptors for 5-hydroxytryptamine on rabbit aortic strips.

abstract：:The distribution of thiamine-immunoreactive structures was studied in the brain of the monkey using an indirect immunoperoxidase technique. Fibers containing thiamine, but no thiamine-immunoreactive cell bodies, were found. The highest density of fibers containing thiamine was observed in the pulvinar nucleus and in t...

journal_title：Life sciences

authors： Mangas A,Coveñas R,Geffard K,Geffard M,Marcos P,Insausti R,Dabadie MP

更新日期：2006-08-15 00:00:00

abstract：:Adenylate cyclase activity in pancreatic acinar cell membranes was determined in rats that had undergone a treatment with pentagastrin (250 micrograms/kg, intraperitoneal three times daily) for 1 week or that had undergone small bowel resection (90%) and were sacrified at 2 weeks, 1 month and 6 months after interventi...

journal_title：Life sciences

authors： Alvaro-Alonso I,Boyano-Adánez MC,Martín-Espinosa A,Arilla E

更新日期：1995-01-01 00:00:00

abstract：AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assay...

journal_title：Life sciences

authors： Sogawa N,Hirai K,Sogawa C,Ohyama K,Miyazaki I,Tsukamoto G,Asanuma M,Sasaki A,Kitayama S

更新日期：2013-04-09 00:00:00

abstract：:Studies have reported that taraxasterol (TAR) is effective in the treatment of immune liver injury and alcoholic liver injury. The mechanism of action is mainly related to the inhibition of inflammation. To determine the key molecular mechanisms for the effect of TAR on alleviating ethanol and high-fat diet-induced li...

journal_title：Life sciences

authors： Li Z,Lian Y,Wei R,Jin L,Cao H,Zhao T,Ma X,Zhong M,Gao Y,Zhang K

更新日期：2020-12-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was d...

journal_title：Life sciences

authors： Margareto J,Aguado M,Osés-Prieto JA,Rivero I,Monge A,Aldana I,Marti A,Martínez JA

更新日期：2000-11-24 00:00:00

abstract：:The effects of the benzodiazepines diazepam and midazolam on the rigidity produced by systemic administration of morphine (15 mg/kg i.p.) were studied in rats. The rigidity was recorded as a tonic activity from the gastrocnemius-soleus muscle of non-anesthetized rats in the electromyogram. Both diazepam (1-5 mg/kg i.p...

journal_title：Life sciences

authors： Turski L,Havemann U,Kuschinsky K

更新日期：1983-01-01 00:00:00

abstract：:A radioreceptor assay using [3H]nitrendipine and rat cerebral cortical membranes, in conjunction with equilibrium dialysis, measures the unbound (free) level of nitrendipine in human sera. The sensitivity of the assay is 0.1-0.2 picomoles/ml and is linear from 4 X 10(-11) to 4 X 10(-9) M nitrendipine. Other dihydropyr...

journal_title：Life sciences

authors： Lee HR,Roeske WR,Yamamura HI

更新日期：1983-10-31 00:00:00

abstract：:[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorp...

journal_title：Life sciences

authors： Young E,Walker JM,Houghten R,Akil H

更新日期：1983-01-01 00:00:00

abstract：:Polyinosinic polycytidylic acid (poly I:C) is an analog of double stranded RNA, which is a common replication intermediate for many viruses. It acts through a toll-like receptor (TLR3) to induce a group of cytokines that can mediate host resistance to viruses and some cancers. The effect of ethanol (EtOH) on induction...

journal_title：Life sciences

authors： Pruett SB,Fan R,Zheng Q

更新日期：2003-03-07 00:00:00

abstract：:The cytokeratins from human bladder and esophageal epithelia were separated using chromatographic techniques. The cytokeratins were first extracted from fresh autopsy tissue using high and low salt buffers. Urea, 8.0-9.5 M, was used to solubilize the resulting cytokeratin pellet. Imidazole was found to increase the so...

journal_title：Life sciences

authors： Meiklejohn B,Nagle RB,McDaniel KM,Wilson GS

更新日期：1990-01-01 00:00:00

abstract：AIM:Epidermal growth factor receptor (EGFR) related reactive oxygen species (ROS) generation results in myocardial damage. We aimed to investigate the role of gefitinib (EGFR-tyrosine kinase inhibitor) in diabetic cardiomyopathy (DbCM). METHOD:DbCM was induced by injecting streptozotocin (55 mg/kg for 5 consecutive da...

journal_title：Life sciences

authors： Shah S,Akhtar MS,Hassan MQ,Akhtar M,Paudel YN,Najmi AK

更新日期：2018-10-01 00:00:00

abstract：AIMS:Neurocardiac dysfunction is a life-threatening systemic consequence of subarachnoid hemorrhage (SAH) that contributes to triggering delayed cerebral ischemia (DCI). This study aimed to determine the impact of dobutamine cardiac support during isoflurane postconditioning on post-SAH DCI. MAIN METHODS:Male C57BL/6 ...

journal_title：Life sciences

authors： Mutoh T,Mutoh T,Sasaki K,Yamamoto Y,Tsuru Y,Tsubone H,Ishikawa T,Taki Y

更新日期：2016-05-15 00:00:00

abstract：:It has been suggested that the myocardial production of nitric oxide, as a consequence of expression of the inducible isoform of nitric oxide synthase (NOS), plays an important role in the pathophysiology of heart failure. We determined the net cardiac production of nitrogen oxides (NOx), as a measure of NOS activity,...

journal_title：Life sciences

authors： Kaye DM,Chin-Dusting J,Esler MD,Jennings GL

更新日期：1998-01-01 00:00:00

abstract：:Acute ethanol treatment in vivo (i.p. injection of 3.5 g ethanol/Kg B. wt.) stimulated the release of beta-endorphin like peptides by the pituitary gland as was indicated by the increased content of beta-endorphin like immunoreactivity (beta-EPLIR) in the plasma. Furthermore, a significant decrease in the anterior lob...

journal_title：Life sciences

authors： Gianoulakis C,Barcomb A

更新日期：1987-01-05 00:00:00

abstract：:Both in men and rats, most of the ethanol ingested at a low dose is metabolized before it reaches the systemic circulation. Oxidation of ethanol (mainly in the stomach) accounts for the bulk of this effect. This "first pass" metabolism (FPM) may be viewed as a barrier which protects against the systemic toxicity of et...

journal_title：Life sciences

authors： Julkunen RJ,Di Padova C,Lieber CS

更新日期：1985-08-12 00:00:00

abstract：:The effect of clotrimazole on Ca2+ signaling in Madin Darby canine kidney (MDCK) cells was investigated by using fura-2 as a Ca2+ indicator. Clotrimazole (1-30 microM) induced a concentration-dependent [Ca2+]i increase. The [Ca2+]i increase comprised an initial rise and a slow decay. External Ca2+ removal partly inhib...

journal_title：Life sciences

authors： Jan CR,Tseng CJ,Chou KJ,Chiang HT

更新日期：2000-01-01 00:00:00

abstract：:Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4,5-bisphosphate (PIP2) was most strongly affected (50% inhibition at 3 mM phenobarbital); p...

journal_title：Life sciences

authors： Deshmukh DS,Kuizon S,Brockerhoff H

更新日期：1987-11-02 00:00:00

abstract：:Cholinergic neurons in the laterodorsal (LDT) and the pedunculopontine (PPT) tegmental nuclei act to promote REM sleep (REMS). The predominantly glutamatergic neurons of the REMS-induction region of the medial pontine reticular formation are in turn activated by cholinergic cells, which results in the occurrence of to...

journal_title：Life sciences

authors： Monti JM,Monti D

更新日期：2000-04-14 00:00:00

abstract：:Chromatin organization was examined in confluent cultures of embryonic lung fibroblasts in the middle and at the end of their replicative lifespan. Age-related modifications resulted in an unusually wide spacing of the chromatin threads induced by a mild loosening treatment and an increased sensitivity of the nucleoso...

journal_title：Life sciences

authors： Puvion-Dutilleul F,Puvion E,Macieira-Coelho A

更新日期：1983-06-13 00:00:00

abstract：AIMS:Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in ovarian cancer is still unknown. MAIN METHODS:Expression of NRSF in n...

journal_title：Life sciences

authors： Deng P,Zuo Y,Feng S,Li Z,Chen W,Li H,Wang X

更新日期：2018-12-15 00:00:00

abstract：:The impact of low level lead exposure on human central nervous system function is a major public health concern. This study addresses the inhibition of the cation pump enzyme Na, K-ATPase by low level lead. Human brain tissue was obtained at autopsy and frozen until use. Brain homogenates were preincubated with PbCl2 ...

journal_title：Life sciences

authors： Bertoni JM,Sprenkle PM

更新日期：1991-01-01 00:00:00

abstract：:In order to determine whether CCl4, CBrCl3, CBr4 or CHCl3 undergo oxidative metabolism to electrophilic halogens by liver microsomes, they were incubated with liver microsomes from phenobarbital pretreated rats in the presence of NADPH and 2,6-dimethylphenol. The analysis of the reaction mixtures by capillary gas chro...

journal_title：Life sciences

authors： Mico BA,Branchflower RV,Pohl LR,Pudzianowski AT,Loew GH

更新日期：1982-01-11 00:00:00

abstract：:Phospholipase C (PLC), an enzyme involved in the hydrolysis of membrane phospholipid- phosphatidylinositol-bisphosphate to inositol triphosphate and diacylglycerol, and Phorbol 12, myristate 13, acetate (PMA), a tumor promoting agent, could significantly stimulate testosterone (T) secretion from Leydig cells. Arachido...

journal_title：Life sciences

authors： Didolkar AK,Sundaram K

更新日期：1987-07-27 00:00:00

abstract：:Ethanol-induced emesis were investigated using Suncus murinus and the emetogenic mechanisms of ethanol were compared with those of cisplatin. Intraperitoneal injection of ethanol caused dose-dependent emesis with ED50 value of 22.3% (v/v) when injection volume was adjusted to 4 ml/kg. Intraperitoneal and subcutaneous ...

journal_title：Life sciences

authors： Chen Y,Saito H,Matsuki N

更新日期：1997-01-01 00:00:00

abstract：:Intravenous (IV) administration of 10 ug/kg of morphine sulfate increased the firing rate of Type A dopamine neurons but decreased the extracellular activity of Type B dopamine cells in the substantia nigra pars compacta and ventral tegmental area of anesthetized male rats. The morphine-produced increase in Type A cel...

journal_title：Life sciences

authors： Ostrowski NL,Hatfield CB,Caggiula AR

更新日期：1982-11-15 00:00:00

abstract：:Prenatal exposure to low concentrations of carbon monoxide (CO, 75 and 150 ppm from day 0 to day 20 of gestation), resulting in maternal blood HbCO concentrations equivalent to those maintained by human cigarette smokers, leads to subtle myelin alterations in the sciatic nerve of male rat offspring. The rapid growth s...

journal_title：Life sciences

authors： Carratù MR,Cagiano R,Desantis S,Labate M,Tattoli M,Trabace L,Cuomo V

更新日期：2000-08-25 00:00:00

abstract：AIMS:slc26a proteins are responsible for a large number of functions either in normal physiology or in human disease. We have previously reported that proximal tubular epithelial (PTE) cells immortalized from spontaneously hypertensive rats (SHRs) were endowed with increased Cl(-)/HCO3(-) exchanger activity and slc26a6...

journal_title：Life sciences

authors： Simão S,Gomes P,Pinho MJ,Soares-da-Silva P

更新日期：2013-10-06 00:00:00

abstract：AIM:Nontuberculous mycobacterial (NTM) infection such as endophthalmitis, dacryocystitis, and canaliculitis are pervasive across the globe and are currently managed by antibiotics. However, the recent cases of Mycobacteroides developing drug resistance reported along with the improper practice of medicine intrigued us ...

journal_title：Life sciences

authors： Satyam R,Bhardwaj T,Jha NK,Jha SK,Nand P

更新日期：2020-06-01 00:00:00

abstract：:Bupleuri radix, a traditional Chinese herb, has been widely used to treat liver diseases such as hepatitis and cirrhosis. The acetone extract of Bupleurum scorzonerifolium (AE-BS) showed a dose-dependently antiproliferative effect on the proliferation of A549 human lung cancer cells. The IC(50) of AE-BS, i.e., the con...

journal_title：Life sciences

authors： Cheng YL,Chang WL,Lee SC,Liu YG,Lin HC,Chen CJ,Yen CY,Yu DS,Lin SZ,Harn HJ

更新日期：2003-09-19 00:00:00

abstract：:The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigat...

journal_title：Life sciences

authors： Watanabe HK,Hoskins B,Ho IK

更新日期：1988-01-01 00:00:00