Abstract:
:The effects of subacute treatment with cocaine on activities of cocaine N-demethylase, UDP-glucuronyltransferase (GT) toward 4-nitrophenol and phenolphthalein and sulfotransferase (ST) toward androsterone and 4-nitrophenol in livers from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigated. Hepatic metabolism of cocaine was different between the sexes (with males having higher N-demethylase activity) and the strains (with WKY rats having higher activity). The effects of subacute cocaine administration on the activity of cocaine N-demethylase were also sex- and strain-related. Whereas cocaine administration increased activity of hepatic N-demethylase in both female strains, it decreased activity in male WKY and had no effect on activity in male SHR. Sex and strain-related as well as cocaine-induced differences were also found in activities of hepatic GT toward 4-nitrophenol and phenolphthalein as well as in activity of hepatic ST towards andersterone and 4-nitrophenol. These results suggest that some of the individual variation in the effects of cocaine may be due to sex and genetic differences in the hepatic metabolism of cocaine and/or in sexually and/or/genetically-determined differences in how cocaine affects hepatic metabolism of other xenobiotics.
journal_name
Life Scijournal_title
Life sciencesauthors
Watanabe HK,Hoskins B,Ho IKdoi
10.1016/0024-3205(88)90626-1subject
Has Abstractpub_date
1988-01-01 00:00:00pages
79-86issue
1eissn
0024-3205issn
1879-0631pii
0024-3205(88)90626-1journal_volume
42pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Repeated, low-intensity electrical stimulation of the heart gradually leads to the development of electrocardiographic abnormalities that culminate in cardiac arrhythmias, mainly A-V block in the isolated heart frog and ventricular and supraventricular tachyarrhythmias in the canine heart in situ. The pattern of devel...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90437-7
更新日期:1988-01-01 00:00:00
abstract:AIM:A variety of evidence suggests that vitamin D can prevent the development of multiple sclerosis (MS). TGF-β pathway genes also play important roles in MS. Here, we aim to study whether vitamin D affects TGF-β pathway gene expression and Expanded Disability Status Scale (EDSS) scores in MS patients. MAIN METHODS:A ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.05.017
更新日期:2015-08-01 00:00:00
abstract::Dietary guidelines published in the past two decades have acknowledged the beneficial effects of myricetin, an important and common type of herbal flavonoid, against several human diseases such as inflammation, cardiovascular pathologies, and cancer. An increasing number of studies have shown the beneficial effects of...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2015.10.004
更新日期:2015-12-01 00:00:00
abstract::The cardio- and neuroprotective effect of the pyridoindole stobadine (S) is conditioned mainly by its good radical scavenging properties. It has been showed by EPR experiment, that the ultimate product of the reaction of stobadine with hydroxyl radical is the nitroxyl radical. However, for the unsaturated dehydrostoba...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00440-3
更新日期:1999-01-01 00:00:00
abstract::DCLHb, a hemoglobin based oxygen carrier, has been extensively studied for the treatment of hemorrhagic shock in both animal models and humans. Numerous accidents resulting in trauma are due to ethanol intoxication, in particular cases of car accidents. Therefore, trauma patients might be intoxicated with drugs of abu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)01040-7
更新日期:2001-02-09 00:00:00
abstract::A microiontophoretic study using rats anesthetized with chloral hydrate and immobilized with gallamine triethiodide was carried out to compare the effect of talipexole (B-HT 920 CL2:2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo [4,5-d]-azepine-dihydrochloride), a dopamine autoreceptor agonist, on dopaminergic neurons...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90071-i
更新日期:1991-01-01 00:00:00
abstract:AIM:To evaluate the therapeutic efficacy of hypoxic cell-sensitizer Sanazole (SAN) -directed targeting of cytotoxic drug Berberine (BBN) and Iron-oxide nanoparticle (NP) complexes, to solid tumor in Swiss albino mice. MAIN METHODS:NP-BBN-SAN complexes were characterized by FTIR, XRD, TEM and Nano-size analyzer. This c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.12.036
更新日期:2018-02-15 00:00:00
abstract::The energy balance equation applicable to all living organisms was used as a framework on which to construct a critical review of some of the more controversial aspects of the obesity problem. The equation matches energy intake against all the known forms of work that the body does in utilizing that energy, including ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(88)90286-x
更新日期:1988-01-01 00:00:00
abstract::The binding of 3H-ouabain to human erythrocytes was analyzed in a population of hospitalized male ethanol addicted patients under long term digitalis treatment. In the non-alcoholic patient group the long term digitalis treatment induced an increase in Bmax and Kd values; such modification was not observed in the alco...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90071-3
更新日期:1987-06-29 00:00:00
abstract::Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118641
更新日期:2021-01-01 00:00:00
abstract::Recent head-twitch response (HTR) studies in mice have indicated that withdrawal from chronic cocaine exposure produces deficits in CNS conversion of L-tryptophan to 5-HT. In the present study, the ability of 5-HT releaser, d-fenfluramine, was utilized to induce the HTR in mice following abstinence from chronic cocain...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01012-6
更新日期:1997-01-01 00:00:00
abstract::We investigated the mechanism mediating cholinergic control of cell-to-cell adhesion of human epidermal keratinocytes (KC) by non-neuronal acetylcholine produced by KC themselves. We first measured cholinergic effects on the expression of desmoglein (Dsg) 1 and 3 in KC using the semi-quantitative immunofluorescence an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00087-0
更新日期:2003-03-28 00:00:00
abstract:UNLABELLED:The present study was conducted to examine whether melatonin impairs serotonin (5HT) release and uptake in rat platelets. Exposure of platelet-rich plasma samples (PRP) to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90261-z
更新日期:1993-01-01 00:00:00
abstract::The ontogeny of endothelin (ET) system in rats was studied in preterm (18 days of gestation), term (21 days of gestation) and 1 week post term rats. Brains were dissected out and (1) processed for the estimation of endogenous ET-1 by RIA and (2) membranes were prepared for radioreceptor binding. Receptor characteristi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90300-e
更新日期:1992-01-01 00:00:00
abstract::The prototypic arylpiperazines, meta-chlorophenylpiperazine (mCPP), meta-trifluoromethylphenylpiperazine (TFMPP) and quipazine are widely studied serotonergic ligands with nonselective effects at 5HT1 and 5HT2 receptor subtypes. The present study was designed to compare the affinities of these arylipiperazines at 5HT3...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90372-v
更新日期:1992-01-01 00:00:00
abstract::As a step in the purification and characterization of the glucose transporter from rat skeletal muscle, we have reconstituted glucose transport activity in liposomes. Plasma membranes were prepared from skeletal muscle which display D-glucose reversible binding of cytochalasin B (10 pmol sites/mg protein; KD = 0.3 mic...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90503-0
更新日期:1987-06-15 00:00:00
abstract:AIMS:Enhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. However, the underlying molecular mechanism...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116966
更新日期:2019-12-15 00:00:00
abstract:AIMS:Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.02.011
更新日期:2016-03-01 00:00:00
abstract::To characterize the mechanism of the analgesic action of H1 antihistaminics the effects of a new, highly selective agonist, 2-(3-trifluoromethylphenyl)histamine dihydrogenmaleate (FMPH), and of the better known H1 agonist, 2-thiazolylethylamine (2-TEA), were studied on pain threshold by means of three different kinds ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00295-1
更新日期:1998-01-01 00:00:00
abstract:AIMS:This study aims to evaluate the relationship between the amount of physical activity and different traditional and novel cardiometabolic risk factors, as well as atheroprotective agents, in male children and adolescents. MAIN METHODS:Cross-sectional study. A total of 337 male children and adolescents aged 7-14 ye...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.05.021
更新日期:2013-07-30 00:00:00
abstract::Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00734-9
更新日期:1994-01-01 00:00:00
abstract::Release of alpha-MSH from the pars intermedia melanotrope cells of Xenopus laevis is regulated by various classical neurotransmitters and neuropeptides. We have examined the effect of two of these regulatory substances, the neurotransmitter GABA and the CRF-related peptide sauvagine, on the adenylate cyclase system of...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90123-s
更新日期:1991-01-01 00:00:00
abstract:AIMS:This study evaluates ocular (iris, ciliary body and ciliary process) and nonocular (atria and lung) beta-adrenoceptors in rabbit to characterize the plasma membrane beta-adrenoceptors and binding affinities of beta-adrenoceptor antagonists. MAIN METHODS:The tissue segment binding method with a hydrophilic radioli...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.11.016
更新日期:2009-01-30 00:00:00
abstract::Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90623-3
更新日期:1982-03-15 00:00:00
abstract::The effect of silymarin on different functions of mitochondria isolated from rat kidneys was studied. Addition of silymarin to mitochondria oxidizing succinate, induced stimulation of the respiratory State 4; while in mitochondria oxidizing NAD-dependent substrates, the drug produced inhibition of the oxygen consumpti...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90542-5
更新日期:1988-01-01 00:00:00
abstract::This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg0 at 6.6 to 7.5 mg/m3 for 4 hr each day for 3 consecutive days. This dosing protocol was lethal to o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00129-0
更新日期:1999-01-01 00:00:00
abstract:AIM:Physical exercise is important in the prevention and treatment of cardiovascular diseases. Nevertheless, controversy remains around type and intensity of effort required for significant biochemical protective changes. This study investigates two exercise protocols on ventricular oxidative parameters in rats post-in...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.01.018
更新日期:2012-04-09 00:00:00
abstract:AIMS:Oxidative stress is involved in cholestasis-induced hepatic damage. Therefore, antioxidant therapy is a recommended therapeutic strategy. Studies have illustrated that chromium can enhance antioxidative capacity leading to a resolution of oxidative stress. The aim of this study was to assess whether chromium has p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.02.003
更新日期:2009-04-24 00:00:00
abstract::Endothelin-1 (ET-1) has been proposed as one of the possible mediators of the vasoconstriction seen following ischemia and reperfusion. We investigated the effect of ischemia and reperfusion on the contractile response of canine renal and iliac arteries to the dihydropyridine-type calcium channel agonist (+/-)Bay K 86...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00267-a
更新日期:1995-01-01 00:00:00
abstract::Red wine, at a final dilution of 1/50, caused release of [14C]5-hydroxytryptamine (5-HT) from preloaded platelets, an effect which was not observed with any white wines or beers tested. Since 5-HT, is probably released from body stores during migraine attacks and red wine is known to provoke migraine episodes in susce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90265-d
更新日期:1991-01-01 00:00:00