Abstract：
AIM:A variety of evidence suggests that vitamin D can prevent the development of multiple sclerosis (MS). TGF-β pathway genes also play important roles in MS. Here, we aim to study whether vitamin D affects TGF-β pathway gene expression and Expanded Disability Status Scale (EDSS) scores in MS patients. MAIN METHODS:A randomized clinical trial was conducted on 31 relapsing-remitting (RR) MS patients. Using real-time RT-PCR, we tested the levels of TGF-β2, TGF-βRI and TGF-βRII mRNAs in the RRMS patients before and after 8 weeks of supplementation with vitamin D. KEY FINDINGS:Expression of TGF-β2 mRNA increased 2.84-fold, while TGF-βRI and TGF-βRII mRNA levels did not change after vitamin D treatment. In addition, these results revealed no correlation between the normalized expression of TGF-β2, TGF-βRI, or TGF-βRII and EDSS scores. SIGNIFICANCE:Here, we demonstrate new evidence for the complex role of vitamin D in the pathogenesis, activity and progression of MS through the TGF-β signaling pathway.
journal_name
Life Scijournal_title
Life sciencesauthors
Shirvani-Farsani Z,Behmanesh M,Mohammadi SM,Naser Moghadasi Adoi
10.1016/j.lfs.2015.05.017subject
Has Abstractpub_date
2015-08-01 00:00:00pages
63-7eissn
0024-3205issn
1879-0631pii
S0024-3205(15)00294-5journal_volume
134pub_type
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