Is highly expressed ACE 2 in pregnant women "a curse" in times of COVID-19 pandemic?

abstract：:Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...

journal_title：Life sciences

authors： Li Y,Li G,Suo L,Zhang J

更新日期：2021-01-01 00:00:00

abstract：:The effect of Rp diastereoisomer of adenosine 3',5'-cyclic monophosphothioate (Rp-cAMPS) on relaxation elicited by histamine (1-100 microM), forskolin (1-60 microM), papaverine (1-100 microM), vinpocetine (1-100 microM), rolipram (0.1-1 mM), Sp-cAMPS (10-300 microM), 8-BrcAMP (10 microM - 1 mM) and 8-BrcGMP (3 microM ...

journal_title：Life sciences

authors： Perez-Vallina JR,Revuelta MP,Cantabrana B,Hidalgo A

更新日期：1997-01-01 00:00:00

abstract：:Intracellular calcium plays an important role on the pathogenesis of hypoxia-induced cellular injury. Calbindin-D(28k), a cytosolic vitamin D-dependent calcium binding protein, can serve as a buffer to limit a surge in intracellular Ca2+ concentration ([Ca2+]i) induced by various stimulations. To evaluate the possible...

journal_title：Life sciences

authors： Wu MJ,Lai LW,Lien YH

更新日期：2002-06-21 00:00:00

abstract：AIMS:Enhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. However, the underlying molecular mechanism...

journal_title：Life sciences

authors： Hu,Zeng Z,Xia Q,Liu Z,Feng X,Chen J,Huang M,Chen L,Fang Z,Liu Q,Zeng H,Zhou X,Liu J

更新日期：2019-12-15 00:00:00

abstract：AIMS:The present study was designed to compare the effects of a low-fat diet (LF), calorie restriction (CR), quercetin (Que) and exercise (Ex) on hepatic steatosis in a high-fat (HF) diet-induced obesity prone (OP) model in the perspective of microRNA (miR)-dependent thyroid hormone (TH) synthesis and action. MAIN MET...

journal_title：Life sciences

authors： Xia SF,Jiang YY,Qiu YY,Huang W,Wang J

更新日期：2020-02-01 00:00:00

abstract：AIMS:In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analgesics in rats with painful diabetic neuropathy. Using mic...

journal_title：Life sciences

authors： Suehiro K,Funao T,Fujimoto Y,Yamada T,Mori T,Nishikawa K

更新日期：2013-06-21 00:00:00

abstract：:Exposure of rats to an acute, uncontrollable stressor can increase brain norepinephrine (NE) turnover and decrease locomotor and exploratory behavior. We examined the ability of exogenous tyrosine, NE's amino acid precursor, to protect rats from developing these neurochemical and behavioral changes when stressed. Anim...

journal_title：Life sciences

authors： Reinstein DK,Lehnert H,Scott NA,Wurtman RJ

更新日期：1984-06-04 00:00:00

abstract：:Nitric oxide (NO) is a highly reactive free radical that is involved in a variety of different biological process. In recent reports, the putative role of NO in the neuropathogenesis of brain inflammation has been demonstrated. And then the relation between neuronal NO and convulsive seizures induced by virus has been...

journal_title：Life sciences

authors： Kawashima H,Inage Y,Ogihara M,Kashiwagi Y,Takekuma K,Hoshika A,Mori T,Watanabe Y

更新日期：2004-01-30 00:00:00

abstract：:Tifluadom, although structurally a 1,4 benzodiazepine, has no affinity for the 3H-flunitrazepam binding site, but is a potent displacer of 3H-bremazocine from its opioid binding site. Tifluadom is characterised as an opiate kappa-receptor agonist in vitro and in vivo with potent analgesic activity in animals and no de...

journal_title：Life sciences

authors： Römer D,Büscher HH,Hill RC,Maurer R,Petcher TJ,Zeugner H,Benson W,Finner E,Milkowski W,Thies PW

更新日期：1982-09-20 00:00:00

abstract：:Obesity, the metabolic syndrome (MetS), and type 2 diabetes (T2DM) are associated with heightened cardiovascular risk. Given the vasoconstrictor and proatherogenic properties of endothelin (ET)-1, increased ET-1 activity has been postulated to participate in the derangement of adiposity-related vascular homeostasis. T...

journal_title：Life sciences

authors： Campia U,Tesauro M,Di Daniele N,Cardillo C

更新日期：2014-11-24 00:00:00

abstract：:The activation of cholinergic pathways by nicotine elicits various physiological and pharmacological effects in mammals. For example, the stimulation of nicotinic acetylcholine receptors (nAChRs) leads to an antinociceptive effect. However, it remains to be elucidated which subtypes of nAChR are involved in the antino...

journal_title：Life sciences

authors： Abdin MJ,Morioka N,Morita K,Kitayama T,Kitayama S,Nakashima T,Dohi T

更新日期：2006-12-03 00:00:00

abstract：AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...

journal_title：Life sciences

authors： Zhao S,Xu K,Jiang R,Li DY,Guo XX,Zhou P,Tang JF,Li LS,Zeng D,Hu L,Ran JH,Li J,Chen DL

更新日期：2020-06-15 00:00:00

abstract：:In this study, we investigated the effects of zinc L-carnosine, an anti-ulcer drug, on acetic acid-induced colonic mucosal injury and the correlation of these effects with expression of 72-kDa heat shock proteins (HSP72) and nuclear factor kappa B (NF-kappaB) activation in rat colonic mucosa in vivo. After intrarectal...

journal_title：Life sciences

authors： Odashima M,Otaka M,Jin M,Wada I,Horikawa Y,Matsuhashi T,Ohba R,Hatakeyama N,Oyake J,Watanabe S

更新日期：2006-11-10 00:00:00

abstract：:We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related pept...

journal_title：Life sciences

authors： McMillen IC,Jenkin G,Haji-Baba AS,Browne CA,Thorburn GD

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...

journal_title：Life sciences

authors： Li F,Long TY,Bi SS,Sheikh SA,Zhang CL

更新日期：2020-09-15 00:00:00

abstract：:We determined by PCR the number of (A-C)n repeats in the 2. 1 kb upstream of the aldose reductase (AR2) gene in healthy control subjects and in patients with NIDDM in Japanese. Sixty-one patients were recruited based on the severity of retinopathy and subdivided into two groups with proliferative retinopathy and witho...

journal_title：Life sciences

authors： Ikegishi Y,Tawata M,Aida K,Onaya T

更新日期：1999-01-01 00:00:00

abstract：:The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels...

journal_title：Life sciences

authors： Polizio AH,Gorzalczany S,Taira C,Peña C

更新日期：2006-07-04 00:00:00

abstract：:Opioid peptides have been demonstrated to stimulate prolactin secretion, and it has been postulated that this is mediated, at least in part, by an effect on hypothalamic prolactin releasing and release-inhibiting factors and neurotransmitters. The aim of this study was to investigate the effect of opioid peptides and ...

journal_title：Life sciences

authors： Burns G,Baker DJ,Brown BL,Dobson PR

更新日期：1987-03-09 00:00:00

abstract：:The effects of free fatty acids in the blood on osmotic fragility and water content of erythrocytes when combined with hyperthermia were investigated. The isotonic buffer, containing the fatty acid, was added to the erythrocyte suspension to a final concentration of 200 microM/L. The samples were kept for one hour in ...

journal_title：Life sciences

authors： Kogawa H,Yabushita N,Nakajima T,Kageyama K

更新日期：1998-01-01 00:00:00

abstract：:10(-4) M ouabain increases aldosterone production at 3.6 and 5.4 mM potassium concentrations, whereas at high potassium concentration (7 mM) even lower concentration of ouabain (10(-8) M) decreases it. As ouabain has been shown to be produced by the adrenal cortex, a local paracrine regulation of aldosterone productio...

journal_title：Life sciences

authors： Szalay KS

更新日期：1993-01-01 00:00:00

abstract：:Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...

journal_title：Life sciences

authors： Wei Z,Hao Y,Yu H,Shi L,Jing X,Zhang X,Liu N,Li T,Zhang X,Yuan F

更新日期：2020-09-15 00:00:00

abstract：:Extracts of Hypericum perforatum (St. John's wort) have antidepressant properties in depressed patients and exert antidepressant-like action in laboratory animals. The phloroglucinol derivative hyperforin has become a topic of interest, as this Hypericum component is a potent inhibitor of monoamines reuptake. The mole...

journal_title：Life sciences

authors： Roz N,Rehavi M

更新日期：2003-06-13 00:00:00

abstract：:To assess the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase activity (a marker of bone formation), and bone mineral density (BM...

journal_title：Life sciences

authors： Ladizesky MG,Cutrera RA,Boggio V,Somoza J,Centrella JM,Mautalen C,Cardinali DP

更新日期：2001-12-21 00:00:00

abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...

journal_title：Life sciences

authors： Maccarrone C,Jarrott B

更新日期：1988-01-01 00:00:00

abstract：:Carbachol (CCH), serotonin (5HT), divalent ionophore A23187, cAMP, and certain neuropeptides, i.e. substance P (SP), inhibit the initial rate of uptake (influx) of 22Na into isolated chicken villus enterocytes. All these agents also increase cytosolic Ca. However, the increases stimulated by CCH, 5HT, and cAMP are not...

journal_title：Life sciences

authors： Chang EB,Musch MW

更新日期：1990-01-01 00:00:00

abstract：AIMS:Lipid soluble vitamin E plays a role in several physiological mechanisms, however, the mechanism of this action is controversial. We investigated how tocopherol (α-tocopherol acid succinate) influences the effects of cyclooxygenase inhibitors (COXi) in the smooth muscles. MAIN METHODS:The contractility of the sam...

journal_title：Life sciences

authors： Kothencz A,Hajagos-Tóth J,Csányi A,Gáspár R

更新日期：2018-01-01 00:00:00

abstract：:The present study was designed to investigate the effect of partial (two-thirds) hepatectomy (PH) on hepatic and intestinal glutathione S-transferases (GSTs) activities. A significant decrease of cytosolic hepatic GSTs activity was observed after the PH. The lowest value of hepatic GSTs was obtained 48 h after the sur...

journal_title：Life sciences

authors： Carnovale CE,Monti JA,Favre C,Scapini C,Carrillo MC

更新日期：1995-01-01 00:00:00

abstract：:Inositol hexaphosphate (InsP6 or IP6) is ubiquitous. At 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) as well as inositol (Ins) are contained in most mammalian cells, wherein they are important in regulating vital cellular functions such as signal transduction, cell proliferation a...

journal_title：Life sciences

authors： Shamsuddin AM,Vucenik I,Cole KE

更新日期：1997-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were given a single electroconvulsive shock (ECS) on alternate days and sacrificed 48 hrs after 1, 3, or 5 seizures. The content of TRH in hippocampus, pyriform cortex and amygdala was increased 2.5-fold, 5.4-fold and 4.3-fold respectively, 48 hrs. after 3 alternate-day electroconvulsive shock...

journal_title：Life sciences

authors： Kubek MJ,Meyerhoff JL,Hill TG,Norton JA,Sattin A

更新日期：1985-01-28 00:00:00

abstract：:It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were...

journal_title：Life sciences

authors： Caronti B,Calderaro C,Passarelli F,Palladini G,Pontieri FE

更新日期：1998-01-01 00:00:00