Unexpected opioid activity in a known class of drug.

abstract：:The bradykinin-induced sensitization of cutaneous nociceptors to heat was previously shown to be abolished by cyclooxygenase blockade suggesting that endogenous prostaglandins exerted a heat-sensitizing action. The present study aimed at investigating the effects of exogenous prostaglandin E(2) (PGE(2)) and I(2) (PGI(...

journal_title：Life sciences

authors： Derow A,Izydorczyk I,Kuhn A,Reeh PW,Petho G

更新日期：2007-12-14 00:00:00

abstract：:The release of endogenous dopamine (DA) has been measured in the rat striatum following the intracardial administration of various doses of beta-phenylethylamine (PEA) or alpha,alpha-dideutero-beta-phenylethylamine (deuterated PEA). The release was significantly increased for a period of approximately 15 minutes by a ...

journal_title：Life sciences

authors： Philips SR

更新日期：1986-12-22 00:00:00

abstract：:This report documents studies on the spontaneous reactivation of human erythrocyte acetylcholinesterase and human serum butyrylcholinesterase following inhibition by organophosphinate esters. The spontaneous reactivation reactions were carried out at 26.0 degrees C in 0.10 M phosphate buffer of pH 7.6. Based upon resu...

journal_title：Life sciences

authors： Lawson MA,Lieske CN,Fox-Talbot MK,Meyer HG

更新日期：1985-05-06 00:00:00

abstract：:Ventricular hypertrophy is a risk factors for arrhythmias, ischemia and sudden death. It involves cellular modifications leading to a pathological remodeling and is associated with heart failure. The activation of the G protein-coupled estrogen receptor (GPER) mediates beneficial actions in the cardiovascular system. ...

journal_title：Life sciences

authors： Di Mattia RA,Mariángelo JIE,Blanco PG,Jaquenod De Giusti C,Portiansky EL,Mundiña-Weilenmann C,Aiello EA,Orlowski A

更新日期：2020-02-01 00:00:00

abstract：:The effects of GABA antagonists, picrotoxin and bicuculline were studied on hyperphagia caused by insulin in free feeding rats. It was found that peripheral administration of GABA antagonists inhibited this hyperphagia. These agents were administered in the VMH and LH through stereotaxically implanted cannulae. It was...

journal_title：Life sciences

authors： Kamatchi GL,Bhakthavatsalam P,Chandra D,Bapna JS

更新日期：1984-06-04 00:00:00

abstract：:The effects of porcine uterine fluid filtrate (PUF) on lymphocyte activity were examined. PUF was added to porcine lymphocyte cultures in the presence or absence of phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM). Lymphocyte response was determined by 3H-thymidine incorporation. Results ind...

journal_title：Life sciences

authors： Li WI,Yang WC

更新日期：1993-01-01 00:00:00

abstract：:We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li(+)), magnesium (Mg(2+)), and potassium (K(+)) were measured in rat plasma and cerebral cortex using an HPLC meth...

journal_title：Life sciences

authors： Sastre E,Nicolay A,Bruguerolle B,Portugal H

更新日期：2005-07-01 00:00:00

abstract：:Abnormal activation of the beta-catenin signaling pathway can cause various types of cancer. Activation of Wnt pathway leads to stabilization of the beta-catenin protein, which results in its translocation to the nucleus and the formation of complexes with lymphoid enhancer factor-1 (LEF-1) and other T-cell factor (TC...

journal_title：Life sciences

authors： Jung HC,Kim K

更新日期：2005-07-29 00:00:00

abstract：:Renal compensatory hypertrophy (RCH) occurs in hypothyroid rate, but it is impaired when compared to RCH found in euthyroid controls. It is due to cellular hypertrophy as the DNA content does not change and the Protein/DNA ratio increases in the compensating kidney. RCH is enhanced by thyroxine (T4) with a rise in the...

journal_title：Life sciences

authors： Stéphan F,Réville P,de Laharpe F,Köll-Back MH

更新日期：1982-02-15 00:00:00

abstract：AIMS:The recent outbreak of pandemic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led the world towards a global health emergency. Currently, no proper medicine or effective treatment strategies are available; therefore, repurposing of FDA approved drugs may play an important role in overcoming the ...

journal_title：Life sciences

authors： Sharma K,Morla S,Goyal A,Kumar S

更新日期：2020-10-15 00:00:00

abstract：:Promoter methylation is an important mechanism of regulating E-cadherin expression. Methylation-specific PCR (MSP) assay was done to evaluate the promoter methylation status of E-cadherin gene in primary tumor samples from 23 cases of Chinese women with invasive ductal breast cancers. Western blotting assay was employ...

journal_title：Life sciences

authors： Hu XC,Loo WT,Chow LW

更新日期：2002-08-09 00:00:00

abstract：:It is known that K(ATP) channel openers inhibit the release and refilling of Ca(2+) from intracellular stores. The present study was designed to test the effects of levcromakalim in human umbilical artery (HUA) rings stimulated by serotonin (5-HT) and KCl in Ca-free medium. Umbilical cords were obtained at vaginal or ...

journal_title：Life sciences

authors： Tufan H,Ayan-Polat B,Tecder-Unal M,Polat G,Kayhan Z,Oğüş E

更新日期：2003-02-07 00:00:00

abstract：AIMS:Coronavirus disease 2019 (COVID-19) has appeared in Wuhan, China but the fast transmission has led to its widespread prevalence in various countries, which has made it a global concern. Another concern is the lack of definitive treatment for this disease. The researchers tried different treatment options which are...

journal_title：Life sciences

authors： Hosseini FS,Amanlou M

更新日期：2020-10-01 00:00:00

abstract：:Reportedly, excitatory amino acids are involved in the control of gonadotropin secretion of rats and non-human primates. The aim of this study was to investigate the effect of chronic blockade of NMDA (N-methyl-D-aspartic acid) receptors by the non competitive receptor antagonist MK-801 on gonadotropin secretion and t...

journal_title：Life sciences

authors： Veneroni O,Cocilovo L,Müller EE,Cocchi D

更新日期：1990-01-01 00:00:00

abstract：:The regulation of G protein-coupled receptor expression is important in the physiology of an organism and can occur at any of the steps between gene transcription to turnover of the receptor protein itself. Agonist stimulation causes receptor desensitization, which is characterized by a rapid reduction in response to ...

journal_title：Life sciences

authors： Heck DA,Bylund DB

更新日期：1998-01-01 00:00:00

abstract：:Using a laterality questionnaire, 138 normal healthy individuals were classified as right-sided and 25 as non-right sided. Interleukin-2 (IL-2) was generated from whole blood obtained from these subjects using mitogen (PHA) stimulation. IL-2 was quantitated in picograms/ml using an enzyme immunoassay (ELISA). Addition...

journal_title：Life sciences

authors： Chengappa KN,Ganguli R,Yang ZW,Schurin G,Cochran J,Brar JS,Rabin B

更新日期：1992-01-01 00:00:00

abstract：AIMS:slc26a proteins are responsible for a large number of functions either in normal physiology or in human disease. We have previously reported that proximal tubular epithelial (PTE) cells immortalized from spontaneously hypertensive rats (SHRs) were endowed with increased Cl(-)/HCO3(-) exchanger activity and slc26a6...

journal_title：Life sciences

authors： Simão S,Gomes P,Pinho MJ,Soares-da-Silva P

更新日期：2013-10-06 00:00:00

abstract：:The human placental villus tissue contains opioid receptors and peptides. The opioid peptides extracted from the villus tissue were fractionated using reverse-phase high performance liquid chromatography and a radio-receptor assay. The presence of dynorphin 1-8 was corroborated by mass spectrometric production of (M +...

journal_title：Life sciences

authors： Ahmed MS,Randall LW,Sibai B,Dass C,Fridland G,Desiderio DM,Tolun E

更新日期：1987-05-25 00:00:00

abstract：:In 6-[18F]fluoro-L-dopa (Fdopa)/positron emission tomography (PET) studies, carbidopa pretreatment increases the Fdopa bioavailability to the brain and enhances the intensity of striatal PET images. Different PET research teams have used various carbidopa doses and routes of administration in non-human primate studies...

journal_title：Life sciences

authors： Chan GL,Doudet DJ,Dobko T,Hewitt KA,Schofield P,Pate BD,Ruth TJ

更新日期：1995-01-01 00:00:00

abstract：AIMS:The purposes of this study were to determine whether Cervi Pantotrichum Cornu (CPC) has osteogenic activities in human osteoblastic MG-63 cells and to investigate the underlying molecular mechanism. MAIN METHODS:The effects of CPC on alkaline phosphatase activity, collagen synthesis, and calcium deposits were mea...

journal_title：Life sciences

authors： Kim JH,Jung TY,Seo J,Lee S,Kim MG,Leem KH,Lim SC

更新日期：2014-01-14 00:00:00

abstract：:Aberrant methylation of promoter CpG islands (CGIs) can inactivate the expression of many tumor suppressor genes and play an important role in the carcinogenesis of gastric cancer. The tumor suppressor gene RB1, which encodes a cell cycle regulator, is hypermethylated and downregulated in multiple kinds of cancer. Act...

journal_title：Life sciences

authors： Cao D,Jia Z,Wu Y,Su T,Zhao D,Wu M,Tsukamoto T,Oshima M,Jiang J,Cao X

更新日期：2020-12-15 00:00:00

abstract：:Upregulation of vascular NAD(P)H oxidase has been considered an important source for elevated levels of reactive oxygen species that contribute to several cardiovascular disease states, including the vascular complications of diabetes mellitus. Previous studies have shown that treatment with antioxidants corrects impa...

journal_title：Life sciences

authors： Cotter MA,Cameron NE

更新日期：2003-08-22 00:00:00

abstract：AIMS:Fenofibrate is a peroxisome proliferator-associated receptor alpha agonist (PPARα) used clinically for the management of dyslipidemia and is a myocardial fatty acid oxidation stimulator. It has also been shown to have cardiac anti-hypertrophic properties but the effects of fenofibrate on the development of eccentr...

journal_title：Life sciences

authors： Dhahri W,Couet J,Roussel É,Drolet MC,Arsenault M

更新日期：2013-01-17 00:00:00

abstract：:Uncontrolled recreational drugs are proliferating in number and variety. Effects of long-term use are unknown, and regulation is problematic, as efforts to control one chemical often lead to several other structural analogs. Advanced analytical instrumentation and methods are continuing to be developed to identify dru...

journal_title：Life sciences

authors： Thomas BF,Pollard GT,Grabenauer M

更新日期：2013-03-19 00:00:00

abstract：:Recent studies suggest that the time of day at which food is consumed dramatically influences clinically-relevant cardiometabolic parameters (e.g., adiposity, insulin sensitivity, and cardiac function). Meal feeding benefits may be the result of daily periods of feeding and/or fasting, highlighting the need for improv...

journal_title：Life sciences

authors： Brewer RA,Collins HE,Berry RD,Brahma MK,Tirado BA,Peliciari-Garcia RA,Stanley HL,Wende AR,Taegtmeyer H,Rajasekaran NS,Darley-Usmar V,Zhang J,Frank SJ,Chatham JC,Young ME

更新日期：2018-03-15 00:00:00

abstract：AIMS:Naturally-derived farnesol has been reported for its chemopreventive and chemotherapeutic efficacy in various cancers. However, the mechanism of action of farnesol is still to be elucidated. The present study demonstrates the chemopreventive potential of farnesol on 9,10-dimethylbenz(a)anthracene (DMBA)-initiated ...

journal_title：Life sciences

authors： Chaudhary SC,Alam MS,Siddiqui MS,Athar M

更新日期：2009-07-31 00:00:00

abstract：:Extracts of increasing polarity of 6 Venezuelan plants belonging to the Chrysobalanaceae family were tested for possible letal toxicity against Biomphalaria glabrata Say, a snail intermediate hosts of Schistosoma mansoni Sambon. The piscicidal toxicity of the active extracts was also evaluated with the aim of findings...

journal_title：Life sciences

authors： Bilia AR,Braca A,Mendez J,Morelli I

更新日期：2000-01-01 00:00:00

abstract：:In vivo benzodiazepine receptor binding has generally been studied by "ex vivo" techniques. In this investigation, we identify the conditions where [3H]-Ro 15-1788 labels benzodiazepine receptors by true "in vivo" binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homoge...

journal_title：Life sciences

authors： Goeders NE,Kuhar MJ

更新日期：1985-07-29 00:00:00

abstract：:Leptin-deficient Ob/Ob mice are hypometabolic and have reduced fat cell expression of beta-3 adrenoceptors (ARs). To determine whether leptin repletion restores beta-3 AR number, C57BL/6J Ob/Ob mice were given exogenous leptin (5 mg/kg I.P. daily) for 21 days. Leptin administration reduced body weight from 43.1+/-3.7 ...

journal_title：Life sciences

authors： Breslow MJ,An Y,Berkowitz DE

更新日期：1997-01-01 00:00:00

abstract：:It has been shown that the antagonism of glutamate receptors activity was able inhibit proliferation and induce apoptosis in several neuronal and non-neuronal cancer cell lines. In addition, it has been shown that glutamate might facilitate the spread and growth of leukemia T cells through interactions with AMPA recep...

journal_title：Life sciences

authors： Parenti S,Casagrande G,Montanari M,Espahbodinia M,Ettari R,Grande A,Corsi L

更新日期：2016-05-01 00:00:00