Abstract：
:Using a laterality questionnaire, 138 normal healthy individuals were classified as right-sided and 25 as non-right sided. Interleukin-2 (IL-2) was generated from whole blood obtained from these subjects using mitogen (PHA) stimulation. IL-2 was quantitated in picograms/ml using an enzyme immunoassay (ELISA). Additionally, sera from these subjects were tested for 7 autoantibodies by standard serological methods. As compared to right sided subjects, non-right sided individuals had significantly lower IL-2 production. Non-right sided individuals with autoantibodies had significantly lower IL-2 production than right sided subjects with or without autoantibodies, but did not differ significantly from their non-right sided counterparts without autoantibodies. These data support the increasing evidence for the differential and lateralized regulation of immune functions by the right and left cerebral regions.
journal_name
Life Scijournal_title
Life sciencesauthors
Chengappa KN,Ganguli R,Yang ZW,Schurin G,Cochran J,Brar JS,Rabin Bdoi
10.1016/0024-3205(92)90035-nsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
1843-9issue
24eissn
0024-3205issn
1879-0631pii
0024-3205(92)90035-Njournal_volume
51pub_type
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