Abstract：
:The ontogenetic development of [3H]-spiroperidol binding sites was measured in the optic tectum, cerebellum, forebrain base, and forebrain roof of 1-, 4-, and 16-day-old chicks. In the chick optic tectum and cerebellum both the density and the total number of [3H]-spiroperidol binding sites increased from 4- to 16-days-posthatch, but no significant differences were found in either brain area across the initial four posthatch days. In the forebrain base, [3H]-spiroperidol receptor density and total binding increased significantly between 1- and 4-days-posthatch, but at 16-days-posthatch there was a slight decrease in receptor density. Binding sites in the forebrain roof were minimal at all ages. As expected, saturation experiments yielded curvilinear plots indicating the presence of high- and low-affinity binding sites. The high-affinity sites probably reflect dopamine D-2 receptors; whereas, the low-affinity sites may reflect other receptor types, possibly serotonin S-2. These results suggest that large doses of haloperidol, which are normally used in chick behavioral research, may produce behavioral effects by antagonizing multiple receptors.
journal_name
Life Scijournal_title
Life sciencesauthors
McDougall SA,Neisewander JL,Bardo MT,Zolman JFdoi
10.1016/0024-3205(89)90331-7subject
Has Abstractpub_date
1989-01-01 00:00:00pages
1515-20issue
20eissn
0024-3205issn
1879-0631pii
0024-3205(89)90331-7journal_volume
44pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Calcitonin secretion is influenced by estrogen. In the present study, basal and calcium-stimulated serum calcitonin levels were reduced in ovariectomized rats, and replacement estrogen administered for 3 weeks increased both calcitonin levels to those in intact rats. Ipriflavone, 7-isopropoxy-3-phenyl-4H-1-benzopyran-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90492-3
更新日期：1986-04-28 00:00:00
abstract：:There is now some evidence that i) the availability of plasma tryptophan, the precursor of serotonin, is significantly lower in pregnant women at the end of term and the first few days after delivery than in nonpregnant women; and ii) both pregnancy and the early puerperium are accompanied by activation of the inflamm...
journal_title：Life sciences
pub_type： 临床试验,杂志文章
doi：10.1016/s0024-3205(02)01853-2
更新日期：2002-09-06 00:00:00
abstract：OBJECTIVE:Metformin, introduced in 1957, is widely used as an anti-diabetic drug and has considerable benefits in cardiovascular disease reportedly, dependent or independent on its glucose-lowering effects. Aim of this study was to investigate the effect of metformin on gap junction and the inducibility of AF. METHODS...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117759
更新日期：2020-08-01 00:00:00
abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117339
更新日期：2020-03-01 00:00:00
abstract：:To study the source of immunoreactive epidermal growth factor (ir-EGF) released by thrombin formation we removed 99.9% of the leukocytes normally present in platelet-rich plasma and induced coagulation with 30 mM of Ca2+. The absence of leukocytes did not reduce the amount of ir-EGF released; thus platelets are most l...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90642-o
更新日期：1991-01-01 00:00:00
abstract：:An in vivo antisense strategy was used to examine the involvement of G-protein subunits in supraspinal (intracerebroventricular; i.c.v.) alpha2-adrenoceptor-mediated antinociception. Mice that were injected with 33-mer antisense oligodeoxyribonucleotides (6 nmol) or vehicle were tested (tail-flick) with an agonist (cl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02301-1
更新日期：1996-01-01 00:00:00
abstract：:We investigated the mechanism by which glucose refeeding can reverse the enhancement of glycolysis caused by glucose starvation. Human fibroblasts were deprived of glucose for 18 hr and then refed for 1 hr with either (a) medium from sister glucose-starved cultures (controls), (b) fresh, glucose-containing medium (fre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90057-x
更新日期：1989-01-01 00:00:00
abstract：:The aim of this study was to assess the anxiolytic effect of berberine (abbrev. BER) using two experimental anxiety models in the mouse. In the black and white test of anxiety, berberine (100, 500 mg/kg) produced an increase in the first time entry, time spent in the white section, and total changes between two compar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.04.032
更新日期：2004-10-01 00:00:00
abstract：:Anorexia is induced by injection of alpha 1-adrenergic receptor agonists into the hypothalamic paraventricular nucleus (PVN) in rats. Of the agonists tested to date, cirazoline is the most potent when administered either into the PVN or systemically. The present experiments assess the effects of systemically administe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90057-v
更新日期：1992-01-01 00:00:00
abstract：AIMS:Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inf...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.064
更新日期：2018-10-01 00:00:00
abstract：:The present study was designed to evaluate the suppressive effect of different frequencies of signaled-shock presentations on mitogenic reactivity of lymphocytes in Lewis rats, and to assess the recovery of that reactivity at varying times after the shocks. The results showed that the magnitude of decreased reactivity...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90699-0
更新日期：1987-10-12 00:00:00
abstract：:11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitors have been shown to treat type 2 diabetes (T2D). Since gossypol is an 11β-HSD1 inhibitor, the objective of the present study was to treat T2D and T2D-related liver fibrosis in rat model using low-dose gossypol. T2D was induced by feeding with high fat diet plus i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.044
更新日期：2016-03-15 00:00:00
abstract：:Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated hypercholesterolemia. To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00658-3
更新日期：1997-01-01 00:00:00
abstract：AIMS:Hepatocyte growth factor (HGF) modulates intestinal epithelial cell proliferation and migration. We previously reported that systemic administration of recombinant human HGF (rh-HGF) ameliorated experimental colitis. However, an increase in serum HGF concentrations may induce undesired systemic effects, limiting t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.06.019
更新日期：2011-08-15 00:00:00
abstract：:The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular levels of biogenic amines. Over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5HT), n...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(92)90236-i
更新日期：1992-01-01 00:00:00
abstract：:Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal myositis is poorly understood. Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotens...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118067
更新日期：2020-09-15 00:00:00
abstract：:We examined the effect of 7-OH-DPAT on spontaneous locomotor activity that is enhanced in diabetic mice. 7-OH-DPAT (0.1-30 mg/kg, s.c.) dose-dependently decreased the enhanced spontaneous locomotor activity in diabetic mice, but not in nondiabetic mice. When mice were pretreated with of 7-OH-DPAT (0.1 mg/kg), morphine...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00363-3
更新日期：1996-01-01 00:00:00
abstract：:The effects of vasoactive intestinal peptide (VIP)-ellipticine (E) derivatives were investigated on breast cancer cells. VIP-ALALA-E and VIP-LALA-E inhibited 125I-VIP binding to MCF-7 cells with an IC(50) values of 1 and 0.2 microM respectively. VIP-ALALA-E and VIP-LALA-E caused elevation of cAMP in MCF-7 cells with E...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01741-1
更新日期：2002-07-19 00:00:00
abstract：:A new indorocarbazole antibiotic SF2370 has been found in the culture broth of Actinomadura sp.; it has also been found to have the activities of antihypertension and diuresis. Derivatives of SF2370, NA0344, NA0345 and NA0346, when injected (0.1-1 mg/kg i.v.) significantly lowered the blood pressure of anesthetized no...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90392-5
更新日期：1989-01-01 00:00:00
abstract：:The effect of fluoride ion on the binding of the specific muscarinic agonist ligand [3H]cis methyldioxolane ([3H]CD) to the mouse cardiac muscarinic receptor was investigated. Utilizing equilibrium ligand binding experiments, sodium fluoride (10mM) was shown to decrease [3H]CD binding, measured at a concentration of 2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90602-6
更新日期：1982-03-08 00:00:00
abstract：:In rodents an action of estrogen is required for the initiation of implantation of the blastocyst into the endometrium of a progesterone-primed uterus. Thus removal of endogenous estrogen, either directly by ovariectomy or indirectly by hypophysectomy, prevents implantation in the pregnant rat. In the present study, d...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00020-3
更新日期：1996-01-01 00:00:00
abstract：:The effects of delta 9-THC and other cannabinoids on cAMP levels in synaptosomes from mouse brains were investigated in order to determine whether cannabinoids produced their behavioral effects through alterations in adenylate cyclase. delta 9-THC (0.01-10 microM) did not significantly alter basal cAMP levels, whereas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90450-p
更新日期：1991-01-01 00:00:00
abstract：:In December 2019, a novel virus, namely COVID-19 caused by SARS-CoV-2, developed from Wuhan, (Hubei territory of China) used its viral spike glycoprotein receptor-binding domain (RBD) for the entrance into a host cell by binding with ACE-2 receptor and cause acute respiratory distress syndrome (ARDS). Data revealed th...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118421
更新日期：2020-11-01 00:00:00
abstract：:The temporal relationship of changes in cAMP and cGMP to oocyte maturation was examined in proestrous hamsters (day 4). The first series of experiments showed, in normal cycling hamsters, an increase in cAMP and a decrease in cGMP at 1400 h shortly after the rise in LH with oocyte maturation beginning at 1800 h. When ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90726-9
更新日期：1983-10-24 00:00:00
abstract：:Down syndrome (DS) is the most common chromosomal abnormality and is associated with an extra copy of the chromosome 21. Although several markers are commonly used during pregnancy for the screening of DS, the definitive diagnosis is based on karyotype after amniocentesis, which is an expensive and laborious analysis....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.09.003
更新日期：2004-12-10 00:00:00
abstract：AIMS:The aim of this work was to examine the antitumor effects and mechanisms of M4IDP, a zoledronic acid derivative, on human colorectal cancer (CRC) HCT116 cells. MAIN METHODS:The effects of M4IDP on proliferation, cell cycle and ROS production were determined by CCK-8 and flow cytometry assays. Annexin-V-FITC/PI, H...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.07.024
更新日期：2017-09-15 00:00:00
abstract：:Prenatal exposure to nicotine has been shown to produce postnatal up-regulation of central nervous system nicotinic receptors and to alter subsequent differentiation of neural tissues. In the current study, pregnant rats received nicotine infusions of 6 mg/kg/day throughout gestation, administered by osmotic minipump ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90113-p
更新日期：1991-01-01 00:00:00
abstract：:Diabetic retinopathy, a common secondary complication of diabetes mellitus, involves extensive damage to the retinal microvasculature. Retina, being a susceptible target, is highly prone to hyperglycemia-induced molecular damages. PPAR receptor, chiefly gamma subtype, mediates numerous responses related to glucose met...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2016.03.054
更新日期：2016-05-15 00:00:00
abstract：:The effect of naloxone upon neurologic deficit was evaluated in a model of transient forebrain ischemia in rats. Awake male Wistar rats were subjected to a 30 minute ischemia by occluding both common carotid arteries 8 days after cauterizing vertebral arteries. Administration of naloxone 1 or 5 mg/kg iv 10 minutes aft...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90068-8
更新日期：1986-02-03 00:00:00
abstract：AIMS:The clinical utilization of the combinations of all-trans-retinoic acid (RA) with antiestrogens, which present synergism of action in breast cancer, has been limited by RA adverse effects, including hepatotoxicity, which may be related with mitochondrial damage. This work evaluated the effects of RA alone and in c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.05.027
更新日期：2013-07-30 00:00:00
