Abstract：
:The effect of naloxone upon neurologic deficit was evaluated in a model of transient forebrain ischemia in rats. Awake male Wistar rats were subjected to a 30 minute ischemia by occluding both common carotid arteries 8 days after cauterizing vertebral arteries. Administration of naloxone 1 or 5 mg/kg iv 10 minutes after carotid occlusion or 1 mg/kg iv one hour after clamp removal failed to reduce immediate and tardive neurologic postischemic deficits. On the other hand, in rats treated by a dose of 1 mg/kg naloxone 10 minutes after carotid occlusion and perfused with an additional dose of 2 mg/kg/h for 80 minutes, neurologic score was improved one hour after ischemia. However mortality was not decreased whatever was the modality of naloxone administration. This result confirms previous data showing that naloxone exerts a protective effect when given at sufficiently high dosage.
journal_name
Life Scijournal_title
Life sciencesauthors
Capdeville C,Pruneau D,Allix M,Plotkine M,Boulu RGdoi
10.1016/0024-3205(86)90068-8subject
Has Abstractpub_date
1986-02-03 00:00:00pages
437-42issue
5eissn
0024-3205issn
1879-0631pii
0024-3205(86)90068-8journal_volume
38pub_type
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