Abstract：
:Recent studies have shown that acyl-CoA:cholesterol acyltransferase (ACAT) plays an important role in the initiation of diabetes-associated hypercholesterolemia. To confirm this hypothesis, effects of a potent ACAT inhibitor, FR145237, on diet-induced hypercholesterolemia were examined in streptozotocin (STZ)-induced diabetic rats. One-week feeding of 1% cholesterol and 0.5% cholic acid to normal rats and STZ-induced diabetic rats increased plasma cholesterol levels in both groups, and the response was more remarkable in the STZ rats than in the normal ones (1266 +/- 476 mg/dl and 146 +/- 7 mg/dl, respectively). FR145237 dose-dependently reduced the rise in plasma cholesterol levels in the STZ rats and the levels were almost normalized by treatment with 1 mg/kg/day of the compound. These results suggest that hyperresponse to dietary cholesterol was induced in the STZ rats and that ACAT is involved in the hyperresponse. The effects of FR145237 on other plasma lipids such as high density lipoprotein (HDL) cholesterol and triglyceride (TG) levels were also examined.
journal_name
Life Scijournal_title
Life sciencesauthors
Sakuma Y,Hagihara H,Nagayoshi A,Ohne K,Mutoh S,Ito Y,Nakahara K,Notsu Y,Okuhara Mdoi
10.1016/s0024-3205(96)00658-3subject
Has Abstractpub_date
1997-01-01 00:00:00pages
351-6issue
6eissn
0024-3205issn
1879-0631pii
S0024320596006583journal_volume
60pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:This work analyzes the 24-hour changes of hypothalamic-pituitary-adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24-hour cycle (n=8-10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland cort...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.06.001
更新日期：2008-07-18 00:00:00
abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.11.040
更新日期：2019-01-01 00:00:00
abstract：:Intestinal mucosa, bone marrow hematopoietic cells and brain have limited capacity for the de novo synthesis of nucleosides (NSs) and nucleotides (NTs). Whereas the role of dietary NS and NT in the former two tissues is known, it is not known in the brain. Therefore we studied the effect of dietary NS and NT mixture o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00526-7
更新日期：1996-01-01 00:00:00
abstract：:Two proteolytic activities that convert big ET to ET at neutral pH were identified in solubilized membranes prepared from rat lung. The endothelin-converting activities were partially purified by using A80227 ((2S,3R,4S)-2-([N-acetylcyclohexylalanyl-isoleucyl]amino)-1-(2-nap hthyl)-3,4-dihydroxy-6-methylheptane) coupl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90033-7
更新日期：1994-01-01 00:00:00
abstract：:Endogenous opioid peptides have been implicated in the pathophysiology of shock (1-5). In anaesthetised mongrel dogs, administration of E coli endotoxin caused a rise in plasma met-enkephalin-like immunoreactivity (MLI). Biochemical characterisation of MLI by gel filtration chromatography revealed various molecular fo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90063-8
更新日期：1984-04-09 00:00:00
abstract：AIMS:Osteoclasts, the unique bone-resorbing polykaryons, are responsible for many bone-destructive diseases, such as osteoporosis and rheumatoid arthritis. Hence, the regulation of osteoclast formation is considered a potential therapeutic approach for these diseases. In this study, we investigated the effect of a nove...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.09.009
更新日期：2012-11-02 00:00:00
abstract：:Methodological shortcomings present in elicitation of male sexual reflexes in anesthetized animals. The present study has demonstrated, however, that intraperitoneal (i.p.) injection of p-chloroamphetamine (PCA), an indirect serotonin (5-HT) agonist, elicited simultaneously both penile erection and ejaculation in anes...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00895-x
更新日期：2000-11-10 00:00:00
abstract：:1,25-dihydroxyvitamin D3 has important physiological effects such as calcium transport and cell growth and differentiation. These biological effects are mediated by their binding to specific intracellular receptor termed vitamin D receptor (VDR). VDR mRNA expression has been demonstrated in several tissues, but to dat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00586-3
更新日期：1997-01-01 00:00:00
abstract：AIMS:The p53 protein, also called guardian of the genome, has a key role in cell cycle regulation. It is activated under stressful circumstances, such as DNA damage which results in permanent arrest or cell death. The protein is disabled in several types of human cancer due to over-expression of the two regulators, Mdm...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.12.047
更新日期：2016-01-15 00:00:00
abstract：:Tramadol is a clinically-effective, centrally-acting analgesic. This drug is a racemic mixture of two enantiomers, each one displaying different mechanisms: (+)tramadol displays opioid agonist properties and inhibits serotonin reuptake while (-)tramadol inhibit preferentially noradrenaline reuptake. The action of tram...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00369-5
更新日期：1998-01-01 00:00:00
abstract：:Collagen is the most abundant protein in mammalian systems; it can be found in organs such as bones, the liver, kidney, heart, teeth, and skin. Collagen provides the necessary structural framework for tissues in which it is found. However, if there are any alterations in the delicate balance of collagen types in the e...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.04.042
更新日期：2019-07-01 00:00:00
abstract：:NF-kappaB that plays an important role in iNOS expression is one of the targets of various potential anti-inflammatory agents including resveratrol. Resveratrol contains a structural similarity with estrogen, and there has been speculation about resveratrol as estrogen agonist. In this study, the mechanism and structu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01971-9
更新日期：2002-09-13 00:00:00
abstract：:Proteinaceous inhibitors with high inhibitory activities against human neutrophil elastase (HNE) were found in seeds of the Tamarind tree (Tamarindus indica). A serine proteinase inhibitor denoted PG50 was purified using ammonium sulphate and acetone precipitation followed by Sephacryl S-300 and Sephadex G-50 gel filt...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.053
更新日期：2005-05-06 00:00:00
abstract：:This study examined the effects of chronic treatment of a new phosphodiesterase type 5 inhibitor, DA-8159, on endothelial dysfunction in stroke-prone spontaneously hypertensive rats (SHR-SP). Six-week-old male SHR-SP were divided into 4 groups; vehicle control, DA-8159 1, 3, and 10 mg/kg/day. During a 32-week experime...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.042
更新日期：2006-02-09 00:00:00
abstract：:The challenge of discovering new, urgently needed anti-TB drugs from natural sources requires a truly interdisciplinary research. Cutting-edge mycobacteriology and innovative natural products chemistry tools have to be developed and employed in tandem, in order to meet these demands. The present review provides cross-...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2005.09.004
更新日期：2005-12-22 00:00:00
abstract：:Abnormal activation of the beta-catenin signaling pathway can cause various types of cancer. Activation of Wnt pathway leads to stabilization of the beta-catenin protein, which results in its translocation to the nucleus and the formation of complexes with lymphoid enhancer factor-1 (LEF-1) and other T-cell factor (TC...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.02.009
更新日期：2005-07-29 00:00:00
abstract：AIMS:Osteoblasts and adipocytes originate from common precursor cells. We examined the effects of bone morphogenetic protein-2 (BMP-2) on the molecular mechanisms governing the diametric actions of BMP-2 on simultaneous mature osteoblast and adipocyte differentiation in a clonal mesenchymal progenitor cell line, ROB-C2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.12.011
更新日期：2009-02-27 00:00:00
abstract：AIMS:Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period. MAIN METHODS:A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.033
更新日期：2018-09-15 00:00:00
abstract：:The potential for a drug interaction between cyclosporin A and phenytoin was investigated in rats. Rats were treated daily for 14 days with cyclosporin A (50 mg/Kg, s.c.) and on the day of the experiment phenytoin (10 mg/Kg) was administered intravenously. The mean residence time, the elimination half-life and the vol...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90140-x
更新日期：1993-01-01 00:00:00
abstract：AIMS:The aim of this study was to evaluate the antinociceptive (acute assays) and anti-inflammatory (chronic assays) effects of kramecyne (KACY), a peroxide isolated from Krameria cytisoides. MAIN METHODS:The antinociceptive activity of KACY was evaluated using the hot plate, acetic acid and formalin tests. The effect...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.11.015
更新日期：2015-01-15 00:00:00
abstract：:Much evidence has gathered that nitric oxide (NO) signaling, via cGMP-dependent mechanisms, may activate pro-survival pathways in hippocampal neurons and inhibit apoptosis. Past research has revealed that the enhancement of monoaminergic neurotransmission via exercise or treatment with antidepressant medications leads...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.09.003
更新日期：2007-09-29 00:00:00
abstract：:We report the presence of p-fluorophenylglycine (p-FPG) in the urine of six baboons treated with HPTP, the tetrahydropyridine dehydration product of haloperidol (HP). Oxidative N-dealkylation, the major metabolic pathway of HP, gives rise to 3-(4-fluorobenzoyl)propionic acid (p-FBPA). Subsequent beta-oxidation of p-FB...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00274-x
更新日期：1999-01-01 00:00:00
abstract：:Acute post-ischemic cardiac failure was studied in isolated rat hearts. Xylitol, glutamine, aspartic acid and glycine were added during reperfusion, resulting in no inotropic effect. Concanavalin A had a moderate inotropic effect. When concanavalin A added with xylitol, glutamine, aspartic acid and glycine, a rapid re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90705-8
更新日期：1993-01-01 00:00:00
abstract：AIMS:A growing body of evidence shows the cardiovascular benefits of fish oil ingredients, including eicosapentaenoic acid (EPA), in humans and experimental animals. However, the effects of EPA on endothelin (ET)-1-induced cardiomyocyte hypertrophy and the involved signaling cascade are largely unknown. A previous stud...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.04.025
更新日期：2014-11-24 00:00:00
abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). DHEA inhibited the growth of two stains of HeLa and WI-38 cells in culture. One of the HeLa strains, TCRC-2, was about 10x as sensitive to growth inhibition a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90557-6
更新日期：1986-04-21 00:00:00
abstract：:Elevated levels of serum free fatty acids (FFA) may be the metabolic alteration in obesity that leads to insulin resistance (IR) and type 2 diabetes mellitus (DM). The obese Zucker rat (ZR) is a genetic model of juvenile-onset obesity and type 2 DM. Compared with its lean sibling, the obese ZR is hyperinsulinemic, hyp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01345-5
更新日期：2001-10-19 00:00:00
abstract：:Insulin therapy remains the standard of care for achieving and maintaining adequate glycemic control, especially in hospitalized patients with critical and noncritical illnesses. Insulin therapy is more effective against elevated fasting glycaemia but less in the reduction of postprandial hyperglycaemia. It is associa...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2013.12.210
更新日期：2014-03-18 00:00:00
abstract：:The isolated cat superior cervical ganglion (SCG) was labeled in vitro with either 3H-norepinephrine (3H-NE) or 3H-choline and stimulated through its preganglionic trunk. The release of 3H-NE and 3H-acetylcholine (3H-ACh) elicited by the stimulation was measured under control conditions and in the presence of drugs. T...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90371-6
更新日期：1985-04-29 00:00:00
abstract：:Nitric oxide is involved in a countless number of physiological processes and is known to have cytoprotective as well as cytotoxic effects. Increased knowledge about the multifaceted role of nitric oxide in a variety of disease states has led to the design of multiple treatment strategies involving the nitric oxide sy...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2003.08.029
更新日期：2004-02-20 00:00:00
abstract：:Treatment of primary cultured chondrocytes from rabbit articular cartilage with interleukin-1 (IL-1)alpha and plasminogen induced the production of pro-matrix metalloproteinase 1 (proMMP-1/interstitial collagenase), proMMP-3 (stromelysin 1) and proMMP-9 (gelatinase B), as well as their active forms. Human urinary tryp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00261-6
更新日期：1998-01-01 00:00:00
