Abstract:
:Prenatal exposure to nicotine has been shown to produce postnatal up-regulation of central nervous system nicotinic receptors and to alter subsequent differentiation of neural tissues. In the current study, pregnant rats received nicotine infusions of 6 mg/kg/day throughout gestation, administered by osmotic minipump implants; the postnatal development of cholinergic receptor reactivity was examined through measurements of the ability of acute nicotine administration to stimulate midbrain + brainstem ornithine decarboxylase (ODC) activity, a key regulatory enzyme in neural cell differentiation and growth. In control rats, the ODC response to nicotine was absent at birth and developed during the second postnatal week in parallel with the known ontogenetic rise of nicotinic receptors. Offspring of the nicotine-infused dams exhibited hyper-reactivity of ODC to postnatal acute nicotine challenge: the response developed earlier than in controls and subsequently the magnitude of the effect was 2-3 times greater. Since the development of cholinergic transmission influences differentiation of target cells, alterations in cholinergic nicotinic receptor mediated responses likely explain the delayed appearance of abnormal cell differentiation associated with prenatal nicotine.
journal_name
Life Scijournal_title
Life sciencesauthors
Slotkin TA,Lappi SE,Tayyeb MI,Seidler FJdoi
10.1016/0024-3205(91)90113-psubject
Has Abstractpub_date
1991-01-01 00:00:00pages
665-70issue
9eissn
0024-3205issn
1879-0631pii
0024-3205(91)90113-Pjournal_volume
49pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::The effect of oral administration of Clostridium butyricum Miyairi on the formation and dissolution of gallstones was examined in a mouse model of cholesterol cholelithiasis, in comparison with that of chenodeoxycholic acid (CDCA). A diet containing cholesterol and sodium cholate was used as a lithogenic diet. The fee...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90149-2
更新日期:1983-01-31 00:00:00
abstract::Diazepam binding inhibitor (DBI) is a 9-kD polypeptide that was first isolated in 1983 from rat brain by monitoring its ability to displace diazepam from the benzodiazepine (BZD) recognition site located on the extracellular domain of the type A receptor for gamma-aminobutyric acid (GABAA receptor) and from the mitoch...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(91)90440-m
更新日期:1991-01-01 00:00:00
abstract::The behavioural and electrocortical (ECoG) effects of human recombinant tumor necrosis factor-alpha (hrTNF-alpha) and various forms of interleukin-1 (IL-1) microinjected into the locus coeruleus (LC) of rats were studied. IL-1 induced a typical, dose-dependent, behavioural sedation and/or sleep which was associated wi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(96)00692-3
更新日期:1997-01-01 00:00:00
abstract:AIMS:To determine whether increased N-acetyltransferase (NAT) activity might have a toxic effect during development and an influence on folate levels since previous work has shown that only low levels of exogenous NAT can be achieved in constitutionally transgenic mice (Cao et al. 2005). MAIN METHODS:A human NAT1 tet-...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.11.008
更新日期:2010-01-16 00:00:00
abstract:AIMS:This study aims to explore factors that influence glucocorticoid (GC)-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction (IUGR) filial rats. MAIN METHODS:An IUGR animal model was established by starvation, and brain tissue was removed after birth. Affymetrix Rat Gene 2.0 S...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.02.079
更新日期:2016-04-01 00:00:00
abstract::Continuous three day administration via implanted minipumps of cocaine hydrochloride (50-450 mg/kg/day, sc and 100-250 mg/kg/day, iv) did not produce axonal degeneration in frontal agranular cortex or neostriatum that was detectable by Fink-Heimer silver staining or tyrosine hydroxylase immunolabeling. This is in cont...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90307-4
更新日期:1988-01-01 00:00:00
abstract::We studied the effects of arachidonic acid (AA) on Cl secretion across primary cultures of dog tracheal epithelium. Cell sheets showed mean values for baseline short-circuit current (Isc) and transepithelial resistance of 33.8 muA/cm2 and 360 omega.cm2 (n = 44). AA (5 x 10(-5) M) added to both sides increased Isc by 2...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90350-x
更新日期:1992-01-01 00:00:00
abstract::Incubation of unfixed, frozen sections of rat pancreas with tritiated guanidinoethylmercaptosuccinic acid (GEMSA) resulted in a localization of [3H]-GEMSA autoradiographic grains over the islets of Langerhans, suggesting that a carboxypeptidase H-like enzyme occurs in the islet. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90072-5
更新日期:1987-06-29 00:00:00
abstract::Tobacco smoke (TS) is a potent source of oxidants and oxidative stress is an important mechanism by which TS exerts its toxicity in the lung. We have shown that TS induces heat shock (HS)/stress protein (HSP) synthesis in human monocytes. Pulmonary surfactant (PS) whose major physiological function is to confer mechan...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00542-6
更新日期:1999-01-01 00:00:00
abstract::The effects of the tricyclic antidepressant imipramine (20 mg/kg) and the beta-adrenoceptor agonist clenbuterol (0.5 mg/kg) on the serum concentrations of tyrosine, tryptophan, glucose and insulin were compared 30 min after intraperitoneal injection. The drugs had nearly identical effects on serum tyrosine, which was ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90621-w
更新日期:1990-01-01 00:00:00
abstract::Despite reductions in beta-adrenoreceptor (beta-AR)-mediated inotropic effects induced by sustained sympathetic activation in cardiac disease, whether these changes necessarily result in reductions in systolic function under resting conditions (baseline function) is not clear. Moreover, possible compensatory mechanism...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.04.047
更新日期:2005-12-12 00:00:00
abstract::Angiogenesis-targeted therapy of cancer is considered a promising strategy for therapeutic management of cancer progression. Over the last two decades, a few anti-angiogenesis monoclonal antibodies (mAbs) blocking VEGF signaling have been developed and approved by the FDA. The most widely used anti-angiogenesis drug i...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.117018
更新日期:2019-12-15 00:00:00
abstract::A previous communication from this laboratory reported that brain uptake of libenzapril, a small polar molecule, was enhanced in chronic hypertension (1). The objective of this investigation was to determine if this was a more generalized phenomenon. Therefore, experiments were undertaken to examine the effect of chro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90033-y
更新日期:1993-01-01 00:00:00
abstract::Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weigh...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00069-7
更新日期:1999-01-01 00:00:00
abstract::Nuclear factor erythroid 2-related factor 2 (Nrf-2) binds to a specific polyamine responsive element (PRE) in the promoter region of the spermidine-spermine acetyltransferase (SSAT) gene, a key component of the polyamine catabolic pathway. Regulation of SSAT gene transcription requires the additional interaction of Nr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.03.042
更新日期:2006-08-22 00:00:00
abstract::The reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (DAT). Though cocaine and methylphenidate have similar in vitro affinities for DAT the abuse of methylphenidate in humans is substantially lower than of cocaine. To test if differences in in vivo pot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00225-8
更新日期:1999-01-01 00:00:00
abstract::This study was undertaken to examine the receptor selectivity of Met-enkephalin-Arg6-Phe7 (MERF) employing radioreceptor binding assays in human cerebral cortex membranes, and to elucidate the responsible receptors that mediate the regulatory action of MERF on high (20 mM) K+-stimulated release of [3H]norepinephrine (...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00606-8
更新日期:2000-05-26 00:00:00
abstract::Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90811-1
更新日期:1983-03-21 00:00:00
abstract::Human alpha-fetoprotein (AFP) was expressed in Saccharomyces cerevisiae, with a plasmid containing the cDNA sequence for human AFP fused with the rat AFP signal peptide. The recombinant AFP was purified from the yeast lysate by DEAE-cellulose and immunoaffinity chromatography. The amino acid composition and the molecu...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90383-3
更新日期:1990-01-01 00:00:00
abstract::The effects of the d- and l-isomers of pentazocine were compared to that of racemic pentazocine on contractions of the mouse isolated vas deferens. L-pentazocine inhibited electrically evoked contractions of the mouse vas deferens (MVD) in a dose-dependent manner (ID50 0.37 +/- 0.04 microM). In contrast, d-pentazocine...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90446-7
更新日期:1986-07-14 00:00:00
abstract::An animal model of haloperidol-induced tardive dyskinesia was studied in relation to the dietary manipulation of tryptophan and its effect on the movement disorder. This study showed a significant negative behavioral response to the neuroleptic drug, haloperidol. Increased dietary tryptophan (1.0 vs. 0.3%) significant...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90602-3
更新日期:1987-10-05 00:00:00
abstract::We studied the incorporation of 14C-formate into uric acid and allantoin in different organs (liver, lung, kidney, spleen), isolated hepatocytes, perfused liver and urine of the rat. Allantoin had a higher specific radioactivity than uric acid after 14C-formate load in the liver in vivo. This was found to be a strictl...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00387-6
更新日期:1996-01-01 00:00:00
abstract::We have previously shown that transforming growth factor-beta1 (TGF-beta1) is involved in the fibroblast-induced organization and differentiation of transformed phenotypically crypt-like T84 intestinal epithelial cells into absorptive enterocyte-like cells, when cultured within a three-dimensional collagen gel. We hav...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01216-4
更新日期:2001-08-10 00:00:00
abstract::[3H]-Spiroperidol specifically binds at sites in human prefrontal cortex. The binding of this ligand is apparently anomalous at 37 degrees C, with a substantial loss of specific binding occurring between 5 and 40 min incubation. However, at 21 degrees C, this loss of binding is not observed even at 60 min. At 21 degre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90282-0
更新日期:1984-06-18 00:00:00
abstract::Nitric oxide (NO) plays an important role in glucose and lipid metabolism. We previously reported that NO synthesis inhibitors, such as NG-nitro-L-arginine methyl ester (L-NAME), deteriorate insulin sensitivity and lipid metabolism, while the addition of L-arginine reverses this deterioration. L-arginine is a precurso...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2003.06.004
更新日期:2003-10-24 00:00:00
abstract:AIMS:Anaphylactic shock sometimes accompanies pulmonary vaso- and broncho-constriction. We previously reported the hemodynamic features of mouse anaphylaxis (Life Sci. 2014; 116: 98-105). However, the effects of anaphylactic chemical mediators on the hemodynamics of in vivo mice are not well known. Furthermore, it is u...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.01.034
更新日期:2016-02-15 00:00:00
abstract::The uptake and acetylation of [3H]-choline, as well as the calcium-dependent release of a newly synthesized [3H]-ACh, was studied in a new rat atrial mince preparation. The hemicholinium-3-sensitive uptake and acetylation of [3H]-choline increased as [3H]-choline concentrations were elevated to 100 microM in atrial mi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90328-0
更新日期:1986-10-13 00:00:00
abstract::Ether à go-go (EAG) potassium channels possess oncogenic properties and have gained great interest as research tools for cancer detection and therapy. Besides, EAG electrophysiological properties are regulated through the cell cycle and determined by cytoskeletal interactions. Thus, because of the pivotal role of extr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.05.014
更新日期:2007-06-27 00:00:00
abstract::Quercetin, a plant flavonoid, blocks signal transduction pathways by inhibiting 1-phosphatidylinositol 4-kinase (EC 2.7.1.67, PI kinase) and 1-phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68, PIP kinase), resulting in a reduction of inositol 1,4,5-trisphosphate (IP3) concentration which decreases the release of...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02085-w
更新日期:1995-01-01 00:00:00
abstract::Acute renal injury (AKI) is a risk factor for the development of hypertension, which involves oxidative stress, changes in Na+ handling, and the intrarenal renin-angiotensin-aldosterone system (RAAS) as underlying mechanisms. We investigated in rats whether renal ischemia-reperfusion (IR) leads to changes in the proxi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118879
更新日期:2021-02-01 00:00:00