Abstract：
:[3H]-Spiroperidol specifically binds at sites in human prefrontal cortex. The binding of this ligand is apparently anomalous at 37 degrees C, with a substantial loss of specific binding occurring between 5 and 40 min incubation. However, at 21 degrees C, this loss of binding is not observed even at 60 min. At 21 degrees C, [3H]-spiroperidol binding in human prefrontal cortex is apparently occurring at multiple sites or multiple affinity states of single classes of sites, or at a combination of both. The overall selectivity is predominantly serotonergic, rather than dopaminergic.
journal_name
Life Scijournal_title
Life sciencesauthors
Andorn AC,Huang EH,Warren AEdoi
10.1016/0024-3205(84)90282-0subject
Has Abstractpub_date
1984-06-18 00:00:00pages
2461-6issue
25eissn
0024-3205issn
1879-0631pii
0024-3205(84)90282-0journal_volume
34pub_type
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