Abstract：
:We report an ongoing within-family selective breeding project for the severity of handling-induced withdrawal seizures in mice made physically dependent on ethanol by inhalation. Two Withdrawal Seizure Prone (WSP) and two Withdrawal Seizure Resistant (WSR) lines have been subjected to five generations of selection, and two control (WSC) lines are maintained. Each WSP line had more severe and each WSR line had less severe withdrawal convulsions than its respective WSC line. Differences relative to control lines were more pronounced in the WSP lines and were not due to differences in effective dose of ethanol. Heritabilities were higher in the WSP lines than in the WSR lines. These lines will be useful for studying physiological determinants of ethanol dependence and withdrawal.
journal_name
Life Scijournal_title
Life sciencesauthors
Crabbe JC,Kosobud A,Young ERdoi
10.1016/0024-3205(83)90751-8subject
Has Abstractpub_date
1983-09-05 00:00:00pages
955-62issue
10eissn
0024-3205issn
1879-0631pii
0024-3205(83)90751-8journal_volume
33pub_type
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