Abstract:
:The aim of the study was to assess how the interruption of enterohepatic circulation may affect the regulation of apolipoprotein synthesis. For this purpose, apolipoprotein mRNA levels were measured in the liver and small intestine of male Wistar rats fed for 3 weeks diets with or without cholestyramine (5% w/w). In order to modulate intestinal lipid flux, we used diets with 2 or 10% lipid content. Cholestyramine treatment decreased plasma triglyceride and cholesterol concentrations (by 63% and 32%, respectively) in rats fed 10% corn oil containing diet but had no significant effect on plasma lipids in rats fed a low-fat diet. Plasma apo B and apo A-IV concentrations were lowered by cholestyramine treatment in both 10 and 2% oil fed groups; however plasma apo E concentration was only affected in rats receiving 10% corn oil in the diet. Cholestyramine treatment had no significant effect on plasma apo A-I concentration. Hepatic apo B, apo E and apo A-IV mRNA levels were similar among dietary groups. Cholestyramine administration caused an increase in hepatic apo A-I mRNA level only in rats fed low-fat diet. In the intestine cholestyramine treatment decreased apolipoprotein mRNA levels in jejunum but had a few effect on apolipoprotein mRNA levels in ileum. These experiments have shown that long-term decrease in the intraluminal availability of bile acids may alter not only lipid and lipoprotein metabolism but also the regulation of apolipoprotein synthesis.
journal_name
Life Scijournal_title
Life sciencesauthors
Felgines C,Mazur A,Rayssiguier Ydoi
10.1016/0024-3205(94)00640-7subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1053-60issue
13eissn
0024-3205issn
1879-0631pii
0024-3205(94)00640-7journal_volume
55pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Brief electrical pulses applied to the rat tail elicit a complex vocal response which includes audible (peeps, chatters) and ultrasonic (USV) components. Aspirin and amitriptyline had no effect on the vocal responses. Morphine showed a dose-dependent and naloxone reversible antinociceptive effect on the 1st and 2nd au...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00450-0
更新日期:1998-01-01 00:00:00
abstract:AIMS:To characterize the effects of a calorie matched high-fat diet (HFD) on spontaneous physical activity (SPA), body weight, inflammatory status and expression of genes related to energy homeostasis in hypothalamus of mice. MAIN METHODS:C57Bl/6 mice (n=5 per group) were fed a control diet (16.5% calories from fat) -...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.04.017
更新日期:2017-06-15 00:00:00
abstract::Involvement of cyclic AMP-dependent protein kinase in the desensitization of GABAB receptor expressed in Xenopus oocytes was studied. GABA produced an outward current in the presence of bicuculline, under voltage-clamp conditions. Baclofen mimicked the effect of GABA, thereby indicating that the response to GABA in th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02235-1
更新日期:1995-11-17 00:00:00
abstract::The effect of psychoactive agents with different clinical actions: three sedative neuroleptics (trifluoperazine, alimemazine tartrate, chlorpromazine), an anticholinergic agent (trihexyphenidyl hydrochloride), two tricyclic antidepressants (imipramine, desipramine) and lithium carbonate on the rotational correlation f...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90144-r
更新日期:1993-01-01 00:00:00
abstract::We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related pept...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90618-8
更新日期:1989-01-01 00:00:00
abstract::S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90253-4
更新日期:1984-08-06 00:00:00
abstract::The conversion of beta-carotene to retinal and the succeeding metabolic process of the retinal leading to production of retinol and retinyl esters are the prerequisite for the utilization of beta-carotene as a provitamin A. These processes are participated by beta-carotene cleavage enzyme, retinal reductase and retino...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00311-2
更新日期:1999-01-01 00:00:00
abstract::Chromatin organization was examined in confluent cultures of embryonic lung fibroblasts in the middle and at the end of their replicative lifespan. Age-related modifications resulted in an unusually wide spacing of the chromatin threads induced by a mild loosening treatment and an increased sensitivity of the nucleoso...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90396-x
更新日期:1983-06-13 00:00:00
abstract::N(G)-Nitro-L-arginine methyl ester (L-NAME), inhibits the three isozymes of nitric oxide synthase (NOS) in vitro and in vivo. The mechanism of NOS inhibition by L-NAME is uncertain. L-NAME was a time-dependent inhibitor of neuronal NOS (nNOS). Concommitantly, L-NAME was hydrolyzed, non-enzymatically, to N(G)-Nitro-L-a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00140-9
更新日期:1997-01-01 00:00:00
abstract::Aim Furowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism. MATE...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.12.027
更新日期:2019-02-01 00:00:00
abstract::The reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (DAT). Though cocaine and methylphenidate have similar in vitro affinities for DAT the abuse of methylphenidate in humans is substantially lower than of cocaine. To test if differences in in vivo pot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00225-8
更新日期:1999-01-01 00:00:00
abstract::Effects of scratching behavior on dermatitis, transepidermal water loss (TEWL) and serum IgE concentrations were examined in NC/Nga (NC) mice with toenails (WIT) and without toenails (WOT). The first study was a preventive treatment done to cut off hind toenails before dermatitis induction and the second study was a t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.07.022
更新日期:2004-12-31 00:00:00
abstract::This study was designed to document possible changes in bupivacaine (B) local anaesthetic activity and pharmacokinetics in mice after a ketamine (K) injection. In the experiments, bupivacaine (8.25 mg.kg(-1)), was injected into the popliteal space of the right posterior limb: the local anaesthetic activity was assesse...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00861-8
更新日期:1997-01-01 00:00:00
abstract::Synaptic mechanisms were studied ex vivo in the aged rat hippocampus, using a slice preparation and intracellular electrophysiological recordings of the CA1 pyramidal neurons. A dramatic depression of the slow cholinergic excitatory postsynaptic potential (EPSP) and of the slow, GABAB-mediated inhibitory postsynaptic ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00321-9
更新日期:1996-01-01 00:00:00
abstract::Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90473-x
更新日期:1986-04-14 00:00:00
abstract::Peptide Histidine Isoleucine (PHI) is generally considered a low affinity agonist for Vasoactive Intestinal Peptide (VIP) receptors. In this study, we investigated the presence and characteristics of [125I]PHI binding sites on rat liver membranes. Detergents at nonsolubilizing concentrations (1 mM CHAPS or 0.01% Tween...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90661-8
更新日期:1987-11-23 00:00:00
abstract:AIMS:Metformin is an insulin sensitizing agent with beneficial effects in diabetic patients on glycemic levels and in the cardiovascular system. We examined whether the metabolic changes and the vascular dysfunction in monosodium glutamate-induced obese non-diabetic (MSG) rats might be improved by metformin. MAIN METH...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.11.005
更新日期:2012-01-30 00:00:00
abstract:AIMS:Mild traumatic brain injury (mTBI) is an important risk factor for cognitive impairment. Despite intense efforts to develop efficient treatments, the current therapies are not often effective and far from satisfactory. Silymarin has been suggested as a therapeutic agent in the treatment of traumatic brain injury. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118049
更新日期:2020-09-15 00:00:00
abstract::Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00128-s
更新日期:1995-01-01 00:00:00
abstract::The ability of selective mu- ([D-Ala2, NHPhe4, Gly-ol]enkephalin: DAMGO), delta1- ([D-Pen2, Pen5]enkephalin: DPDPE) and delta2- ([D-Ala2]deltorphin II: DELT II) opioid receptor agonists to activate G-proteins in the midbrain and forebrain of mice and rats was examined by monitoring the binding of guanosine-5'-O-(3-[35...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00422-1
更新日期:1999-01-01 00:00:00
abstract:AIMS:Reactive oxygen species (ROS) are generated in the ischaemic myocardium especially during early reperfusion and affect myocardial function and viability. Monoterpenes have been proposed to play beneficial roles in diverse physiological systems; however, the mechanisms of action remain largely unknown. This study a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.01.008
更新日期:2017-03-01 00:00:00
abstract::Unconjugated bilirubin (UCB), like trifluoperazine (TFP), dibucaine (DBC) and praziquantel (PZQ), induces erythrocyte morphological changes, lysis and lipid exfoliation. In the present study we determined whether TFP, DBC and PZQ toxicity to erythrocytes was potentiated or reverted by UCB. Human erythrocytes were eith...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01171-7
更新日期:2001-07-13 00:00:00
abstract::Treatment of primary cultured chondrocytes from rabbit articular cartilage with interleukin-1 (IL-1)alpha and plasminogen induced the production of pro-matrix metalloproteinase 1 (proMMP-1/interstitial collagenase), proMMP-3 (stromelysin 1) and proMMP-9 (gelatinase B), as well as their active forms. Human urinary tryp...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00261-6
更新日期:1998-01-01 00:00:00
abstract::Addition of synthesized atriopeptin II (AP-2), a 23 amino acid peptide of rat atria, to rat thoracic aorta smooth muscle cells results in the stimulation of cyclic GMP production by the cells. The EC50 for the effect is 81 nM and a 7 fold increase occurs at 10 microM AP-2. Cyclic GMP levels increased within 15 seconds...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90425-4
更新日期:1985-08-19 00:00:00
abstract::The present study shows that morphine reduces the pulmonary inflammatory response to intranasal influenza virus infection in rats. Rats were infected with rat-adapted influenza virus (RAIV), which is a unique infectious agent because normal rats develop an acute pulmonary inflammatory response to RAIV and rapidly clea...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00348-3
更新日期:1999-01-01 00:00:00
abstract::SR 142801 is the first potent and selective non-peptide antagonist of the tachykinin NK3 receptor. It inhibited [MePhe7]NKB binding to its receptor from various species, including humans. SR 142801 was a competitive antagonist of [MePhe7]NKB-mediated contractions of guinea-pig ileum and inhibited the acetylcholine rel...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00413-m
更新日期:1995-01-01 00:00:00
abstract::Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90198-x
更新日期:1984-02-27 00:00:00
abstract::We recently labeled with carbon-11, a high affinity, selective, 5-HT3 receptor (5-HT3R) ligand, S21007, for potential positron emission tomography (PET) applications. To evaluate the in vivo binding properties of [11C]S21007, its brain regional distribution, tissue and plasma pharmacokinetics and plasma metabolisation...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01058-8
更新日期:1998-01-01 00:00:00
abstract::Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02169-0
更新日期:2002-11-08 00:00:00
abstract:AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2009.11.019
更新日期:2010-01-30 00:00:00