Ethanol consumption and serum lipid profiles in Sinclair(S-1) miniature swine.

abstract：:The nonsteroidal anti-inflammatory drug zomepirac (ZP) is metabolised to a chemically reactive acyl glucuronide conjugate (ZAG) which can form covalent adducts with proteins. In vivo, such adducts could initiate immune or toxic responses. In rats given ZP, the major band detected in liver homogenates by immunoblotting...

journal_title：Life sciences

authors： Wang M,Gorrell MD,McGaughan GW,Dickinson RG

更新日期：2001-01-05 00:00:00

abstract：:Cholinergic neurons in the laterodorsal (LDT) and the pedunculopontine (PPT) tegmental nuclei act to promote REM sleep (REMS). The predominantly glutamatergic neurons of the REMS-induction region of the medial pontine reticular formation are in turn activated by cholinergic cells, which results in the occurrence of to...

journal_title：Life sciences

authors： Monti JM,Monti D

更新日期：2000-04-14 00:00:00

abstract：:By use of ion exchange chromatography we have isolated two discrete classes of "free" glycosaminoglycans (GAG) from human plasma. The GAG fractions were tested for their effects on two lipoprotein lipase (LPL) enzyme systems containing an apolipoprotein C-II activated emulsion as the triglyceride substrate and bovine ...

journal_title：Life sciences

authors： Felts JM,Staprans I,Gorman RA

更新日期：1983-04-04 00:00:00

abstract：:The present experiment was designed to determine whether scavenging capacity of serum, in addition to glucose level, influences hemoglobin and serum protein glycosylation in non-insulin dependent diabetic patients. For this purpose forty-seven patients homogeneous for age, disease duration, therapy and glyco-metabolic...

journal_title：Life sciences

authors： Testa R,Testa I,Manfrini S,Bonfigli AR,Piantanelli L,Marra M,Pieri C

更新日期：1996-01-01 00:00:00

abstract：:Iron imbalance has been implicated in oxidative injury associated with many brain diseases. The present study investigated the importance of iron location in hydroxyl radical (.OH) generation and the link between .OH production evaluated by the salicylate method and lipid peroxidation monitored by thiobarbituric acid-...

journal_title：Life sciences

authors： Demougeot C,Marie C,Beley A

更新日期：2000-06-16 00:00:00

abstract：OBJECTIVE:To explore the effect of urantide on atherosclerotic myocardial injury by antagonizing the urotensin II/urotensin II receptor (UII/UT) system and regulating the mitogen-activated protein kinase (MAPK) signalling pathway. METHODS:Atherosclerosis (AS) was established in rats by administering a high-fat diet an...

journal_title：Life sciences

authors： Zhao J,Miao G,Wang T,Li J,Xie L

更新日期：2020-12-01 00:00:00

abstract：AIMS:The present study aimed to investigate the mechanism of bone repair mediated by recombination BMP-2 (rhBMP-2)/recombination CXC chemokine ligand-13 (rhCXCL13)-loaded hollow hydroxyapatite (HA) microspheres/chitosan (CS) composite. MATERIALS AND METHODS:Firstly, the biological activity of rhBMP-2 and rhCXCL13 rele...

journal_title：Life sciences

authors： Zeng J,Xiong S,Ding L,Zhou J,Li J,Qiu P,Liao X,Xiong L,Long Z,Liu S

更新日期：2019-10-01 00:00:00

abstract：AIMS:Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inf...

journal_title：Life sciences

authors： Chen L,Li W,Qi D,Lu L,Zhang Z,Wang D

更新日期：2018-10-01 00:00:00

abstract：:A simple, selective reverse-phase HPLC-fluorometric method is described for the determination of serotonin (5HT) in cisternal CSF of the rat. The mean (+/- SE) value of CSF 5HT observed in control adult rats was 457 +/- 83 pg/ml (N = 16). In an attempt to validate the measure as an index of extracellular, or functiona...

journal_title：Life sciences

authors： Anderson GM,Teff KL,Young SN

更新日期：1987-06-08 00:00:00

abstract：:Although exposure to broad band (0.2-20 MHz) electromagnetic fields (EMF) is part of the treatment of several diseases, little is known as to their effects on myocardial protein expression and resistance to ischemia-reperfusion (I/R). We exposed Sprague-Dawley rats to either high (H, 10 min/day at 200 V/m, 36.1 microT...

journal_title：Life sciences

authors： Ronchi R,Marano L,Braidotti P,Bianciardi P,Calamia M,Fiorentini C,Samaja M

更新日期：2004-09-03 00:00:00

abstract：:Acetyltransferase was isolated by histone-Sepharose affinity chromatography from human cord blood red cells. The enzyme was detected only in very young red cells. The semipurified enzyme and [14C]acetyl-CoA were used to acetylate isolated Hb F tetramer and alpha and gamma subunits. The in vitro acetylated products wer...

journal_title：Life sciences

authors： Qiu CC,Kasten-Jolly J,Abraham EC

更新日期：1988-01-01 00:00:00

abstract：:By using multiple time-point constant-rate infusions of deuterium-labeled phosphorylcholine, appropriate kinetic parameters were obtained for use in the calculation of the turnover rate of acetylcholine (TRACh) in selected mouse brain regions. After obtaining these data, the relationship between the analgesic agent co...

journal_title：Life sciences

authors： Chen R,Robinson SE

更新日期：1992-01-01 00:00:00

abstract：:The hypocholesterolemic effect of taurine was examined in mice fed a high-cholesterol diet containing 1% cholesterol and 0.25% sodium cholate. Male C57BL/6 mice were divided into 3 groups: control group (HC), 1% taurine-supplemented group (HCT+), and taurine-deficient group (HCT-) produced by supplying 0.5% guanidinoe...

journal_title：Life sciences

authors： Chen W,Matuda K,Nishimura N,Yokogoshi H

更新日期：2004-02-27 00:00:00

abstract：:Benzodiazepines are frequently used for the treatment of maternal psychiatric disorders during pregnancy. Besides their anxiolytic effect, they are reported to exert a direct relaxing action on several smooth muscle preparations, including the uterus. In the present study, the possibility of the involvement of alpha(1...

journal_title：Life sciences

authors： Zupkó I,Jánossy K,Maul K,Márki A,Falkay G

更新日期：2003-01-24 00:00:00

abstract：:The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...

journal_title：Life sciences

authors： Chen SW,Xin Q,Kong WX,Min L,Li JF

更新日期：2003-11-07 00:00:00

abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...

journal_title：Life sciences

authors： Matsui M,Yamada S,Oki T,Manabe T,Taketo MM,Ehlert FJ

更新日期：2004-11-05 00:00:00

abstract：:We conducted a study to determine whether angiotensin converting enzyme inhibitors (ACEIs) inhibit endothelin secretion from cultured human endothelial cells. Confluent umbilical vein endothelial cells were incubated in multi-well plates with culture medium containing either captopril (10(-6), 10(-5), 10(-4) M) or ena...

journal_title：Life sciences

authors： Yoshida H,Nakamura M

更新日期：1992-01-01 00:00:00

abstract：:The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different ag...

journal_title：Life sciences

authors： Henry JM,Roth GS

更新日期：1984-08-20 00:00:00

abstract：:Retinoic acids and their cognate nuclear receptors exert a substantial regulatory role in cell growth and development as well as in the neuroendocrine system. These effects are primarily mediated by all-trans retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor superfamily of ligand inducibl...

journal_title：Life sciences

authors： Brtko J,Knopp J,Kvetnanský R

更新日期：2000-03-24 00:00:00

abstract：:In rodents an action of estrogen is required for the initiation of implantation of the blastocyst into the endometrium of a progesterone-primed uterus. Thus removal of endogenous estrogen, either directly by ovariectomy or indirectly by hypophysectomy, prevents implantation in the pregnant rat. In the present study, d...

journal_title：Life sciences

authors： Johnson DC

更新日期：1996-01-01 00:00:00

abstract：:The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylact...

journal_title：Life sciences

authors： Hu QW,Liu GT

更新日期：2006-07-04 00:00:00

abstract：AIMS:Despite the advanced cancer treatments, there is increased resistance to chemotherapy and subsequent mortality. In lack of reliable data in monolayer cultures and animal models, researchers are shifting to 3D cancer spheroids, which represents the in vivo robust tumour morphology. Calcium is essential in cell sign...

journal_title：Life sciences

authors： Kumari N,Bhargava A,Rath SN

更新日期：2020-11-01 00:00:00

abstract：:The presence of gonadotropin-releasing hormone (GnRH) binding sites in biopsy samples of human epithelial ovarian cancer and ovarian tumor cell lines as well as the demonstration of the inhibitory effects of GnRH analogues on the growth of these cells raised the possibility that GnRH is produced locally by ovarian can...

journal_title：Life sciences

authors： Yin H,Cheng KW,Hwa HL,Peng C,Auersperg N,Leung PC

更新日期：1998-01-01 00:00:00

abstract：:Several different vasodilator substances can be released by vascular endothelium in response to mechanical stimuli and vasoactive agents. The purpose of this study was to determine whether there is a male-female difference in the relative contributions of nitric oxide (NO) and endothelium-derived hyperpolarizing facto...

journal_title：Life sciences

authors： Pak KJ,Geary GG,Duckles SP,Krause DN

更新日期：2002-08-23 00:00:00

abstract：:The modulation of Ca2+ release by synthetic bee venom melittin was examined in equine and human terminal cisternae-containing fractions. Melittin (0.1 microM) decreased the threshold of Ca(2+)-induced Ca2+ release by 20% in equine muscle and by 36% in human muscle. If terminal cisternae fractions were first preloaded ...

journal_title：Life sciences

authors： Fletcher JE,Tripolitis L,Beech J

更新日期：1992-01-01 00:00:00

abstract：:Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of gr...

journal_title：Life sciences

authors： Fisher CE,Hughes RN

更新日期：1996-01-01 00:00:00

abstract：:Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...

journal_title：Life sciences

authors： Nobre MJ,Borelli KG,Brandão ML

更新日期：2002-11-08 00:00:00

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：:We produced thiamine-deficient (TD) mice by TD diet treatment. The growth curve of mice on TD feeding was sharply increased until on the 10th day and subsequently the body weight gradually decreased. The mortality rate in mice was about 67% on the 30th day after the start of TD feeding. We performed the forced swimmin...

journal_title：Life sciences

authors： Nakagawasai O,Tadano T,Hozumi S,Taniguchi R,Tan-No K,Esashi A,Niijima F,Kisara K

更新日期：2001-07-27 00:00:00

abstract：:Chlorin e(6) and its derivatives are promising sensitizers for photodynamic therapy (PDT). In order to compare the photodynamic effects of 8 novel derivatives of chlorin e(6) and to explore some mechanisms of their effects at the cellular level, we studied PDT-induced changes in bioelectric activity of crayfish mechan...

journal_title：Life sciences

authors： Uzdensky AB,Dergacheva OY,Zhavoronkova AA,Reshetnikov AV,Ponomarev GV

更新日期：2004-03-12 00:00:00