Abstract：
:Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of greater sensitivity to cyclohexyladenosine (but not diazepam) as determined by its effects on grooming behavior and tendencies to occupy the center squares of the apparatus. This suggested that adenosine (A1) rather than benzodiazepine receptor activity had been affected by the perinatal caffeine experience which also reduced locomotor activity while increasing center occupancy. The acute effects of diazepam and cyclohexyladenosine also depended largely on the sex of the subjects. Diazepam affected locomotor activity more and both drugs affected defecation less in females than in males. No other interaction involving sex was significant.
journal_name
Life Scijournal_title
Life sciencesauthors
Fisher CE,Hughes RNdoi
10.1016/s0024-3205(96)80009-9subject
Has Abstractpub_date
1996-01-01 00:00:00pages
701-9issue
8eissn
0024-3205issn
1879-0631pii
0024320595023399journal_volume
58pub_type
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