Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures.

abstract：:In the present study, we examined the effects of ethanol treatment on the subsequent expression of opioid and nonopioid forms of swim stress-induced analgesia (SSIA). In Experiment 1, mice were injected with ethanol (2.5 g/kg, i.p.) or an equal volume of saline once a day for two days. Animals received no treatment on...

journal_title：Life sciences

authors： Bell RL,Soignier RD,Olson RD,Vaccarino AL

更新日期：1998-01-01 00:00:00

abstract：:Strips of bovine mesenteric arteries brought to sustained contraction by the addition of 3.0 microM phenylephrine relaxed when exposed to ultraviolet radiation (366 nm). The relaxation was reversible and associated with a rapid increase in the cGMP content. After termination of the radiation the cGMP level rapidly dec...

journal_title：Life sciences

authors： Karlsson JO,Axelsson KL,Andersson RG

更新日期：1984-04-16 00:00:00

abstract：:Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants. It is also known that some convulsant and anticonvulsant drug actions are mediated by the GABA-receptor chloride-ionophore complex. Drugs acting at this complex appear to induce convu...

journal_title：Life sciences

authors： Malatynska E,Knapp RJ,Ikeda M,Yamamura HI

更新日期：1988-01-01 00:00:00

abstract：:Rats with experimental allergic encephalomyelitis (EAE) induced with myelin or spinal cord show decreases in the content of sulphatides and cerebrosides and increases in the level of esterified cholesterol in the CNS. In this work it is shown that brain sulphatide changes can be obtained by injection of mixtures conta...

journal_title：Life sciences

authors： Roth GA,Monferran CG,Maggio B,Cumar FA

更新日期：1982-03-08 00:00:00

abstract：:Chronic voluntary running of mice is known to increase the circadian peak of plasma corticosterone without change in the level of adrenocorticotropic hormone (ACTH). In order to investigate how chronic exercise modulates the circadian HPA axis, we used two weeks of voluntary wheel running of mice and confirmed the sig...

journal_title：Life sciences

authors： Otawa M,Arai H,Atomi Y

更新日期：2007-01-30 00:00:00

abstract：:Diazepam (0.4-4 mg/kg i.p.) reduced the spontaneous tonic activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus muscle of spastic mutant Han-Wistar rats in a dose-dependent manner. The muscle relaxant effect of diazepam was antagonized by the benzodiazepine antagonists Ro 15-1788 (5 mg/kg i.p.), ...

journal_title：Life sciences

authors： Schwarz M,Turski L,Sontag KH

更新日期：1984-10-01 00:00:00

abstract：:Site-directed mutagenesis has been used to evaluate the roles of the key aspartate and arginine residues in transmembrane domain three of the muscarinic receptors. The results suggest that the formation of an ionic bond between the Asp carboxylate group and the onium headgroup is essential to anchor acetylcholine in i...

journal_title：Life sciences

authors： Hulme EC,Curtis CA,Page KM,Jones PG

更新日期：1995-01-01 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic interactions between simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and diltiazem, a calcium antagonist, were investigated in 7 male and 4 female patients with hypercholesterolemia and hypertension. The patients were given, for one in a three con...

journal_title：Life sciences

authors： Watanabe H,Kosuge K,Nishio S,Yamada H,Uchida S,Satoh H,Hayashi H,Ishizaki T,Ohashi K

更新日期：2004-12-03 00:00:00

abstract：AIMS:RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation (CNV) is a frequent characteristic in soft tissue sarcomas (STS). However, little is known regarding their possible roles in STS. MAIN METHODS:RNA sequence profiles and CNV data of 255 STS patie...

journal_title：Life sciences

authors： Wang X,Han Y,Li J,Hong D,Xue Z,Huang H,Du Z,Hou Y,Li H,Li H,Liao H,Xie X,Ding C

更新日期：2021-01-15 00:00:00

abstract：:The hypocholesterolemic effect of taurine was examined in mice fed a high-cholesterol diet containing 1% cholesterol and 0.25% sodium cholate. Male C57BL/6 mice were divided into 3 groups: control group (HC), 1% taurine-supplemented group (HCT+), and taurine-deficient group (HCT-) produced by supplying 0.5% guanidinoe...

journal_title：Life sciences

authors： Chen W,Matuda K,Nishimura N,Yokogoshi H

更新日期：2004-02-27 00:00:00

abstract：:Oxidative stress induced cell injury is reported to contribute to the pathogenesis of cerebral ischemia. Reactive oxygen species such as hydrogen peroxide (H2O2) and superoxide radical along with nitric oxide and peroxynitrite generated during ischemia-reperfusion injury, causes the overactivation of poly (ADP-ribose)...

journal_title：Life sciences

authors： Kaundal RK,Shah KK,Sharma SS

更新日期：2006-11-10 00:00:00

abstract：:As a step in the purification and characterization of the glucose transporter from rat skeletal muscle, we have reconstituted glucose transport activity in liposomes. Plasma membranes were prepared from skeletal muscle which display D-glucose reversible binding of cytochalasin B (10 pmol sites/mg protein; KD = 0.3 mic...

journal_title：Life sciences

authors： Wheeler TJ,Hauck MA

更新日期：1987-06-15 00:00:00

abstract：:The kinetic parameters of serotonin (5-HT) uptake and imipramine binding of the synaptosomes and blood platelets of male Fawn-hooded rats, which have a 5-HT storage abnormality, and normal Sprague-Dawley rats were compared. The Vmax for 5-HT uptake of synaptosomes from Fawn-hooded rats was significantly greater than t...

journal_title：Life sciences

authors： Arora RC,Tong C,Jackman HL,Stoff D,Meltzer HY

更新日期：1983-08-01 00:00:00

abstract：:Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...

journal_title：Life sciences

authors： Kelsoe JR Jr,Gillin JC,Janowsky DS,Brown JH,Risch SC,Lumkin B

更新日期：1986-04-14 00:00:00

abstract：:An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...

journal_title：Life sciences

authors： Sun GY,Lin TN

更新日期：1989-01-01 00:00:00

abstract：:We have previously shown that matrix metalloproteinases (MMPs) play a role in osteoclastic bone resorption by facilitating migration of osteoclastic cells toward bone surface through matrices. Of MMPs identified so far, MMP-9 is likely the most important proteinase for the action, since osteoclasts express this enzyme...

journal_title：Life sciences

authors： Ishibashi O,Niwa S,Kadoyama K,Inui T

更新日期：2006-09-20 00:00:00

abstract：:The survival of osteoblast cells is one of the determinants of the development of osteoporosis in patients with inflamed synovium, such as in rheumatoid arthritis (RA). By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, I have shown that myricetin exhibits a significant induction of different...

journal_title：Life sciences

authors： Kuo PL

更新日期：2005-10-21 00:00:00

abstract：:Memory impairment induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats is associated with impaired brain glucose and energy metabolism, oxidative stress and impaired cholinergic neurotransmission. Treatment with antioxidants and cholinergic agonists has been reported to produce beneficial...

journal_title：Life sciences

authors： Pathan AR,Viswanad B,Sonkusare SK,Ramarao P

更新日期：2006-11-02 00:00:00

abstract：AIMS:Few studies have compared the interaction of single and repeated administration of amitriptyline (amit) with the nitrergic system and glutamatergic system in the experimental model of neuropathic pain. We aimed to evaluate the antinociceptive effect of single and repeated administration of amit and to assess wheth...

journal_title：Life sciences

authors： Farghaly HSM,Elbadr MM,Ahmed MA,Abdelhaffez AS

更新日期：2019-09-15 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

journal_title：Life sciences

authors： Privratsky JR,Newman DK,Newman PJ

更新日期：2010-07-17 00:00:00

abstract：:Nitric oxide (NO) is generated from L-arginine by different isoforms of the enzyme nitric oxide synthase (NOS) and is known to be involved in mediating several biological functions, some of which are associated with reproduction. In this study, we examined the ability of the prepubertal ovary to express the inducible ...

journal_title：Life sciences

authors： Srivastava V,Jones BJ,Dookwah H,Hiney JK,Dees WL

更新日期：1997-01-01 00:00:00

abstract：:Pregnant mice are more susceptible to flurothyl-induced seizures than are non-pregnant controls. The possibility that the well-known increase in beta-endorphin concentration which accompanies pregnancy was involved in this effect was examined by testing whether naloxone administration could block the increased seizure...

journal_title：Life sciences

authors： Smolen A,Smolen TN,van de Kamp JL

更新日期：1986-05-26 00:00:00

abstract：:The present study is undertaken to investigate whether the phospholipase A(2) (PLA(2)) influences mRNA nucleocytoplasmic transport evaluated by nucleoside triphosphatase (NTPase) activity and mRNA export in isolated hepatic nuclear envelope. Isolated hepatic nuclei from rat liver were exposed to PLA(2) (10(-5) approxi...

journal_title：Life sciences

authors： Li JX,Li ZQ,Pang YZ,Tang CS

更新日期：2003-07-11 00:00:00

abstract：AIMS:Benidipine, a dihydropyridine Ca(2+) channel blocker, has been reported to block T-type Ca(2+) channels; however, the mechanism underlying this effect was unclear. In this study, we characterized the mechanism responsible for this blocking activity. Furthermore, the blocking activity was compared between two enant...

journal_title：Life sciences

authors： Inayoshi A,Sugimoto Y,Funahashi J,Takahashi S,Matsubara M,Kusaka H

更新日期：2011-05-09 00:00:00

abstract：:Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrat...

journal_title：Life sciences

authors： Fischman AJ,Kastin AJ,Graf MV

更新日期：1984-11-12 00:00:00

abstract：AIMS:We investigated the implication of PKA and Epac proteins in the endothelium-independent vasorelaxant effects of cyclic AMP (cAMP). MAIN METHODS:Cytosolic Ca(2+) concentration ([Ca(2+)]c) was measured by fura-2 imaging in rat aortic smooth muscle cells (RASMC). Contraction-relaxation experiments were performed in ...

journal_title：Life sciences

authors： Cuíñas A,García-Morales V,Viña D,Gil-Longo J,Campos-Toimil M

更新日期：2016-06-15 00:00:00

abstract：AIMS:Short-chain acyl-CoA dehydrogenase (SCAD) is a key enzyme in fatty acid oxidation. In the present study we aim to investigate the changes in SCAD between pathological and physiological cardiomyocyte hypertrophy. We also explore the different signaling pathways of pathological and physiological cardiomyocyte hypert...

journal_title：Life sciences

authors： Huang Q,Huang J,Zeng Z,Luo J,Liu P,Chen S,Liu B,Pan X,Zang L,Zhou S

更新日期：2015-03-01 00:00:00

abstract：:The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min...

journal_title：Life sciences

authors： Cuccheddu T,Floris S,Serra M,Porceddu ML,Sanna E,Biggio G

更新日期：1995-03-10 00:00:00

abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...

journal_title：Life sciences

authors： Zhao Q,Mao A,Yan J,Si J,Zhou R,Gan L,Liu Y,Zhang H

更新日期：2016-07-15 00:00:00

abstract：:The profile of endogenous opioid peptides in the peptide-rich fraction obtained from a homogenate of an ACTH-secreting human pituitary tumor is presented. Gradient RP-HPLC is used to separate the mixture into peptide constituents. A preparation of opioid receptors is used in a radioreceptor assay with ethorphine - a r...

journal_title：Life sciences

authors： Desiderio DM,Cezayirli RC,Fridland G,Robertson JT,Sacks H

更新日期：1985-11-11 00:00:00