CGS 8216, Ro 15-1788 and methyl-beta-carboline-3-carboxylate, but not EMD 41717 antagonize the muscle relaxant effect of diazepam in genetically spastic rats.

abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...

journal_title：Life sciences

authors： Chen SJ,Wu CC,Yang SN,Lin CI,Yen MH

更新日期：2000-12-29 00:00:00

abstract：:A sensitive method for quantitation of beta-endorphin in biological fluids and tissues using ELISA methodology has been developed. This assay is sensitive to as low as 30 picograms of beta-endorphin per measurement and can be carried out in approximately 5 hours. The determination of antibody titer levels to beta-endo...

journal_title：Life sciences

authors： Sarma JM,Houghten RA

更新日期：1983-01-01 00:00:00

abstract：:The stability of epidermal growth factor (EGF) in the gastrointestinal humen of 3-day-old suckling and 45-day-old weaned pigs was examined by incubating iodine labeled recombinant human EGF (hEGF) in the gastrointestinal fluids at 37 degrees C and monitoring the generation of acid soluble radioactivity. Chromatographi...

journal_title：Life sciences

authors： Shen WH,Xu RJ

更新日期：1996-01-01 00:00:00

abstract：AIMS:Excessive production of nitric oxide (NO) and reactive oxygen species (ROS) in sepsis modulates different cell functions. Since the sepsis severity is associated with the degree of platelet activation, we decided to investigate the role of systemic generation of NO and ROS in modulating the platelet adhesion of li...

journal_title：Life sciences

authors： Casarin AL,Lopes-Pires ME,Morganti RP,Antunes E,Marcondes S

更新日期：2011-11-21 00:00:00

abstract：AIMS:Periodic acceleration (pGz) is a method that applies repetitive sinusoidal head-to-foot motion to the horizontally positioned body. pGz adds pulses to the circulation as a function of frequency, thereby increasing shear stress to the endothelium. Pulsatile shear stress increases release of cardioprotective endothe...

journal_title：Life sciences

authors： Adams JA,Wu H,Bassuk JA,Arias J,Uryash A,Jorapur V,Lamas GA,Kurlansky P

更新日期：2010-05-08 00:00:00

abstract：:The induction of aldose reductase (AR) mRNA expression and its activity by glucose were investigated in fetal rat aortic smooth muscle (A10) cells. The increase in the expression of AR mRNA was observed at 6 h, and reached a maximum (2.3 fold) at 12 h after exposure to 80 mM glucose. On the other hand, increase in AR ...

journal_title：Life sciences

authors： Tawata M,Ohtaka M,Hosaka Y,Onaya T

更新日期：1992-01-01 00:00:00

abstract：:Phencyclidine hydrochloride (PCP) was tested for its ability to alter a variety of immune effector and regulatory functions in vitro. B6C3F1 murine splenic lymphocytes or elicited peritoneal macrophages were cultured in vitro with medium only or medium containing 10(-10)-10(-4) M PCP. Macrophages cultured with or with...

journal_title：Life sciences

authors： Thomas PT,House RV,Bhargava HN

更新日期：1993-01-01 00:00:00

abstract：:Liquid protein diet (LPD) has been shown previously to produce maternal and fetal weight loss and fetal congenital anomalies, including cataracts and craniofacial malformations. Therefore, to examine the effects of LPD in pregnancy upon the central nervous system of pups, pregnant dams were fed either a 20% casein die...

journal_title：Life sciences

authors： Mori M,Wilber JF,Nakamoto T

更新日期：1983-04-04 00:00:00

abstract：:This study examines the role of dopaminergic mechanisms in the regulation of human pancreatic polypeptide (hPP) secretion in 11 normal male volunteers. Administration of domperidone (20 mg iv), an extracerebral inhibitor of dopamine receptors, resulted in a hPP rise (p less than 0.05) within 10 min and a peak response...

journal_title：Life sciences

authors： Sowers JR,Stern N,Taylor IL

更新日期：1982-12-27 00:00:00

abstract：:The additive effects of combined valsartan and spironolactone on plasma and cardiac aldosterone escape were evaluated in spontaneously hypertensive rats (SHRs). Twenty-four SHRs were treated with valsartan (30 mg/kg body weight per day), spironolactone (20 mg/kg body weight per day) and a combination of both for 4 mon...

journal_title：Life sciences

authors： Liang YH,Wang JM,Zhou Y,Jiang XJ,Jiang H,Huang CX

更新日期：2004-08-27 00:00:00

abstract：:Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androg...

journal_title：Life sciences

authors： Wing LY

更新日期：1990-01-01 00:00:00

abstract：AIMS:Perinatal hypoxic-ischemic insult has acute and long term deleterious effects on many organs including heart. Although tumor necrosis factor alpha (TNF-α) has been reported to increase soon after hypoxia, the inhibition of this mediator has not been documented. The aim of this study was to investigate the effects ...

journal_title：Life sciences

authors： Büyükakilli B,Atici A,Özkan A,Balli E,Güneş S,Turhan AH,Hallioglu O,Kanik A

更新日期：2012-06-06 00:00:00

abstract：:Although (-)-125I-iodopindolol (IPIN) can be used to label beta-adrenergic receptors in the central nervous system (CNS) in vivo, use of this ligand for receptor imaging studies in humans may be limited due to its relatively poor penetration into the CNS. A series of derivatives related to pindolol was therefore studi...

journal_title：Life sciences

authors： Tejani-Butt SM,Brunswick DJ

更新日期：1987-08-24 00:00:00

abstract：:BIM 23014 is a somatostatin analog displaying an increased biological half life due to resistance to enzymatic degradation. This peptide inhibits GH release directly at the level of pituitary somatotrophs. In addition, an action of BIM 23014 at the level of the hypothalamus is possible since somatostatinergic fibers a...

journal_title：Life sciences

authors： Magnan E,Cataldi M,Guillaume V,Conte-Devolx B,Graziani N,Figaroli JC,Thomas F,Chihara K,Oliver C

更新日期：1992-01-01 00:00:00

abstract：:Inhaled antimuscarinics, often called anticholinergics in clinical medicine, are established as first line bronchodilators in COPD. Tiotropium has been developed as a new generation antimuscarinic following ipratropium. Tiotropium is a specific, highly potent antimuscarinic, demonstrating very slow dissociation from m...

journal_title：Life sciences

authors： Disse B,Speck GA,Rominger KL,Witek TJ Jr,Hammer R

更新日期：1999-01-01 00:00:00

abstract：:Effects of PK 11195 and flumazenil on cardiac responses to diazepam, clonazepam and zolpidem were compared. Coronary flow rate was increased at relatively low doses of diazepam and decreased at higher doses. Clonazepam induced a dose-dependent increase, and zolpidem a decrease of coronary flow rate. PK 11195 reduced t...

journal_title：Life sciences

authors： Zeegers A,van Wilgenburg H,Leeuwin RS

更新日期：1998-01-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. The iNOS and COX-2 proteins and their mRNA expressions in cultured vascul...

journal_title：Life sciences

authors： Hirafuji M,Tsunoda M,Machida T,Hamaue N,Endo T,Miyamoto A,Minami M

更新日期：2002-01-11 00:00:00

abstract：:Prolonged use of glucocorticoids is associated with decreased bone formation, increased resorption and osteonecrosis, through direct and indirect effects on the activity and viability of bone effector cells, osteoblasts and osteoclasts, and osteocytes. This study has investigated molecular pathways implicated in Dexam...

journal_title：Life sciences

authors： Kogianni G,Mann V,Ebetino F,Nuttall M,Nijweide P,Simpson H,Noble B

更新日期：2004-10-29 00:00:00

abstract：:The effects of agents that modulate intracellular release of calcium and protein kinase C (PKC) activation on noradrenaline (NA)-induced contractions of epididymal vas deferens in calcium-free/EGTA (1 mM) medium were investigated. NA (100 microM) or methoxamine (100 microM) evoked repeatable contractions. Clonidine (1...

journal_title：Life sciences

authors： Amobi NI,Sugden D,Smith IC

更新日期：1999-01-01 00:00:00

abstract：:The effects of melatonin treatment and pituitary transplants on serum total and free cholesterol levels, cholesterol esterification index, phospholipid levels and prolactin, thyroid-stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3) levels were examined in rats. Male rats were grafted an anterior pitu...

journal_title：Life sciences

authors： Esquifino A,Agrasal C,Velázquez E,Villanúa MA,Cardinali DP

更新日期：1997-01-01 00:00:00

abstract：:Classical studies have demonstrated that the visual centers in primates consist of cortical areas V1, V2 and V4 and their branches. However, nothing is known about how these visual areas change in postnatal development. In the present studies, therefore, pigs aged 2, 4, and 6 months old, were stimulated visually with ...

journal_title：Life sciences

authors： Fang M,Li J,Rudd JA,Wai SM,Yew JC,Yew DT

更新日期：2006-02-09 00:00:00

abstract：AIMS:Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifi...

journal_title：Life sciences

authors： Li W,Dong M,Guo P,Liu Y,Jing Y,Chen R,Zhang M

更新日期：2019-03-15 00:00:00

abstract：AIMS:Currently, chronic gastritis is a high incidence of digestive diseases, along with loss of appetite, abdominal pain and diarrhea. Baicalin belongs to the major bioactive flavonoids compounds from Scutellariae Radix, it exhibited anti-inflammatory and anti-bacteria activities. Nonetheless, the protective effects of...

journal_title：Life sciences

authors： Ji W,Liang K,An R,Wang X

更新日期：2019-12-15 00:00:00

abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

journal_title：Life sciences

authors： Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

更新日期：2021-02-01 00:00:00

abstract：:We evaluated the effects of FR901533, endothelin converting enzyme inhibitor, on development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension. Pulmonary hypertension was induced by a single injection of monocrotaline (80 mg/kg). Twenty-...

journal_title：Life sciences

authors： Takahashi T,Kanda T,Inoue M,Sumino H,Kobayashi I,Iwamoto A,Nagai R

更新日期：1998-01-01 00:00:00

abstract：AIMS:Nicotine is known to promote body weight loss and to disturb glucose homeostasis and lipoprotein metabolism. Electronic cigarettes, as a substitute to nicotine, are becoming increasingly popular, although there is no evidence regarding their safety. Considering the dearth of information about e-cigarette toxicity,...

journal_title：Life sciences

authors： El Golli N,Dkhili H,Dallagi Y,Rahali D,Lasram M,Bini-Dhouib I,Lebret M,Rosa JP,El Fazaa S,Allal-El Asmi M

更新日期：2016-02-01 00:00:00

abstract：:Biliary excretion is the main route of disposal of bilirubin and impaired excretion results in jaundice, a well recognisable symptom of liver disease. Conjugation of bilirubin in the liver is essential for its clearance. The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1...

journal_title：Life sciences

authors： Bustamante N,Cantarino MH,Arahuetes RM,Cubero FJ,Ortiz A

更新日期：2006-03-06 00:00:00

abstract：:Involvement of cannabinoid CB2 receptors in the IgE-mediated cutaneous reaction was investigated. Epicutaneous challenge with 2,4-dinitrofluorobenzene caused a triphasic swelling in the ear of BALB/c and C57BL/6 mice passively sensitized with anti-dinitrophenol IgE. Peak responses of the ear swelling appeared at 1 h, ...

journal_title：Life sciences

authors： Ueda Y,Miyagawa N,Wakitani K

更新日期：2007-01-09 00:00:00

abstract：:To clarify the mechanism of meconium-induced cellular injury, we examined the effect of meconium on the alveolar macrophages (AM) and bronchial epithelial cells (AK-D). Meconium obtained from healthy newborns was added to culture medium of AM and/or AK-D, which were cultured for 1 hour. Superoxide anion production of ...

journal_title：Life sciences

authors： Kojima T,Hattori K,Fujiwara T,Sasai-Takedatsu M,Kobayashi Y

更新日期：1994-01-01 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzohydroxamidoxime), a recently synthesized inhibitor of ribonucleotide reductase (RR), was shown to exert anti-proliferative activities in HL-60 and K562 human leukemia cell lines and to prolong the life span of mice inoculated with L1210 mouse leukemia cells. Here we test whether trimidox...

journal_title：Life sciences

authors： Rosenberger G,Fuhrmann G,Grusch M,Fassl S,Elford HL,Smid K,Peters GJ,Szekeres T,Krupitza G

更新日期：2000-11-17 00:00:00