Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.

abstract：:Rats implanted subcutaneously with an empty osmotic pump connected by a polyethylene catheter to a jugular vein for 5 to 10 days evinced a decreased splenocyte responsiveness to blastogenic stimulation in vitro to bacterial lipopolysaccharide, a known B cell stimulator, as well as to the plant mitogens pokeweed mitoge...

journal_title：Life sciences

authors： Pross S,Newton C,Widen R,Klein TW,Friedman H,Spitzer JA

更新日期：1992-01-01 00:00:00

abstract：:To determine how protein kinase C (PKC) activity influences properties of the tetrodotoxin-resistant sodium current (TTX-R I(Na)) in neonatal rat nodose ganglion (NG) neurons, we assessed the effects of phorbol,-12-myristate,13-acetate (PMA), one of the PKC activators, and staurosporine, one of the PKC inhibitors, on ...

journal_title：Life sciences

authors： Ikeda M,Yoshida S,Kadoi J,Nakano Y,Mastumoto S

更新日期：2005-11-19 00:00:00

abstract：:The potencies of several opioid agonists are reduced in diabetic animals and in animals made hyperglycemic via injections of glucose. In this report we examined the effects of streptozotocin-induced diabetes on the feeding responses to centrally administered opioid agonists with differing receptor selectivities. The s...

journal_title：Life sciences

authors： Gosnell BA,Grace M,Billington CJ,Levine AS

更新日期：1989-01-01 00:00:00

abstract：:Cardiovascular risk factors associated with hypertension include alterations in arterial compliance and an increased tendency to thrombosis. In this study we examined the relationship between arterial compliance and endothelial derived components of the hemostatic system: von Willebrand factor (vWF) and tissue plasmin...

journal_title：Life sciences

authors： Smith DH,Vaziri ND,Winer RL,Neutel JM,Graettinger WF,Gonzales E,Weber MA

更新日期：1993-01-01 00:00:00

abstract：:The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic re...

journal_title：Life sciences

authors： Yano T,Nakagawa A,Tsuji M,Noda K

更新日期：1986-09-22 00:00:00

abstract：:Decidualization of endometrial tissues, which is essential for implantation and the continuation of pregnancy, is induced by pituitary hormones that are regulated by gonadotropin releasing hormone (GnRH). Our objective was to determine the role of a direct action of GnRH on endometrial tissues by comparing the charact...

journal_title：Life sciences

authors： Takeuchi S,Futamura N,Minoura H,Toyoda N

更新日期：1998-01-01 00:00:00

abstract：:We reported recently that ventromedial hypothalamic (VMH) lesions increased the synthesis of DNA in the gastrointestinal tract of rats by the firing of vagus nerve activity, mainly via cholinergic receptor mechanisms. In the present study, we examined whether the mitotic response is due to proliferation of a cell popu...

journal_title：Life sciences

authors： Kiba T,Tanaka K,Hoshino M,Numata K,Okano K,Inoue S

更新日期：1995-01-01 00:00:00

abstract：:This study was undertaken to compare the activity of muscarinic and beta adrenergic receptors in bovine peripheral lung to the corresponding receptor activity in tracheal smooth muscle. We used [3H] quinuclidinyl benzilate (QNB) and [3H]dihydroalprenolol (DHA) to measure muscarinic and beta receptor activity, respecti...

journal_title：Life sciences

authors： Cheng JB,Townley RG

更新日期：1982-06-14 00:00:00

abstract：:The accumulation of inositol monophosphate (IP1) was measured after stimulation of 5-hydroxytryptamine2 (5-HT2) receptors on platelets from alcoholics and healthy controls. In controls, 5-HT induced a dose-dependent response with an EC50 = 2 x 10(-6) M and a maximal response at 10(-5) M. Ritanserin, a selective 5-HT2 ...

journal_title：Life sciences

authors： Simonsson P,Alling C

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...

journal_title：Life sciences

authors： Li F,Long TY,Bi SS,Sheikh SA,Zhang CL

更新日期：2020-09-15 00:00:00

abstract：AIM:Irisin, the adipomyokine, released mainly by exercised muscles, participate in the browning of adipose tissue and contribute to the restriction of insulin resistance and diabetes mellitus 2 development. Because of the limited reports describing the effect of irisin on inflammation and immunocompetent cells activati...

journal_title：Life sciences

authors： Mazur-Bialy AI

更新日期：2017-05-01 00:00:00

abstract：:The pure estrogen antagonist ICI-182780, at doses above 50 micrograms/kg, effectively inhibited the initiation of embryo implantation in rats when administered on day 4 of pregnancy (day 1 = sperm positive). The same dose inhibited the implantation initiating effect of intravenous 25 ng of estradiol-17 beta in delayed...

journal_title：Life sciences

authors： Chatterjee S,Johnson DC

更新日期：1993-01-01 00:00:00

abstract：:Pulmonary fibrosis (PF), which is characterized by excessive matrix formation, may ultimately lead to irreversible lung damage and thus death. Fibroblast activation has been regarded as a central event during PF pathogenesis. In our previous study, we confirmed that the miR-627/high-mobility group box protein 1 (HMGB1...

journal_title：Life sciences

authors： Li J,Zhang X,Wang T,Li J,Su Q,Zhong C,Chen Z,Liang Y

更新日期：2021-01-20 00:00:00

abstract：:We investigated the involvement of alpha 1-adrenoceptor subtypes in the positive chronotropic response to norepinephrine (NE) in neonatal rat cardiac myocytes at day 3 of culture. The cardiac myocytes at day 3 of culture exhibited a dose-dependent positive chronotropic response to NE in the presence of propranolol, a ...

journal_title：Life sciences

authors： Kimura H,Kawana S,Kanaya N,Sakano S,Miyamoto A,Ohshika H

更新日期：1994-01-01 00:00:00

abstract：AIMS:The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats. MAIN METHODS:Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypob...

journal_title：Life sciences

authors： Cui F,Guan Y,Guo J,Tian YM,Hu HF,Zhang XJ,Zhang Y

更新日期：2018-07-15 00:00:00

abstract：:This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observe...

journal_title：Life sciences

authors： Brown-Croyts LM,Caton PW,Radecki DT,McPherson SL

更新日期：2000-06-30 00:00:00

abstract：:Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocy...

journal_title：Life sciences

authors： Albert SG

更新日期：1982-07-19 00:00:00

abstract：AIMS:Interleukin-1β (IL-1β) is a cytokine that is known to activate the stress axis and suppress the reproductive axis. Different brain areas are involved in the regulation of these two axes. However, they are both under the stimulatory control of the catecholamine, norepinephrine (NE). Here, we hypothesized that IL-1β...

journal_title：Life sciences

authors： Sirivelu MP,MohanKumar PS,MohanKumar SM

更新日期：2012-10-29 00:00:00

abstract：AIMS:Toll-like receptor (TLR)9 ligand CpG-oligodeoxynucleotide (CpG-ODN) exerts preconditioning in myocardial ischemia/reperfusion. We hypothesized a postconditioning effect of CpG-ODN in a murine closed-chest model of myocardial infarction. MATERIALS AND METHODS:C57BL/6 (12 weeks, male, WT) mice were instrumented at ...

journal_title：Life sciences

authors： Kim SC,Wu S,Fang X,Neumann J,Eichhorn L,Schleifer G,Boehm O,Meyer R,Frede S,Hoeft A,Baumgarten G,Knuefermann P

更新日期：2014-12-05 00:00:00

abstract：:Effects of scratching behavior on dermatitis, transepidermal water loss (TEWL) and serum IgE concentrations were examined in NC/Nga (NC) mice with toenails (WIT) and without toenails (WOT). The first study was a preventive treatment done to cut off hind toenails before dermatitis induction and the second study was a t...

journal_title：Life sciences

authors： Hashimoto Y,Arai I,Nakanishi Y,Sakurai T,Nakamura A,Nakaike S

更新日期：2004-12-31 00:00:00

abstract：:DHEA improves insulin sensitivity and has anti-obesity effect in animal models and men. However, the molecular mechanisms by which DHEA improves insulin action have not been clearly understood. In the present study, we examined the protein levels and phosphorylation state of insulin receptor (IR), IRS-1 and IRS-2, the...

journal_title：Life sciences

authors： Campbell CS,Caperuto LC,Hirata AE,Araujo EP,Velloso LA,Saad MJ,Carvalho CR

更新日期：2004-11-19 00:00:00

abstract：:Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Japan and Taiwan. Studies have shown the hypoglycemic effects of Chlorella in alloxan-induced and Streptozocin (STZ)-induced diabetic animals. However, the mechanisms by which Chlorella treatment affects blood glucose homeostasis have ...

journal_title：Life sciences

authors： Cherng JY,Shih MF

更新日期：2006-02-09 00:00:00

abstract：:Alterations in the cyclic AMP-dependent protein kinase activity ratio in response to putative neurotransmitters and other cyclic AMP-elevating agents in intact cerebral cortical slices and Krebs-Ringer particulate preparations from cerebral cortex were examined. Both norepinephrine (30 microM) and forskolin (20 microM...

journal_title：Life sciences

authors： Davis CW

更新日期：1985-07-08 00:00:00

abstract：:Three continuous cell lines isolated from small cell carcinoma of the lung (SCCL) have been examined for their ability to take up and metabolize the biogenic amine precursors, L-DOPA and 5-hydroxytryptophane (5-HTP). In two of the three lines formaldehyde-induced fluorescence (FIF) and mass-spectrographic analysis ind...

journal_title：Life sciences

authors： Pettengill OS,Bacopoulos NG,Sorenson GD

更新日期：1982-04-19 00:00:00

abstract：AIMS:Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sepsis. Endothelin (ET)-1, a potent vasoconstrictor, is implicated in the ...

journal_title：Life sciences

authors： Jesmin S,Shimojo N,Yamaguchi N,Mowa CN,Oki M,Zaedi S,Sultana SN,Rahman A,Islam M,Sawamura A,Gando S,Kawano S,Miyauchi T,Mizutani T

更新日期：2014-05-02 00:00:00

abstract：:Progressive lysis of bone in loose total hip replacement has been ascribed to the capacity of the synovial-like membrane present at the bone interface to produce prostaglandin E2 and cytokines such as tumor necrosis factor (TNF alpha). Phospholipase A2 (PLA2) produces rate limiting precursor i.e. arachidonic acid in t...

journal_title：Life sciences

authors： Cirino G,Misasi M,Loffredo A,Sorrentino L,Caivano P,Bucci M,Cicala C

更新日期：1996-01-01 00:00:00

abstract：:Inflammation, inflammatory mediators, cyclooxygenase (COX)-2, and inducible nitric oxide (iNOS) are all influenced by age-related oxidative status. To investigate the effect of dietary fish oil (FO) and calorie restriction (CR) on oxidative stress-related inflammatory status with age, (NZB/NZW) F1 (B/W) mice were fed ...

journal_title：Life sciences

authors： Kim YJ,Kim HJ,No JK,Chung HY,Fernandes G

更新日期：2006-04-18 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

journal_title：Life sciences

authors： Privratsky JR,Newman DK,Newman PJ

更新日期：2010-07-17 00:00:00

abstract：:The use of neuroleptic drugs to treat schizophrenia is almost invariably associated with extrapyramidal movement disorders. One of these disorders, tardive dyskinesia (TD), can persist long after neuroleptic withdrawal suggesting that permanent neurological damage is produced. However, there appears to be no convincin...

journal_title：Life sciences

authors： Eyles DW,Pond SM,Van der Schyf CJ,Halliday GM

更新日期：2000-02-25 00:00:00

abstract：:Following a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contents, Ki) for four ...

journal_title：Life sciences

authors： Rehavi M,Weiss H,Nissenkorn I,Rubinstein R,Cohen S

更新日期：1987-05-04 00:00:00