Abstract:
:Rats implanted subcutaneously with an empty osmotic pump connected by a polyethylene catheter to a jugular vein for 5 to 10 days evinced a decreased splenocyte responsiveness to blastogenic stimulation in vitro to bacterial lipopolysaccharide, a known B cell stimulator, as well as to the plant mitogens pokeweed mitogen (PWM), a known stimulator of T and B cells, and Concanavilan A, a known T cell stimulator. The surface of the implanted pumps became infiltrated with lymphoid cells, especially macrophages. Suppression of blastogenic responsiveness after implantation for 10 days with an empty pump or even a pump dispensing pyrogen free saline only in a continuous manner was nearly as marked as that which occurred at 2-5 days after continuous infusion with endotoxin. These depressed blastogenic responses, although less, were also evident when rats were implanted with a catheter into a jugular vein connected by means of a swivel to either an empty pump or one dispensing pyrogen free saline. Suppression of blastogenic responsiveness was not related to alteration in serum complement or corticosteroid levels. Since administration of immunomodulatory substances systemically to individuals often involves implantation of an osmotic pump, investigation into the mechanisms of lymphoid cell suppression associated with an implanted pump itself has potential significance.
journal_name
Life Scijournal_title
Life sciencesauthors
Pross S,Newton C,Widen R,Klein TW,Friedman H,Spitzer JAdoi
10.1016/0024-3205(92)90291-vsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
99-108issue
2eissn
0024-3205issn
1879-0631pii
0024-3205(92)90291-Vjournal_volume
50pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:AIMS:To examine the effects of metoprolol on expression of myocardial inflammatory cytokines and myocardial function in rats following coronary microembolization (CME). MAIN METHODS:Male rats were randomly assigned to receive either sham-operation (control group), CME plus saline (CME group), or CME plus metoprolol (m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.03.012
更新日期:2011-06-06 00:00:00
abstract::The important immunological activities of Thymosin alpha 1 (T alpha 1), a peptide derived from the thymus, led to its use in combination therapies in cancer patients. Prothymosin alpha (ProT alpha) is a highly acidic polypeptide, first isolated as the putative precursor of T alpha 1. However ProT alpha is now known to...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00157-9
更新日期:1996-01-01 00:00:00
abstract::A new indorocarbazole antibiotic SF2370 has been found in the culture broth of Actinomadura sp.; it has also been found to have the activities of antihypertension and diuresis. Derivatives of SF2370, NA0344, NA0345 and NA0346, when injected (0.1-1 mg/kg i.v.) significantly lowered the blood pressure of anesthetized no...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90392-5
更新日期:1989-01-01 00:00:00
abstract::The effect of the diterpene forskolin on vascular permeability alone and in combination with bradykinin, prostaglandin E1, adenosine or histamine has been investigated in rats. Vascular permeability in rat skin was measured using [125I]-labelled bovine serum albumin ([125I]BSA) as a tracer. In addition, the effect of ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90712-9
更新日期:1983-07-04 00:00:00
abstract::Although renin-angiotensin system (RAS) imbalance is manifested in cardiomyopathies with different etiologies, the impact of RAS effectors on Chagas cardiomyopathy and skeletal myositis is poorly understood. Given that diminazene aceturate (DMZ) shares trypanocidal, angiotensin-converting enzyme 2 (ACE2) and angiotens...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118067
更新日期:2020-09-15 00:00:00
abstract::Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.01.007
更新日期:2008-03-26 00:00:00
abstract::A single intravenous injection of alloxan in mice induced hyperglycemia in a dose dependent fashion. This diabetogenic action of alloxan was prevented by a single intraperitoneal injection of the alpha 2-adrenergic agonists, i.e. oxymetazoline, clonidine or epinephrine 40 min prior to the injection of alloxan. The alp...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90301-6
更新日期:1983-02-14 00:00:00
abstract::Since somatostatin inhibits basal and stimulated gastric acid secretion and gastrin release, it is conceivable that decreased gastric somatostatin concentration may be one of the factors responsible for gastric hypersecretion found in patients who have undergone long-term pylorotomy for hypertrophic pyloric stenosis. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00734-9
更新日期:1994-01-01 00:00:00
abstract::A simple and sensitive method using high performance liquid chromatography with fluorometric detection has been developed for the identification and quantitation of the endogeneous tryptamine metabolites, indoleacetic acid (IAA) and tryptophol (TOL) in the normal mouse brain. The limits of sensitivity are 5pg for both...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90744-0
更新日期:1983-11-14 00:00:00
abstract:AIMS:This study sought to determine the impact of in vitro exposure to the herbicide atrazine (ATR) or its major mammalian metabolite diaminochlorotriazine (DACT) on dopaminergic cell differentiation. MAIN METHODS:N27 dopaminergic cells were exposed for 24 or 48 h to ATR or DACT (12-300 μM) and their effects on cell v...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.10.027
更新日期:2013-01-17 00:00:00
abstract::Propentofylline (PPF) is a xanthine derivative with pharmacological effects that are distinct from those of classic methylxanthines. It depresses the activation of microglial cells and astrocytes, which is associated with neuronal damage during neural inflammation and hypoxia. Our previous studies showed that PPF impr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.02.028
更新日期:2016-03-01 00:00:00
abstract::P75(NTR) is a common neurotrophin receptor which binds all neurotrophins with similar affinities and has been shown to be capable of mediating programmed cell death. In this study, we investigated effects of the antipsychotic drugs (APDs) haloperidol, clozapine, quetiapine, and risperidone on p75(NTR) mRNA levels in P...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.01.039
更新日期:2006-07-04 00:00:00
abstract::Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptor in the rabbit mesenteric blood vessels. It had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro study...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90502-9
更新日期:1987-06-15 00:00:00
abstract:AIMS:We investigated the pathophysiological changes in mice lacking α2-antiplasmin (α2-AP) and plasminogen activator inhibitor type-1 (PAI-1) genes, and elucidated the involvement of these inhibitors for fibrinolysis in immune response. MAIN METHODS:The pathophysiological changes induced by a lack of both α2-AP and PA...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.05.023
更新日期:2013-07-30 00:00:00
abstract::The effects of nicotine on normal physiological function are of increasing concern. Preliminary to studies on the effects of prenatal exposure to nicotine, we examined methods of administering nicotine to rats. Drinking water containing nicotine was not palatable to rats and was an unsatisfactory method in our hands, ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90020-8
更新日期:1987-04-27 00:00:00
abstract::Levels of delta-sleep-inducing peptide-like immunoreactivity (DSIP-LI) in rat plasma were measured by radioimmunoassay and found to exhibit a circadian rhythm that parallelled the normal rhythm for corticosterone. The maximal plasma levels of both substances were observed to occur at about 1700h. The lowest concentrat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90566-6
更新日期:1984-11-12 00:00:00
abstract::Ether à go-go (EAG) potassium channels possess oncogenic properties and have gained great interest as research tools for cancer detection and therapy. Besides, EAG electrophysiological properties are regulated through the cell cycle and determined by cytoskeletal interactions. Thus, because of the pivotal role of extr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.05.014
更新日期:2007-06-27 00:00:00
abstract::In recent years several synthetic peptides have been shown to be active in inducing GH secretion in different mammalian species. Among them GHRP-6, GHRP-1 and GHRP-2 have demonstrated high effectiveness and high selectivity in stimulating GH release. In the present paper we report studies on the GH-secreting propertie...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00510-9
更新日期:1994-01-01 00:00:00
abstract::To analyze the metabolisms of platelet-activating factor (PAF) and Thromboxane A2 (TxA2) when platelets and mesangial cells (MC) interact, immunoreactive thromboxane B2 (TxB2) and PAF were measured after incubation of cultured rat MC with platelets (P) and with platelet supernatants (PS). In both cases, TxB2 significa...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)02030-m
更新日期:1995-01-01 00:00:00
abstract:AIMS:This study aims to investigate the value of the expression of miR-208, miR-494, miR-499 and miR-1303 in the early diagnosis of acute myocardial infarction (AMI). MAIN METHODS:Patients were divided into two groups: AMI group (n = 41), and Stable angina pectoris (SAP) group (n = 32). Peripheral venous blood was sam...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116547
更新日期:2019-09-01 00:00:00
abstract::The influence of different neuropeptides related to pro-opiomelanocortin were tested on acquisition of heroin self-administration in rats. The animals were allowed to self-administer heroin intravenously on a continuous reinforcement schedule during 6 h daily sessions on 5 consecutive days. Treatment was performed sub...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90261-8
更新日期:1983-12-05 00:00:00
abstract::Active uptake of serotonin (5-hydroxytryptamine, 5-HT) into blood platelets from healthy donors exhibited a lower Vmax value in buffer media than in plasma. Also in plasma ultrafiltrate Vmax was reduced, but it returned to the level measured in plasma upon addition of human serum albumin (40 milligrams) containing fat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90361-5
更新日期:1989-01-01 00:00:00
abstract::Catecholamine uptake into PC12 cells, in the presence and absence of ATP, was measured in a bicarbonate-buffered Krebs Ringer. ATP enhanced significantly the uptake in a dose-dependent manner with maximal uptake at 1-3 mM. ATP increased the Vmax of uptake by 3-5 fold for both dopamine and norepinephrine, without a sig...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(95)00128-s
更新日期:1995-01-01 00:00:00
abstract::We explored the mechanism whereby maltitol causes an increase of calcium absorption in the lower small intestine using everted ileal segments of rats. Under the calcium concentrations tested (1-20mM), which enabled us to assess the diffusional calcium transfer, maltitol in the mucosal-side medium (100mM) caused a 155%...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00430-4
更新日期:1996-01-01 00:00:00
abstract::Kainic acid (KA) is a potent convulsant which, when administered subcutaneously, induces sustained limbic seizures and a pattern of limbic brain damage that is thought to be seizure-mediated. Diazepam suppresses and morphine enhances both the seizures and brain damage induced by KA. Here we show that morphine enhancem...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(82)90582-3
更新日期:1982-07-19 00:00:00
abstract::The objective of this study was to understand the mechanism of action of nitric oxide (NO) in the heart by determining whether nitric oxide (NO) released from sodium nitroprusside (SNP) induces p38 mitogen activated protein kinase (p38 MAPK) phosphorylation and whether this is mediated through a cyclic GMP (cGMP)/prot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.06.022
更新日期:2007-08-02 00:00:00
abstract::Chronopharmacokinetics deals with the study of the temporal changes in absorption, distribution, metabolism and elimination and thus takes into account the influence of time of administration on these different steps. In the last decade, numerous studies have been devoted to chronokinetics: recent advances will be rev...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(93)90001-j
更新日期:1993-01-01 00:00:00
abstract::Male, adult mice of the Binghamton heterogeneous stock received one of two doses of ethanol (1.0 g/kg or 2.0 g/kg in saline) alone or in combination with the calcium (Ca2+) slow channel blocker, verapamil (5.45 mg/kg in 25% v/v ethanol in saline). Hypothermic responses and motor incoordination were assessed in terms o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90357-7
更新日期:1986-12-01 00:00:00
abstract::The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different ag...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90416-8
更新日期:1984-08-20 00:00:00
abstract::Cultured adult skin fibroblasts were studied for binding and functional evidence of muscarinic receptors in order to assess their utility as a model of cholinergic function in affective illness. Saturable, specific, high affinity binding could be demonstrated in intact cells from some cell lines with [3H]-NMS, but not...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90473-x
更新日期:1986-04-14 00:00:00