Abstract:
:Radio-binding assay, bioassay and HPLC detection were used to observe the antagonistic effects of dextrorphan on PCP's actions. Dextrorphan displayed high affinity to PCP receptor in the rabbit mesenteric blood vessels. It had weak PCP-like bioactivity, but could antagonize PCP's action dose-dependently in vitro study with the rabbit ear artery preparation and shifted the dose-response curve of PCP to the right. After PCP administration, the content of norepinephrine in the vascular bath medium was increased, which was reversed by dextrorphan. Thus suggests that dextrorphan is an antagonist with very mild agonistic action for PCP receptors.
journal_name
Life Scijournal_title
Life sciencesauthors
Sun FY,Zhu H,Zhang LM,Xu XR,Zhang AZdoi
10.1016/0024-3205(87)90502-9subject
Has Abstractpub_date
1987-06-15 00:00:00pages
2303-7issue
24eissn
0024-3205issn
1879-0631pii
0024-3205(87)90502-9journal_volume
40pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:AIMS:Mild traumatic brain injury (mTBI) is an important risk factor for cognitive impairment. Despite intense efforts to develop efficient treatments, the current therapies are not often effective and far from satisfactory. Silymarin has been suggested as a therapeutic agent in the treatment of traumatic brain injury. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118049
更新日期:2020-09-15 00:00:00
abstract::Accumulation of excess fluoride in the environment poses serious health risks to plants, animals, and humans. This endangers human health, affects organism growth and development, and negatively impacts the food chain, thereby affecting ecological balance. In recent years, numerous studies focused on the molecular mec...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.02.001
更新日期:2018-04-01 00:00:00
abstract:AIM:The aim of this study was to investigate the effect of protolichesterinic acid, a lichen secondary metabolite, on anti-proliferative activity of doxorubicin in three human cancer cell lines, HeLa, SH-SY5Y and K562 cells. MAIN METHODS:The data obtained from MTT assays, performed on cells treated with protolichester...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.06.023
更新日期:2016-08-01 00:00:00
abstract::Hemi-pituitary glands of ovariectomized rats were superfused for 4 h with either LHRH or the analog buserelin (HOE 766) at several concentrations, and thereafter with medium only for another 1.5 h. In a further experiment glands were exposed for 2.5 h to LHRH or buserelin at a single concentration (5 ng/ml) and subseq...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90524-2
更新日期:1986-08-04 00:00:00
abstract::The effects of (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin of tea, on Ca(2+)-permeable non-selective cation currents (NSCC) and voltage-operated Ca(2+) channels (VOCC) have been investigated in cultured rat aortic smooth muscle cells using the whole-cell voltage-clamp technique. Under the Cs(+)/t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.04.005
更新日期:2007-05-16 00:00:00
abstract:AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.06.020
更新日期:2017-08-15 00:00:00
abstract::As a decrease in cholinergic neurons has been observed in Alzheimer's Disease (AD), therapeutic approaches to AD include inhibition of acetylcholinesterase to increase acetylcholine levels. Evidence suggests that acetylcholine release in the CNS is modulated by negative feedback via presynaptic M2 receptors, blockade ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00598-0
更新日期:1999-01-01 00:00:00
abstract::The effect of various fractions of black tea [(Camellia Sinensis) (L) O. Kuntze (Theaceae)] on the function of mammalian skeletomotor apparatus was studied. The theaflavin fraction (Tfs) produced a concentration- dependent facilitation of indirect twitch responses of the rat phrenic nerve diaphragm preparation and the...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.12.018
更新日期:2005-05-13 00:00:00
abstract::Extracts of Hypericum perforatum (St. John's wort) have antidepressant properties in depressed patients and exert antidepressant-like action in laboratory animals. The phloroglucinol derivative hyperforin has become a topic of interest, as this Hypericum component is a potent inhibitor of monoamines reuptake. The mole...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00295-9
更新日期:2003-06-13 00:00:00
abstract::The effects of methyl vitamin B12 (5-6 mg/kg, p.o.) on the entrainment of circadian running wheel activity rhythm to a new lighting schedule were measured in rats. After the light-dark (LD) cycle was abruptly reversed, rats given vitamin B12 took less time to entrain their circadian locomotor activity rhythm to the ne...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90544-y
更新日期:1992-01-01 00:00:00
abstract::A set of synaptic proteins have been shown to be essential for the life cycle and exocytosis of synaptic vesicles at the nerve terminal. Recently, these proteins have also been identified in certain endocrine cells. Here we analysed the presence and location of some of these synaptic proteins in anterior pituitary cel...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)01156-9
更新日期:1998-01-01 00:00:00
abstract:AIMS:Induction of heme oxygenase-1 (HO-1) has been widely accepted to be neuro-protective. This study aimed to examine whether hemin (a HO-1 inducer) attenuates neuronal damage in the hippocampus induced by orthotopic autologous liver transplantation (OALT) in adult rats. MAIN METHODS:Rats were randomly allocated into...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.05.021
更新日期:2015-08-15 00:00:00
abstract::The α chain of interleukin 3 receptor (IL-3Rα or CD123), together with the common β (βc) subunit, forms a high-affinity IL-3R with biological function. In recent years, emerging research has found that CD123 is highly expressed on the surface of various cells (e.g., leukemia stem cells, LSCs), and it is associated wit...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2014.10.013
更新日期:2015-02-01 00:00:00
abstract::Differences in prevalence and mortality from coronary artery disease (CAD) were observed among the different Israeli ethnic groups. The incidence of CAD in Israel is highest among Ashkenazi Jews and is much lower among Yemenite Jews. In this present study, we selected 15 single nucleotide polymorphisms (SNPs) from 14 ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.02.012
更新日期:2004-07-09 00:00:00
abstract::Tobacco smoke (TS) is a potent source of oxidants and oxidative stress is an important mechanism by which TS exerts its toxicity in the lung. We have shown that TS induces heat shock (HS)/stress protein (HSP) synthesis in human monocytes. Pulmonary surfactant (PS) whose major physiological function is to confer mechan...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00542-6
更新日期:1999-01-01 00:00:00
abstract:AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118618
更新日期:2021-01-01 00:00:00
abstract::The biosynthesis of phospholipids during differentiation of normal and dystrophic muscle cells was studied using [32Pi] added to primary culture media. Labeled phosphatides were separated by two-dimensional thin-layer chromatography, exposing the plates to HCl vapors between solvents to cleave the alk-1-enyl bonds. Ph...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90006-8
更新日期:1986-01-13 00:00:00
abstract::Arsenic has been proposed as a chemotherapeutic agent for leukemia and other solid tumors. However, its environmental exposure has been linked epidemiologically with an elevated carcinoma risk (i.e. skin, bladder and lung), with cellular oxidative stress being implicated in both induced-arsenic toxicity and carcinogen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.09.008
更新日期:2007-10-13 00:00:00
abstract:AIMS:Insulin receptor signaling in osteoblasts has been well established, but the effects of insulin on osteoclast proliferation are poorly explored. The objective of this study was to investigate the roles and the mechanisms of insulin on osteoclast proliferation. MAIN METHODS:After insulin treatment to primary osteo...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.07.006
更新日期:2014-10-02 00:00:00
abstract::Atherosclerosis (AS) is a chronic inflammatory disease that results from Oxidized low-density lipoprotein (Ox-LDL) induced endothelial dysfunction. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is closely related to the development of epithelial cells, but the role of CPEB1 in AS remains unknown. The R...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116874
更新日期:2019-12-15 00:00:00
abstract::We had previously hypothesized that linoleic acid (LA) was essential for development of alcoholic induced liver injury in our rat model. Male Wistar rats were fed a nutritionally adequate diet (25% calories as fat) with ethanol (8-17 g/kg/day). The source of fat was tallow (0.7% LA), lard (2.5% LA) or tallow supplemen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90599-7
更新日期:1989-01-01 00:00:00
abstract:AIMS:Uric acid nephropathy (UAN) is due to excessive uric acid, which leads to hyperuricemia and kidney damage via the deposition of urate microcrystals in the kidneys. Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from the traditional Chinese herb P. scandens (LOUR.) MERRILL (Rubi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.08.013
更新日期:2012-10-05 00:00:00
abstract::The distribution of thiamine-immunoreactive structures was studied in the brain of the monkey using an indirect immunoperoxidase technique. Fibers containing thiamine, but no thiamine-immunoreactive cell bodies, were found. The highest density of fibers containing thiamine was observed in the pulvinar nucleus and in t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.03.017
更新日期:2006-08-15 00:00:00
abstract::Gastrin is mitogenic for several colon cancers and is postulated as an autocrine growth factor for colon cancer cells. In the present study we report the development of a simple competitive polymerase chain reaction (PCR) method for measuring relative abundance of gastrin gene expression in colon cancer cells. Primers...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00550-8
更新日期:1994-01-01 00:00:00
abstract::We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00978-4
更新日期:2000-12-29 00:00:00
abstract::The present study shows that morphine reduces the pulmonary inflammatory response to intranasal influenza virus infection in rats. Rats were infected with rat-adapted influenza virus (RAIV), which is a unique infectious agent because normal rats develop an acute pulmonary inflammatory response to RAIV and rapidly clea...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00348-3
更新日期:1999-01-01 00:00:00
abstract::Hydroxyethyl starch (HES) found in rat serum and spleen after single and daily administrations of 0.9 g/kg for 1 week was characterized by gas-liquid chromatography. There was very little difference in the degree of substitution (D.S.) and molar substitution (M.S.) of HES in serum samples obtained at 1 hour and 57 day...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90737-3
更新日期:1983-11-14 00:00:00
abstract::A variety of milk proteins including lactoferrin, angiogenin-1, alpha-lactalbumin, beta-lactoglobulin, lactoperoxidase, casein and the novel whey proteins lactogenin and glycolactin were tested for inhibitory activity toward human immunodeficiency virus-1 reverse transcriptase (HIV-1 RT), alpha-glucosidase, beta-gluco...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00853-5
更新日期:2000-10-20 00:00:00
abstract::This study examined the effects of chronic treatment of a new phosphodiesterase type 5 inhibitor, DA-8159, on endothelial dysfunction in stroke-prone spontaneously hypertensive rats (SHR-SP). Six-week-old male SHR-SP were divided into 4 groups; vehicle control, DA-8159 1, 3, and 10 mg/kg/day. During a 32-week experime...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.06.042
更新日期:2006-02-09 00:00:00
abstract::Puromycin is an experimental anti-tumor antibiotic acting through inhibition of protein synthesis. Because of its untoward side effects (as inner ear and renal lesions) the antibiotic was not approved for clinical trials. The mechanism underlying the organ specificity of the side effect is not understood. In view of t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.10.070
更新日期:2005-06-17 00:00:00