Maltitol increases transepithelial diffusional transfer of calcium in rat ileum.

abstract：:The Sertoli cells play an essential role in the maintenance and control of spermatogenesis. The ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) and 5'-nucleotidase activities can modulate the extracellular adenine nucleotide levels, controlling nucleotide-mediated signaling events in Sertoli cells. Since t...

journal_title：Life sciences

authors： Zamoner A,Bruno AN,Casali EA,Corbelini PF,Diniz GP,Barreto-Chaves ML,Silva FR,Sarkis JJ,Pessoa-Pureur R

更新日期：2006-12-03 00:00:00

abstract：:Recent head-twitch response (HTR) studies in mice have indicated that withdrawal from chronic cocaine exposure produces deficits in CNS conversion of L-tryptophan to 5-HT. In the present study, the ability of 5-HT releaser, d-fenfluramine, was utilized to induce the HTR in mice following abstinence from chronic cocain...

journal_title：Life sciences

authors： Darmani NA

更新日期：1997-01-01 00:00:00

abstract：:The in vivo effect of trazodone on the density of [(3)H]5-HT binding sites and 5-HT(1A) receptors and adenylyl cyclase (AC) response was studied in regions of rat brain. The chronic administration of trazodone (10 mg/Kg body wt, 40 days) resulted in a significant downregulation of [(3)H]5-HT binding sites and 5-HT(1A)...

journal_title：Life sciences

authors： Subhash MN,Srinivas BN,Vinod KY

更新日期：2002-08-16 00:00:00

abstract：:To study the source of immunoreactive epidermal growth factor (ir-EGF) released by thrombin formation we removed 99.9% of the leukocytes normally present in platelet-rich plasma and induced coagulation with 30 mM of Ca2+. The absence of leukocytes did not reduce the amount of ir-EGF released; thus platelets are most l...

journal_title：Life sciences

authors： Kiuru J,Viinikka L,Myllylä G,Pesonen K,Perheentupa J

更新日期：1991-01-01 00:00:00

abstract：:The available preclinical literature on the antihyperlipidemic properties of beta-pyridylcarbinol is reviewed. Similarities between the pharmacological profiles for beta-pyridylcarbinol and nicotinic acid, and evidence for the metabolic conversion of beta-pyridylcarbinol to nicotinic acid are discussed. Several review...

journal_title：Life sciences

authors： Cohen M

更新日期：1985-11-25 00:00:00

abstract：AIMS:Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its GABAergic activity. Other aromatic alcohols have also been reported as able to protect neurons agains...

journal_title：Life sciences

authors： Delgado-Marín L,Sánchez-Borzone M,García DA

更新日期：2017-04-15 00:00:00

abstract：:Systemic administration of the selective D1 antagonist, SCH 23390, caused significant motor changes in healthy African green monkeys. The effects included the parkinsonian signs of motor freezing, incoordination, bradykinesia, poverty of movement, tremor and depressed blink rate. SCH 23390 administered to MPTP-treated...

journal_title：Life sciences

authors： Lawrence MS,Redmond DE Jr,Elsworth JD,Taylor JR,Roth RH

更新日期：1991-01-01 00:00:00

abstract：:Orthodontic tooth movement induced alveolar bone resorption and formation around the teeth applied mechanical force. Although mechanical force can promote bone formation, the molecular mechanism that underlies this phenomenon is not fully understood. The purposes of this study were to determine how mechanical stress a...

journal_title：Life sciences

authors： Mitsui N,Suzuki N,Maeno M,Yanagisawa M,Koyama Y,Otsuka K,Shimizu N

更新日期：2006-05-01 00:00:00

abstract：:In the present report, the putative effect of a single electrical stimulation (75, 150 or 300 microA) to the baso-lateral amygdala (BLA) nucleus was assessed in shock probe defensive burying behavior test (DB) and elevated plus maze (EPM). These models have been used for measuring anxiety levels and screening putative...

journal_title：Life sciences

authors： Saldívar-González JA,Posadas-Andrews A,Rodríguez R,Gómez C,Hernández-Manjarrez ME,Ortiz-León S,Martínez-Pineda A,Gómez-Laguna D,Salgado V,Manjarrez J,Alvarado R

更新日期：2003-01-03 00:00:00

abstract：:Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors, CysLT1 and CysLT2, have been cloned and functionally characterised using potent CysLT1 receptor antagonists and the dual CysLT1/CysLT2 receptor...

journal_title：Life sciences

authors： Bäck M

更新日期：2002-06-28 00:00:00

abstract：:In this study, we investigated the effects of zinc L-carnosine, an anti-ulcer drug, on acetic acid-induced colonic mucosal injury and the correlation of these effects with expression of 72-kDa heat shock proteins (HSP72) and nuclear factor kappa B (NF-kappaB) activation in rat colonic mucosa in vivo. After intrarectal...

journal_title：Life sciences

authors： Odashima M,Otaka M,Jin M,Wada I,Horikawa Y,Matsuhashi T,Ohba R,Hatakeyama N,Oyake J,Watanabe S

更新日期：2006-11-10 00:00:00

abstract：AIMS:Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have only examined the eff...

journal_title：Life sciences

authors： Lacy RT,Strickland JC,Brophy MK,Witte MA,Smith MA

更新日期：2014-10-02 00:00:00

abstract：:In rat prefrontal cortical slices, the excitatory amino acids N-methyl-D-aspartate (NMDA), ibotenate, L-aspartate, quisqualate, kainate and L-glutamate inhibit carbachol-induced phosphoinositide hydrolysis as measured by the accumulation of [3H]inositol-1-phosphate ([3H]IP1). NMDA dose-dependently inhibited the carbac...

journal_title：Life sciences

authors： Noble EP,Sincini E,Bergmann D,ten Bruggencate G

更新日期：1989-01-01 00:00:00

abstract：AIMS:MicroRNA-1 (miR-1) has been demonstrated as a tumor-suppressive miRNA, which shows a down-regulated pattern in several human malignancies including hepatocellular carcinoma (HCC). However, the pathophysiologic roles of miR-1 and their mechanisms in HCC tumorigenesis are still not totally elucidated. MAIN METHODS:...

journal_title：Life sciences

authors： Li D,Yang P,Li H,Cheng P,Zhang L,Wei D,Su X,Peng J,Gao H,Tan Y,Zhao Z,Li Y,Qi Z,Rui Y,Zhang T

更新日期：2012-10-05 00:00:00

abstract：:CYP2J2 is one of the cytochrome P450 epoxygenases involved in the metabolism of arachidonic acid. CYP2J2 has been identified in several tissues, especially cardiovascular tissues. CYP2J2 has cardiovascular effects, as epoxyeicosatrienoic acid, one of its metabolites, has anti-inflammatory and vasodilative activities. ...

journal_title：Life sciences

authors： Nakayama K,Nitto T,Inoue T,Node K

更新日期：2008-08-29 00:00:00

abstract：:An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...

journal_title：Life sciences

authors： Fregly MJ,Threatte RM

更新日期：1982-02-15 00:00:00

abstract：:It has been reported that naloxone, an opioid antagonist, has antiarrhythmic activity in vivo. In Langendorff perfused rat hearts, we found that ischemia-reperfusion-induced ventricular tachyarrhythmia reverted to normal sinus rhythm after the treatment with naloxone (3 approximately 10 microM). The method of voltage ...

journal_title：Life sciences

authors： Hung CF,Wu MH,Tsai CH,Chu SH,Chi JF,Su MJ

更新日期：1998-01-01 00:00:00

abstract：:The effect of dihydropyridine calcium channel antagonist isradipine (PN 200-110) on morphine reinforcement has been investigated using i.v. self-administration test in rats. Rats were given the opportunity to self-administer a solution of morphine (1 mg/ml, i.v.) in a 1 hr limited access paradigm (FR = 1). Within 5-7 ...

journal_title：Life sciences

authors： Kuzmin A,Martellotta MC,Fratta W,Gessa GL,Zvartau E

更新日期：1996-01-01 00:00:00

abstract：AIMS:Sepsis is a major cause of morbidity and mortality in the elderly population. In prior studies, we have shown that in vivo, the inflammatory response in aged animals is exaggerated as compared to young animals and that this response likely accounts for the increased morbidity and mortality. Part of this uncontroll...

journal_title：Life sciences

authors： Leong J,Zhou M,Jacob A,Wang P

更新日期：2010-05-08 00:00:00

abstract：:The present experiment was designed to determine whether scavenging capacity of serum, in addition to glucose level, influences hemoglobin and serum protein glycosylation in non-insulin dependent diabetic patients. For this purpose forty-seven patients homogeneous for age, disease duration, therapy and glyco-metabolic...

journal_title：Life sciences

authors： Testa R,Testa I,Manfrini S,Bonfigli AR,Piantanelli L,Marra M,Pieri C

更新日期：1996-01-01 00:00:00

abstract：:Different ligands of both the "peripheral" and the "central" benzodiazepine receptors were tested for their ability to induce human monocyte chemotaxis. Only the ligands interacting with the "peripheral receptor" (diazepam and Ro 5-4864) were active, and their action was blocked by the specific antagonist PK 11-195, b...

journal_title：Life sciences

authors： Sacerdote P,Locatelli LD,Panerai AE

更新日期：1993-01-01 00:00:00

abstract：:Studies were performed to compare in vitro and in vivo effects of morphine on the phagocytic function of murine peritoneal macrophages. Macrophage monolayers were incubated with Candida albicans for 30 min in the absence of autologous serum. Morphine added in vitro was found to decrease both the phagocytic activity (p...

journal_title：Life sciences

authors： Rojavin M,Szabo I,Bussiere JL,Rogers TJ,Adler MW,Eisenstein TK

更新日期：1993-01-01 00:00:00

abstract：:The reproductive system effects of cocaine were studied in male rats. The analysis included measurements of circulating levels of luteinizing hormone (LH) and testosterone (T) by radioimmunoassay (RIA). The weights of the testes and sex accessory organs were also assessed and compared with control animals. Dosage leve...

journal_title：Life sciences

authors： Berul CI,Harclerode JE

更新日期：1989-01-01 00:00:00

abstract：AIMS:The type 2 muscarinic receptor (M2R) differs from the other G-protein-coupled muscarinic receptor (type 4, or M4R) in tissue distribution and physiologic effects. We studied the impact of these receptors on sleep and arousal by using M2R and M4R knock-out (KO) mice. MAIN METHODS:M2R and M4R KO and genetically int...

journal_title：Life sciences

authors： Turner J,Hughes LF,Toth LA

更新日期：2010-01-30 00:00:00

abstract：:Effects of amphetamine on concentrations of dopamine, norepinephrine and serotonin in several monoamine-containing cell body and terminal regions were examined left and right separately in rats. Results suggest that amphetamine reduced the L-R asymmetry of most of these measures, and this effect is more significant in...

journal_title：Life sciences

authors： Lee EH,Huang SL,Chai CY

更新日期：1987-04-06 00:00:00

abstract：:To examine the direct effects of tributyltin acetate (TBTA) on osteoclasts and osteoblasts, teleost scale, which has both osteoclasts and osteoblasts and is similar to mammalian membrane bone, was used in the present study. The activities of tartrate-resistant acid phosphatase and alkaline-phosphatase, as respective i...

journal_title：Life sciences

authors： Suzuki N,Tabata MJ,Kambegawa A,Srivastav AK,Shimada A,Takeda H,Kobayashi M,Wada S,Katsumata T,Hattori A

更新日期：2006-04-18 00:00:00

abstract：:Using a laterality questionnaire, 138 normal healthy individuals were classified as right-sided and 25 as non-right sided. Interleukin-2 (IL-2) was generated from whole blood obtained from these subjects using mitogen (PHA) stimulation. IL-2 was quantitated in picograms/ml using an enzyme immunoassay (ELISA). Addition...

journal_title：Life sciences

authors： Chengappa KN,Ganguli R,Yang ZW,Schurin G,Cochran J,Brar JS,Rabin B

更新日期：1992-01-01 00:00:00

abstract：:This study examined the effects of chronic treatment of a new phosphodiesterase type 5 inhibitor, DA-8159, on endothelial dysfunction in stroke-prone spontaneously hypertensive rats (SHR-SP). Six-week-old male SHR-SP were divided into 4 groups; vehicle control, DA-8159 1, 3, and 10 mg/kg/day. During a 32-week experime...

journal_title：Life sciences

authors： Choi SM,Kim JE,Kang KK

更新日期：2006-02-09 00:00:00

abstract：:We have previously shown that transforming growth factor-beta1 (TGF-beta1) is involved in the fibroblast-induced organization and differentiation of transformed phenotypically crypt-like T84 intestinal epithelial cells into absorptive enterocyte-like cells, when cultured within a three-dimensional collagen gel. We hav...

journal_title：Life sciences

authors： Lindfors K,Halttunen T,Kainulainen H,Mäki M

更新日期：2001-08-10 00:00:00

abstract：AIMS:Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality worldwide. Decrease in NKG2D ligand levels and exhaustion of NK cells in HCC patients are major causes of immune escape, high recurrence, poor prognosis, and low overall survival. Enhancing the susceptibility of HCC to NK cells by upregulating N...

journal_title：Life sciences

authors： Bian J,He L,Wu Y,Liu W,Ma H,Sun M,Yu J,Yu Z,Wei M

更新日期：2020-04-01 00:00:00