当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation.

Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation.

Abstract：

:In this study, we investigated the effects of zinc L-carnosine, an anti-ulcer drug, on acetic acid-induced colonic mucosal injury and the correlation of these effects with expression of 72-kDa heat shock proteins (HSP72) and nuclear factor kappa B (NF-kappaB) activation in rat colonic mucosa in vivo. After intrarectal administration of zinc L-carnosine, the rats received intrarectal infusion of 5% acetic acid (1 ml). The colonic mucosal damage was evaluated by macroscopic assessments 24 h after the intrarectal infusion of acetic acid. Expression of HSP72 in rat colonic mucosa was evaluated by Western blot analysis before and after zinc L-carnosine administration. NF-kappaB activation was evaluated by electrophoretic mobility shift assays (EMSA). Zinc L-carnosine inhibited visible damage in rat colonic mucosa by acetic acid. Expression of HSP72 was significantly increased at 6 h after zinc L-carnosine administration. Furthermore, NF-kappaB activation in colonic mucosa was suppressed 6 h after zinc L-carnosine treatment. These results suggested that zinc L-carnosine protects the colonic mucosa against acetic acid by induction of HSP72 and suppression of NF-kappaB activation and zinc L-carnosine may be a novel therapeutic agent for the therapy of inflammatory bowel disease.

journal_name

Life Sci

journal_title

Life sciences

authors

Odashima M,Otaka M,Jin M,Wada I,Horikawa Y,Matsuhashi T,Ohba R,Hatakeyama N,Oyake J,Watanabe S

doi

10.1016/j.lfs.2006.07.032

subject

Has Abstract

pub_date

2006-11-10 00:00:00

pages

2245-50

issue

24

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(06)00575-3

journal_volume

79

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • The influence of reproductive hormones on ANF release by rat atria.

    abstract：:The effects of subcutaneous (sc) administration of estradiol (50 micrograms/100 microliters/day x 10 day) or testosterone (15 mg/100 microliters twice a week x 2 weeks) on ANF release were examined in isolated perfused rat atria. The concentration of ANF in the perfusate was measured by radioimmunoassay, under basal c...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(93)90245-x

    authors： Deng Y,Kaufman S

    更新日期：1993-01-01 00:00:00

  • Preconditioning modulates pulmonary endothelial dysfunction following ischemia-reperfusion injury in the rat lung: role of potassium channels.

    abstract：:Ischemic preconditioning (IP) may protect the lung from ischemia-reperfusion (I/R) injury following cardiopulmonary by-pass and lung or heart transplantation. The present study was undertaken to investigate the role of ATP-dependent potassium channels (K(ATP)) in IP in the isolated buffer-perfused rat lung (IBPR) unde...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.07.011

    authors： Kandilci HB,Gümüşel B,Demiryürek AT,Lippton H

    更新日期：2006-11-02 00:00:00

  • Autophagy alleviates mitochondrial DAMP-induced acute lung injury by inhibiting NLRP3 inflammasome.

    abstract：AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118833

    authors： Peng W,Peng F,Lou Y,Li Y,Zhao N,Shao Q,Chen J,Qian K,Zeng Z,Zhan Y,Jiang R,Liu F

    更新日期：2021-01-15 00:00:00

  • Trinucleotide repeats in neurologic diseases: an hypothesis concerning the pathogenesis of Huntington's disease, Kennedy's disease, and spinocerebellar ataxia type I.

    abstract：:Three neurodegenerative diseases, Huntington's disease (HD), Kennedy's disease (hereditary spinobulbar muscular atrophy, SBMA), and type 1 spinocerebellar ataxia (SCA-1) have been found to share a common genetic defect: an unstable region of repeated CAG trinucleotides which are thought to be translated into a polyglu...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/0024-3205(94)90012-4

    authors： Cha JH,Dure LS 4th

    更新日期：1994-01-01 00:00:00

  • Aerobic exercise training prevents kidney lipid deposition in mice fed a cafeteria diet.

    abstract：AIM:The objective of this study was to investigate the potential of aerobic exercise training (AET) to prevent kidney lipid accumulation and the contribution of renal metabolism to mediate this response. MAIN METHODS:Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n = 13), CHOW-TR (chow di...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2018.09.017

    authors： Muller CR,Américo ALV,Fiorino P,Evangelista FS

    更新日期：2018-10-15 00:00:00

  • Effect of low flow ischemia-reperfusion injury on liver function.

    abstract：:The release of liver enzymes is typically used to assess tissue damage following ischemia-reperfusion. The present study was designed to determine the impact of ischemia-reperfusion on liver function and compare these findings with enzyme release. Isolated, perfused rat livers were subjected to low flow ischemia follo...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00668-2

    authors： Bailey SM,Reinke LA

    更新日期：2000-01-01 00:00:00

  • Heterogeneity in the performance of outbred Sprague-Dawley rats in an elevated-plus maze test: a possible animal model for anxiety disorder.

    abstract：:A wide variation in the performance of inbred rats measured in the evaluated plus maze test suggests a possible genetic basis for anxiety response (AR). To gain further insight into the role of genetics in AR, we have characterized AR in male outbred S-D rats. Rats were placed in the black compartment (BC) facing the ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(96)00480-8

    authors： Prasad A,Henry M,Prasad C

    更新日期：1996-01-01 00:00:00

  • Degradation and covalent cross-linking of glutathione reductase by hemin.

    abstract：:Hemin (ferriprotoporphyrin IX-chloride) can mediate the covalent cross-linking and degradation of yeast glutathione reductase. This reaction requires both NADPH and oxygen suggesting the involvement of a reduced oxygen species in the cross-linking and degradation process. During the course of the reaction the enzymati...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(85)90312-1

    authors： Aft RL,Mueller GC

    更新日期：1985-06-03 00:00:00

  • Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice.

    abstract：AIMS:Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on u...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2012.09.023

    authors： Mutlu O,Gumuslu E,Ulak G,Celikyurt IK,Kokturk S,Kır HM,Akar F,Erden F

    更新日期：2012-12-17 00:00:00

  • Enzymatic activity and distribution of phospholipase A2 in human cartilage.

    abstract：:Extracellular phospholipase A2 (PLA2) with proinflammatory activity has recently been discovered in synovial fluids in inflammatory arthritides. In the search for the sources of synovial fluid PLA2, human synovium and articular cartilage were found to contain large quantities of the enzyme. In rheumatoid arthritis (RA...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90381-k

    authors： Pruzanski W,Bogoch E,Stefanski E,Wloch M,Vadas P

    更新日期：1991-01-01 00:00:00

  • Identification of prognostic markers for hepatocellular carcinoma based on miRNA expression profiles.

    abstract：AIMS:The aim of the study was to identify key miRNAs related to hepatocellular carcinoma (HCC) and then to explore their potential function and clinical significance. MATERIALS AND METHODS:The miRNA expression profiles of 387 HCC and 62 normal liver tissues were obtained from the Gene Expression Omnibus (GEO) and The ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116596

    authors： Wang X,Gao J,Zhou B,Xie J,Zhou G,Chen Y

    更新日期：2019-09-01 00:00:00

  • Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes.

    abstract：:Osteoarthritis (OA) is a complex joint disorder with a number of underlying physical, biochemical, biomechanical and genetic causes. Obesity is considered to be one of the major risk factors for the development and progression of OA. It actively contributes to the inflammatory status and to cartilage degradation in th...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2015.05.025

    authors： Scotece M,Mobasheri A

    更新日期：2015-11-01 00:00:00

  • A photoaffinity probe for the cardiac adenosine transporter.

    abstract：:We have developed and utilized a photoaffinity probe to identify the adenosine transporter in cardiac sarcolemmal (SL) vesicles. The probe is an azidosalicylate derivative of adenosine made by reacting adenosine with N-hydroxysuccinimidyl-4-azidosalicylic acid (NHS-ASA). Following synthesis and radiolabeling of the pr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(95)00268-b

    authors： Hale CC,Rovetto MJ

    更新日期：1995-01-01 00:00:00

  • Involvement of asymmetric dimethylarginine (ADMA) in glomerular capillary loss and sclerosis in a rat model of chronic kidney disease (CKD).

    abstract：AIMS:Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, has been reported to be a novel marker for the progression of chronic kidney disease (CKD). We have recently found that accumulation of ADMA could trigger peritubular capillary loss, thus contributing to tubulointerstitial ischemia ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2009.03.018

    authors： Ueda S,Yamagishi S,Matsumoto Y,Kaida Y,Fujimi-Hayashida A,Koike K,Tanaka H,Fukami K,Okuda S

    更新日期：2009-06-05 00:00:00

  • Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms.

    abstract：AIMS:The aim of this study was to comparatively investigate the potential gastroprotective effect and underlying mechanisms of coptisine free base (CFB, 8-hydroxy-7, 8-dihydrocoptisine), berberine and lansoprazole against indomethacin-induced gastric ulcer in rats. MATERIALS AND METHODS:CFB (10, 20 and 40mg/kg), berbe...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2017.12.004

    authors： Luo C,Chen H,Wang Y,Lin G,Li C,Tan L,Su Z,Lai X,Xie J,Zeng H

    更新日期：2018-01-15 00:00:00

  • Tissue transglutaminase was up-regulated by EGF-retinoid interplay in epithelial carcinoma cells.

    abstract：:Retinoids have been shown the most powerful inducers of transglutaminase activity, a well known marker of differentiation. In this work, we tested the effects of all-trans retinoic acid and EGF, used alone or in combination, on transglutaminase activity in a squamous, epithelial carcinoma cell line, HEp-2. We demonstr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.04.047

    authors： Caccamo D,Currò M,Cannavò G,Ientile R

    更新日期：2004-10-15 00:00:00

  • Characterization of specific binding of atrial natriuretic peptide (ANP) to rat PC12 phaeochromocytoma cells.

    abstract：:Specific binding sites for atrial natriuretic peptide have been identified in membrane of the phaeochromocytoma cell line PC12. Scatchard analysis of binding studies revealed a Kd of 794 pM and a density (Bmax) of 254 fmol/mg protein. Hormones unrelated to ANP such as angiotensin II, bradykinin and arginine-8-vasopres...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90577-2

    authors： Boumezrag A,Lyall F,Dow JA

    更新日期：1988-01-01 00:00:00

  • The response to analgesia testing is affected by gonadal steroids in the rat.

    abstract：:The effect of gonadal steroids on the response to analgesia testing was determined in castrated male and female rats and castrated male and female rats treated with testosterone propionate (TP) and estradiol benzoate (EB), respectively. The time to respond to a noxious somatic stimulus in the form of heat was assessed...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(89)90631-0

    authors： Forman LJ,Tingle V,Estilow S,Cater J

    更新日期：1989-01-01 00:00:00

  • Haloperidol and atypical antipsychotics share a same action of decreasing P75(NTR) mRNA levels in PC12 cells.

    abstract：:P75(NTR) is a common neurotrophin receptor which binds all neurotrophins with similar affinities and has been shown to be capable of mediating programmed cell death. In this study, we investigated effects of the antipsychotic drugs (APDs) haloperidol, clozapine, quetiapine, and risperidone on p75(NTR) mRNA levels in P...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2006.01.039

    authors： Bai O,Xu H,Li XM

    更新日期：2006-07-04 00:00:00

  • The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement.

    abstract：AIMS:Previous investigations demonstrated that tramadol, as a painkiller, similar to morphine induces tolerance and dependence. Furthermore, the cannabinoid receptor 1 (CB1R) located in the nucleus accumbens (NAc) plays a critical role in morphine-induced conditioning. Therefore, the main objective of this study was to...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118430

    authors： Sadeghi-Adl M,Sadat-Shirazi MS,Shahini F,Akbarabadi A,Khalifeh S,Borzabadi S,Nasehi M,Zarrindast MR

    更新日期：2020-11-01 00:00:00

  • Inhibition of intestinal glucose uptake by aporphines and secoaporphines.

    abstract：:The effects of aporphines and secoaporphines on glucose uptake by isolated intestinal brush-border membrane vesicles (BBMV) or basolateral membrane vesicles (BLMV) and glucose absorption during in situ intestinal perfusion were studied. Of the tested compounds, N-allylsecoboldine was the most potent glucose uptake inh...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.12.031

    authors： Lin CJ,Chen CH,Liu FW,Kang JJ,Chen CK,Lee SL,Lee SS

    更新日期：2006-06-06 00:00:00

  • Human urinary trypsin inhibitor inhibits the activation of pro-matrix metalloproteinases and proteoglycans release in rabbit articular cartilage.

    abstract：:Treatment of primary cultured chondrocytes from rabbit articular cartilage with interleukin-1 (IL-1)alpha and plasminogen induced the production of pro-matrix metalloproteinase 1 (proMMP-1/interstitial collagenase), proMMP-3 (stromelysin 1) and proMMP-9 (gelatinase B), as well as their active forms. Human urinary tryp...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(98)00261-6

    authors： Hashimoto K,Nagao Y,Kato K,Mori Y,Ito A

    更新日期：1998-01-01 00:00:00

  • Opiate binding sites spectrum on bovine adrenal medullas and six human pheochromocytomas.

    abstract：:Opiate binding sites have been characterized on membranes from bovine adrenal medullas and six human pheochromocytomas. In human tumors, large variations in site distribution were observed. Kappa and benzomorphan sites represented the majority of the sites detected. The heterogeneity of the opiate sites on these tissu...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(83)90501-5

    authors： Castanas E,Giraud P,Audigier Y,Drissi R,Boudouresque F,Conte-Devolx B,Oliver C

    更新日期：1983-01-01 00:00:00

  • Surgical and pharmacological reductions in sympathetic nerve activity increase the neuropeptide Y-immunoreactivity content of the rat iris but not the vas deferens.

    abstract：:Decentralization of the superior cervical ganglion (S.C.G.) of the rat elevated the neuropeptide-Y immunoreactivity (NPY-ir) content of the ganglion on day 1 (+43%) but not on day 3 post-surgery. The content of NPY-ir in the iris was increased by decentralization (+40%) 3 days post-surgery, and treatment with clonidin...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(88)90333-5

    authors： Maccarrone C,Jarrott B

    更新日期：1988-01-01 00:00:00

  • Targeted anti-inflammatory therapy is a new insight for reducing cardiovascular events: A review from physiology to the clinic.

    abstract：:Despite considerable progressions, cardiovascular disease (CVD) is still one of the major causes of mortality around the world, indicates an important and unmet clinical need. Recently, extensive studies have been performed on the role of inflammatory factors as either a major or surrogate factor in the pathophysiolog...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.117720

    authors： Soroureddin Z,Nouri-Vaskeh M,Maleki M,Baghbanzadeh A,Hajiasgharzadeh K,Taban Sadeghi M,Baradaran B

    更新日期：2020-07-15 00:00:00

  • Characterization of monoamine oxidase isoforms in human islets of Langerhans.

    abstract：:In this paper, we describe the characterization of the expression of monoamine oxidase (MAO) in whole pancreas and in isolated islets of Langerhans from human. Classical monamine oxidase activity assays reveal that both isoforms A & B are present in human pancreas. Two complementary approaches indicated that both MAO ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(99)00265-9

    authors： Pizzinat N,Chan SL,Remaury A,Morgan NG,Parini A

    更新日期：1999-01-01 00:00:00

  • Troglitazone acutely activates AMP-activated protein kinase and inhibits insulin secretion from beta cells.

    abstract：:Changes in AMP-activated protein kinase (AMPK) activity contribute to the regulation of insulin secretion. Troglitazone has been shown to lower serum insulin levels and protect beta cell function. The aim of the present study was to examine the effects of troglitazone on AMPK activity and insulin secretion in beta cel...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.04.034

    authors： Wang X,Zhou L,Shao L,Qian L,Fu X,Li G,Luo T,Gu Y,Li F,Li J,Zheng S,Luo M

    更新日期：2007-06-20 00:00:00

  • Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats.

    abstract：:Coxsackievirus B3 (CVB3) is a major pathogen for acute and chronic viral myocarditis. The aim of this study was to investigate the antiviral effects of sophoridine, an alkaloid extracted from Chinese medicinal herb, Sophora flavescens, against CVB3, and the underlying pharmacokinetics. First, we determined the antivir...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.09.034

    authors： Zhang Y,Zhu H,Ye G,Huang C,Yang Y,Chen R,Yu Y,Cui X

    更新日期：2006-03-20 00:00:00

  • Environmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptors.

    abstract：AIMS:Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and m...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2016.02.011

    authors： Gergerlioglu HS,Oz M,Demir EA,Nurullahoglu-Atalik KE,Yerlikaya FH

    更新日期：2016-03-01 00:00:00

  • Plasma levels and biochemical characterisation of circulating met-enkephalin in canine endotoxin shock.

    abstract：:Endogenous opioid peptides have been implicated in the pathophysiology of shock (1-5). In anaesthetised mongrel dogs, administration of E coli endotoxin caused a rise in plasma met-enkephalin-like immunoreactivity (MLI). Biochemical characterisation of MLI by gel filtration chromatography revealed various molecular fo...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90063-8

    authors： Evans SF,Medbak S,Hinds CJ,Tomlin SJ,Varley JG,Rees LH

    更新日期：1984-04-09 00:00:00