Abstract：
:The effects of subcutaneous (sc) administration of estradiol (50 micrograms/100 microliters/day x 10 day) or testosterone (15 mg/100 microliters twice a week x 2 weeks) on ANF release were examined in isolated perfused rat atria. The concentration of ANF in the perfusate was measured by radioimmunoassay, under basal conditions (atrial wall unstressed), and during atrial distention (intraluminal pressure raised to 4, 6, and 10 cm water). In both male and female control (vehicle-injected) groups, increased atrial pressure resulting in distention of the atrium caused a significant increase in ANF release. Estradiol increased basal secretion of ANF but did not influence stretch-induced stimulation of ANF secretion. By contrast, although testosterone did not affect basal secretion, it completely abolished the stretch-induced increase in ANF secretion. Neither estradiol nor testosterone affected atrial compliance.
journal_name
Life Scijournal_title
Life sciencesauthors
Deng Y,Kaufman Sdoi
10.1016/0024-3205(93)90245-xsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
689-96issue
9eissn
0024-3205issn
1879-0631pii
0024-3205(93)90245-Xjournal_volume
53pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Pitavastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor that is used for suppressing cholesterol biosynthesis. Previously, we have reported that pitavastatin induces the activation of endothelial nitric oxide synthase (eNOS) and increases nitric oxide (NO) production in vascular endothelial cells (...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.12.003
更新日期：2005-03-25 00:00:00
abstract：:The sodium-ion coupled transporters for 5-hydroxytryptamine (5HT), noradrenaline and dopamine function to reduce extracellular levels of biogenic amines. Over the past fifteen years selective inhibitors of these transport systems have been developed including fluoxetine, citalopram, paroxetine, litoxetine (for 5HT), n...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(92)90236-i
更新日期：1992-01-01 00:00:00
abstract：:The nephrotic syndrome is a renal disease characterized by proteinuria, hypoproteinemia, edema and hyperlipidemia. It has been reported that female nephrotic rats are characterized by loss of the oestrus cycle, follicle atresia, low gonadotropin and steroid concentrations; particularly, undetectable estradiol levels. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.023
更新日期：2006-07-10 00:00:00
abstract：:Efonidipine is a dihydropyridine Ca2+ antagonist with inhibitory effects on both L-type and T-type Ca2+ channels and potent bradycardiac activity especially in patients with high heart rate. In the present study, we examined the frequency dependence of efonidipine action on the T-type Ca2+ channel in isolated guinea-p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00932-2
更新日期：2000-12-08 00:00:00
abstract：:The lymphatic vessels have been implicated in maintenance of interstitial fluid homeostasis and immune responses, and pathological conditions including inflammation, wound healing, lymphedema and tumor progression. The knowledge about the lymphatic structure and function in muscles, especially in muscular disorders, r...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.09.043
更新日期：2018-10-15 00:00:00
abstract：:An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90175-0
更新日期：1988-01-01 00:00:00
abstract：:Certain things have not changed since my colleague and I last reviewed the role of dietary salt in hypertension [Haddy, F.J., Pamnani, M.B., 1995. Role of dietary salt in hypertension. Journal of the American College of Nutrition 14, 428-438]. Over half of hypertensives are still salt sensitive, i.e., they respond to ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2006.05.017
更新日期：2006-09-20 00:00:00
abstract：:The development of the specific uptake of dopamine in the rat striatum during the early postnatal period is compared with the ontogenetic changes of the specific binding of (3H)GBR 12783 to the site of uptake inhibition. During maturation, the increase in the specific binding of (3H)GBR 12783 parallels the increase in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90563-8
更新日期：1989-01-01 00:00:00
abstract：:The metabolic capability of hepatocytes prepared by the perfusion method (P cells) and the tissue slice method (S cells) has been compared using standardised procedures. Yields of P cells were four times greater than for S cells. Trypan blue exclusion viability and oxygen utilization were similar although the viabilit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90912-8
更新日期：1983-03-28 00:00:00
abstract：:The ability of metformin (MF) to acutely relax phenylephrine (PE)-induced contraction in the isolated rat tail artery is reported to be accompanied by repolarization of the arterial smooth muscle cell (SMC) membranes. These membranes contain potassium (K) channels which if opened could mediate such repolarization and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00522-6
更新日期：1999-10-29 00:00:00
abstract：:Immunoreactive- (IR-) somatostatin (SRIF), neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) contents were investigated in the brain of tremor rats with absence-like seizure and spontaneously epileptic rats (SER), which is a genetically defined double-mutant (zi/zi, tm/tm) obtained by mating zitter homozyg...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00302-m
更新日期：1995-01-01 00:00:00
abstract：:The binding of 3H-ouabain to human erythrocytes was analyzed in a population of hospitalized male ethanol addicted patients under long term digitalis treatment. In the non-alcoholic patient group the long term digitalis treatment induced an increase in Bmax and Kd values; such modification was not observed in the alco...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90071-3
更新日期：1987-06-29 00:00:00
abstract：:The objective of this study was to determine the primary event that occurs in Ca2+-regulatory sarcoplasmic-reticular (SR) proteins during subacute transition from concentric/mechanically-compensated left ventricular (LV) hypertrophy to eccentric/decompensated hypertrophy. Using Dahl salt-sensitive rats with hypertensi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01383-2
更新日期：2001-11-30 00:00:00
abstract：AIMS:Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.02.028
更新日期：2019-03-15 00:00:00
abstract：AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119140
更新日期：2021-01-29 00:00:00
abstract：:Oleuropein (Ole) is the main bioactive phenolic compound present in olive leaves, fruits and olive oil. This molecule has been shown to exert beneficial effects on several human pathological conditions. In particular, recent preclinical and observational studies have provided evidence that Ole exhibits chemo-preventiv...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118694
更新日期：2021-01-01 00:00:00
abstract：AIMS:Oxaliplatin (l-OHP) is a key drug in therapeutic regimens for metastatic or advanced-stage colorectal cancer, but causes peripheral neuropathy as a dose-limiting adverse effect. It is reported that this peripheral neuropathy results from l-OHP accumulation in dorsal root ganglion (DRG) neurons, and that one of the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.07.006
更新日期：2018-08-15 00:00:00
abstract：:Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity. A higher percentage of SP pre-treated cells in RA exposures resembled mature myelocytes or granulocytes; greater increase in ALP activity was observed. In cel...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90688-y
更新日期：1993-01-01 00:00:00
abstract：:Thymic and spleen cells were treated in vitro or in vivo with insulin. The in vitro treatments were done with 10(-6), 10(-9), 10(-12) and 10(-15) M concentrations for 30 min and after that histamine, serotonin, endorphin and triiodothyronine (T3) content of the cells were detected by using antibodies to the hormones a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.05.084
更新日期：2006-02-02 00:00:00
abstract：:We have developed an assay for serotonin (5-HT) stimulation of adenylate cyclase activity in membranes from adult guinea pig hippocampus. The response to 5-HT is concentration-dependent, with an EC50 of 0.01 microM, a shallow slope, and mean maximal stimulation of 90% over basal activity. The response to 5-HT is GTP-d...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90763-4
更新日期：1983-05-16 00:00:00
abstract：:The tendency to associate a given response-reinforcement combination reflects the adaptive significance of the association. Biologically relevant reinforcement can be much more effective in modifying certain responses. For example, treatments that result in various types of illness readily condition aversions to novel...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90571-7
更新日期：1989-01-01 00:00:00
abstract：:Earlier studies from the authors' laboratory showed that malnourishment induces alterations in the cardiovascular homeostasis increasing the basal mean arterial pressure and heart rate. In this study, the authors evaluated whether the sympathetic and parasympathetic efferent activities contribute to changes in the car...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.08.005
更新日期：2007-08-23 00:00:00
abstract：:Homocysteine (Hcy), an intermediate in methionine metabolism, has been proposed to be involved in hepatic fibrogenesis. Impaired liver function can alter Hcy metabolism. The aim of the present study was to determine plasma Hcy alterations in acute obstructive cholestasis and the subsequent biliary cirrhosis. Cholestas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.12.009
更新日期：2005-04-08 00:00:00
abstract：AIMS:Skeletal muscle diseases have become to be the most common complication in patients with type 2 diabetic mellitus (T2DM). However, the effective therapies against skeletal muscle diseases are not yet available. Sulforaphane (SFN) is an organic isothiocyanate found in cruciferous plants. Our aim was to explore whet...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117823
更新日期：2020-08-15 00:00:00
abstract：:In a series of in vitro experiments we characterised the relationship between DNA distribution in the G1, S and G2/M phases of cell cycle and PDE and GST activity in CaCo-2 cells. The DNA distribution in CaCo-2 cells, was assessed by flow cytometry, with fluorescent dyes at different time points of culture. The expone...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00169-7
更新日期：1995-01-01 00:00:00
abstract：:G protein-coupled receptors (GPCRs) are integral membrane proteins that, in response to activation by extracellular stimuli, regulate intracellular second messenger levels via their coupling to heterotrimeric G proteins. GPCR activation also initiates a series of molecular events that leads to G protein-coupled recept...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2003.09.009
更新日期：2003-12-05 00:00:00
abstract：AIMS:Hypoxia is implicated in the pathogenesis of rheumatoid arthritis (RA), contributing to the tumor-like phenotypes of RA fibroblast-like synoviocytes (RA-FLSs). Andrographolide is the main bioactive component of Andrographis paniculata, an herbal medicine that shows therapeutic benefits in RA patients. Here, we exp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.06.019
更新日期：2015-09-01 00:00:00
abstract：:The anticonvulsant effects and duration of protective action of midazolam against Metrazol induced seizures were studied in 528 rats aged 7,12,18,25 and 90 days. The doses of 0.025, 0.05, 0.25, 0.5 and 1.0 mg/kg were administered immediately before Metrazol (100 mg/kg in all but 18-day-old animals where 90 mg/kg were ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90421-k
更新日期：1992-01-01 00:00:00
abstract：:Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-dep...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90786-5
更新日期：1983-08-22 00:00:00
abstract：:Relationship between in vivo down-regulation of cardiac muscarinic receptors and changes in their encoding mRNA was investigated. Rats were treated either once or for ten days with an irreversible inhibitor of acetylcholinesterase, followed by measurements of cardiac acetylcholinesterase, the density and affinity of m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90615-i
更新日期：1991-01-01 00:00:00
