Altered brain contents of neuropeptides in spontaneously epileptic rats (SER) and tremor rats with absence seizures.

Abstract:

:Immunoreactive- (IR-) somatostatin (SRIF), neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) contents were investigated in the brain of tremor rats with absence-like seizure and spontaneously epileptic rats (SER), which is a genetically defined double-mutant (zi/zi, tm/tm) obtained by mating zitter homozygote (zi/zi) with tremor heterozygote (tm/+) and shows both absence-like seizure and tonic convulsions. Increased levels of IR-NPY and IR-CRF were observed in several regions including the amygdala and hippocampus in homozygous SER compared to heterozygous SER (zi/zi, tm/+ or +/+). Homozygous tremor rats (tm/tm) showed lower levels of IR-NPY and IR-CRF contents mainly in the hippocampus and mesolimbic system (entorhinal and pyriform cortex and nucleus accumbens) than heterozygous tremor rats. IR-SRIF contents of homozygous SER were higher in frontal cortex than heterozygous SER and in amygdala than homozygous tremor rats. No change of IR-SRIF between groups was noted in the hippocampus among brain structures underlying epileptogenicity. The results suggest that the change of neuropeptide levels, most conspicuous in NPY among three peptides tested, may be involved in the phenotypical manifestation of seizures in SER and tremor rats, and that the development of tonic convulsion and absence seizures may be differently associated with the change of brain neuropeptide levels.

journal_name

Life Sci

journal_title

Life sciences

authors

Sadamatsu M,Kanai H,Masui A,Serikawa T,Yamada J,Sasa M,Kato N

doi

10.1016/0024-3205(95)00302-m

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

523-31

issue

6

eissn

0024-3205

issn

1879-0631

pii

002432059500302M

journal_volume

57

pub_type

杂志文章
  • Captopril attenuates reflex adrenergic response in essential hypertension.

    abstract::An attenuation of adrenergic activity during the inhibition of endogenous angiotensin II formation was evaluated by determining plasma norepinephrine concentration after a single oral administration of captopril compared to that after nifedipine in essential hypertension. Captopril produced a fall in mean arterial pre...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(91)90415-8

    authors: Mohara O,Masuyama Y

    更新日期:1991-01-01 00:00:00

  • Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats.

    abstract::alpha-lactorphin (Tyr-Gly-Leu-Phe) lowers blood pressure in conscious adult SHR. This tetrapeptide is originally released from milk protein alpha-lactalbumin by enzymatic hydrolysis. In order to evaluate the antihypertensive mechanisms of alpha-lactorphin, the effects of the tetrapeptide on vascular function were inve...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(02)01793-9

    authors: Sipola M,Finckenberg P,Vapaatalo H,Pihlanto-Leppälä A,Korhonen H,Korpela R,Nurminen ML

    更新日期:2002-08-02 00:00:00

  • Effect of clonidine on the chronic morphine tolerance and on the sensitivity of the smooth muscles in mice.

    abstract::Clonidine, when administered for prolonged period showed no tolerance to its analgesic activity. Prior exposure to clonidine attenuated the tolerance development to morphine-induced analgesia and the supersensitivity to acetylcholine (ACh) in ileum during chronic morphine treatment. Further, acute administration of lo...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(83)90021-8

    authors: Ramaswamy S,Pillai NP,Gopalakrishnan V,Ghosh MN

    更新日期:1983-09-19 00:00:00

  • The effects of cannabinoids on the regulation of reproduction.

    abstract::It has been shown that the main psychoactive component of marihuana, delta9-tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its s...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/s0024-3205(99)00292-1

    authors: Wenger T,Tóth BE,Juanéda C,Leonardelli J,Tramu G

    更新日期:1999-01-01 00:00:00

  • Transcriptional up-regulation of nNOS in the dorsal vagal complex during low endotoxemia.

    abstract::The present study analyses the expression and distribution of neuronal nitric oxide synthase (nNOS) in the brainstem of animals pre-treated with Escherichia coli or Helicobacter pylori LPS, at doses that modulate gastric motor function. Systemic administration of H. pylori LPS prevented in a dose-dependent manner (5, ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2005.03.007

    authors: Quintana E,Hernández C,Moran AP,Esplugues JV,Barrachina MD

    更新日期:2005-07-15 00:00:00

  • Melanin concentrating hormone. III. Melanin concentrating hormone (MCH): the message sequence.

    abstract::Melanin concentrating hormone (MCH) is a heptadecapeptide synthesized by the hypothalamus and secreted by the neurohypophysis of the teleost pituitary gland. MCH stimulates melanosome aggregation within teleost melanocytes but also exhibits MSH-like (melanosome dispersing) activity on tetrapod (frog and lizard) melano...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(89)90501-8

    authors: Castrucci AM,Lebl M,Hruby VJ,Matsunaga TO,Hadley ME

    更新日期:1989-01-01 00:00:00

  • Modulation of inflammatory and oxidative status by exercise attenuates cardiac morphofunctional remodeling in experimental Chagas cardiomyopathy.

    abstract:AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility i...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2016.03.053

    authors: Novaes RD,Gonçalves RV,Penitente AR,Bozi LH,Neves CA,Maldonado IR,Natali AJ,Talvani A

    更新日期:2016-05-01 00:00:00

  • Gastrin gene expression in human colon cancer cells measured by a simple competitive PCR method.

    abstract::Gastrin is mitogenic for several colon cancers and is postulated as an autocrine growth factor for colon cancer cells. In the present study we report the development of a simple competitive polymerase chain reaction (PCR) method for measuring relative abundance of gastrin gene expression in colon cancer cells. Primers...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)00550-8

    authors: Xu Z,Dai B,Dhruva B,Singh P

    更新日期:1994-01-01 00:00:00

  • Verapamil counteracts depression but not long-lasting potentiation of the hippocampal population spike.

    abstract::In transversely sectioned rat hippocampal slices, population spikes and population "EPSPs" were recorded from CA1 neurones in response to the stimulation of Schaffer collateral and commissural inputs. High frequency tetanic stimulation (400 Hz, 200 pulses) of an input induced LLP of the homosynaptic response without s...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(84)90021-3

    authors: Sastry BR,Chirwa SS,Goh JW,Maretic H,Pandanaboina MM

    更新日期:1984-03-12 00:00:00

  • Effects of dietary nucleoside-nucleotide mixture on memory in aged and young memory deficient mice.

    abstract::Intestinal mucosa, bone marrow hematopoietic cells and brain have limited capacity for the de novo synthesis of nucleosides (NSs) and nucleotides (NTs). Whereas the role of dietary NS and NT in the former two tissues is known, it is not known in the brain. Therefore we studied the effect of dietary NS and NT mixture o...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(96)00526-7

    authors: Chen TH,Huang HP,Matsumoto Y,Wu SH,Wang MF,Chung SY,Uezu K,Moriyama T,Uezu E,Korin T,Sato S,Yamamoto S

    更新日期:1996-01-01 00:00:00

  • Common cannabimimetic pharmacophoric requirements between aminoalkyl indoles and classical cannabinoids.

    abstract::Aminoalkylindoles (AAIs) are structurally dissimilar from the classical cannabinoids (CCs), however, both AAIs and CCs appear to bind at the same site on the cannabinoid receptor. To obtain better insights on the structural correlation between AAIs and CCs, we have studied the conformational properties of the potent c...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(95)00177-8

    authors: Xie XQ,Eissenstat M,Makriyannis A

    更新日期:1995-01-01 00:00:00

  • Changes in the activities of protein kinases A, C, and M in dog heart and liver following endotoxin administration.

    abstract::Changes in the activities of protein kinase A (cAMP-dependent), protein kinase C (Ca2+/phospholipid-dependent), and protein kinase M (Ca2+/calmodulin-dependent) in dog heart and liver were studied 4 hr following endotoxin injection. Protein kinases A and C were extracted and partially purified by DEAE-cellulose chroma...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)00838-8

    authors: Hsu HK,Tao YP,Chen XY,Huang J,Liu MS

    更新日期:1994-01-01 00:00:00

  • Meconium-induced lung injury mediated by activation of alveolar macrophages.

    abstract::To clarify the mechanism of meconium-induced cellular injury, we examined the effect of meconium on the alveolar macrophages (AM) and bronchial epithelial cells (AK-D). Meconium obtained from healthy newborns was added to culture medium of AM and/or AK-D, which were cultured for 1 hour. Superoxide anion production of ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)90026-4

    authors: Kojima T,Hattori K,Fujiwara T,Sasai-Takedatsu M,Kobayashi Y

    更新日期:1994-01-01 00:00:00

  • The response of chloride transport to cyclic AMP, calcium and hypotonic shock in normal and cystic fibrosis fibroblasts.

    abstract::It has widely been established that Cl- transport is defective in cystic fibrosis fibroblasts. In the present study, the effect of elevation of intracellular concentration of cyclic AMP and calcium on the efflux of Cl- from human fibroblasts has been investigated. Cyclic AMP analogs (8-bromo cAMP and dibutyryl cAMP) a...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(90)90381-z

    authors: Mastrocola T,Rugolo M

    更新日期:1990-01-01 00:00:00

  • Specific binding of atrial natriuretic factor to renal glomeruli during day or night antiorthostatic suspension in the rat.

    abstract::We observed a significant increase in plasma atrial natriuretic factor (ANF) in antiorthostatic hypokinetic suspension (AOH) rats after 2 h of suspension when the experiment was made during day. Plasma ANF was investigated in relation to renal glomerular ANF receptors during AOH at night. The aim of this study was 1) ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(88)80008-0

    authors: Gauquelin G,Schiffrin EL,Garcia R,Entresangles M,Cantin M,Gharib C

    更新日期:1988-01-01 00:00:00

  • Development of a radioiodinated ligand for characterising alpha 1-adrenoceptors.

    abstract::Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(82)90623-3

    authors: Adams A,Jarrott B

    更新日期:1982-03-15 00:00:00

  • Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats.

    abstract::The effect of resveratrol, a polyphenolic compound present in grapes and other plants, on proteinuria, hypoalbuminemia and hyperlipidemia was studied in rats with glomerulonephritis. The nephritis was induced by an intravenous injection of anti-rat kidney glomerular basement membrane rabbit antiserum. Nephritic rats w...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(01)01061-x

    authors: Nihei T,Miura Y,Yagasaki K

    更新日期:2001-05-11 00:00:00

  • Molecular docking prediction and in vitro studies elucidate anti-cancer activity of phytoestrogens.

    abstract:AIM:The study is aimed at evaluating the chemosensitization and apoptotic effect of aglycone rich extracts of dietary phytoestrogens (derived from soybean and flaxseed) on estrogen receptor positive, MCF-7 and estrogen receptor negative, MDA-MB-231 cells. The extracts show potent activity on both the cell lines, hence,...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2017.07.015

    authors: Dutta S,Kharkar PS,Sahu NU,Khanna A

    更新日期:2017-09-15 00:00:00

  • MDR- and CYP3A4-mediated drug-herbal interactions.

    abstract::According to recent epidemiological reports, almost 40% of American population use complimentary and alternative medicine (CAM) during their lifetime. Patients detected with HIV or cancer often consume herbal products especially St. John's wort (SJW) for antidepressants in combination with prescription medicines. Such...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2005.12.010

    authors: Pal D,Mitra AK

    更新日期:2006-03-27 00:00:00

  • Neurosteroids and neuroactive drugs in mental disorders.

    abstract::Clinical and preclinical studies have suggested that fluctuations in the peripheral and brain concentrations of progesterone and deoxycorticosterone and its metabolites 3alpha,5alpha-tetrahydroprogesterone and 3alpha,5alpha-tetrahydrodeoxycorticosterone, respectively, might play an important role in certain pathologic...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2003.12.002

    authors: Pisu MG,Serra M

    更新日期:2004-05-14 00:00:00

  • Characterization of Wistar-Kyoto rats showing hyperadiponectinemia.

    abstract:AIMS:Wistar-Kyoto rats (HA-WKY) kept in the author's laboratory showed higher levels of serum adiponectin (approximately 4-fold) compared with Wistar-Kyoto/Izm rats (WKY/Izm), a WKY standard strain, at 6weeks old. In a preliminary study, HA-WKY but not WKY/Izm showed hyperinsulinemia and severe hypercholesterolemia whe...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2010.01.003

    authors: Inoue T,Takemori K,Yamamoto K,Ito H

    更新日期:2010-02-27 00:00:00

  • Cardiovascular actions of adenosines, but not adenosine receptors, differ in rat and guinea pig.

    abstract::This study compared the structure-activity relationships of 16 analogues at the A1 and A2 adenosine receptors (A1AR, A2AR) of rat and guinea pig. Radioligand binding studies revealed no marked differences in the affinities of each analogue at the A1AR of brain cortex or the A2AR of brain striatum. Bioassay employing L...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(91)90199-l

    authors: Ueeda M,Thompson RD,Padgett WL,Secunda S,Daly JW,Olsson RA

    更新日期:1991-01-01 00:00:00

  • Role of angiotensin II in renal hemodynamic functions during the initial stages of acute ureteral obstruction.

    abstract::This investigation examines the role of Angiotensin II in renal hemodynamic functions during acute unilateral ureteral obstruction (UUO) in a dog model. An electro magnetic flow probe was utilized to assess renal blood flow while the arteriovenous extraction technique of technetium 99m DTPA was utilized for the assess...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(88)90495-x

    authors: Katzberg RW,DiMarco PL,Morris TW,Harnish PP,Graves RF,Merguerian PA,Ventura JA,Proskin HM

    更新日期:1988-01-01 00:00:00

  • Upregulation of CRH gene expression and downregulation of arginine vasopressin gene expression in the hypothalamus of bilateral nephrectomized rats.

    abstract::The expression of the corticotropin-releasing hormone (CRH) gene and the arginine vasopressin (AVP) gene in the hypothalamus examined in bilateral nephrectomized rats by in situ hybridization histochemistry. The expression of the CRH gene was significantly increased in the parvocellular part of the paraventricular nuc...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(02)02287-7

    authors: Nomura M,Serino R,Yamamoto Y,Ozaki Y,Saito J,Matsumoto T,Yamashita H,Ueta Y

    更新日期:2002-12-20 00:00:00

  • Discriminative stimulus effects of caffeine: tolerance and cross-tolerance with methylphenidate.

    abstract::Twice daily injection of caffeine (30 mg/kg) for 3-1/2 days shifted the caffeine stimulus generalization curve to the right by 3-fold in rats trained to discriminate saline from 30 mg/kg of caffeine, and by 4-fold in rats trained to discriminate saline from 10 mg/kg of caffeine. The latter group was also tested for cr...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(87)90140-8

    authors: Holtzman SG

    更新日期:1987-01-26 00:00:00

  • Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats.

    abstract::The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2008.06.013

    authors: Abe F,Ueyama J,Kimata A,Kato M,Hayashi T,Nadai M,Saito H,Takeyama N,Noguchi H,Hasegawa T

    更新日期:2008-08-15 00:00:00

  • Catcholamine and nitric oxide systems as targets of chronic lead exposure in inducing selective functional impairment.

    abstract::Rats were exposed for ten months to 60 ppm of lead (Pb, as acetate) in drinking water to further assess cardiovascular effects of chronic Pb exposure. At the end of the treatment, mean blood Pb was 3.1+/-0.3 microg/dL in the control rats and 22.8+/-1.2 microg/dL in the Pb-exposed rats (means+/-SE, n=12 in each group);...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(00)00954-1

    authors: Carmignani M,Volpe AR,Boscolo P,Qiao N,Di Gioacchino M,Grilli A,Felaco M

    更新日期:2000-12-15 00:00:00

  • Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.

    abstract:AIMS:In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between noradrenaline (NA) release in the LC and efficacy of analgesics in rats with painful diabetic neuropathy. Using mic...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2013.04.015

    authors: Suehiro K,Funao T,Fujimoto Y,Yamada T,Mori T,Nishikawa K

    更新日期:2013-06-21 00:00:00

  • Ketamine effects on bupivacaine local anaesthetic activity and pharmacokinetics of bupivacaine in mice.

    abstract::This study was designed to document possible changes in bupivacaine (B) local anaesthetic activity and pharmacokinetics in mice after a ketamine (K) injection. In the experiments, bupivacaine (8.25 mg.kg(-1)), was injected into the popliteal space of the right posterior limb: the local anaesthetic activity was assesse...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(97)00861-8

    authors: Gantenbein M,Abat C,Attolini L,Pisano P,Emperaire N,Bruguerolle B

    更新日期:1997-01-01 00:00:00

  • Neutralizing IL-6 reduces heart injury by decreasing nerve growth factor precursor in the heart and hypothalamus during rat cardiopulmonary bypass.

    abstract:AIMS:To investigate whether the expression of nerve growth factor precursor (proNGF) changes during cardiopulmonary bypass (CPB) and whether neutralizing interleukin-6 (IL-6) during CPB has cardiac benefits. MAIN METHODS:Thirty patients undergoing CPB were recruited and their serum proNGF and troponin-I (TNI) were det...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2017.04.007

    authors: Cheng C,Xu JM,Yu T

    更新日期:2017-06-01 00:00:00