Self-administration of morphine contingent on heart rate in the rat.

Abstract:

:The tendency to associate a given response-reinforcement combination reflects the adaptive significance of the association. Biologically relevant reinforcement can be much more effective in modifying certain responses. For example, treatments that result in various types of illness readily condition aversions to novel flavors, but electric shock is relatively ineffective. While opioid self-administration contingent on lever pressing has been extensively studied, the potential for opioids to reinforce visceral responses remains to be determined. An approach to reinforcing changes in heart rate with drug infusions is described. Methods to control for unconditioned drug effects include reversing the direction of change in heart rate required for infusions and addition of a yoked control subject. In several instances, rats exposed to .1 mg/kg infusions of morphine sulfate contingent on tachycardia showed trends for elevated heart rate, with increased locomotor and grooming activity preceding infusions. Increases in heart rate were most pronounced during daytime, normally inactive periods.

journal_name

Life Sci

journal_title

Life sciences

authors

Grasing KW,Miller NE

doi

10.1016/0024-3205(89)90571-7

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

1967-76

issue

21

eissn

0024-3205

issn

1879-0631

pii

0024-3205(89)90571-7

journal_volume

45

pub_type

杂志文章
  • ATP and ADP hydrolysis in brain membranes of zebrafish (Danio rerio).

    abstract::Nucleotides, e.g. ATP and ADP, are important signaling molecules, which elicit several biological responses. The degradation of nucleotides is catalyzed by a family of enzymes called NTPDases (nucleoside triphosphate diphosphohydrolases). The present study reports the enzymatic properties of a NTPDase (CD39, apyrase, ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(03)00596-4

    authors: Rico EP,Senger MR,Fauth Mda G,Dias RD,Bogo MR,Bonan CD

    更新日期:2003-09-05 00:00:00

  • Changes in the activities of protein kinases A, C, and M in dog heart and liver following endotoxin administration.

    abstract::Changes in the activities of protein kinase A (cAMP-dependent), protein kinase C (Ca2+/phospholipid-dependent), and protein kinase M (Ca2+/calmodulin-dependent) in dog heart and liver were studied 4 hr following endotoxin injection. Protein kinases A and C were extracted and partially purified by DEAE-cellulose chroma...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)00838-8

    authors: Hsu HK,Tao YP,Chen XY,Huang J,Liu MS

    更新日期:1994-01-01 00:00:00

  • SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor.

    abstract::SR 142801 is the first potent and selective non-peptide antagonist of the tachykinin NK3 receptor. It inhibited [MePhe7]NKB binding to its receptor from various species, including humans. SR 142801 was a competitive antagonist of [MePhe7]NKB-mediated contractions of guinea-pig ileum and inhibited the acetylcholine rel...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)00413-m

    authors: Emonds-Alt X,Bichon D,Ducoux JP,Heaulme M,Miloux B,Poncelet M,Proietto V,Van Broeck D,Vilain P,Neliat G

    更新日期:1995-01-01 00:00:00

  • Leukotriene D4 role in allergic asthma pathogenesis from cellular and therapeutic perspectives.

    abstract::Asthma is a chronic inflammatory and allergic disease that is mainly characterized by reversible airway obstruction and bronchial hyperresponsiveness. The incidence of asthma is increasing with more than 350 million people worldwide are affected. Up to now, there is no therapeutic option for asthma and most of the pre...

    journal_title:Life sciences

    pub_type: 杂志文章,评审

    doi:10.1016/j.lfs.2020.118452

    authors: Al-Azzam N,Elsalem L

    更新日期:2020-11-01 00:00:00

  • The Chinese medicine Bu-Zhong-Yi-Qi-Tang inhibited proliferation of hepatoma cell lines by inducing apoptosis via G0/G1 arrest.

    abstract::Bu-Zhong-Yi-Qi-Tang (BZYQT), a Chinese herbal medicine, inhibited the proliferation of human hepatoma cell lines (Hep3B, HepG2 and HA22T) dose-dependently. The IC50s of BZYQT on the proliferation of Hep3B, HepG2 and HA22T were 432.5+/-31.8 microg/ml, 455.4+/-24.2 microg/ml, and 2284.3+/-77.2 microg/ml respectively on ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(01)01226-7

    authors: Kao ST,Yeh CC,Hsieh CC,Yang MD,Lee MR,Liu HS,Lin JG

    更新日期:2001-08-17 00:00:00

  • Effect of aminophylline on the respiratory depressant action of intravenous adenosine in neonatal rabbits.

    abstract::We administered intravenous adenosine to 11 neonatal rabbits. Adenosine depressed respiration in 10 of 11 rabbits. For the group as a whole the adenosine-induced respiratory depression was highly significant (p less than 0.001). After aminophylline administration to the same animals the respiratory effect of intraveno...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(87)90248-7

    authors: Watt AH,Buss DC,Routledge PA

    更新日期:1987-01-05 00:00:00

  • Involvement of the dopaminergic and serotonergic systems in the antidepressant-like effect caused by 4-phenyl-1-(phenylselanylmethyl)-1,2,3-triazole.

    abstract:AIMS:The study investigated the antidepressant-like effect and acute toxicity of 4-phenyl-1-(phenylselanylmethyl)-1,2,3-triazole (Se-TZ), an organoselenium-containing heterocycle compound in mice. MAIN METHODS:The antidepressant-like effect of Se-TZ (1-50mg/kg) and its mechanism of action, was analyzed in the tail sus...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2013.07.024

    authors: Donato F,de Gomes MG,Goes AT,Seus N,Alves D,Jesse CR,Savegnago L

    更新日期:2013-09-17 00:00:00

  • Effects of losartan on the blood-brain barrier permeability in long-term nitric oxide blockade-induced hypertensive rats.

    abstract::Hypertension is closely associated with vascular endothelial dysfunction. The aim of this study was to investigate the effects of Angiotensin II (ANG II) receptor antagonist losartan on the blood-brain barrier (BBB) permeability in L-NAME-induced hypertension and/or in ANG II-induced acute hypertension in normotensive...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(02)01772-1

    authors: Kucuk M,Kaya M,Kalayci R,Cimen V,Kudat H,Arican N,Elmas I,Korkut F

    更新日期:2002-07-12 00:00:00

  • Baicalin protects against ethanol-induced chronic gastritis in rats by inhibiting Akt/NF-κB pathway.

    abstract:AIMS:Currently, chronic gastritis is a high incidence of digestive diseases, along with loss of appetite, abdominal pain and diarrhea. Baicalin belongs to the major bioactive flavonoids compounds from Scutellariae Radix, it exhibited anti-inflammatory and anti-bacteria activities. Nonetheless, the protective effects of...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2019.117064

    authors: Ji W,Liang K,An R,Wang X

    更新日期:2019-12-15 00:00:00

  • MMP-9 antisense oligodeoxynucleotide exerts an inhibitory effect on osteoclastic bone resorption by suppressing cell migration.

    abstract::We have previously shown that matrix metalloproteinases (MMPs) play a role in osteoclastic bone resorption by facilitating migration of osteoclastic cells toward bone surface through matrices. Of MMPs identified so far, MMP-9 is likely the most important proteinase for the action, since osteoclasts express this enzyme...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2006.05.024

    authors: Ishibashi O,Niwa S,Kadoyama K,Inui T

    更新日期:2006-09-20 00:00:00

  • Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma.

    abstract:OBJECTIVE:The aim of this study was to investigate the role of HLA-DR, HLA-G and CD99 during cervical carcinogenesis and to examine the prognostic significance of these protein expressions in invasive squamous cell carcinoma (SCC). METHODS:Using specific antibodies for HLA-DR, HLA-G and CD99, we examined protein expre...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2005.10.039

    authors: Zhou JH,Ye F,Chen HZ,Zhou CY,Lu WG,Xie X

    更新日期:2006-04-25 00:00:00

  • Effect of phenobarbital on metabolism of polyphosphoinositides of rat brain synaptosomes.

    abstract::Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4,5-bisphosphate (PIP2) was most strongly affected (50% inhibition at 3 mM phenobarbital); p...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(87)90530-3

    authors: Deshmukh DS,Kuizon S,Brockerhoff H

    更新日期:1987-11-02 00:00:00

  • Striatal D-2 dopamine agonist binding sites fluctuate during the rat estrous cycle.

    abstract::Striatal D-2 dopamine (DA) antagonist and agonist binding sites were measured during the rat estrous cycle and compared to ovariectomized (OVX) rats. Dopaminergic D-2 antagonist binding sites were constant during the estrous cycle while agonist binding sites show a rapid and significant decrease of the ratio of high t...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(88)90137-3

    authors: Di Paolo T,Falardeau P,Morissette M

    更新日期:1988-01-01 00:00:00

  • Effect of age and photoperiodic conditions on metabolism and oxidative stress related markers at different circadian stages in rat liver and kidney.

    abstract::It has been shown that some cytochrome P450-dependent enzyme activities could present daily fluctuations, particularly CYP3A isoenzymes which are enhanced during the dark period. The aim of this study was to investigate whether age and photoperiodic conditions at different circadian stages could influence these fluctu...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(03)00271-6

    authors: Martin C,Dutertre-Catella H,Radionoff M,Debray M,Benstaali C,Rat P,Thevenin M,Touitou Y,Warnet JM

    更新日期:2003-06-06 00:00:00

  • Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia.

    abstract::In critically ill patients various conditions may lead to the activation of poly(ADP-ribose) polymerase (PARP). By promoting cellular energetic dysfunction, and by enhancing pro-inflammatory gene expression, PARP activation significantly contributes to the pathogenesis of shock. PARP activation is usually triggered by...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2007.11.001

    authors: Horváth EM,Benko R,Gero D,Kiss L,Szabó C

    更新日期:2008-01-16 00:00:00

  • Species dependent dual modulation of the benzodiazepine/GABA receptor chloride channel by dihydroergosine.

    abstract::Dihydroergosine (50 and 100 mg/kg) enhanced the incidence of bicuculline (3 mg/kg)-induced convulsions in female rats, while 100 mg/kg of dihydroergosine given to female mice made 45% convulsive dose of bicuculline (2.5 mg/kg) to be subconvulsive. The same dose of dihydroergosine enhanced in mice the latency of bicucu...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(90)90608-t

    authors: Pericić D,Tvrdeić A

    更新日期:1990-01-01 00:00:00

  • iTRAQ-based proteomics implies inflammasome pathway activation in the prefrontal cortex of CSDS mice may influence resilience and susceptibility.

    abstract:AIMS:Major depressive disorder, as a destructive mental health disorder, is a major contributor to disability and death. Numerous studies have illustrated that activation of inflammation and fluctuating immune reactions play a crucial role in the physiopathology of depression. The effectiveness of antidepressants is af...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2020.118501

    authors: Lan T,Bai M,Chen X,Wang Y,Li Y,Tian Y,He Y,Wu Z,Yu H,Chen Z,Chen C,Yu Y,Cheng K,Xie P

    更新日期:2020-12-01 00:00:00

  • Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats.

    abstract:AIMS:This study was performed to examine whether hypertension affects the sympathetic transmission to resistance vessels of pithed rats via inhibitory presynaptic cannabinoid CB1 receptors and whether endocannabinoids are involved in this response. MATERIALS AND METHODS:We compared uninephrectomised rats rendered hype...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2015.03.022

    authors: Toczek M,Schlicker E,Grzęda E,Malinowska B

    更新日期:2015-10-01 00:00:00

  • D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs.

    abstract::Monocyte chemoattractant protein-1 (MCP-1) is a 76-amino-acid chemokine thought to be the major chemotactic factor for monocytes. MCP-1 is found in macrophage-rich areas of atherosclerotic lesions. Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitu...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2007.06.019

    authors: Murao K,Yu X,Cao WM,Imachi H,Chen K,Muraoka T,Kitanaka N,Li J,Ahmed RA,Matsumoto K,Nishiuchi T,Tokuda M,Ishida T

    更新日期:2007-07-26 00:00:00

  • Thiamine-like fibers in the monkey brain: an immunocytochemical study.

    abstract::The distribution of thiamine-immunoreactive structures was studied in the brain of the monkey using an indirect immunoperoxidase technique. Fibers containing thiamine, but no thiamine-immunoreactive cell bodies, were found. The highest density of fibers containing thiamine was observed in the pulvinar nucleus and in t...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2006.03.017

    authors: Mangas A,Coveñas R,Geffard K,Geffard M,Marcos P,Insausti R,Dabadie MP

    更新日期:2006-08-15 00:00:00

  • A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels.

    abstract::The multiple functions of the blood-brain barrier (BBB) consist mostly in membrane properties controlling the bidirectional exchange of molecules between the general circulation and the central nervous system. As lipophilic molecules are able to easily penetrate the membrane of brain microvessels endothelial cells, an...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(88)90351-7

    authors: Ghersi-Egea JF,Minn A,Siest G

    更新日期:1988-01-01 00:00:00

  • Characterization and distribution of 3H-(3MeHis2)thyrotropin releasing hormone receptors in rat brain.

    abstract::The characteristics and distribution of putative thyrotropin releasing hormone (TRH) receptors were studied in rat central nervous system using the TRH analogue 3H-(3MeHis2)TRH as a radiolabeled ligand. The analogue had a dissociation constant of 2.3 +/- 0.2 nM and a receptor density of 34 +/- 2 fm/mg protein in whole...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(82)90315-0

    authors: Simasko SM,Horita A

    更新日期:1982-05-24 00:00:00

  • Antioxidant, a pro-oxidant and cytotoxic effects of Achyrocline satureioides extracts.

    abstract::In this study we compared the antioxidant properties of five different extracts of different composition obtained from Achyrocline satureioides' inflorescences (Compositae), a widely used Brazilian folk medicinal herb. All of the extracts presented significant antioxidant potential identified by TRAP assay, which incr...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2003.09.073

    authors: Polydoro M,de Souza KC,Andrades ME,Da Silva EG,Bonatto F,Heydrich J,Dal-Pizzol F,Schapoval EE,Bassani VL,Moreira JC

    更新日期:2004-04-23 00:00:00

  • Basic fibroblast growth factor messenger RNA is expressed strongly at the acute stage of cerebral contusion.

    abstract::Basic fibroblast growth factor (bFGF) has a neurotrophic effect both in vitro and in vivo, and is considered to play an important role in the maintenance of neuronal functions in the normal brain. Neural damage in brain contusion progresses after the primary injury of trauma because of cerebral hemodynamic and metabol...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(94)00332-7

    authors: Iwamoto Y,Yamaki T,Murakami N,Sugawa N,Yoshino E,Ueda S,Nosaka K,Nishino H,Iwashima A

    更新日期:1994-01-01 00:00:00

  • Effects of endurance physical training on hydroxyl radical generation in rat tissues.

    abstract::Physical exercise is known to increase oxygen consumption to compensate for enhanced ATP consumption and thus to induce oxidative stress in tissues. Our previous data indicate that training significantly increased the hydroxyl radical level in rat tissues after physical exercise, but reduced the basal level in aged ra...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(98)00468-8

    authors: Itoh H,Ohkuwa T,Yamamoto T,Sato Y,Miyamura M,Naoi M

    更新日期:1998-01-01 00:00:00

  • Inhibitory effect of mitragynine, an alkaloid with analgesic effect from Thai medicinal plant Mitragyna speciosa, on electrically stimulated contraction of isolated guinea-pig ileum through the opioid receptor.

    abstract::Effect of mitragynine, an indole alkaloid isolated from Thai medicinal plant kratom (Mitragyna speciosa), on electrically stimulated contraction was studied in the guinea-pig ileum. Mitragynine (1 nM-3 microM) inhibited the ileum contraction elicited by electrical stimulation, and its pD2 value was 6.91 +/- 0.04 (n = ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(97)00023-4

    authors: Watanabe K,Yano S,Horie S,Yamamoto LT

    更新日期:1997-01-01 00:00:00

  • Nitric oxide-active compounds modulate the intensity of glutamate-evoked responses in the globus pallidus of the rat.

    abstract:AIM:The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. MAIN METHODS:Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG)...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2011.04.010

    authors: Sardo P,Carletti F,Rizzo V,Lonobile G,Friscia S,Ferraro G

    更新日期:2011-06-20 00:00:00

  • Alteration of hepatic lipidperoxide levels during cataract formation caused by glucocorticoids in developing chick embryos.

    abstract::The level of hepatic lipidperoxides in chick embryos was determined during cataract formation resulting from glucocorticoid treatment. When 15 day old chick embryos were administered 0.25 mumol of hydrocortisone acetate their hepatic lipidperoxide level, determined by thio-barbituric acid, increased after a lag time o...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/0024-3205(84)90664-7

    authors: Nishigori H,Lee JW,Iwamoto Y,Hayashi R,Maruyama K,Iwatsuru M

    更新日期:1984-08-27 00:00:00

  • Delayed cytoprotection induced by hypoxic preconditioning in cultured neonatal rat cardiomyocytes: role of GRP78.

    abstract::Hypoxic preconditioning (HPC) has been well demonstrated to have potent protective effects in many cell types; however, the mechanisms responsible for this phenomenon are not fully understood. Recently, glucose-regulated protein 78 (GRP78), an inducible molecular chaperon, was indicated to be associated with ischemic ...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/j.lfs.2007.08.015

    authors: Pan YX,Ren AJ,Zheng J,Rong WF,Chen H,Yan XH,Wu C,Yuan WJ,Lin L

    更新日期:2007-09-08 00:00:00

  • Modulation of diaspirin crosslinked hemoglobin induced systemic and regional hemodynamic response by ethanol in normal rats.

    abstract::DCLHb, a hemoglobin based oxygen carrier, has been extensively studied for the treatment of hemorrhagic shock in both animal models and humans. Numerous accidents resulting in trauma are due to ethanol intoxication, in particular cases of car accidents. Therefore, trauma patients might be intoxicated with drugs of abu...

    journal_title:Life sciences

    pub_type: 杂志文章

    doi:10.1016/s0024-3205(00)01040-7

    authors: Palaparthy R,Saini BK,Gulati A

    更新日期:2001-02-09 00:00:00