Naloxone-induced hypodipsia: a CNS mapping study.

Abstract:

:Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-deprived rats. Water intake was measured at 5, 15, 30 and 60 minutes post drug injection. Compared to saline control injections, naloxone reliably depressed water intake, in a dose-related manner, in lateral hypothalamus, preoptic area and zona incerta. Previous research has repeatedly implicated these areas in drinking behavior. Placements which were not generally effective included lateral ventricle, nucleus accumbens, substantia nigra and cortex/corpus callosum. Latency to drink was never affected by any dose of naloxone injected into any site, suggesting an opioid influence on mechanisms involved in termination and/or maintenance rather than on initiation of drinking.

journal_name

Life Sci

journal_title

Life sciences

authors

Czech DA,Stein EA,Blake MJ

doi

10.1016/0024-3205(83)90786-5

subject

Has Abstract

pub_date

1983-08-22 00:00:00

pages

797-803

issue

8

eissn

0024-3205

issn

1879-0631

pii

0024-3205(83)90786-5

journal_volume

33

pub_type

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