当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Influence of in vitro and in vivo insulin treatment on the hormone (histamine, serotonin, endorphin and triiodothyronine) content of thymus and spleen cells.

Influence of in vitro and in vivo insulin treatment on the hormone (histamine, serotonin, endorphin and triiodothyronine) content of thymus and spleen cells.

Abstract：

:Thymic and spleen cells were treated in vitro or in vivo with insulin. The in vitro treatments were done with 10(-6), 10(-9), 10(-12) and 10(-15) M concentrations for 30 min and after that histamine, serotonin, endorphin and triiodothyronine (T3) content of the cells were detected by using antibodies to the hormones and flow cytometry as well as confocal microscopy. For in vivo treatment 1 IU/kg insulin was given for adult rats and 1 h after that the target hormone contents were determined by the same manner. Histamine and T3 content radically decreased in the thymus after in vitro treatment independent on the insulin concentrations administered. In vivo treatment halved histamine and T3 content. Serotonin content also decreased after in vitro treatment with the two higher concentrations, however the in vivo treatment did not cause a change. Histamine content was elevated after in vitro treatment in the spleen, independent on the insulin concentration. Endorphin level was not influenced at all. The experiments demonstrate that insulin is a factor which regulates the content (production, storage, secretion?) of some immunologically important molecules of the immune cells. Since each hormone molecule studied has important immunomodulatory role, the experiment points to the indirect immunomodulatory role of insulin.

journal_name

Life Sci

journal_title

Life sciences

authors

Csaba G,Kovács P,Pállinger E

doi

10.1016/j.lfs.2005.05.084

subject

Has Abstract

pub_date

2006-02-02 00:00:00

pages

1034-7

issue

10

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(05)00769-1

journal_volume

78

pub_type

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