Abstract：
:Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity. A higher percentage of SP pre-treated cells in RA exposures resembled mature myelocytes or granulocytes; greater increase in ALP activity was observed. In cells exposed to RA alone for only a period of 24h, the ALP activity could still increase and reach a similar maximum ALP activity (8.5-10.0 units/mg protein) at 48h as it was under continuous RA treatment. In all cells with longer exposures (24-96h) to RA, SP pre-treatment increased ALP activity to more or less the same higher maximum (14.0-15.5 units/mg protein). SP, added 24h before or concomitantly, but not 24 nor 48h after the addition of RA, could potentiate the RA-induced differentiation and increase of ALP activity.
journal_name
Life Scijournal_title
Life sciencesauthors
Wei LL,Hui EK,Wei JS,Tzeng WF,Yung BYdoi
10.1016/0024-3205(93)90688-ysubject
Has Abstractpub_date
1993-01-01 00:00:00pages
2035-43issue
25eissn
0024-3205issn
1879-0631pii
0024-3205(93)90688-Yjournal_volume
52pub_type
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