Abstract：
:The anticonvulsant activity of U-54494A was studied in a 4-aminopyridine (4-AP) epilepsy model using extracellular recordings in in vitro hippocampal slices. Field potentials were evoked by stimulation of Schaffer collaterals, and recorded from the CA1 region of the hippocampus after infusion of 4-AP in the absence and presence of U-54494A. The number and the total area of after discharges (AD) in the presence of 4-AP were significantly decreased by increasing concentrations of U-54494A. In contrast, U-54494A did not significantly change the latency, duration, or area of the evoked PS in this paradigm. Phenytoin, a standard anticonvulsant, decreased the PS area without affecting either the PS latency or duration, or the AD number or area in the same paradigm. These present results provide more evidence that U-54494A is a novel and effective anticonvulsant that may be useful in the treatment of paroxysmal activity, without having generalized depressive effects.
journal_name
Life Scijournal_title
Life sciencesauthors
Camacho-Ochoa M,VonVoigtlander PF,Hoffmann WE,Piercey MPdoi
10.1016/0024-3205(92)90381-xsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
457-63issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(92)90381-Xjournal_volume
50pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The effects of 100 microM norepinephrine (NE), GABA, aspartate, glutamate, and carbachol on the release of endogenous NE, GABA, aspartate, and glutamate from slices of rat cerebellum were examined. The 35 mM K+-stimulated release of NE was potentiated by GABA (136% of control), glutamate (123%), and carbachol (123%); ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90308-5
更新日期：1986-01-20 00:00:00
abstract：:Biphasic cutaneous reaction with peak response at 1 (early phase) and 24 to 48 hour (late phase) was elicited by epicutaneous challenge with antigen in actively and passively sensitized mice. Mice were actively immunized with dinitrophenylated (DNP) ascaris antigen and challenged with dinitrofluorobenzene (DNFB). Pass...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00859-0
更新日期：1994-01-01 00:00:00
abstract：:The effects of 14-day physical exercise or iloprost treatment (0.5-2 ng/Kg/min) on endogenous nitric oxide production and neutrophil adhesion were evaluated in 20 patients with peripheral arterial occlusive disease (Fontaine Stage II). Peripheral venous blood samples and 4-h urine samples were collected before, immedi...
journal_title：Life sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0024-3205(99)00550-0
更新日期：1999-01-01 00:00:00
abstract：:Abbott-81282 (A-81282) has been identified among a series of related compounds as being a highly potent and selective antagonist of angiotensin receptors. At AT1 receptors of the rabbit aorta, A-81282 exhibited a pA2 of 9.64 (+/- 0.33) vs. angiotensin-II, and demonstrated characteristics consistent with competitive an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90445-9
更新日期：1993-01-01 00:00:00
abstract：:Angiotensin-converting enzyme 2 (ACE 2) is a membrane-bound enzyme that cleaves angiotensin II (Ang II) into angiotensin (1-7). It also serves as an important binding site for SARS-CoV-2, thereby, facilitating viral entry into target host cells. ACE 2 is abundantly present in the intestine, kidney, heart, lungs, and f...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118676
更新日期：2021-01-01 00:00:00
abstract：:Alpha-adrenergic receptors may play an important role in regulating vascular tone and reactivity. To study alpha-adrenergic receptors in blood vessels, we have developed a method to characterize and quantitate alpha-adrenergic receptors in a particulate fraction of individual rabbit aortas using the high specific acti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90227-3
更新日期：1984-02-13 00:00:00
abstract：:In the early 1970's, some papers appeared reporting an immune response to opiates in animals treated with morphine and in heroin addicts, but further researches failed to confirm these results in humans. The aim of the present work is investigating with a newly developed enzyme immunoassay the existence of specific an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90656-n
更新日期：1993-01-01 00:00:00
abstract：:Fissistigma oldhamii (Hemsl.) Merr [F. oldhamii], a traditional Chinese herb medicine, is widely used for treating rheumatoid arthritis (RA) in China. Following bioactivity-guided isolation, a representative immunosuppressive compound with low cytotoxicity, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.10.004
更新日期：2007-12-14 00:00:00
abstract：:Involvement of cyclic AMP-dependent protein kinase in the desensitization of GABAB receptor expressed in Xenopus oocytes was studied. GABA produced an outward current in the presence of bicuculline, under voltage-clamp conditions. Baclofen mimicked the effect of GABA, thereby indicating that the response to GABA in th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02235-1
更新日期：1995-11-17 00:00:00
abstract：:Maternal malnutrition is known to impair fetal growth and predispose to the development of hypertension and type 2 diabetes. Recently, studies have demonstrated that intrauterine malnutrition is followed later in male offspring by oxidative stress characterized by increased superoxide generation due to activation of N...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.10.028
更新日期：2007-01-30 00:00:00
abstract：AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.009
更新日期：2009-01-16 00:00:00
abstract：AIM:Investigation whether androgen/androgen receptor (AR) might regulate megalin expression and/or functionality and thus affecting Gentamicin-induced nephrotoxicity (GIN). MAIN METHODS:Male Wistar rats were treated with gentamicin with/out AR ligands (testosterone as agonist and flutamide as antagonist). Megalin expr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117628
更新日期：2020-06-15 00:00:00
abstract：:The effects of naloxone or thyrotropin releasing hormone (TRH) upon neurologic outcome were evaluated in gerbil models of cerebral ischemia. Following temporary bilateral carotid occlusion, hypotension was transiently reversed by these endorphin antagonists. However, neither drug altered time to awaken, time to death,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90419-2
更新日期：1982-07-26 00:00:00
abstract：:We have developed and utilized a photoaffinity probe to identify the adenosine transporter in cardiac sarcolemmal (SL) vesicles. The probe is an azidosalicylate derivative of adenosine made by reacting adenosine with N-hydroxysuccinimidyl-4-azidosalicylic acid (NHS-ASA). Following synthesis and radiolabeling of the pr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00268-b
更新日期：1995-01-01 00:00:00
abstract：:Myelin basic protein and phosphatidylinositol-4-phosphate are phosphorylated in vitro by ATP and solubilized rat brain myelin. When both substrates are present together, the rate of phosphorylation of each is increased about eight-fold. It appears likely that the phosphate turnover of myelin basic protein and of phosp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90597-6
更新日期：1984-01-16 00:00:00
abstract：:The effects of exposure to ionizing radiation on the nociceptive thresholds of CF-1 mice were examined. Significant increases in thermal response latencies, indicative of analgesia were observed after exposure to either high or low doses of radiation. However, the onset of analgesia occurred significantly more rapidly...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90352-7
更新日期：1984-10-08 00:00:00
abstract：:The effects of t-butylhydroperoxide (TBH) and cigarette smoke on lung mechanics (CDYN and RL) and glutathione status (GSH) were studied using an isolated perfused and ventilated rat lung preparation. TBH (200, 400, 1000 microM) infused via the pulmonary circulation caused a dose-related bronchoconstriction. The lung G...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90054-9
更新日期：1988-01-01 00:00:00
abstract：:This study was undertaken to investigate whether or not alpha 2-adrenergic pathways would negatively modulate the hypothalamic somatostatin release in rats. To induce pharmacological changes in SS release, three groups of male Sprague-Dawley rats (n = 30/group) were separately anesthetized by ip administration of uret...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90277-a
更新日期：1993-01-01 00:00:00
abstract：:Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118641
更新日期：2021-01-01 00:00:00
abstract：:The cellular electrophysiology of left ventricular preparations from guinea pig hearts was studied 1 hour, 24 hours, and 4-6 weeks after myocardial infarction produced by 6-8 single ties of the distal left coronary artery system or after sham operation. Microelectrode recordings were used to monitor cells from the end...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90343-1
更新日期：1985-06-24 00:00:00
abstract：:To study the source of immunoreactive epidermal growth factor (ir-EGF) released by thrombin formation we removed 99.9% of the leukocytes normally present in platelet-rich plasma and induced coagulation with 30 mM of Ca2+. The absence of leukocytes did not reduce the amount of ir-EGF released; thus platelets are most l...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90642-o
更新日期：1991-01-01 00:00:00
abstract：:Immunoreactive (ir) beta-endorphin (b-END) and dynorphin (DYN) in rat brain and pituitary were measured after food and water deprivation and from brains taken during either day or night. In other rats, eating and drinking were measured following lesions in the arcuate n. Ir-DYN levels are higher in hypothalamus and lo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90221-1
更新日期：1982-10-18 00:00:00
abstract：AIMS:Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery. M...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118547
更新日期：2020-12-15 00:00:00
abstract：:The mechanism for the development of insulin resistance in normal pregnancy is complex and is associated with serum levels of sex hormones. However, the influence of these hormones on the early steps of insulin action has not been extensively studied, although the potentially beneficial effect of estradiol on glucose ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01489-3
更新日期：2002-02-22 00:00:00
abstract：:Aminoalkylindoles (AAIs) are structurally dissimilar from the classical cannabinoids (CCs), however, both AAIs and CCs appear to bind at the same site on the cannabinoid receptor. To obtain better insights on the structural correlation between AAIs and CCs, we have studied the conformational properties of the potent c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00177-8
更新日期：1995-01-01 00:00:00
abstract：:A number of potential functions of thioredoxin have been proposed in literature, including a role for DNA replication. The aim of our study was to investigate the effects of thioredoxin from Streptomyces aureofaciens (Trx S.a.) on plasmid DNA. Trx S.a. was incubated with plasmid forms and the incubation product(s) cha...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01133-8
更新日期：1998-01-01 00:00:00
abstract：:Rats implanted subcutaneously with an empty osmotic pump connected by a polyethylene catheter to a jugular vein for 5 to 10 days evinced a decreased splenocyte responsiveness to blastogenic stimulation in vitro to bacterial lipopolysaccharide, a known B cell stimulator, as well as to the plant mitogens pokeweed mitoge...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90291-v
更新日期：1992-01-01 00:00:00
abstract：:alpha-Difluoromethylornithine (DFMO) directly infused into a brain-lateral ventricle (12.5, 25 and 50 micrograms/rat) dose- and time-dependently inhibited brain ODC activity. While having no influence per se on pain threshold, DFMO significantly inhibited the analgesic activity of morphine (15 mg/kg i.p.), this effect...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90614-0
更新日期：1989-01-01 00:00:00
abstract：:The melanocortins are a family of bioactive peptides derived from proopiomelanocortin. Those peptides, included among hormones and comprising ACTH, alpha-MSH, beta-MSH and gamma-MSH, are best known mainly for their physiological effects, such as the control of skin pigmentation by alpha-MSH, and ACTH effects on pigmen...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(03)00349-7
更新日期：2003-07-04 00:00:00
abstract：:The renal hemodynamic and tubular effects of ANF were investigated using the Sperber technique in chickens. This technique takes advantage of the unique portal circulation of the avian kidney and permits direct access to the renal peritubular space independent of renal arterial blood flow and glomerular filtration. In...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90309-2
更新日期：1987-03-09 00:00:00
