Mutual stimulation by phosphatidylinositol-4-phosphate and myelin basic protein of their phosphorylation by the kinases solubilized from rat brain myelin.

abstract：AIMS:The beneficial effects of cannabinoid type 2 receptor (CB2R) activation have been verified in various tissue repair processes. Our recent study revealed CB2R activation promotes myogenesis partly through Nrf2 signaling in a mouse skeletal muscle ischemia-reperfusion (IR) injury model. Other relevant mechanisms nee...

journal_title：Life sciences

authors： Jiang P,Wang L,Zhang M,Zhang M,Wang C,Zhao R,Guan D

更新日期：2020-09-01 00:00:00

abstract：:Premazepam (PRZ) in vitro competitively displaced 3H-diazepam (DIA), 3H-flunitrazepam (FLU) and 3H-RO 15-1788 from their binding sites on rat brain synaptosomes, with a potency intermediate to other benzodiazepines (BDZs), and Hill coefficients near 1 in different brain regions. Incubation at 37 degrees C reduced prem...

journal_title：Life sciences

authors： Barone D,Colombo G,Glasser A,Luzzani F,Mennini T

更新日期：1984-07-23 00:00:00

abstract：:Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), ni...

journal_title：Life sciences

authors： Zbuzek VK,Cohen B,Wu W

更新日期：1997-01-01 00:00:00

abstract：AIMS:Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS). NO has been involved in the pathophysiology of epilepsy, but available data are conflicting and the actual role...

journal_title：Life sciences

authors： Prieto-Martín AI,Llorens S,Pardal-Fernández JM,Muñoz LJ,López DE,Escribano J,Nava E,de Cabo C

更新日期：2012-04-09 00:00:00

abstract：AIMS:We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet. MAIN METHODS:Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Di...

journal_title：Life sciences

authors： Barros MAV,de Brito Alves JL,Barros RGN,Santana E Silva M,Nasser S,Tourneur Y,Leandro CVG,Vidal H,Pirola L,Costa-Silva JH

更新日期：2020-12-15 00:00:00

abstract：:Male Sprague-Dawley rats were castrated and given daily sc. injections of estradiol (E2, 10 micrograms/day), testosterone propionate (TP, 1.0 mg/day), dihydrotestosterone (DHT, 1.0 mg/day) or sesame oil (SO, 0.2 ml/day). A group of sham castrate males received daily sc. injections of SO (0.2 ml/day). On day 8 of stero...

journal_title：Life sciences

authors： Haisenleder DJ,Lawson DM,Gala RR

更新日期：1984-01-02 00:00:00

abstract：:Three distinct peptidyldipeptidases (exopeptidases releasing carboxyl terminal dipeptide residues) can be solubilized from nerve terminal membrane fractions from whole rat brain or striatum, and separated by ion exchange chromatography. Brain angiotensin-converting enzyme (PDP-1) cleaves Hip-His-Leu, but not 80 nM [3H...

journal_title：Life sciences

authors： Cushman DW,Gordon EM,Wang FL,Cheung HS,Tung R,Delaney NG

更新日期：1983-01-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) is capable of protecting cells, tissues, organs, and animals from a subsequent, normally lethal heating, as well as from numerous disease states. Therefore, it would be of great therapeutic benefit to discover compounds that are clinically safe yet able to induce Hsp70 in patients. Carben...

journal_title：Life sciences

authors： Nagayama S,Jono H,Suzaki H,Sakai K,Tsuruya E,Yamatsu I,Isohama Y,Miyata T,Kai H

更新日期：2001-11-02 00:00:00

abstract：AIMS:Hypertension is one of the leading causes of cardiovascular mortality and morbidity. It is associated with severe cardiac and vascular dysfunction. Double-stranded RNA-dependent protein kinase (PKR), is a known inducer of inflammation and apoptosis. However, no research has been done to elucidate the role of the P...

journal_title：Life sciences

authors： Kalra J,Dasari D,Bhat A,Mangali S,Goyal SG,Jadhav KB,Dhar A

更新日期：2020-12-01 00:00:00

abstract：:Imidazole (IMI) (from 18.7 to 300 mg/Kg) i.p. injected in adult rats induced shaking, which was antagonized by both morphine (MOR) and haloperidol (HALO) but not by methysergide (MET). I.p. IMI pretreatment inhibited the penile erections (PE) and stretching and yawning (SY) typically elicited by N-n-propylnorapomorphi...

journal_title：Life sciences

authors： Francesca F,Baggio G

更新日期：1985-04-08 00:00:00

abstract：:To determine the mechanism of anoxic vasoconstriction, precontracted rat aortic rings were exposed to 95% N2, which caused additional contraction. Reoxygenation (95% O2) resulted in initial relaxation followed by contraction. Indomethacin did not affect anoxic contraction or reoxygenation-mediated events, but NG-monom...

journal_title：Life sciences

authors： Mehta JL,Lawson DL,Yang BC,Haught WH,Hintze T

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Cisplatin resistance has been found to contribute to the failure of ovarian carcinoma treatment. Oridonin is a natural en-kaurane tetracyclic diterpenoid compound discovered in Rabdosia rubescene (Henmsl.) Hara. Herein, we tested whether oridonin could exert chemo-sensitization activity on cisplatin-resistan...

journal_title：Life sciences

authors： Zhao Y,Xia H

更新日期：2019-09-15 00:00:00

abstract：:The available preclinical literature on the antihyperlipidemic properties of beta-pyridylcarbinol is reviewed. Similarities between the pharmacological profiles for beta-pyridylcarbinol and nicotinic acid, and evidence for the metabolic conversion of beta-pyridylcarbinol to nicotinic acid are discussed. Several review...

journal_title：Life sciences

authors： Cohen M

更新日期：1985-11-25 00:00:00

abstract：AIMS:We elucidated the therapeutic potential of human umbilical vein endothelial cells (HUVECs) for ameliorating progressive heart failure in a myocardial infarction (MI) rat model. MAIN METHODS:MI was induced by ligation of left anterior descending artery, and HUVEC was transplanted 1week after MI. Cardiac function w...

journal_title：Life sciences

authors： Kwon JS,Kim YS,Cho AS,Cho HH,Kim JS,Hong MH,Jeong HY,Kang WS,Hwang KK,Bae JW,Jeong MH,Cho MC,Ahn Y

更新日期：2014-04-17 00:00:00

abstract：:We previously showed that N1-phenyl-3,5-dinitro-N4,N4-di-n-butylsulfanilamide (denoted GB-II-150) possesses selective antimicrotubule activity against Leishmania donovani and Trypanosoma brucei in vitro [Bhattacharya, G., Herman, J., Delfin, D., Salem, M.M., Barszcz, T., Mollet, M., Riccio, G., Brun, R., Werbovetz, K....

journal_title：Life sciences

authors： Wu D,George TG,Hurh E,Werbovetz KA,Dalton JT

更新日期：2006-08-08 00:00:00

abstract：:Specific binding sites for atrial natriuretic peptide have been identified in membrane of the phaeochromocytoma cell line PC12. Scatchard analysis of binding studies revealed a Kd of 794 pM and a density (Bmax) of 254 fmol/mg protein. Hormones unrelated to ANP such as angiotensin II, bradykinin and arginine-8-vasopres...

journal_title：Life sciences

authors： Boumezrag A,Lyall F,Dow JA

更新日期：1988-01-01 00:00:00

abstract：AIMS:Incidence of stroke increases in postmenopausal women with dangerous consequences. In this study we used zeranol to protect ovariectomized (OVX) rats against cerebral I/R damage and our target is to identify the mechanism of its protection, in addition to investigating whether this mechanism inhibits inflammation ...

journal_title：Life sciences

authors： Mohamed SK,Ahmed AAE,Elmorsy EM,Nofal S

更新日期：2019-06-15 00:00:00

abstract：:Bacterial endotoxin or lipopolysaccharide (LPS) can trigger inflammatory responses and cause damage in organs such as liver and lungs when it is introduced into mammals, but the exact molecular events that mediate these responses have remained obscure. In this study, by using 2D gel electrophoresis and cDNA microarray...

journal_title：Life sciences

authors： Xie W,Shao N,Ma X,Ling B,Wei Y,Ding Q,Yang G,Liu N,Wang H,Chen K

更新日期：2006-10-04 00:00:00

abstract：:Arsenic as a one of the most important toxic metals could induce hepatotoxicity. Previous reports revealed the significance of oxidative stress in promoting of arsenic-induced liver toxicity. The aim of the present investigation is to evaluate the effect of chrysin (CHR), a natural flavonoid with potent antioxidant ac...

journal_title：Life sciences

authors： Fatemi I,Khalili H,Mehrzadi S,Basir Z,Malayeri A,Goudarzi M

更新日期：2021-02-15 00:00:00

abstract：:The effects of leucine- and methionine-enkephalin, opiate peptides, on Ca2+ efflux from cultured bovine adrenal chromaffin cells were examined. These enkephalins stimulated the efflux of 45Ca2+ from cells in a concentration-dependent manner (10(-8) M-10(-6) M). Leucine-enkephalin did not increase the intracellular fre...

journal_title：Life sciences

authors： Umeda T,Azuma M,Houchi H,Ikehara T,Shono F,Yoshizumi M,Tamaki T,Minakuchi K

更新日期：1999-01-01 00:00:00

abstract：:To elucidate the pharmacological profile of P2X receptors and the probable expression of P2Y receptors in otic ganglion neurons from 17-day-old rats, single neurons were enzymatically isolated and maintained in tissue culture for up to 30 h. Whole-cell voltage-clamp recording was carried out at a holding potential of ...

journal_title：Life sciences

authors： Ma B,Yu LH,Fan J,Ni X,Burnstock G

更新日期：2008-08-01 00:00:00

abstract：:This investigation examines the role of Angiotensin II in renal hemodynamic functions during acute unilateral ureteral obstruction (UUO) in a dog model. An electro magnetic flow probe was utilized to assess renal blood flow while the arteriovenous extraction technique of technetium 99m DTPA was utilized for the assess...

journal_title：Life sciences

authors： Katzberg RW,DiMarco PL,Morris TW,Harnish PP,Graves RF,Merguerian PA,Ventura JA,Proskin HM

更新日期：1988-01-01 00:00:00

abstract：:Metalloproteinases (MMP), particularly MMP-9 produced by the intratumor monocyte/macrophages, play an important role in tumor invasion and metastases. Recent clinical trials in patients with primary breast cancer suggest that bisphosphonates (BP), above all clodronate, may reduce bone metastases. The aim of the presen...

journal_title：Life sciences

authors： Valleala H,Hanemaaijer R,Mandelin J,Salminen A,Teronen O,Mönkkönen J,Konttinen YT

更新日期：2003-09-26 00:00:00

abstract：AIMS:High fat diet consumes and thyroid hormones (THs) disorders may affect nutrients metabolism, but their impact on the absorptive epithelium, the first place of nutrients access, remains unknown. Our aim was to evaluate the intestinal morphology and nutrients transporters content in mice fed standard (LFD) or high f...

journal_title：Life sciences

authors： Losacco MC,de Almeida CFT,Hijo AHT,Bargi-Souza P,Gama P,Nunes MT,Goulart-Silva F

更新日期：2018-06-01 00:00:00

abstract：AIMS:This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity. MAIN METHODS:Gene expression analyses with microarray gene chip and/or quantitative PCR were performed using 1,4-benzodiazepine-treated ...

journal_title：Life sciences

authors： Haenisch B,Huber M,Wilhelm T,Steffens M,Molderings GJ

更新日期：2013-03-14 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) accumulation and endothelial cell dysfunction are associated with pathogenesis of atherosclerosis. Long noncoding RNA taurine up-regulated gene 1 (TUG1) has been reported to play an important role in cardiovascular diseases, including atherosclerosis. However, the regulatory mechanis...

journal_title：Life sciences

authors： Wu X,Zheng X,Cheng J,Zhang K,Ma C

更新日期：2020-02-15 00:00:00

abstract：:Sodium-dependent transport of D-glucose has been reported only in epithelial cells of small intestine and kidney, and well-differentiated tumors thereof. We observed a two-fold decrease (p < 0.05) in the intracellular distribution volume (Vic, defined as steady-state intracellular uptake divided by extracellular conce...

journal_title：Life sciences

authors： Bading JR,Mircheff AK,Kan-Mitchell J

更新日期：1996-01-01 00:00:00

abstract：:Thymic hormones have immunomodulatory effects on T cells and hence have been used clinically to restore the immunity of immunodeficient patients as well as to enhance the cellular immunity of cancer patients. Prothymosin alpha, which is a member of the thymic hormone family, has recently been suggested to act as a nuc...

journal_title：Life sciences

authors： Wu CL,Shiau AL,Lin CS

更新日期：1997-01-01 00:00:00

abstract：:Growth-related oncogene protein-alpha (GRO-alpha) is a member of the C-X-C chemokine family with a wide variety of biological activities. We studied the production of GRO-alpha by human umbilical vein endothelial cells (HUVEC) in response to the stimulation with soluble form of interleukin-6 receptor alpha (sIL-6R). s...

journal_title：Life sciences

authors： Matsumiya T,Imaizumi T,Itaya H,Shibata T,Yoshida H,Sakaki H,Kimura H,Satoh K

更新日期：2002-05-17 00:00:00

abstract：AIMS:To identify the target of an adipose specific aptamer adipo-8, predict the potential interaction between adipo-8 and its target, and investigate lipid-lowering effect of adipo-8 in vitro and in vivo. MAIN METHODS:Distinct membranous protein of 3T3-L1 adipocyte pulled-down by adipo-8 was mass-spectrometry analyzed...

journal_title：Life sciences

authors： Zhong W,Zhang Y,Tan W,Zhang J,Liu J,Wang G,Liao J,Liu B,Chen K,Yu B,Deng Y,Zou Y,Pu Y,Liu H

更新日期：2020-06-15 00:00:00