Abstract：
:Heat shock protein 70 (Hsp70) is capable of protecting cells, tissues, organs, and animals from a subsequent, normally lethal heating, as well as from numerous disease states. Therefore, it would be of great therapeutic benefit to discover compounds that are clinically safe yet able to induce Hsp70 in patients. Carbenoxolone, an antiulcer drug, protects gastric mucosal cells against irritants in vivo and in vitro. We assessed here whether carbenoxolone induces Hsp70 expression in human cell lines. We found that carbenoxolone increased the expression of Hsp70 protein and mRNA, and Hsp70 promoter activity.
journal_name
Life Scijournal_title
Life sciencesauthors
Nagayama S,Jono H,Suzaki H,Sakai K,Tsuruya E,Yamatsu I,Isohama Y,Miyata T,Kai Hdoi
10.1016/s0024-3205(01)01362-5subject
Has Abstractpub_date
2001-11-02 00:00:00pages
2867-73issue
24eissn
0024-3205issn
1879-0631pii
S0024-3205(01)01362-5journal_volume
69pub_type
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