Abstract:
:Studies were performed to compare in vitro and in vivo effects of morphine on the phagocytic function of murine peritoneal macrophages. Macrophage monolayers were incubated with Candida albicans for 30 min in the absence of autologous serum. Morphine added in vitro was found to decrease both the phagocytic activity (percent of phagocytic cells) and the phagocytic index (average number of ingested yeasts per cell) in a concentration-dependent manner, with maximal effects of 26% and 41%, respectively, at 10(-6) M. When morphine was administered in vivo via an implanted 75-mg pellet, there was a 22% decrease in phagocytic activity and a 40% decrease in the phagocytic index. Naltrexone completely blocked the effects of morphine both in vitro and in vivo. The results suggest that morphine is capable of interacting directly with opioid receptors on macrophages, resulting in a decrease in phagocytic function.
journal_name
Life Scijournal_title
Life sciencesauthors
Rojavin M,Szabo I,Bussiere JL,Rogers TJ,Adler MW,Eisenstein TKdoi
10.1016/0024-3205(93)90122-jsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
997-1006issue
12eissn
0024-3205issn
1879-0631pii
0024-3205(93)90122-Jjournal_volume
53pub_type
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