Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages.

Abstract:

:Studies were performed to compare in vitro and in vivo effects of morphine on the phagocytic function of murine peritoneal macrophages. Macrophage monolayers were incubated with Candida albicans for 30 min in the absence of autologous serum. Morphine added in vitro was found to decrease both the phagocytic activity (percent of phagocytic cells) and the phagocytic index (average number of ingested yeasts per cell) in a concentration-dependent manner, with maximal effects of 26% and 41%, respectively, at 10(-6) M. When morphine was administered in vivo via an implanted 75-mg pellet, there was a 22% decrease in phagocytic activity and a 40% decrease in the phagocytic index. Naltrexone completely blocked the effects of morphine both in vitro and in vivo. The results suggest that morphine is capable of interacting directly with opioid receptors on macrophages, resulting in a decrease in phagocytic function.

journal_name

Life Sci

journal_title

Life sciences

authors

Rojavin M,Szabo I,Bussiere JL,Rogers TJ,Adler MW,Eisenstein TK

doi

10.1016/0024-3205(93)90122-j

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

997-1006

issue

12

eissn

0024-3205

issn

1879-0631

pii

0024-3205(93)90122-J

journal_volume

53

pub_type

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