Inhibition by 1,3-dipropyl-8(p-sulfophenyl)xanthine of the respiratory stimulation induced by common carotid occlusion in rats.

abstract：:Previous studies from this laboratory have shown that rats with experimental cirrhosis of the liver induced by the combined administration of oral phenobarbital and inhaled carbon tetrachloride show an hyperdynamic status with enhanced cardiac output (CO), and decreased mean arterial pressure (MAP) and peripheral vasc...

journal_title：Life sciences

authors： Villamediana LM,Sanz E,Fernandez-Gallardo S,Caramelo C,Sanchez Crespo M,Braquet P,Lopez-Novoa JM

更新日期：1986-07-21 00:00:00

abstract：:Tissue-type plasminogen activator (tPA) is a key enzyme in the fibrinolysis system and the regulation of its expression has been extensively studied in cultured vascular endothelial cells. Many kinds of supplements including growth factors are needed, however, to keep endothelial cells viable, which leads the culture ...

journal_title：Life sciences

authors： Yoshino A,Suzuki K,Urano T,Aoki K,Takada Y,Kazui T,Takada A

更新日期：2002-02-08 00:00:00

abstract：AIMS:Interleukin-1β (IL-1β) is a cytokine that is known to activate the stress axis and suppress the reproductive axis. Different brain areas are involved in the regulation of these two axes. However, they are both under the stimulatory control of the catecholamine, norepinephrine (NE). Here, we hypothesized that IL-1β...

journal_title：Life sciences

authors： Sirivelu MP,MohanKumar PS,MohanKumar SM

更新日期：2012-10-29 00:00:00

abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...

journal_title：Life sciences

authors： Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

更新日期：1999-10-29 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00

abstract：:Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats. ...

journal_title：Life sciences

authors： Bolander HG,Kourtopoulos H

更新日期：1985-03-11 00:00:00

abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...

journal_title：Life sciences

authors： Satomi S,Morio A,Miyoshi H,Nakamura R,Tsutsumi R,Sakaue H,Yasuda T,Saeki N,Tsutsumi YM

更新日期：2020-03-15 00:00:00

abstract：:3-methylglutaconic (MGT), 3-methylglutaric (MGA) and occasionally 3-hydroxyisovaleric (OHIVA) acids accumulate in a group of diseases known as 3-methylglutaconic aciduria (MGTA). Although the clinical presentation of MGTA is mainly characterized by neurological symptoms, the mechanisms of brain damage in this disease ...

journal_title：Life sciences

authors： Leipnitz G,Seminotti B,Amaral AU,de Bortoli G,Solano A,Schuck PF,Wyse AT,Wannmacher CM,Latini A,Wajner M

更新日期：2008-03-12 00:00:00

abstract：AIM:Ischemia/reperfusion (I/R) injury is the major cause of neurological deficit following stroke. Our previous study showed neuroprotective effects of hispidulin against cerebral ischemia reperfusion injury (IRI). In this study, we further examined the involvement of pyroptosis in this neuroprotective function. MATER...

journal_title：Life sciences

authors： An P,Xie J,Qiu S,Liu Y,Wang J,Xiu X,Li L,Tang M

更新日期：2019-09-01 00:00:00

abstract：:Calcium ionophores, such as the A23187, cause endothelium-dependent relaxation of arterial strips with intact endothelium, whereas the effect of the ionophore should result from the combination of a relaxation caused by the endothelium-dependent factors and of a contraction of the smooth muscles. In addition, the appl...

journal_title：Life sciences

authors： Budel S,Beny JL

更新日期：2000-06-23 00:00:00

abstract：:Extracts of plasma obtained from adult humans before and immediately after physical stress were subjected to high pressure liquid chromatography (HPLC); extracts or HPLC fractions, resp., were analysed for the presence of human beta-endorphin (beta H-endorphin) or fragments thereof by several radioimmunoassays using a...

journal_title：Life sciences

authors： Wiedemann K,Teschemacher H

更新日期：1983-01-01 00:00:00

abstract：:The effects of free fatty acids in the blood on osmotic fragility and water content of erythrocytes when combined with hyperthermia were investigated. The isotonic buffer, containing the fatty acid, was added to the erythrocyte suspension to a final concentration of 200 microM/L. The samples were kept for one hour in ...

journal_title：Life sciences

authors： Kogawa H,Yabushita N,Nakajima T,Kageyama K

更新日期：1998-01-01 00:00:00

abstract：:Purification of endothelin converting enzyme (ECE) from endothelial cells has been hindered by the difficulty in obtaining primary endothelial cells in large quantity. We therefore tested transformed human umbilical vein endothelial cells (EA.hy926) for ECE activity. Our data clearly demonstrate that this transformed ...

journal_title：Life sciences

authors： Ahn K,Pan S,Beningo K,Hupe D

更新日期：1995-01-01 00:00:00

abstract：:To study the source of immunoreactive epidermal growth factor (ir-EGF) released by thrombin formation we removed 99.9% of the leukocytes normally present in platelet-rich plasma and induced coagulation with 30 mM of Ca2+. The absence of leukocytes did not reduce the amount of ir-EGF released; thus platelets are most l...

journal_title：Life sciences

authors： Kiuru J,Viinikka L,Myllylä G,Pesonen K,Perheentupa J

更新日期：1991-01-01 00:00:00

abstract：:Recently, single-dose drug packaging systems, allowing the administration of multiple drugs in a single pill, have become popular for the convenience of the patient. The quality of drugs and an accurate measurement of their photostabilities within this system, however, have not been carefully addressed. Drugs that are...

journal_title：Life sciences

authors： Uwai K,Tani M,Ohtake Y,Abe S,Maruko A,Chiba T,Hamaya Y,Ohkubo Y,Takeshita M

更新日期：2005-12-12 00:00:00

abstract：AIMS:The present study was designed to compare the effects of a low-fat diet (LF), calorie restriction (CR), quercetin (Que) and exercise (Ex) on hepatic steatosis in a high-fat (HF) diet-induced obesity prone (OP) model in the perspective of microRNA (miR)-dependent thyroid hormone (TH) synthesis and action. MAIN MET...

journal_title：Life sciences

authors： Xia SF,Jiang YY,Qiu YY,Huang W,Wang J

更新日期：2020-02-01 00:00:00

abstract：AIMS:T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular Ca2+ concentration ([Ca2+]i). Our aim in the present study was to assess whether autocrine ACh released from T lymphocytes regulates their p...

journal_title：Life sciences

authors： Mashimo M,Iwasaki Y,Inoue S,Saito S,Kawashima K,Fujii T

更新日期：2017-03-01 00:00:00

abstract：:Neuropeptide Y (NPY) was found in high concentrations in the male genital tract. NPY levels were highest in the seminal vesicles, prostate, corpus cavernosum and vas deferens, where large numbers of immunoreactive nerve fibres were detected. Considerable quantities were also found in the epididymis and spongiosum. Low...

journal_title：Life sciences

authors： Adrian TE,Gu J,Allen JM,Tatemoto K,Polak JM,Bloom SR

更新日期：1984-12-24 00:00:00

abstract：:The effects of GABA antagonists, picrotoxin and bicuculline were studied on hyperphagia caused by insulin in free feeding rats. It was found that peripheral administration of GABA antagonists inhibited this hyperphagia. These agents were administered in the VMH and LH through stereotaxically implanted cannulae. It was...

journal_title：Life sciences

authors： Kamatchi GL,Bhakthavatsalam P,Chandra D,Bapna JS

更新日期：1984-06-04 00:00:00

abstract：:Differences in prevalence and mortality from coronary artery disease (CAD) were observed among the different Israeli ethnic groups. The incidence of CAD in Israel is highest among Ashkenazi Jews and is much lower among Yemenite Jews. In this present study, we selected 15 single nucleotide polymorphisms (SNPs) from 14 ...

journal_title：Life sciences

authors： Nakai K,Habano W,Nakai K,Fukushima N,Fujita T,Gurwitz D

更新日期：2004-07-09 00:00:00

abstract：AIMS:The aim of the present study was to characterize TRPV4 channels in pregnant and nonpregnant mouse uterus and examine their functional role in spontaneous and agonist-induced contractions. MAIN METHODS:We used RT-PCR, Western blot and immunohistochemistry experiments to demonstrate the presence of TRPV4 mRNA and p...

journal_title：Life sciences

authors： Singh V,Ram M,Kandasamy K,Thangamalai R,Choudhary S,Dash JR,Kumar D,Parida S,Singh TU,Mishra SK

更新日期：2015-02-01 00:00:00

abstract：:U-54494A, a 1,2-diamine anticonvulsant, and U-50488H, a structurally related agonist for opiate kappa receptors, were tested for effects on spontaneous and glutamate-evoked firing rates in cerebral cortex of urethane-anesthetized male Sprague-Dawley rats. Iontophoretic application of 1,2-diamines, glutamate diethyl et...

journal_title：Life sciences

authors： Ochoa MC,Vogelsang GD,Lum JT,VonVoigtlander PF,Piercey MF

更新日期：1992-01-01 00:00:00

abstract：:Using electric eel acetylcholinesterase (AChE) which was either membrane-bound (AChEm) or solubilized (AChEs), similar kinetics were seen in the absence of inhibitor or in the presence of edrophonium, trimethylammonium ion or paraoxon. Thus, both forms of the enzyme appear to behave similarly toward various inhibitors...

journal_title：Life sciences

authors： Lenz DE,Maxwell DM,Walden MB

更新日期：1984-01-16 00:00:00

abstract：AIM:Over-expression of histone deacetylase 8 (HDAC8) has been demonstrated in breast cancer. But the underlying molecular mechanism of HDAC8 on the progression of breast cancer remains unknown. MicroRNAs (miRs) are proposed as important molecules in cancer progression by targeting specific oncogenes or tumor-suppressor...

journal_title：Life sciences

authors： Menbari MN,Rahimi K,Ahmadi A,Elyasi A,Darvishi N,Hosseini V,Mohammadi-Yeganeh S,Abdi M

更新日期：2019-11-15 00:00:00

abstract：:The decrease of m-AChR density observed in neurodegenerative disorders has generated considerable interest in non-invasive mapping of muscarinic acetylcholine receptors (m-AChR) in the central nervous system. The aim of our study was to evaluate the selectivity of 4-bromodexetimide for the M1, M2, M3 and M4 m-AChR sub...

journal_title：Life sciences

authors： Strijckmans V,Coulon C,Kassiou M,Loc'h C,Mazière B

更新日期：1996-01-01 00:00:00

abstract：:The herbal medicine, Echinacea, is used for treatment and prevention of upper respiratory tract infections. Among the phytochemicals found in Echinacea, the bioavailable alkylamides are thought to be the compounds responsible for its effects on the human immune system. Cytochrome P450 enzymes (P450s) appear to be the ...

journal_title：Life sciences

authors： Toselli F,Matthias A,Gillam EM

更新日期：2009-07-17 00:00:00

abstract：AIMS:Colorectal cancer (CRC) is one of the most common cancers with poor prognosis worldwide. The advent of immunotherapy has greatly improved survival in refractory patients of CRC. In this study, we aimed to identify reliable immune classification and biomarkers that predict immunotherapeutic responses in CRC patient...

journal_title：Life sciences

authors： Li M,Li W,Yang X,Wang H,Peng Y,Yin J,Lu Y,Liu L,Shang J,Zhao Q

更新日期：2020-11-15 00:00:00

abstract：:Green tea polyphenols like epigallocatechin gallate (EGCG) have been proposed as a cancer chemopreventative. Several studies have shown that EGCG can act as an antioxidant by trapping proxyl radicals and inhibiting lipid peroxidation. The main propose of this study is to investigate the antioxidant capacity of EGCG us...

journal_title：Life sciences

authors： Saffari Y,Sadrzadeh SM

更新日期：2004-02-06 00:00:00

abstract：AIMS:The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by melatonin and serotonin. Agomelatine, which acts as an antidepressant and can synchronize disturbed circadian rhythms, displays a unique mechanism of action involving both melatonergic agonist and ...

journal_title：Life sciences

authors： Yang J,Jin HJ,Mocaër E,Seguin L,Zhao H,Rusak B

更新日期：2016-06-15 00:00:00

abstract：AIMS:To investigate how Placental Mesenchymal Stem Cells (P-MSCs) would adapt themselves and survive under hypoxic conditions which are prevalent in most injury sites. MAIN METHODS:P-MSCs were isolated from term placenta and characterised under normoxia and hypoxia (2-2.5% O2). Cells were examined for morphology and s...

journal_title：Life sciences

authors： Mathew SA,Chandravanshi B,Bhonde R

更新日期：2017-08-01 00:00:00