Abstract：
:Extracts of plasma obtained from adult humans before and immediately after physical stress were subjected to high pressure liquid chromatography (HPLC); extracts or HPLC fractions, resp., were analysed for the presence of human beta-endorphin (beta H-endorphin) or fragments thereof by several radioimmunoassays using antibodies directed against the C-terminus and two "middle" regions of beta H-endorphin. Using an antibody ("Don Antonio") apparently directed against a beta H-endorphin fragment including positions 17 to 22 or somewhat adjacent regions, concentrations of beta H-endorphin immunoreactivity were found to be in the well-known range under normal conditions and to increase after physical stress. However, only a minor portion of this material proved to be identical with beta H-endorphin, whereas the major portion behaved like a smaller fragment thereof. In addition, high amounts of an immunoreactive material obviously containing a C-terminal sequence of beta H-endorphin were found, indicating the presence of an immunologically relevant beta H-endorphin fragment in the plasma.
journal_name
Life Scijournal_title
Life sciencesauthors
Wiedemann K,Teschemacher Hdoi
10.1016/0024-3205(83)90451-4subject
Has Abstractpub_date
1983-01-01 00:00:00pages
89-92eissn
0024-3205issn
1879-0631pii
0024-3205(83)90451-4journal_volume
33 Suppl 1pub_type
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